Patents Assigned to Hoechst
  • Ring fused dihydropyrans, process for preparation and use thereof
    Patent number: 6399653
    Abstract: The invention relates to compounds of the formula I in which the radicals R1, R2, R3 and A have the meaning mentioned in the description. The invention further relates to a process for the preparation of the compounds of the formula I by means of solid-phase synthesis, and use thereof as pharmaceuticals.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: June 4, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Stephan Henke
  • Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals
    Publication number: 20020058838
    Abstract: Benzenesulfonylureas and -thioureas of the formula I 1
    Type: Application
    Filed: November 29, 2001
    Publication date: May 16, 2002
    Applicant: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Dieter Mania, Jens Hartung, Heinz Gogelein, Joachim Kaiser, Wolfgang Linz, David Wettlaufer
  • Vitronectin receptor antagonists, their preparation and their use
    Patent number: 6387895
    Abstract: The present invention relates to compounds of the formula I A—B—D—E—F—G  (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: May 14, 2002
    Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Cell-specific active compounds regulated by the cell cycle
    Patent number: 6384202
    Abstract: A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated in a cell-specific or virus-specific manner and this activation is regulated by the promoter module in a cell cycle-specific manner. The choice of activator sequence and active substance depends on the indication area. The DNA sequence is inserted into a viral or non-viral vector which is supplemented by a ligand having affinity for the target cell.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: May 7, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans-Harald Sedlacek, Rolf Müller
  • Benzoylcyclohexanediones, process for their preparation and their use as herbicides and plant growth regulators
    Patent number: 6376429
    Abstract: Benzoylcyclohexanediones of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described. In this formula (I), R11, R2, R3, R4, R5, R6 and R7 are various radicals, L is an alkylene chain, and Y and Z are a monoatomic bridge element.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: April 23, 2002
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Andreas Van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Christopher Rosinger
  • Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
    Publication number: 20020045583
    Abstract: Substituted benzothiepine 1,1-dioxide derivatives of formula I: 1
    Type: Application
    Filed: February 2, 2001
    Publication date: April 18, 2002
    Applicant: Hoechst Marion Roussel Deutschland
    Inventors: Wendelin Frick, Alfons Enhsen, Heiner Glombik, Hubert Heuer
  • Supported catalysts having a high sintering stability and a process for producing them
    Patent number: 6372687
    Abstract: Supported catalysts having a high sintering stability and comprising one or more noble metal cluster carbonyl compounds of the formula (1) [HaMbNcLd(CO)x]n−An+ and their use for the dehydrogenation, hydrogenation and oxidation of organic compounds where M and N are, independently of one another, one or more metals selected from the group consisting of Pt, Rh, Ir, Os, Ru, Ag, Pd, Au, Ni, Fe, Co, Cu, Re, Mn; L is one or more neutral or anionic ligands which may be identical or different; (A)n+ is one or more cations which balance the charge of the complex; a is an integer from 0 to 10, preferably from 0 to 6; b is an integer from 2 to 60; c is an integer from 0 to 30; d is an integer from 0 to 60; x is an integer from 1 to 120; n is the total charge of the complex which results from the individual charges of the constituents and is greater than 0, wher
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: April 16, 2002
    Assignee: Hoechst Research & Technology
    Inventors: Alfred Hagemeyer, Harald Werner, Uwe Dingerdissen, Klaus Kühlein, John Meurig Thomas, Brian F. G. Johnson, D. S. Shephard, T. Maschmeyer
  • Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use
    Publication number: 20020042381
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described.
    Type: Application
    Filed: April 13, 2001
    Publication date: April 11, 2002
    Applicant: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Krammer, Hans-Ludwig Schafer
  • Method of priming polyolefin articles for coating
    Patent number: 6368677
    Abstract: A method for providing a waterborne, inorganic barrier coating to a polyolefin substrate is described. The method involves applying a primer composition containing a vinyl polymer, wherein at least 75% of the polymer repeat units contain side groups having hydroxyl moieties, to the substrate. This primer coating facilitates the application and binding of the subsequently applied barrier coating composition to the substrate.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: April 9, 2002
    Assignee: Hoechst Trespaphan GmbH
    Inventors: Michael A. Hubbard, James A. McCaulley, Douglas R. Holcomb
  • Process for preparation of hydrophilic or partially hydrophilic inorganic aerogels
    Patent number: 6365638
    Abstract: Process for preparation of hydrophilic or partially hydrophilic inorganic aerogels. The invention relates to a process for the preparation of hydrophilic or partially hydrophilic inorganic aerogels, which comprises pyrolyzing a hydrophobic inorganic aerogel in the presence of oxygen at temperatures in the range from 100 to 1000° C.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: April 2, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Fritz Schwertfeger, Andreas Zimmermann
  • Process for the preparation of 4,6-disubstituted 2-isocyanatopyrimidines and their use as intermediates for active compound syntheses
    Patent number: 6365739
