Patents Assigned to Hisamitsu Pharmaceutical Co., Inc.
  • KIT AND METHOD FOR IDENTIFICATION OF CAUSATIVE BACTERIUM OF NAIL TINEA
    Publication number: 20120309005
    Abstract: It is an object of the invention to provide a kit and method for identification of causative fungi of tinea unguium, which allows rapid and accurate identification of causative fungi by real-time PCR using primer sets and probes specific for fungal species.
    Type: Application
    Filed: December 3, 2010
    Publication date: December 6, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Koichi Makimura, Yoshiharu Miyajima, Shinichi Watanabe
  • ADHESIVE PATCH FOR TREATMENT OF TINEA UNGUIUM
    Publication number: 20120302644
    Abstract: The present invention provides an adhesive patch for the treatment of tinea unguium intended to be applied once a day, comprising terbinafine and/or a pharmacologically acceptable salt thereof in an amount of 3 mg/cm2, wherein the adhesive patch is used so that the terbinafine concentration in nails may be 295±127 ng/mg and the terbinafine concentration in plasma may be 23 pg/mL or less, 8 weeks after the start of application, per cm2 of the patch size.
    Type: Application
    Filed: February 7, 2011
    Publication date: November 29, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Arata Toshimitsu, Naoko Fujita, Toshihiro Kogure
  • MICRONEEDLE DEVICE
    Publication number: 20120283642
    Abstract: A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 8, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toshiyuki MATSUDO, Tetsuji KUWAHARA, Seiji TOKUMOTO
  • Method of manufacturing microneedle
    Patent number: 8292696
    Abstract: A method of manufacturing a microneedle including the steps of forming a plurality of first linear grooves on a substrate in parallel to one another along a first direction using grinding, and forming a plurality of second linear grooves on the substrate in parallel to one another in a second direction intersecting the first direction using grinding.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: October 23, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Hiroshi Sugimura, Gaku Suzuki, Masahiro Ueno, Yoshihiro Kodama, Takao Tomono
  • ADHESIVE PATCH
    Publication number: 20120253255
    Abstract: An adhesive patch easily applied to the skin. An adhesive patch 10 according to the present invention includes a support 12, a pressure-sensitive adhesive agent layer 14 provided on one surface of the support, a release sheet 16 which is releasably attached to the pressure-sensitive adhesive agent layer, and a weakened part 20 which is formed in the release sheet, that is for easily dividing the release sheet, and further, a pinching piece forming sheet 18 is fixed so as to cover the weakened part 20 on the release sheet, and portions of the pinching piece forming sheet other than the fixed portions 22 function as pinching pieces 18a and 18b, and in the pinching piece forming sheet as well, a weakened part 20 for easily dividing the release sheet is formed at a position corresponding to the weakened part of the release sheet.
    Type: Application
    Filed: September 30, 2010
    Publication date: October 4, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Mitsutoshi Tsuruta, Kentaro Ishimatsu, Kiyotaka Takada
  • Iontophoresis device activated in use
    Patent number: 8275454
    Abstract: An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided. This iontophoresis device activated in use comprises: an absorber 11 formed of a material containing a dry drug 10 and capable of absorbing a liquid; a wall material 13 disposed around the absorber 11, having an adhesive layer 12 on the undersurface thereof; a support 15 disposed on the absorber 11 and the wall material 13, having an opening 14 in the central portion thereof; an electrode 25 disposed on the undersurface of the support 15; a diaphragm 20 disposed on the support 15; and a dissolution liquid reservoir 18 disposed on the diaphragm 20, retaining a dissolution liquid for dissolving the drug between the diaphragm 20 and itself, and having a protruding portion 17 for destroying the diaphragm 20 by pressing force.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: September 25, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Hirotoshi Adachi, Seiji Tokumoto, Naruhito Higo
  • METHOD AND APPARATUS FOR MANUFACTURING ADHESIVE PATCH
    Publication number: 20120234484
    Abstract: A method and an apparatus for manufacturing an adhesive patch which is easily applied to the skin. The method includes a first step of forming a pressure-sensitive adhesive agent layer 14 on a support 12, a second step of fixing a pinching piece forming sheet 18 on a release sheet 16, a third step of forming a weakened part 20 in the release sheet 16 and the pinching piece forming sheet 18, and a fourth step of releasably adhering the release sheet 16 to which the pinching piece forming sheet 18 is fixed, that has been obtained in the third step, to the pressure-sensitive adhesive agent layer 14 on the support 12, that has been obtained in the first step.
    Type: Application
    Filed: September 30, 2010
    Publication date: September 20, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventor: Kiyotaka Takada
  • PERCUTANEOUS ABSORPTION TYPE PLASTER
    Publication number: 20120171278
    Abstract: A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is 1/3 times by mass to 4 times by mass as that of the rosin-based resin.
