Abstract: An object of the present invention is to provide an echinomycin derivative that has anti-cancer activity equal to or greater than that of echinomycin, and a production method therefor based on a chemical procedure. Provided are an echinomycin derivative represented by formula (I), and a production method therefor based on a chemical procedure.

Abstract: The present invention pertains to a polycrystalline membrane containing metal nitride particles represented by the general formula MNx (where M is a metal element in which the Fermi energy is in a position higher than ?4.4 eV vs L.V. and x is the range over which a rock salt-type structure can be assumed), in which the crystallite size determined by transmission electron microscopy is 10 nm or less, at least some of the crystallites have rock salt-type structure, and the crystallites exhibit (111) orientation but substantially do not exhibit (100) orientation. The present invention also pertains to a method for manufacturing a polycrystalline membrane, comprising forming, by sputtering, a polycrystalline membrane on a substrate having a temperature of less than 200° C.

Abstract: Provided are: a multilayer structure in which a titanium oxide layer exhibits excellent photocatalytic activity; and a method for producing this multilayer structure. The above-described multilayer structure comprises: a conductive part which contains a metal element A other than Ti, while having electrical conductivity; and a titanium oxide layer which is arranged on the conductive part and contains 1.0% by atom or more of the metal element A.

Abstract: Provided is a composition for suppressing pain which contains a monovalent metal salt of alginic acid, the composition being applied to a nucleus pulposus cavity part to suppress pain at a surgical site and/or a surrounding site thereof which occurs after surgery. Accordingly, a composition is provided, which suppresses pain and/or inflammation at a surgical site and/or a surrounding site thereof which occurs after surgery performed on an intervertebral disc as typified by intervertebral discectomy.

Abstract: A quantum cryptographic key output apparatus includes a semiconductor laser device that repeatedly generates pulsed laser light, an encoder that encodes the pulsed laser light based on a quantum cryptographic key, an optical branching unit that branches the pulsed laser light, and an attenuator that attenuates a light intensity of first pulsed laser light so that the number of photons of the first pulsed laser light has any one of a plurality of candidate values that are values equal to or smaller than 1. Further, the output apparatus includes a light intensity determination unit that determines whether or not a light intensity of a second pulsed laser light is in a predetermined range, and an information output unit that outputs specifying information for specifying the first pulsed laser light corresponding to second pulsed laser light of which the light intensity is not in the predetermined range to an input apparatus.

Abstract: The present invention pertains to a pharmaceutical composition comprising ?-galactosylceramide and/or dendritic cells pulsed with ?-galactosylceramide, said pharmaceutical composition being for preventing and/or treating drug-induced myocardial dysfunction. The present invention also pertains to a pharmaceutical composition comprising ?-galactosylceramide and/or dendritic cells pulsed with ?-galactosylceramide, said pharmaceutical composition being to be administered to a subject, who develops drug-induced myocardial dysfunction or is at a risk of developing the same, before and after administering the drug that is likely causative of the drug-induced myocardial dysfunction.

Abstract: Provided is a functional structure which can suppress functional degradation of a functional material to achieve longer life, which can save resources without complicated replacement operations, and which, used for example as a catalyst, exhibits excellent catalytic activity. The functional structure includes supports each having a porous structure and including a zeolite-type compound, and at least one functional material present in the supports and including a metal element (M), in which each of the supports has channels communicating with one another, the functional material is present at least in the channel of each of the supports, and the metal element (M) having constituted the functional material is partially substituted with an element having constituted the supports.

Abstract: In order to provide an antibody having high therapeutic and prophylactic effects against cancer and the like, three types of mouse monoclonal antibodies were prepared which exhibit high affinities for a human-derived Eva1 protein. Moreover, constant regions of these antibodies were substituted with human-derived constant regions to also prepare chimeric antibodies. Further, these mouse antibodies and chimeric antibodies were found to have high ADCC and/or CDC activities. Furthermore, it was also revealed that administering these antibodies to mice having been subjected to melanoma cell administration suppresses the metastasis and the like of the cells to the lungs.

Abstract: [Problem] The purpose of the present invention is to provide a modified adenovirus having a cytocidal activity on a target cell and high safety. [Solution] The present invention pertains to: a modified adenovirus which comprises an E1A gene, an enhancer sequence having a function of enhancing the expression of the E1A gene, and an AU-rich element introduced into the 3?-untranslated region of a viral gene, which is essentially required for the self-propagation thereof, or a position adjacent to the 3?-untranslated region, or a modified adenovirus which comprises an E1A gene and an enhancer sequence having a function of enhancing the expression of the E1A gene and cannot express normal E4orf6 protein, wherein the distance between the 5?-terminus of the E1A gene and the terminus of the enhancer sequence is 1500-4500 bp; and a medicine comprising the same.

Abstract: An image processor applies computation processing to a plurality of CT images formed by irradiation of radiation of a plurality of energy levels to acquire monochromatic CT images. The image processor acquires a first energy level CT image formed by irradiation of first energy level radiation and a second energy level CT image formed by irradiation of second energy level radiation, applies a plurality of weighted computations to the first and second energy level CT images to compute a plurality of monochromatic CT images as a result of the weighted computations, segments a surrounding region of a highly-absorbent material circumferentially into a plurality of regions of interest having a predetermined area and calculates a standard deviation of the surrounding region by using a mean value of image data of each region of interest, for each monochromatic CT image, and selects a monochromatic CT image with a small standard deviation.

