Abstract: This invention relates to a process for the preparation of a product of the formula ##STR1## wherein R is loweralkyl; R.sub.1 is hydrogen, loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, lowerbicycloalkyl, aryl or arylloweralkyl; Rs is loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, lowerbicycloalkyl, aryl or arylloweralkyl; or R.sub.1 and R.sub.2 taken together with the nitrogen atom to which they are attached form a group of the formula (Ia) ##STR2## wherein Y is hydrogen or loweralkyl and Z is hydrogen, loweralkyl, halogen, loweralkoxy or hydroxy; X is loweralkyl, loweralkoxy, halogen or trifluoromethyl; and m is 0, 1 or 2; or a pharmaceutically acceptable salt thereof; which process comprises(a) contacting a compound of formula (II) as defined herein with fortified hydrogen bromide to afford a compound of formula (III) as defined herein; contacting the reaction mixture containing a compound of formula (III) with either (1) an isocyanate of formula R.sub.
Abstract: The present invention relates to novel processes for preparing intermediates of the formula I ##STR1## and to novel intermediates thereof which are useful in the preparation of inhibitors of enkephalinase and angiotensin converting enzyme.
Type:
Grant
Filed:
November 4, 1996
Date of Patent:
March 31, 1998
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gary A. Flynn, Michael J. Genin, Douglas W. Beight
Abstract: Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.
Type:
Grant
Filed:
February 26, 1997
Date of Patent:
March 17, 1998
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
David M. Fink, Barbara E. Kurys, Gregory M. Shutske, John D. Tomer, IV
Abstract: The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and b) treating the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100.degree. C. to about 20.degree. C. The cis-4-O-protected-substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.
Type:
Grant
Filed:
February 1, 1996
Date of Patent:
March 17, 1998
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
Timothy T. Curran, David A. Hay, Jonathan C. Evans
Abstract: This invention relates to 4- and 6-carbamates related to physostigmine of the formula ##STR1## where R.sub.1 is alkyl, cycloalkyl, bicycloalkyl, aryl or arylloweralkyl; R.sub.2 is hydrogen or alkyl or the group --NR.sub.1 R.sub.2 taken together forms a monocyclic or bicyclic ring of 5 to 12 carbons; m is 0, 1, or 2; each X is independently hydrogen, halogen, loweralkyl, nitro or amino; and the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and optical isomers and racemic mixtures thereof. This invention also relates to novel intermediates useful in the preparation of the 4- and 6-carbamates. The compounds of this invention display utility for alleviating various memory dysfunctions characterized by a decreased cholinergic function, such as Alzheimer's disease.
Abstract: This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.5 and Y.sub.9 are each nitrogen and Y.sub.7 and Y.sub.8 are a CH group,R is a C.sub.1 -C.sub.7 alkyl acyl or aryl acyl,Q is NH.sub.2, halogen or hydrogen,Z is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
March 3, 1998
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
Abstract: These are disclosed novel 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives of the formula ##STR1## where the substituents are as defined in the specification, which are useful as acetylcholinesterase inhibitors and as such may be useful for the treatment of Alzheimer's disease and other senile dementias.
Abstract: This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.
Type:
Grant
Filed:
March 7, 1996
Date of Patent:
December 16, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gilbert Marciniak, Richard A. Schnettler, Timothy A. Ayers, Damian J. Krysan
Abstract: Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
December 9, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gregory M. Shutske, Brian S. Freed, John D. Tomer, IV, R. Richard L. Hamer
Abstract: This invention relates to compounds of the formula ##STR1## wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.
Type:
Grant
Filed:
June 27, 1996
Date of Patent:
December 9, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Mark G. Palermo, Lawrence L. Martin, Peter A. Nemoto
Abstract: The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.
Abstract: The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.
Abstract: This invention relates to oxazolidine inhibitors of calpain and/or cathepsin B and to compositions containing them. As inhibitors of calpain and/or cathepsin B, the compounds are useful in the treatment of patients afflicted with acute or chronic neurodegenerative disorders.
Type:
Grant
Filed:
December 11, 1995
Date of Patent:
November 25, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Norton P. Peet, Shujaath Mehdi, Matthew D. Linnik, Michael R. Angelastro, Hwa-Ok Kim
Abstract: This invention relates to compounds of the formula ##STR1## where R.sub.1 -R.sub.6, X and Y are as defined in the specification, which are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit and thus may be indicated in the treatment of Alzheimer's disease.
Type:
Grant
Filed:
May 31, 1995
Date of Patent:
November 18, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Richard C. Effland, Larry Davis, Gordon E. Olsen
Abstract: Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
November 11, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gregory M. Shutske, Brian S. Freed, John D. Tomer, IV, R. Richard L. Hamer
Abstract: Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
November 11, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gregory M. Shutske, Brian S. Freed, John D. Tomer, IV, R. Richard L. Hamer
Abstract: This invention relates to 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; or R.sub.2 and R.sub.3 together form a cycloalkane ring of 4 to 6 carbons or a spiro-fused aryl cycloalkane or heterocycloalkyl selected from the group consisting of piperidine and tetrahydropyran; X and Y are independently hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; m and n are independently integers of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and, where applicable the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics, anticonvulsants, for enhancing memory and for the treatment of Alzheimer's disease.
Type:
Grant
Filed:
April 28, 1995
Date of Patent:
November 11, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Richard C. Effland, David G. Wettlaufer
Abstract: Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
November 11, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gregory M. Shutske, Brian S. Freed, John D. Tomer, IV, R. Richard L. Hamer
Abstract: Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
November 4, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Gregory M. Shutske, Brian S. Freed, John D. Tomer, IV, R. Richard L. Hamer
Abstract: The present invention relates to a novel process for preparing (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, also known in the art as (E)-(p-fluorophenethyl)-3-fluoroallylamine, novel intermediates thereof, a novel process for the preparing (E)-2-(fluoromethylene)-4-(p-fluorophenyl)butan-1-ol, and a novel process for preparing alkali metal salts of diformylamide.
Type:
Grant
Filed:
August 25, 1995
Date of Patent:
October 21, 1997
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Jonathan C. Evans, Christian T. Goralski, Daniel R. Henton, Cynthia L. Rand, Paul C. Vosejpka