Patents Assigned to Horiba ABX SAS
  • Patent number: 11385158
    Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: July 12, 2022
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS
    Inventors: Pierre Blandin, Anais Ali-Cherif, Aurelien Daynes, Estelle Gremion, Damien Isebe
  • Patent number: 11376556
    Abstract: A device for shaking and sampling biological liquids that is able to take a sample of a biological liquid in a tube including a shaker designed to mix a rack holding one or more tubes by performing a succession of tilting movements between two shaking positions. The shaker is also arranged to tilt beyond the shaking position furthest away from the insertion position of a rack to discharge same by gravity.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: July 5, 2022
    Assignee: HORIBA ABX SAS
    Inventors: Jean Emmanuel Laravine, Charlène Muzellier
  • Publication number: 20220196538
    Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).
    Type: Application
    Filed: April 24, 2020
    Publication date: June 23, 2022
    Applicants: HORIBA ABX SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE MONTPELLIER
    Inventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NlCOUD
  • Patent number: 11366128
    Abstract: A biological analysis system comprising at least one inlet and one outlet, at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising a region for the exchange of tube holding racks with the conveyor. The conveyor and the at least one inlet of the biological analysis system comprise a reader of an identifier of a tube holding rack which reader is designed to communicate an identifier it has read to a controller of the biological analysis system, which controller is designed to apply a specific treatment to a tube holding rack identified by the reader of the conveyor and the identifier of which has not previously been read by the reader of the at least one inlet of the biological analysis system.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 21, 2022
    Assignee: HORIBA ABX SAS
    Inventors: Florent Beauducel, Philippe Benezeth, Thibault Cres
  • Patent number: 11360109
    Abstract: A biological analysis system comprises at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising at least one inlet and one outlet for racks of tubes, and at least one exchange region for exchanging racks of tubes with the conveyor, which exchange region is distinct from the inlet and from the outlet. The inlet of at least two biological analysis devices each form an inlet of the biological analysis system for racks of tubes, and the outlet of at least two biological analysis devices each form an outlet of the biological analysis system for racks of tubes. The biological analysis system further comprises a controller designed to command the transfer of a rack of tubes received in the biological analysis system via the conveyor to another biological analysis device according to the operations to be performed on the tubes in that rack and/or according to a respective workload status of the biological analysis devices.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 14, 2022
    Assignee: HORIBA ABX SAS
    Inventors: Florent Beauducel, Philippe Benezeth, Thibault Cres
  • Publication number: 20220018756
    Abstract: A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.
    Type: Application
    Filed: December 16, 2019
    Publication date: January 20, 2022
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS, IPRASENSE SAS
    Inventors: Pierre BLANDIN, Cédric ALLIER, Olivier CIONI, Lionel HERVE, Pierre JOLY, Jean-Marc DINTEN
  • Publication number: 20210387190
    Abstract: A device for preparing a solution from a sample and a reagent, the device includes a microfluidic array having a sample supply inlet, a reagent supply inlet, a discharge outlet, a solution collection outlet, a sampling zone to which the inlets are connected, first and second preparation chambers connected to the sampling zone, arranged to either side of the sampling zone such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone, the first preparation chamber having a volume that is variable between a minimum volume and a calibrated volume. The device includes valves interrupting the flow of the fluid at least at the two inlets and the collection and discharge outlets.
    Type: Application
    Filed: November 7, 2019
    Publication date: December 16, 2021
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS
    Inventors: Yves FOUILLET, Anais ALI-CHERIF
  • Patent number: 11199488
    Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 14, 2021
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS
    Inventors: Pierre Blandin, Anais Ali-Cherif, Estelle Gremion, Sebastien Raimbault, Olivier Cioni, Aurelien Daynes
  • Publication number: 20210131944
    Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 6, 2021
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES AlTERNATIVES, HORIBA ABX SAS
    Inventors: Pierre BLANDIN, Anais ALI-CHERIF, Estelle GREMION, Sebastien RAIMBAULT, Oliver CIONI, Aurelien DAYNES
  • Patent number: 10845286
    Abstract: A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: November 24, 2020
    Assignees: COMMISSARIAT Á L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, HORIBA ABX SAS, IPRASENSE SAS
    Inventors: Cedric Allier, Anais Ali Cherif, Pierre Blandin, Geoffrey Esteban, Lionel Herve, Damien Isebe
  • Publication number: 20200326269
    Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (
    Type: Application
    Filed: October 30, 2018
    Publication date: October 15, 2020
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS
    Inventors: Pierre BLANDIN, Anais ALI-CHERIF, Aurelien DAYNES, Estelle GREMION, Damien ISEBE
  • Patent number: 10794922
    Abstract: A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes and a sampling apparatus capable of collecting a biological liquid sample in a tube. The device also comprises a scheduler arranged to specify an order of sampling from the tubes independently of the order in which the tubes are positioned in the respective racks and the order in which the racks are inserted into the device. The scheduler is arranged to control the agitator and the sampling apparatus to process the tubes in accordance with the sampling order.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: October 6, 2020
    Assignee: HORIBA ABX SAS
    Inventors: Sylvain Andlauer, Florent Beauducel, Philippe Benezeth
