Patents Assigned to Hokkaido University
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Patent number: 11220763Abstract: Disclosed herein is cellulose acetate fibers that have an excellent affinity for resins and is capable of reinforcing resins. The cellulose acetate fibers have a cellulose triacetate I crystal structure and a number-average fiber diameter of 2 nm or more but 400 nm or less.Type: GrantFiled: March 9, 2017Date of Patent: January 11, 2022Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NIPPON PAPER INDUSTRIES CO., LTD., DAICEL CORPORATIONInventors: Yasumitsu Uraki, Haruo Konno, Shu Shimamoto
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Patent number: 11218069Abstract: A power conversion device, including: a voltage detector that detects a common mode voltage generated upon a switching operation of a power semiconductor device; a voltage superimposer that superimposes the common mode voltage detected by the voltage detector onto an output of the power conversion device to cancel the common mode voltage having a frequency greater than or equal to a switching frequency generated upon the switching operation of the power semiconductor device; and a residual voltage detector that detects the common mode voltage of the power conversion device superimposed by the voltage superimposer. The voltage superimposer includes a feedback mechanism for adding and superimposing the common mode voltage detected by the residual voltage detector onto the output of the power conversion device. The voltage detector includes a first choke coil and a first capacitor.Type: GrantFiled: March 7, 2019Date of Patent: January 4, 2022Assignees: TOSHIBA MITSUBISHI-ELECTRIC INDUSTRIAL SYSTEMS CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yushin Yamamoto, Satoshi Ogasawara, Shunsuke Ohara
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Publication number: 20210405011Abstract: The present invention pertains to a medicine, said medicine comprising as an active ingredient a substance which suppresses the expression of at least one molecule selected from the group consisting of TMEM5, VSTM2L, C2CDD4D, VSTM2A, LY6G6C and ADRA2C or inhibits the activity thereof, for preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death. Also, the present invention pertains to a method for screening a substance, which is capable of preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death, with the use of the expression or activity of the aforesaid molecule as an index.Type: ApplicationFiled: September 2, 2019Publication date: December 30, 2021Applicant: National University Corporation Hokkaido UniversityInventors: Masaaki Murakami, Daisuke Kamimura
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Patent number: 11203615Abstract: A peptide that includes a partial amino acid sequence of the C16orf74 protein, includes the cysteine at position 7 and/or the cysteine at position 14 of the C16orf74 protein, and inhibits dimer formation of the C16orf74 protein is provided. A pharmaceutical composition for cancer treatment that includes the peptide is also provided. A screening method for cancer treatment drugs that takes as the indicator inhibition of dimer formation of the C16orf74 protein is also provided.Type: GrantFiled: September 10, 2018Date of Patent: December 21, 2021Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventor: Toru Nakamura
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Patent number: 11198730Abstract: The present invention provides an anti-LAG-3 antibody capable of repeated administration even to animals other than rat. An anti-LAG-3 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLLDSDGNTY (SEQ ID NO: 16), CDR2 having the amino acid sequence of SVS and CDR3 having the amino acid sequence of MQATHVPFT (SEQ ID NO: 17) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GFDFDTYP (SEQ ID NO: 18), CDR2 having the amino acid sequence of ITIKTHNYAT (SEQ ID NO: 19) and CDR3 having the amino acid sequence of NREDFDY (SEQ ID NO: 20) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above anti-LAG-3 antibody as an active ingredient. A method for preparing the above anti-LAG-3 antibody is also provided.Type: GrantFiled: August 10, 2017Date of Patent: December 14, 2021Assignees: Fuso Pharmaceutical Industries, Ltd., National University Corporation Hokkaido UniversityInventors: Satoru Konnai, Kazuhiko Ohashi, Shiro Murata, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Yasuhiko Suzuki, Chie Nakajima
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Patent number: 11196073Abstract: The present invention relates to a proton ceramic fuel cell which has a hydrogen-permeable film as an anode and in which an electrolyte material is BaZrxCe1-x-zYzO3 (x=0.1 to 0.8, z=0.1 to 0.25, x+z?1.0) (BZCY). An electron-conducting oxide thin film having a film thickness of 1-100 nm is present between a cathode and an electrolyte comprising the material. The present invention also relates to a method for producing a proton ceramic fuel cell having a hydrogen-permeable film as an anode. The method comprises forming a thin film having a thickness of 1-100 nm between a cathode and an electrolyte comprising BZCY, the thin film comprising an electron-conducting oxide. The present invention provides a novel means for improving the output of a PCFC in which BZCY is used in an electrolyte material, and provides a PCFC having an output that exceeds a benchmark of 0.5 W cm?2 at 500° C.Type: GrantFiled: February 22, 2019Date of Patent: December 7, 2021Assignee: National University Corporation Hokkaido UniversityInventors: Yoshitaka Aoki, Hiroki Habazaki, Tomoyuki Yamaguchi
