Abstract: Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.

Abstract: Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving ?-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

Abstract: A charge pump (CP) that operates at low input voltage with high power conversion efficiency is disclosed. A first embodiment provides a negative CP used for controlling load switches of a voltage doubler. Using a negative CP extends the operating region below ground to relieve the power delivery limitation of the CP. A second embodiment provides a low power adaptive dead-time circuit, which has several dead-time signals having different lengths of dead-times and selects one according to the input voltage level. A low input voltage detector in the adaptive dead-time circuit is used to determine which dead-time should be used. A third embodiment provides a switching body bias used for the low input voltage CP. The switching body bias uses both forward and reverse body bias applied to the CP to minimize reverse current and maximize power transfer. The first, second, and third embodiments can be used together or independently.

Abstract: The present invention provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising the use of artemisinin derivatives having anti-viral activity.

Abstract: Disclosed are ways to generate a melody. Currently, no algorithm exists for automatically composing a melody based on music lyrics. However, according to some recent studies, within a song, there usually exists a correlation between a song's notes and a song's lyrics wherein a melody can be generated based on such correlation. Disclosed herein, are systems, methods and algorithms that consider the correlation between a song's lyrics and a song's notes to compose a melody.

Abstract: Provided herein are fluorescent bioprobes comprising fluorogens that exhibit aggregation-induced emission (AIE) labeled on biomolecules. The present subject matter relates to a fluorescent bioprobe comprising one or more fluorogen labeled on chitosan. The present subject matter is also directed to methods of preparing the fluorescent bioprobes, methods of labeling and detecting DNA and/or proteins with the fluorescent bioprobe, and methods of cell imaging including live cell tracking.

Abstract: A thermal interface material provides thermal conduction or thermal dissipation across an interface, using a three-dimensional interconnected porous graphene (3D-IPG) foam structure. The 3D-IPG foam structure is constructed of three-dimensional interconnected graphene sheets formed as a plurality of monolayers, and having an flexible interconnection architecture. The flexible interconnection architectures allow the 3D-IPG to maintain a high interfacial thermal conductance by the 3D-IPG filling a gap between a heat source and a heat sink across the interface, and by capping small features up to nanoscale roughened surfaces.

Abstract: The present invention provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising the use of artemisinin derivatives having anti-viral activity.

Abstract: The present invention provides high potency 3,3?-diindolylmethane (DIM) and analogue compounds as antifouling agents. The present invention further provides methods of preventing or reducing settlement and/or fouling of marine fouling organisms on surfaces of submerged objects by coating the surfaces with the 3,3?-diindolylmethane (DIM) and analogue compounds provided.

Abstract: A multi-vinylsulfone containing molecule is described herein. The multi-vinylsulfone containing molecule can be formed by dissolving a water soluble polymer containing a hydroxyl group in an aqueous solution to form a polymer solution; adding a molecule containing two vinylsulfone groups to the polymer solution; and forming a modified polymer by controlling a number of the vinylsulfone groups that are added to the polymer. A hydrogel is also described herein that can include the multi-vinylsulfone containing molecule and a multi-thiol containing molecule. The hydrogel can be formed from an aqueous solution that includes the multi-vinylsulfone containing molecule and the multi-thiol containing molecule by undergoing gelatation upon delivery to a site in the body. Also described is a drug delivery system that employs the hydrogel.

Abstract: Systems, methods and apparatus facilitating joint channel and routing assignment are provided. In some embodiments, a system includes nodes in a network configured to perform distributed joint channel and routing assignment of traffic through exchange of information with one another. The assignments are iteratively updated based on whether the update will result in an increase in a value of a function associated with throughput for traffic in the network. In some embodiments, the assignments are determined based on random decisions that are adopted if the function is improved utilizing the routing and channel information in the assignment. In some embodiments, the assignments are determined based on traffic prioritization in which destination nodes having a high level of traffic are assigned routes and channels having characteristics amenable to reduction of interference in the network.

Abstract: A liquid crystal cell structure is provided. The liquid crystal cell structure includes: two polarizers; and a liquid crystal diffractive light modulating cell placed between the two polarizers. The cell includes: two transparent substrates treated by photoalignment; and a ferroelectric liquid crystal layer disposed between the two transparent substrates with current conducting layers, the ferroelectric liquid crystal layer comprising ferroelectric liquid crystals. The two transparent substrates treated by photoalignment are configured to provide multiple alignment domains in the ferroelectric liquid crystals with a planar surface orientation. Adjacent domains of the multiple alignment domains are oriented at an angle with respect to each other.