  • Patent number: 10641697
    Abstract: A device for counting particles comprises a detector arranged to produce an electrical measurement signal in response to the passage of one or more particles, and a comparator arranged to compare the measurement signal with a threshold signal and to increment a counting value when the measurement signal exceeds the threshold signal, characterized in that it furthermore comprises a threshold-adjusting circuit that applies a lowpass filter to the measurement signal, and that is connected to the comparator in order to use the resulting signal as threshold signal.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: May 5, 2020
    Assignee: HORIBA ABX SAS
    Inventor: Guilhem Couderc
  • Patent number: 10481076
    Abstract: A method for identifying a state of a cell contained in a sample, including: illuminating the sample using a light source by producing an incident light wave propagating toward the sample; then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between the light source and the matrix-array photodetector such that the matrix-array photodetector is exposed to a light wave resulting from interference between the incident light wave and a diffraction wave produced by each cell; applying a numerical reconstruction algorithm to the image acquired by the matrix-array photodetector, to estimate a characteristic quantity of the light wave reaching the matrix-array detector, at a plurality of distances from the matrix-array photodetector. The value of the characteristic quantity, or its variation as a function of distance, allows the state of the cell to be determined from among predetermined states.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: November 19, 2019
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, IPRASENSE SAS, HORIBA ABX SAS
    Inventors: Cedric Allier, Geoffrey Esteban, Lionel Herve
  • Patent number: 10471421
    Abstract: The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: November 12, 2019
    Assignee: HORIBA ABX SAS
    Inventors: Didier Cremien, Damien Isebe
  • Patent number: 10379027
    Abstract: A method for identifying a particle contained in a sample, including illuminating the sample using a light source, the light source producing an incident light wave propagating toward the sample, then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between the light source and the photodetector such that the matrix-array photodetector is exposed to a light wave that is the result of interference between the incident light wave and a diffraction wave produced by each particle. The method further includes applying a numerical reconstruction algorithm to the image acquired by the photodetector, to estimate a characteristic quantity of the light wave reaching the detector, at a plurality of distances from the detector. The variation in the characteristic quantity as a function of distance allows the particle to be identified.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 13, 2019
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS, IPRASENSE SAS
    Inventors: Cedric Allier, Pierre Blandin, Anais Ali Cherif, Lionel Herve
  • Patent number: 10302242
    Abstract: The subject of the invention is a device for positioning an object in space, comprising at least 4 plates, each one able to move with respect to another of said plates which is contiguous with it along one of the 3 axes of space, it being possible for the movement of one plate with respect to another plate to be guided by a tenon/mortise assembly in which said tenon is secured to one of the plates and its mortise is produced in the other plate, the spatial orientation of each of the tenon/mortise assemblies being different from the other 2 and along one of the 3 axes of space.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 28, 2019
    Assignee: HORIBA ABX SAS
    Inventor: Nathalie Henon
  • Publication number: 20190101482
    Abstract: A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave.
    Type: Application
    Filed: March 22, 2017
    Publication date: April 4, 2019
    Applicants: COMMISSARIAT Á L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES AL TERNATIVES, HORIBA ABX SAS, IPRASENSE SAS
    Inventors: Cedric ALLIER, Anais ALI CHERIF, Pierre BLANDIN, Geoffrey ESTEBAN, Lionel HERVE, Damien ISEBE
  • Patent number: 10243316
    Abstract: The invention relates to a method for triggering a pulsed light source, wherein it comprises at least one iteration of the following steps: receiving a control signal; determining what is called a separation time between the reception of said control signal and at least one preceding control signal; adjusting at least one control parameter of said pulsed light source depending at least on said separation; generating at least one electrical signal for triggering the pulsed light source depending on said at least one control parameter adjusted during the preceding step; and triggering the pulsed light source depending on said at least one triggering electrical signal.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: March 26, 2019
    Assignees: HORIBA ABX SAS, UNIVERSITE DE LIMOGES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Vincent Couderc, Roland Grando, Alexis Labruyere, Nelly Rongeat, Denisa Subtirelu
  • Patent number: 10150119
    Abstract: The invention relates to a sampling valve and to a device equipped with such a valve notably allowing haematology measurements to be taken from a blood sample. The valve comprise two external parts, one internal part clamped between said external parts, and means for regulating the relative angular position of these parts about an axis of rotation. The internal part has opposite surfaces pressing in a sealed and sliding manner against adjacent surfaces of the external parts. The external parts comprise orifices, loops and ducts, said loops and said ducts being arranged in such a way as to communicate selectively with orifices passing through the internal part. The valve parts have no aliquot return groove or recess or labyrinth, thereby eliminating regions of turbulence. The valve is characterized in that two of the parts are able to rotate about the axis of rotation with respect to one of the said parts which is stationary, the rotary parts preferably being the external parts.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: December 11, 2018
    Assignee: HORIBA ABX SAS
    Inventors: Nathalie Henon, Florent Beauducel