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Patent number: 11192791Abstract: The present disclosure relates to a partial oxidation catalyst that causes a light hydrocarbon partial oxidation reaction to proceed readily with high activity and high selectivity and a high-yield carbon monoxide production method using the same. The present disclosure further relates to a light hydrocarbon partial oxidation catalyst containing a zeolite supporting cobalt and rhodium.Type: GrantFiled: March 25, 2019Date of Patent: December 7, 2021Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, TOSOH CORPORATIONInventors: Atsushi Fukuoka, Hirokazu Kobayashi, Sae Someya
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Publication number: 20210360865Abstract: An indicator capable of determining accumulated temperatures of about 500° C.·h and about 1000° C.·h are important indexes in quality management for cut flowers. The indicator includes a first packet containing first solution and a second packet containing second solution. The first and second solutions are brought into contact by pressing either packet, and a first color change from transparent color to pale blue color and a second color change from blue color to brown color are generated by Maillard reaction. The first solution includes sugar and solvent, and the second solution includes amino acid, pH adjuster, and solvent. An accumulated temperature is within 500° C.·h when the indicator shows a transparent color, and the accumulated temperature is within 1000° C.·h when the indicator shows a blue color. The accumulated temperatures can be readily checked by one look so that remaining vase life of the cut flowers can be determined.Type: ApplicationFiled: July 8, 2020Publication date: November 25, 2021Applicants: Impack Corporation, National University Corporation Hokkaido UniversityInventors: Hekiro Morishige, Shigenobu Koseki
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Patent number: 11179096Abstract: A scoliosis diagnosis assistance device includes: a first shape information acquisition module configured to acquire back shape information representing the three-dimensional shape of a back of a subject; a second shape information acquisition module configured to acquire minor-symmetry information representing a three-dimensional shape having a minor-symmetry relationship with the three-dimensional shape of the back of the subject with respect to a sagittal plane of the three-dimensional shape; a deviation distribution acquisition module configured to acquire a distribution of deviation between the three-dimensional shape represented by the back shape information and the three-dimensional shape represented by the mirror-symmetry information; and an output controller configured to cause a display to display the distribution of deviation, for example.Type: GrantFiled: April 4, 2017Date of Patent: November 23, 2021Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NOA CO., LTD.Inventors: Satoshi Kanai, Hideki Sudo, Yuichiro Abe, Hiroshi Nagaeda
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Publication number: 20210341488Abstract: A fluorescence polarization immunoassay that uses a fluorescent labeling substance in which a single domain antibody is labeled with a fluorescent dye. A fluorescent labeling substance obtained by labeling a single domain antibody, such as a VHH antibody or a vNAR antibody, having a binding ability to a target substance with a fluorescent dye is used. The fluorescence polarization immunoassay includes a binding step for binding the fluorescent labeling substance to a target substance; and a measuring step for measuring a change in the fluorescence polarization of the fluorescent labeling substance to which the target substance is bound.Type: ApplicationFiled: April 27, 2021Publication date: November 4, 2021Applicants: TOHOKU UNIVERSITY, Tianma Japan, Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Mao Fukuyama, Akihide Hibara, Ayuko Imai, Koji Shigemura, Manabu Tokeshi
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Publication number: 20210333287Abstract: Disclosed is a method for acquiring information of a target polypeptide, comprising: acquiring a diffusion time of a fluorescently labeled target polypeptide and a diffusion time of each of a plurality of fluorescently labeled reference polypeptides by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy, and acquiring information on size of the fluorescently labeled target polypeptide from the diffusion time of the fluorescently labeled target polypeptide with reference to the diffusion times of the plurality of fluorescently labeled reference polypeptides, wherein information on size of each of the plurality of fluorescently labeled reference polypeptides is known, and the sizes of the plurality of reference polypeptides are different from each other.Type: ApplicationFiled: April 27, 2021Publication date: October 28, 2021Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, SYSMEX CORPORATIONInventors: Masataka KINJO, Akshay GANGULY, Lausonia RAMASWAMY
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Patent number: 11155582Abstract: An antiviral peptide provided according to the present invention includes (1) an amino acid sequence (TM sequence) constituting a transmembrane region of G protein of vesicular stomatitis virus (VSV) or a modified amino acid sequence formed by conservative substitutions of 1, 2, or 3 amino acid residues in the TM sequence; and (2) an amino acid sequence (CPP sequence) functioning as a cell penetrating peptide (CPP), wherein a total number of amino acid residues is 100 or less.Type: GrantFiled: October 3, 2019Date of Patent: October 26, 2021Assignees: TOAGOSEI CO., LTD, National University Corporation Hokkaido UniversityInventors: Tetsuhiko Yoshida, Ayato Takada, Nahoko Baileykobayashi
