Abstract: A method is directed to synthesis of poly(triphenylacrylonitrite)s (PTPANs) comprising polycoupling dibromoarenes, internal diynes, and potassium ferrocyanide, resulting in polycoupled dibromoarenes, internal diynes, and potassium ferrocyanide; and producing poly(triphenylacrylonitrite)s (PTPANs) by catalysis of the polycoupled dibromoarenes, internal diynes, and potassium ferrocyanide with palladium acetate and sodium bicarbonate, wherein the catalysis is allowed to proceed in dimethylacetamide under nitrogen at a prescribed temperature for a prescribed time.
Type:
Grant
Filed:
October 9, 2017
Date of Patent:
March 9, 2021
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.
Type:
Grant
Filed:
June 24, 2016
Date of Patent:
March 2, 2021
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vectors are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.
Type:
Grant
Filed:
July 31, 2015
Date of Patent:
March 2, 2021
Assignees:
The Hong Kong University of Science and Technology, THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Abstract: The invention relates to the systems and methods for isolating single cells, capturing selected prey biomolecules within said cells, and detecting said prey biomolecules using a sensitive assay method. Also described herein are functionalized substrates and compositions for enabling the low limit of detection of selected prey biomolecules of selected cells.
Type:
Application
Filed:
August 21, 2020
Publication date:
February 25, 2021
Applicant:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: Aspects of the subject disclosure may include, for example, a device in which a processing system receives from a multimedia content server a plurality of content streams; each of the content streams includes a portion of an original content stream. The processing system transcodes the plurality of content streams based on a viewport prediction to produce a plurality of viewport streams; the viewport prediction is based at least in part on a visibility map associated with a viewer of the content. The processing system delivers each of the viewport streams to a client device associated with the viewer; each of the viewport streams is buffered at the client device in a separate buffer. Other embodiments are disclosed.
Type:
Application
Filed:
December 13, 2019
Publication date:
February 18, 2021
Applicants:
AT&T Intellectual Property I, L.P., The Hong Kong University of Science and Technology
Inventors:
Bo Han, Wenxiao Zhang, Pan Hui, Tan Xu, Cheuk Yiu Ip
Abstract: A device is designed to remove blockages in a lumen such as a thrombus, blood clot, or embolus. The device comprises a manipulating wire and a structure that can conduct electrical current to a lumen blockage. The electrical current is preferably in radio frequency (RF). The RF electric current in the blockage can excite the contents such as proteins of the blockage, so that cross-linking density and interfacial adsorption of the entire blockage is enhanced. The enhanced cross-linking density can result in increased fracture resistance of the blockage such that fracture of the blockage during the removal process is unlikely. The enhanced interfacial adsorption results in increased interfacial fracture resistance between the device and blockage so that the blockage can be securely captured during the removal process without using radially applied force.
Type:
Grant
Filed:
June 6, 2016
Date of Patent:
February 9, 2021
Assignee:
The Hong Kong University of Science and Technology
Inventors:
David Chuen Chun Lam, Chi Hang Chon, John Ching Kwong Kwok, Matthew Ming Fai Yuen, Zhen Qin, Alexander Ka Ngai Lam
Abstract: The technology described herein is generally directed towards an integrated high-radix strictly non-blocking optical switching fabric, such as for use for intra-rack communication within racks in a data center. The fabric may be configured with any number of ports. A general topology of optical components, along with a routing controller (e.g., algorithm/mechanism), results in an optical switching fabric architecture that provides bidirectional routing, in a high-performance, high bandwidth, highly robust switching fabric that is also low in power consumption and low latency.
Type:
Grant
Filed:
March 30, 2017
Date of Patent:
February 2, 2021
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Zhifei Wang, Jiang Xu, Zhehui Wang, Peng Yang
Abstract: A UV radiation detector includes: a diode including a substrate having a first side and a second side, the first side and the second side being located on opposing faces of the substrate, an active layer including rocksalt phase crystalline structure CaS disposed on the first side of the substrate, an electrical contact disposed on the second side of the substrate, and a semi-transparent conducting layer disposed on the active layer; and a circuit connecting the semi-transparent conducting layer and the electrical contact. The UV radiation detector detects radiation having a wavelength between 200 and 280 nm.
Type:
Grant
Filed:
February 1, 2019
Date of Patent:
December 22, 2020
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Qinglin He, Ying Hoi Lai, Yi Liu, Iam Keong Sou
Abstract: A three-broadside-mode patch antenna includes: a rotationally symmetric radiator; a patch, wherein the patch is separated from the rotationally symmetric radiator by a dielectric and configured to capacitively feed the rotationally symmetric radiator; and three antenna probes, connected to the patch, configured to provide three antenna ports corresponding to three respective broadside radiation polarizations.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
December 1, 2020
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE & TECHNOLOGY
Abstract: Methods and formulations for antimicrobial and anti-biofouling coating comprising: a hollow round colloidal structure, comprising: an active polymer shell; and an active or inert core; wherein the active polymer shell comprises one and more polymers with antimicrobial and anti-biofouling activities selected from the group consisting of polyethylenimine (PEI), functionalized chitosan (CHI), polyquaternium, poly(diallyldimethylammonium chloride) (PDDA) and polyhexamethylene biguanide (PHMD); wherein the active or inert core contains one and more disinfectants, biocides, fragrances or inert solvent; and wherein the hollow round colloidal structure is stable for at least 3 months.