    Type: Application
    Filed: March 13, 2012
    Publication date: July 5, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yasunori TAKADA, Koji TANAKA, Yasuhiro IKEURA
  • Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration
    Publication number: 20120156258
    Abstract: An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
    Type: Application
    Filed: February 7, 2012
    Publication date: June 21, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Hirotoshi Adachi, Tetsuji Kuwahara
  • Cancer marker and therapeutic agent for cancer
    Patent number: 8202690
    Abstract: A novel cancer marker is provided. A method for detecting cancer using a level of BMCC1 gene expression as an indication is provided, in which the cancer is selected from the group consisting of prostate cancer, lung cancer, gastric cancer, bladder cancer, and uterine cancer.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: June 19, 2012
    Assignees: Hisamitsu Pharmaceutical Co., Inc., Chiba-Prefecture
    Inventors: Yasutoshi Tatsumi, Akira Nakagawara
  • MICRONEEDLE ARRAY
    Publication number: 20120136312
    Abstract: Relations between crystallinity and performance of a biodegradable resin, between weight-average molecular weight and strength thereof, and between weight-average molecular weight and performance thereof were clarified. As a result thereof, when a microneedle array was provided with microneedles containing noncrystalline polylactic acid which had a weight-average molecular weight of 40,000 to 100,000, it was possible to obtain a microneedle array which could maintain its functional performance.
    Type: Application
    Filed: July 15, 2010
    Publication date: May 31, 2012
    Applicants: TOPPAN PRINTING CO., LTD., HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takaaki Terahara, Seiji Tokumoto, Akira Tamura, Yumiko Yamada
  • MICRONEEDLE DEVICE
    Publication number: 20120130306
    Abstract: Provided is a microneedle device where a coating agent has been applied to microneedles having a biodegradable resin. It has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength allows the microneedles to have excellent performance. Further, with regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate performance. Accordingly, when a microneedle device 1 is arranged so that at least a part of a microneedle array 2 provided with microneedles 3 made from polylactic acid having a weight average molecular weight of 40,000 or more is coated with a carrier containing physiologically active ingredients, it is possible to attain excellent migration characteristics of the physiologically active ingredients to a living body.
    Type: Application
    Filed: June 10, 2010
    Publication date: May 24, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takaaki Terahara, Seiji Tokumoto
  • Method for avoiding crystallization of anti-inflammatory agent in plaster formulation
    Patent number: 8173156
    Abstract: An anti-inflammatory-containing plaster is provided. The anti-inflammatory-containing plaster may include, e.g., a styrene-isoprene-styrene block copolymer, a high molecular weight polyisobutylene, a low molecular weight polyisobutylene, a tackifier, a plasticizer, a dispersant, and an anti-inflammatory having a carboxyl group or a salt thereof. However, the anti-inflammatory-containing plaster does not contain L-menthol. The anti-inflammatory-containing plaster has medicament release rates of 20-64% by mass and 40-93% by mass at one hour and three hours, respectively.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: May 8, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Yasuhiro Ikeura, Miyuki Shinmura
  • Adhesive patch
    Patent number: 8173155
    Abstract: The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: May 8, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Takashi Yasukochi, Tetsuro Tateishi, Naruhito Higo
  • NEEDLE DEVICE
    Publication number: 20120101457
    Abstract: A needle device is provided, which includes a support portion having a first and second main surface and at least one projecting portion extending from the first main surface of the support portion. The projecting portion is constituted of a material includes pectin and an alginate.
    Type: Application
    Filed: December 9, 2011
    Publication date: April 26, 2012
    Applicants: HISAMITSU PHARMACEUTICAL CO., INC., TOPPAN PRINTING CO., LTD
    Inventor: Hiroyuki KATO
  • ADHESIVE PATCH-CONTAINING PACKAGE BAG AND METHOD FOR STORING ADHESIVE PATCH
    Publication number: 20120090275
    Abstract: The present invention relates to an adhesive patch-containing package bag 1, having: a package bag 8; and an adhesive patch 10 stored inside the package bag 8, wherein the adhesive patch 10 has a backing 12, an adhesive layer 14 laminated on at least one side of the backing 12 and containing ropinirole and/or a pharmaceutically acceptable salt thereof, and a release liner 16 covering the adhesive layer 14, and a relative humidity at 4° C. is maintained at 35% or higher inside the package bag 8.
    Type: Application
    Filed: April 23, 2010
    Publication date: April 19, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoyuki Uchida, Yuka Takagi, Yasunori Takada
  • COMPOSITION AND DEVICE STRUCTURE FOR IONTOPHORESIS
    Publication number: 20120095386
    Abstract: Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
    Type: Application
    Filed: October 1, 2010
    Publication date: April 19, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Hirotoshi Adachi, Noriyuki Kuzumaki, Tetsuya Arimoto, Naruhito Higo
  • Spray container
    Patent number: D660706
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: May 29, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Sayaka Mochizuki, Yuichi Toyofuku, Tomoko Handa
  • Medical patch
    Patent number: D668766
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 9, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc
    Inventors: Isao Miyachi, Yuichi Takano, Hiromitsu Tsunoda
  • Medical transdermal patch
    Patent number: D670395
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: November 6, 2012
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Masato Wakamatsu, Kazuyuki Hirose, Yukiko Sueyoshi