Abstract: An object of the present disclosure is to provide a cellulose acetate film having excellent bending properties and high transparency. The subject cellulose acetate film contains cellulose acetate having a cellulose triacetate I crystal structure, the cellulose acetate film having a light transmittance of 70% or higher at 660 nm.

Abstract: The present invention provides an anti-PD-L1 antibody capable of repeated administration even to animals other than rat. An anti-PD-L1 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLLYSENQKDY (SEQ ID NO: 37), CDR2 having the amino acid sequence of WAT and CDR3 having the amino acid sequence of GQYLVYPFT (SEQ ID NO: 38) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GYTFTSNF (SEQ ID NO: 39), CDR2 having the amino acid sequence of IYPEYGNT (SEQ ID NO: 40) and CDR3 having the amino acid sequence of ASEEAVISLVY (SEQ ID NO: 41) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above anti-PD-L1 antibody as an active ingredient. A method for preparing the above anti-PD-L1 antibody is also provided.

Abstract: A power supply control device according to one or more embodiments may be provided to: control a power conversion device that has a configuration in which a resonant circuit is provided on an output side of a matrix converter including switching circuits having snubber elements, and that performs AC-AC conversion of output from a multi-phase AC power supply. The power supply control device performs control such that: the output current, which has a phase difference caused by the resonant circuit, is negative during a period in which an absolute value of a positive-going output voltage that is output from the power conversion device increases while the output current is positive during a period in which the absolute value of a negative-going output voltage increases; and a polarity of the output current does not change within a period in which the snubber element is discharged.

Abstract: A rare earth compound including: one or a plurality of rare earth ions; and a ligand coordinated with the rare earth ion and having a condensed polycyclic aromatic group. At least part of the rare earth ions is a terbium(III) ion. The condensed polycyclic aromatic group is a residue formed by removing a hydrogen atom bonded to a condensed aromatic ring in formula (1) below from a condensed polycyclic aromatic compound represented by the following formula (1). Also disclosed is a luminescent body including the rare earth compound.

Abstract: Provided are a moving body tracking apparatus that contributes to shortening treatment time and a radiation therapy system including the moving body tracking apparatus, a program, and a moving body tracking method. The moving body tracking apparatus includes a fluoroscopic apparatus that acquires fluoroscopic images including the target 2 from at least two directions, and the moving body tracking control apparatus 30A that obtains a position of the target 2 from the fluoroscopic images acquired by the fluoroscopic apparatus. The moving body tracking control apparatus 30A creates a simulated fluoroscopic image from the CT image including the target 2, creates a two-dimensional region including the target 2 from the simulated fluoroscopic image as a template, matches each of at least two fluoroscopic images with the template, and obtains a three-dimensional position of the target 2 from a plurality of matching results.

Abstract: An oxidation inhibitor containing, as an active ingredient, an aminocarbonyl compound having a structure resulting from binding of an amino group of a compound having sphingoid base structure and a carbonyl group of a carbonyl compound. The oxidation inhibitor has high oxidation inhibitory effects, and inhibits oxidation of fats and oils, in particular, fats and oils containing a large proportion of polyunsaturated fatty acids to prevent deterioration due to oxidation of fats and oils.

Abstract: A functional structure which can resist a decrease in the functions of the functional material caused by influences such as force and heat and thus have a long life. The functional structure includes supports each having a porous structure and including a zeolite-type compound, and at least one functional material present in the supports, in which each of the supports has channels communicating with one another, the functional material is present at least in the channel of each of the supports, the functional material present in the supports includes a metal element (M), and the content of the metal element (M) is more than 2.5 mass % with respect to the functional structure.

Abstract: A temperature-responsive hydrogel which contains a carboxyl group-bearing polymer and a divalent-metal salt of an organic acid is provided. The carboxyl group-bearing polymer may be a homopolymer of a carboxyl group-bearing monomer or a copolymer of a plurality of monomers including the monomer. A method for producing the temperature-responsive hydrogel involves immersing a carboxyl group-bearing polymer in an aqueous solution of a divalent-metal salt of an organic acid. The concentration of the divalent-metal salt of an organic acid in the aqueous solution may be 50 mM to the saturation concentration. It is possible to provide a temperature-responsive gel having an LCST with no volume phase transition and a method for producing the temperature-responsive gel.

Abstract: A functional structure which can resist a decrease in the function of the functional material and thus have a long life, can be free from the need for complicated replacement operation, can contribute to resource-saving, and can exhibit high catalytic activity when used, for example, as a catalyst. The functional structure includes supports each having porous structure and including a zeolite-type compound, and at least one functional substance present in the supports, in which each of the supports has channels communicating with one another, the functional material is present at least in the channel of each of the supports, and the supports have an average external size of 20 ?m or less.

Abstract: A functional structure which can prevent metal fine particles from aggregating, can suppress bonding of an active metal species and a support, and can easily undergo catalyst activation before being used for reactions. The functional structure includes supports each having a porous structure and including a zeolite-type compound, and at least one functional material precursor present in the supports and including a metal element (M), in which each of the supports has channels communicating with one another, the functional material precursor is present at least in the channel of each of the supports, and the metal element (M) having constituted the functional material precursor is partially substituted with an element having constituted the supports.