Abstract: Cooperative caching systems incorporating Plug-and-Play base stations are described herein. Plug-and-Play base stations with large caching capacities are employed in a wireless network to perform cooperative transmission with macro base stations. Each Plug-and-Play base station can either have wireless backhaul or a low-cost wired backhaul connection to the macro base stations. Cooperative caching systems can direct traffic between the Plug-and-Play base stations and the macro base stations.

Abstract: An integrated capacitor can be fabricated with both electrodes formed by trenches for low resistance. According to one embodiment, the capacitor can comprise a first trench electrode, one or more dielectric layers, and a second trench electrode. The first trench electrode and the second trench electrode can be fabricated in different trenches to improve capacitance density and resistance of the integrated capacitor.

Abstract: A lighting device is provided. The lighting device includes a substrate, integrated circuits (22?, 24), embedded passive components (26, 27), and a lighting component (22), the device being arranged in an architecture having three layers: an integrated circuits layer (11) including the integrated circuits (22?, 24), wherein the integrated circuits layer (11) is integrated on a first side of the substrate; an embedded passive components layer (12) including the embedded passive components (26, 27), wherein the embedded passive components (26, 27) are embedded in grooves formed in the substrate and wherein the embedded passive components are connected to the integrated circuits (22?, 24) through vias (28) in the substrate; and a bonded layer (13), including the lighting component (22), the lighting component (22) being connected to the integrated circuit layer (11) through flip-chip bonding or monolithic integration.

Abstract: Described herein are systems and methods that employ a widgetless and buttonless multi-touch interface for constrained manipulations of 3D objects. The widget-less multi-touch user interface can map different multi-touch gestures to different 3D object manipulation tasks, allowing a user to manipulate 3D objects without operating widgets or performing mode switchings or tool selections. User interaction is greatly simplified by using single touch actions that simultaneously specify the transformation constraint, the transformation type, and the magnitude of transformation and apply the transformation to the focus object. Additionally, the axis-based constrained manipulations support active snapping and axis transfer. Active snapping allows the user to draw a free touch path connecting two 3D objects to be snapped together, avoiding tedious operations required with standard transformation manipulations.

Abstract: Provided herein are magnetic silica fluorescent nanoparticles and fluorescent silica nanoparticles comprising an aggregation induced emission luminogen and magnetite nanoparticles and use of the same as a fluorescent bioprobe for intracellular imaging and a protein carrier. Also provided are processes for preparing and fabricating the same.

Abstract: A substantially acoustically transparent planar, rigid frame divided into a plurality of individual, substantially two-dimensional cells is used to construct a sound absorption panel. A sheet of a flexible material is fixed to the rigid frame, and a plurality of platelets fixed to the sheet of flexible material such that each cell is provided with a respective platelet, thereby establishing a resonant frequency, establishing an increase in an absorption coefficient of the panel. The flexible material has a wrinkle or corrugation to permit distortion with reduced material elasticity. The wrinkle or corrugation permits the flexible material to distort beyond that afforded by a planar material of the same type, while retaining mechanical strength in supporting the plurality of platelets.

Abstract: The present invention is drawn toward luminogens and chemical compositions comprising a target recognition motif, a hydrophilic moiety, a linking moiety, and at least one luminogen. Additionally presented are methods of: assessing the conversion of a prodrug into its active form, assessing the therapeutic efficacy of a prodrug, detecting glutathione in a biological sample, detecting alkaline phosphatase in a sample, and conducting fluorescence imaging or magnetic resonance imaging with the use of luminogen-containing compositions.

Abstract: A communications device includes: a light-emitting diode (LED) or LED array; an internet protocol (IP)-based radiofrequency (RF) wireless unit, configured to transmit and receive data over a RF wireless communications network; a visible light communication (VLC) unit, configured to drive the LED or LED array and modulate light generated by the LED or LED array with data; a control unit, connected to the IP-based RF wireless unit and the VLC unit, configured to facilitate communications between the VLC unit and IP-based RF wireless unit.