Patents Assigned to Hexima Limited
-
Publication number: 20150158918Abstract: The present invention relates to compositions and methods for preventing or treating proliferative diseases. In particular, the present invention relates to the use of compositions derived or derivable from plants, such as plant defensins, particularly in methods for the prevention or treatment of proliferative diseases such as cancer. The present invention also relates to associated uses, systems and kits.Type: ApplicationFiled: October 19, 2012Publication date: June 11, 2015Applicants: HEXIMA LIMITED, BALMORAL AUSTRALIA PTY LTDInventors: Mark Darren Hulett, Fung Tso Lay
-
Publication number: 20140259231Abstract: A multigene expression vehicle (MGEV) consisting essentially of a polynucleotide comprising 2 to 8 domain segments, D, each domain encoding a functional protein, each domain being joined to the next in a linear sequence by a Linker (L) segment encoding a Linker peptide, the D and L segments all being in the same reading frame, and at least one of the domains is not a type two protease inhibitor.Type: ApplicationFiled: February 14, 2014Publication date: September 11, 2014Applicant: Hexima LimitedInventors: Marilyn Anne Anderson, Robyn Louise Heath
-
Publication number: 20140208461Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: ApplicationFiled: March 24, 2014Publication date: July 24, 2014Applicant: HEXIMA LIMITEDInventors: Marilyn Anne ANDERSON, Fung Tso LAY, Robyn Louise HEATH
-
Patent number: 8722968Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: GrantFiled: August 28, 2012Date of Patent: May 13, 2014Assignee: Hexima LimitedInventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
-
Publication number: 20140130209Abstract: This disclosure relates generally to the field of anti-pathogenic agents, including a modified defensin molecule with anti-pathogen activity. Genetically modified plants and their progeny or parts expressing or containing the modified defensin and anti-pathogen compositions for use in horticulture and agriculture and as animal and human medicaments are also provided.Type: ApplicationFiled: February 7, 2012Publication date: May 8, 2014Applicant: HEXIMA LIMITEDInventors: Nicole Van Der Weerden, Marily Anne Anderson
-
Publication number: 20130269059Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: ApplicationFiled: March 15, 2013Publication date: October 10, 2013Applicant: Hexima LimitedInventors: Robyn Louise HEATH, Marilyn Anne Anderson, Nicole Louise van der Weerden, James Anthony McKenna, Simon Poon
-
Publication number: 20130047299Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: ApplicationFiled: August 28, 2012Publication date: February 21, 2013Applicant: Hexima LimitedInventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
-
Patent number: 8252898Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: GrantFiled: February 18, 2010Date of Patent: August 28, 2012Assignee: Hexima LimitedInventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
-
Patent number: 8242250Abstract: The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as acyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation.Type: GrantFiled: August 26, 2009Date of Patent: August 14, 2012Assignees: The University of Queensland, Hexima LimitedInventors: David James Craik, Marilyn Anne Anderson, Cameron Victor Jennings
-
Publication number: 20100218280Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: ApplicationFiled: February 18, 2010Publication date: August 26, 2010Applicant: HEXIMA LIMITEDInventors: MARILYN ANNE ANDERSON, FUNG TSO LAY, ROBYN LOUISE HEATH
-
Publication number: 20100095408Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: ApplicationFiled: August 4, 2009Publication date: April 15, 2010Applicant: Hexima LimitedInventors: Robyn Louise Heath, Marilyn Anne Anderson, Nicole Louise van Der Weerden, James Anthony McKenna, Simon Poon
-
Publication number: 20100068762Abstract: The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as acyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation.Type: ApplicationFiled: August 26, 2009Publication date: March 18, 2010Applicants: THE UNIVERSITY OF QUEENSLAND, HEXIMA LIMITEDInventors: David James Craik, Marilyn Anne Anderson, Cameron Victor Jennings
-
