Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
Abstract: There is disclosed a process for the preparation of 1-aminoacetamidopyrroles and 1-amino-2-(substituted)-pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias which comprises treating a 1-phthalimidopyrrole of the formula ##STR2## with a base to yield a 1-aminopyrrole of the formula ##STR3## which is reacted with a compound of the formula ##STR4## to obtain the compound of Formula (I).
Type:
Grant
Filed:
November 7, 1994
Date of Patent:
December 3, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Lawrence L. Martin, Raymond W. Kosley, Jr., Denise M. Flanagan, Gert U. Kuerzel, Peter A. Nemoto, David G. Wettlaufer
Abstract: There are disclosed 1-aminoacetamidopyrroles and 1-amino-2-(substituted)pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias.
Type:
Grant
Filed:
November 7, 1994
Date of Patent:
November 19, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Lawrence L. Martin, Raymond W. Kosley, Jr., Denise M. Flanagan, Gert U. Kuerzel, Peter A. Nemoto, David G. Wettlaufer
Abstract: The present invention provides an oral pharmaceutical composition in solution form, comprising,a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; andb) a suitable solvent systems, comprising propylene glycol and glacial acetic acid.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
November 12, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Thomas T. Ortyl, Paul F. Skultety, Gail H. Hurst
Abstract: 2,3-dihydro-1H-isoindole derivatives of the formula ##STR1## where R.sub.1 -R.sub.5 and X are defined herein which are useful as serotonin reuptake inhibitors are disclosed. As such, these compounds may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
Abstract: There are disclosed compounds having the formula ##STR1## wherein X, Y, Z and R.sub.1 -R.sub.6 are defined in the specification and pharmaceutically acceptable addition salts thereof, or where applicable, the optical or geometrical isomers or racemic mixtures thereof, intermediates in the process for making the compounds, a process for making the compounds and pharmaceutical compositions and method of use as neuroprotective agents.
Type:
Grant
Filed:
March 25, 1994
Date of Patent:
October 15, 1996
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
Raymond W. Kosley, Jr., Denise M. Flanagan, Lawrence L. Martin, Peter A. Nemoto
Abstract: The present invention is new 3-(heterocyclic)-propenoic acid derivatives and pharmaceutical compositions thereof. These new 3-(heterocyclic)-propenoic acid derivatives are useful as NMDA antagonist.
Type:
Grant
Filed:
October 31, 1994
Date of Patent:
October 8, 1996
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
Boyd L. Harrison, Philip L. Nyce, Robert A. Farr
Abstract: There are disclosed various compounds of the formula below, ##STR1## where the parameters X, Y, R.sub.1 and R.sub.2 are as defined in the specification which are useful as antidepressant and analgesic agents.
Abstract: A compressed tablet comprising aminoguanidine or a pharmaceutically acceptable salt thereof and a suitably compatible binder prepared by spray drying techniques from an aminoguanidine solution, and methods of making same.
Type:
Grant
Filed:
December 22, 1994
Date of Patent:
July 9, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Phillip E. Page, Jonathan Berman, Janet M. Pence, Sharon K. Minish
Abstract: A coupling device is provided for coupling peripheral flanges of first and second pipes. The device comprises first and second arcuate retaining members, coupling structure and a latching mechanism. The coupling device is capable of being initially set via the latching mechanism so as to permit the coupling device to securely couple two pipe flanges of a given diameter. After being initially set, the device is capable of being easily and quickly disassembled and reassembled about the peripheral flanges of the two pipes.
Type:
Grant
Filed:
November 29, 1994
Date of Patent:
June 4, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
David L. Flick, Perry J. Parkhurst, Lauren W. Burnett
Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.
Type:
Grant
Filed:
October 6, 1993
Date of Patent:
May 21, 1996
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
Richard C. Effland, Joseph T. Klein, Lawrence L. Martin
Abstract: This application relates to a process for the preparation of indolylpyridooxazines of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification which comprises cyclizing compound of the formula ##STR2## in the presence of a strong base such as sodium hydride or potassium t-butoxide.
Type:
Grant
Filed:
October 20, 1993
Date of Patent:
May 21, 1996
Assignee:
Hoechst Marion Roussel Inc.
Inventors:
Richard C. Effland, Larry Davis, Gordon E. Olsen
Abstract: Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.
Type:
Grant
Filed:
October 24, 1991
Date of Patent:
April 23, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
Lawrence L. Martin, Joseph F. Payack, Salvatore M. Brucato
Abstract: This invention relates to quaternary ammonium salts of certain 2H-1-benzopyran derivatives, to the intermediates and processes useful for their preparation, to their free-radical scavenger and cellular protective properties and to their end-use application as therapeutic agents.
Type:
Grant
Filed:
September 27, 1994
Date of Patent:
March 19, 1996
Assignee:
Hoechst Marion Roussel, Inc.
Inventors:
J. Martin Grisar, Margaret A. Petty, Frank Bolkenius