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Publication number: 20210313873Abstract: A power conversion device, including: a voltage detector that detects a common mode voltage generated upon a switching operation of a power semiconductor device; a voltage superimposer that superimposes the common mode voltage detected by the voltage detector onto an output of the power conversion device to cancel the common mode voltage having a frequency greater than or equal to a switching frequency generated upon the switching operation of the power semiconductor device; and a residual voltage detector that detects the common mode voltage of the power conversion device superimposed by the voltage superimposer. The voltage superimposer includes a feedback mechanism for adding and superimposing the common mode voltage detected by the residual voltage detector onto the output of the power conversion device. The voltage detector includes a first choke coil and a first capacitor.Type: ApplicationFiled: March 7, 2019Publication date: October 7, 2021Applicants: TOSHIBA MITSUBISHI-ELECTRIC INDUSTRIAL SYSTEMS CORPORATION, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yushin YAMAMOTO, Satoshi OGASAWARA, Shunsuke OHARA
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Patent number: 11131583Abstract: An object state detection and transmission system includes a spectrometer configured to measure a reflectance spectrum based on reflected light reflected by a target object, a spectroscopic terminal apparatus integrally provided with an electronic device, the spectroscopic terminal apparatus being configured to receive a measured reflection spectrum; and a server apparatus connected to the spectroscopic terminal apparatus via a communication line. The electronic device includes a photographic camera configured to photograph the target object to capture a photographed image; a Global Positioning System (GPS) communication unit configured to measure a position of the target object; a sensor configured to measure an azimuth and an angle of the target object; a Central Processing Unit (CPU) configured to clock a current time of the photographing and the measurement; and a wireless communication unit configured to transmit resultant data to the server apparatus.Type: GrantFiled: August 21, 2017Date of Patent: September 28, 2021Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yukihiro Takahashi, Nobuyasu Naruse
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Publication number: 20210292168Abstract: An alkali metal amide is dissolved in a cyclic alkylene urea represented by the formula (1) (wherein each of R1 and R2 represents a C1 to C3 alkyl group, and R3 represents a C1 to C4 alkylene group).Type: ApplicationFiled: August 20, 2019Publication date: September 23, 2021Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NISSAN CHEMICAL CORPORATIONInventors: Kiyoharu TADANAGA, Akira MIURA, Tadayuki ISAJI, Shinichi MAEDA
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Publication number: 20210292321Abstract: The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.Type: ApplicationFiled: June 29, 2019Publication date: September 23, 2021Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, Shionogi & Co., Ltd.Inventors: Akihiro ISHII, Akihiko SATO, Makoto KAWAI, Yoshiyuki TAODA
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Publication number: 20210294009Abstract: This light absorbing device includes: a light reflecting layer; a dielectric layer disposed on the light reflecting layer; and a plurality of metal nanostructures disposed on the dielectric layer. A portion of each of the plurality of metal nanostructures is buried in the dielectric layer and another portion thereof is exposed to the outside.Type: ApplicationFiled: December 25, 2018Publication date: September 23, 2021Applicant: National University Corporation Hokkaido UniversityInventors: Hiroaki MISAWA, Xu SHI, Kosei UENO, Tomoya OSHIKIRI, Quan SUN, Keiji SASAKI
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Patent number: 11116793Abstract: A modified metal nanoparticle comprising a metal nanoparticle and a cyclic polyether modifying the metal nanoparticle.Type: GrantFiled: November 13, 2018Date of Patent: September 14, 2021Assignee: National University Corporation Hokkaido UniversityInventors: Takuya Yamamoto, Jose Enrico Quinsaat
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Publication number: 20210269460Abstract: Disclosed is a rare-earth complex including a rare-earth ion, and a ligand coordinate-bonded to the rare-earth ion and having a condensed polycyclic aromatic group. The condensed polycyclic aromatic group is a residue formed by removing a hydrogen atom bonded to a condensed aromatic ring from a condensed polycyclic aromatic compound represented by the following Formula (I). In Formula (I), R1 and R2 represent hydrogen atoms or groups which are bonded to each other to form one aromatic ring or a condensed aromatic ring including two or more aromatic rings.Type: ApplicationFiled: July 4, 2019Publication date: September 2, 2021Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yuichi KITAGAWA, Marina KUMAGAI, Yasuchika HASEGAWA, Takayuki NAKANISHI, Koji FUSHIMI
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Publication number: 20210260248Abstract: The present invention provides a medical film material which comprises a flat-plate-like or film-like demineralized dentin matrix (DDM) that is derived from a removed bovine tooth and completely demineralized, and which has an area falling within the range front 2 to 50 cm2. The present invention also provides a method for surgerizing a non-human animal using the medical film material. The present invention also provides a method for producing the medical film material, which comprises thinning and demineralizing a removed bovine tooth to produce a demineralized dentin matrix (DDM) film that is completely demineralized, wherein either one of the thinning procedure and the demineralization procedure may be carried out first.Type: ApplicationFiled: July 22, 2019Publication date: August 26, 2021Applicant: National University Corporation Hokkaido UniversityInventor: Naoto Okubo