Patent number: 7592433Abstract: The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems or chemical means. The cyclised amino acid sequence is generally in the form of a stabilized folded structure such as a cyclic knotted peptide, polypeptide or protein or functional equivalent. The nucleic acid molecules and cyclic and linear peptides are useful inter alia in the generation of molecules having animal or plant therapeutic properties, as well as in a range of diagnostic, industrial and agricultural, including horticultural, applications. Of particular importance is the use of these molecules in the protection of plants, such as crop plants, from pest and/or pathogen infestation.Type: GrantFiled: November 3, 2000Date of Patent: September 22, 2009Assignee: The University of Queensland; Hexima LimitedInventors: David James Craik, Marilyn Anne Anderson, Cameron Victor Jennings
-
Publication number: 20090197809Abstract: A system for reducing the incidence or severity of fungal infection of a plant, comprising a chemical fungicide component, which may be provided by foliar or root (soil or liquid nutrient) application, together with an antifungal plant defensin not in nature expressed in the plant being protected or expressed in lower amounts or in different tissues, provides synergistic improvement in protection against infection by a plant pathogenic fungus which is susceptible to the defensin and the fungicide. The fungicide can be a strobilurin or a triazole, and the defensin can be selected from a wide range of known defensins, for example, NaD1 and others, or it can be a chimeric defensin engineered for low toxicity to the plant. The defensin can be provided as a protein formulation, optionally together with the fungicide, or it can be provided by recombinant expression in the plant to be protected from fungal infection.Type: ApplicationFiled: January 30, 2009Publication date: August 6, 2009Applicant: Hexima LimitedInventors: Marilyn Anderson, Robyn Heath, James McKenna, Nicole van der Weerden
-
Publication number: 20090188010Abstract: The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut of Helicoverpa armigera and Helicoverpa punctigera insect larvae when fed the serine proteinase inhibitors of Nicotiana alata. The novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control of Helicoverpa spp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity.Type: ApplicationFiled: November 20, 2008Publication date: July 23, 2009Applicant: Hexima LimitedInventors: Kerry Michelle Dunse, Robyn Louise Heath, Marilyn Anne Anderson
-
Patent number: 7544861Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: GrantFiled: March 10, 2006Date of Patent: June 9, 2009Assignee: Hexima LimitedInventors: Marilyn Anne Anderson, Fung Tso Lay, Robyn Louise Heath
-
Publication number: 20090069545Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: ApplicationFiled: July 30, 2007Publication date: March 12, 2009Applicant: HEXIMA LIMITEDInventors: MARILYN ANNE ANDERSON, FUNG TSO LAY, ROBYN LOUISE HEATH
-
Patent number: 7462695Abstract: The present invention relates generally to a novel chymotrypsin that exhibits resistance to a plant serine proteinase inhibitor. More particularly, the present invention provides a chymotrypsin which is up-regulated in the gut of Helicoverpa armigera and Helicoverpa punctigera insect larvae when fed the serine proteinase inhibitors of Nicotiana alata. The novel chymotrypsin represents, therefore, a target for the identification of antagonists including inhibitors which are proposed to be useful in the control of Helicoverpa spp. populations that have become resistant to serine proteinase inhibitors produced in plants. The antagonists of the chymotrypsin may be topically applied to the plants or, when in proteinaceous form, may be produced by genetic means in plant cells. The antagonists may act at the level of gene expression or protein activity.Type: GrantFiled: April 23, 2004Date of Patent: December 9, 2008Assignee: Hexima LimitedInventors: Kerry Michelle Dunse, Robyn Louise Heath, Marilyn Anne Anderson
-
Patent number: 7410796Abstract: The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complementary to a sequence which encodes a type II serin proteinase inhibitor (PI) precursor from a plant wherein the precursor comprises at least three PI monomers and wherein at least one of the monomers has a chymotrypsin specific site and at least one other of the monomers has a trypsin specific site.Type: GrantFiled: November 13, 2006Date of Patent: August 12, 2008Assignee: Hexima LimitedInventors: Marilyn Anne Anderson, Angela Hilary Atkinson, Robyn Louise Heath, Adrienne Elizabeth Clarke
-
Publication number: 20080134367Abstract: The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to isolated monomers of a type II serine proteinase inhibitor.Type: ApplicationFiled: October 31, 2007Publication date: June 5, 2008Applicant: HEXIMA LIMITEDInventors: Marilyn Anne Anderson, Angela Hilary Atkinson, Robyn Louise Heath, Adrienne Elizabeth Clarke