    Abstract: Isocyanates of the formula (I) in which X and Y are defined as in formula (I) of claim 1 can be prepared by reacting a compound of the formula (II) or its salts in which X and Y are defined as in formula (I), with 1 to 6 mol of phosgene per mole of compound of the formula (II), in the presence of 2 to 3.5 molar equivalents of a base per mole of compound of the formula (II) and in the presence of an aprotic organic solvent at a reaction temperature in the range from −30 to +60° C. to give the compound of the formula (I). The compounds (I) can be converted by reaction with nucleophiles to give addition products, such as carbamates, ureas and sulfonylureas and corresponding products, e.g. herbicidal sulfonylureas.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: April 2, 2002
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Mark James Ford, Stephen Lachhein
  • Process for patterning poly(arylenevinylene) polymer films by irradiation with light
    Patent number: 6361917
    Abstract: A process for forming a pattern which comprises irradiating with light a film of a poly(arylenevinylene) polymer represented by the following formula (I) —(Ar—CR1=CR2)n—  (I) wherein Ar is a substituted or unsubstituted divalent aromatic hydrocarbon group or a substituted or unsubstituted divalent heterocyclic ring group, and the aromatic hydrocarbon group and the heterocyclic ring group may be a fused ring, R1, R2 independently of each other, are H, CN, alkyl, alkoxy are substituted or unsubstituted aromatic hydrocarbon groups or substituted or unsubstituted aromatic heterocycles, which may both be fused rings, and n is an integer of 2 or more. It is preferred that either R1 or R2 is H and more preferred that both R1 and R2 are H.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: March 26, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wen-Bing Kang, Nu Yu, Akihiko Tokida
  • Method for producing glufosinates and intermediate products for the same
    Patent number: 6359162
    Abstract: Glufosinate and the 2-methyl analog thereof can be prepared in a multi-step synthesis from methylphosphorus compounds (II) with unsaturated keto compounds (III) via adducts (IV), subsequent reaction under the conditions of a Strecker synthesis and finally hydrolysis of the aminonitrile (V): Step 1: Step 2: Step 3: Hydrolysis of (V) to give glufosinate Depending on process conditions and substrates, various compounds can be identified as adducts (IV).
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: March 19, 2002
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventor: Lothar Willms
  • Process for the purification of wastewater from the aldolization reaction
    Patent number: 6358419
    Abstract: Wastewater from the aldolization reaction is purified by adjusting its pH to 0 to 6, followed by extraction with monohydric alcohols having at least 8 carbon atoms, hydrocarbons having at least 6 carbon atoms, and mixtures thereof. In some cases, adjustment of the pH causes the formation of an organic phase, which is separated from the remaining wastewater before extraction.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: March 19, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Mariola Rötzheim, Wolfgang Greb, Wolfgang Zgorzelski, Carl Dieter Frohning, Klaus Denkmann, Heinz Kalbfell
  • New derivatives of erythromycin, their preparation process and their use as medicaments
    Publication number: 20020028781
    Abstract: A subject of the invention is, as new chemical products, the compounds of formula (I) 1
    Type: Application
    Filed: December 11, 2000
    Publication date: March 7, 2002
    Applicant: Hoechst Marion Roussel
    Inventors: Constantin Agouridas, Alexis Denis, Claude Fromentin
  • Use of xanthine derivatives for reducing the pathological hyperreactivity of eosinophilic granulocytes, novel xanthine compounds and process for their preparation
    Publication number: 20020010333
    Abstract: Use of xanthine derivatives for reducing the pathological hyperreactivity of eosinophilic granulocytes, novel xanthine compounds and process for their preparation.
    Type: Application
    Filed: February 8, 2001
    Publication date: January 24, 2002
    Applicant: Hoechst Aktiengesellschaft
    Inventors: Ulrich Gebert, Hiristo Anagnostopulos, Claus Kroegel, Alexander Kapp
  • Spiro[cyclopent[b]indole-piperidines]
    Publication number: 20020004601
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Application
    Filed: January 24, 2001
    Publication date: January 10, 2002
    Applicant: Hoechst Marion Roussel, Inc.
    Inventors: Mark G. Palermo, Gerard J. O'Malley
  • Combined preparation for the therapy of immune diseases
    Patent number: 6337325
    Abstract: A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca2+ content, is suitable for the treatment of immunological diseases.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: January 8, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Martin Schönharting, Stefan Müllner, Peter Zabel
  • Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them
    Publication number: 20020002155
    Abstract: The subject of the invention is the products of formula (I): 1
    Type: Application
    Filed: June 25, 2001
    Publication date: January 3, 2002
    Applicant: Hoechst Marion Roussel
    Inventors: Neerja Bhatnagar, Andre Claussner, Christian Marchandeau, Michele Resche Rigon, Jean-Georges Teutsch
  • Process for the preparation of L-phosphinothricin by a coupled enzymatic reaction
    Patent number: 6335186
    Abstract: A coupled enzyme reaction of a transaminase with GOT activity and of a transaminase with L-phosphinothricin transaminase activity produces phosphinothricin in virtually quantitative yield and virtually without any contamination whatever by a natural amino acid when the amino donor glutamate is employed in catalytic amounts and the amino donor aspartate is employed in approximately equimolar amounts relative to 4-(hydroxymethylphosphinyl)-2-oxobutyric acid.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: January 1, 2002
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Bartsch, Gerd Fülling, Arno Schulz