Type:
Grant
Filed:
June 30, 2017
Date of Patent:
November 24, 2020
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
King Lun Yeung, Hanrong Zhang, Ying Li, Awais Farid
Abstract: Provided herein are spirocyclic polymers that exhibit aggregation-enhanced emission properties and methods of preparation thereof. The spirocyclic polymers can be used in the construction of integrated silicon photonics and to prepare two-dimensional fluorescent photopatterns useful for the manufacture of biological sensing and probing systems, optical writing and reading, anti-counterfeiting applications and the construction of optical display devices.
Type:
Grant
Filed:
April 16, 2019
Date of Patent:
November 24, 2020
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are polymers containing chlorinated benzodithiophene units, methods for their preparation and intermediates used therein, the use of formulations containing the same as semiconductors in organic electronic devices, especially in organic photovoltaic and organic field-effect transistor devices, and to organic electronic and organic photovoltaic devices made from these formulations.
Type:
Application
Filed:
January 7, 2019
Publication date:
November 19, 2020
Applicant:
The Hong Kong University of Science and Technology
Abstract: Methods, compositions, and kits for diagnosing or treating neurodegenerative or neuroinflammatory conditions are provided. Also provided are methods for identifying modulators of neurodegenerative or neuroinflammatory conditions.
Type:
Grant
Filed:
July 7, 2016
Date of Patent:
October 27, 2020
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Kit Yu Fu, Foo Yew Liew, Nancy Yuk-Yu Ip
Abstract: A composite photoalignment layer for aligning liquid crystal molecules includes: a monomeric material; a photoinitiator or a thermal initiator; and an azo dye material. A method for preparing a composite photoalignment layer for aligning liquid crystal molecules includes: mixing, in solution form, a monomeric material, a photoinitiator or a thermal initiator, and an azo dye material; coating the mixed solution onto a substrate to form a thin film; exposing the thin film to polarized light; and, with a thermal initiator, heating the thin film to polymerize the monomeric material and form a solid thin film.
Type:
Grant
Filed:
October 17, 2017
Date of Patent:
October 27, 2020
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Man Chun Tseng, Abhishek Kumar Srivastava, Cuiling Meng, Hoi Sing Kwok, Yeuk Lung Jacob Ho
Abstract: A processing system having at least one processor may obtain a feature set from a camera frame of a client device, perform a feature reduction of the feature set to produce a reduced feature set, generate a compressed representation from the reduced feature set, compare the compressed representation of the reduced feature set to a plurality of compressed representations of known objects stored in one or more hash tables to identify an object in the camera frame, and provide an identification of the object to the client device.
Type:
Grant
Filed:
December 27, 2018
Date of Patent:
October 20, 2020
Assignees:
AT&T INTELLECTUAL PROPERTY I, L.P., THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Bo Han, Muhammad Bilal Anwer, Vijay Gopalakrishnan, Wenxiao Zhang, Pan Hui
Abstract: A sound absorber can include a back wall, a plurality of absorber elements disposed on the back wall and arranged periodically in a first direction, and a plurality of frames disposed between the plurality of absorber elements. The plurality of absorber elements can make a periodic meta-surface due to a different thickness. The plurality of absorber elements can be made of a porous material.
Type:
Grant
Filed:
October 16, 2017
Date of Patent:
October 6, 2020
Assignee:
The Hong Kong University of Science and Technology
Abstract: The moisture-resistant catalyst for air pollution remediation is a catalyst with moisture-resistant properties, and which is used for removing nitrogen compound pollutants, such as ammonia (NH3), from air. The moisture-resistant catalyst for air pollution remediation includes at least one metal oxide catalyst, at least one inorganic oxide support for supporting the at least one metal oxide catalyst, and a porous framework for immobilizing the at least one metal oxide catalyst and the at least one inorganic oxide support, where the porous framework is moisture-resistant. As non-limiting examples, the at least one metal oxide catalyst may be supported on the at least one inorganic oxide support by precipitation, impregnation, dry milling, ion-exchange or combinations thereof. The at least one metal oxide catalyst supported on the at least one inorganic oxide support may be physically embedded in the porous framework.
Type:
Application
Filed:
March 20, 2020
Publication date:
September 24, 2020
Applicant:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
Type:
Grant
Filed:
September 3, 2012
Date of Patent:
August 25, 2020
Assignees:
The Hong Kong University of Science and Technology, National University of Singapore
Inventors:
Benzhong Tang, Wei Qin, Jianzhao Liu, Sijie Chen, Tsz Kin Kwok, Bin Liu, Kai Li, Dan Ding, Haibin Shi, Jun Long Geng, Jingzhi Sun, Anjun Qin, Qiuli Zhao
Abstract: Pharmacological compositions comprising a cationic nonribosomal peptide (CNRP) or a salt thereof are described. Further, methods of treating a bacterial infection in a subject by administering to the subject a CNRP or a salt thereof are provided.
Type:
Grant
Filed:
January 23, 2019
Date of Patent:
August 11, 2020
Assignees:
The Hong Kong University of Science and Technology, China Ocean Mineral Resources R&D Assocation (COMRA)
Abstract: Devices having nanochannels suitable for confinement and alignment of DNA molecules, as well as methods of fabricating the same and methods of using the same for DNA analysis, are provided. A device can include a dynamically-controlled, unified microchannel-nanochannel platform suitable for confinement and alignment of DNA molecules. The nanochannels can be reversibly formed within nanoslits formed in a deformable substrate or base layer.
Type:
Grant
Filed:
June 30, 2016
Date of Patent:
July 28, 2020
Assignee:
The Hong Kong University of Science and Technology