Patents Assigned to Horiba ABX SAS
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Patent number: 12196662Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).Type: GrantFiled: April 24, 2020Date of Patent: January 14, 2025Assignee: HORIBA ABX SASInventors: Pierre Taraconat, Damien Isebe, Simon Mendez, Franck Nicoud
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Patent number: 12135273Abstract: A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.Type: GrantFiled: December 16, 2019Date of Patent: November 5, 2024Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS, IPRASENSE SASInventors: Pierre Blandin, Cédric Allier, Olivier Cioni, Lionel Herve, Pierre Joly, Jean-Marc Dinten
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Patent number: 12005409Abstract: A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes, a sampling apparatus capable of collecting a biological liquid sample in a tube, and a changer capable of gripping a tube on a rack received in the agitator and moving it to the sampling apparatus.Type: GrantFiled: November 9, 2016Date of Patent: June 11, 2024Assignee: HORIBA ABX SASInventors: Florent Beauducel, Philippe Benezeth
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Patent number: 11867607Abstract: An electro-optical device for taking flow measurements includes a measurement tank through which a flow of fluid to be characterized flows, at least first and second guns for emitting light having separate spectra, a triggering gun allowing diffraction to be measured at small angles and a receiving gun allowing a measurement of attenuation and at least one fluorescence to be taken. The first emitting gun includes a light source defining a main optical axis perpendicular to the fluid flow, and the second emitting gun includes a second light source defining a secondary optical axis substantially orthogonal to the main optical axis and fluid flow. The first and second emitting guns are placed on one side of the measurement tank, the receiving gun is placed on the other side of the measurement tank along the main optical axis and the triggering gun is placed on the other side of the tank.Type: GrantFiled: January 15, 2021Date of Patent: January 9, 2024Assignee: HORIBA ABX SASInventors: Philippe Genevaux, Nelly Rongeat
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Publication number: 20230066255Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.Type: ApplicationFiled: January 15, 2021Publication date: March 2, 2023Applicants: HORIBA ABX SAS, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NICOUD
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Publication number: 20230052921Abstract: An electro-optical device for taking flow measurements includes a measurement tank through which a flow of fluid to be characterized flows, at least first and second guns for emitting light having separate spectra, a triggering gun allowing diffraction to be measured at small angles and a receiving gun allowing a measurement of attenuation and at least one fluorescence to be taken. The first emitting gun includes a light source defining a main optical axis perpendicular to the fluid flow, and the second emitting gun includes a second light source defining a secondary optical axis substantially orthogonal to the main optical axis and fluid flow. The first and second emitting guns are placed on one side of the measurement tank, the receiving gun is placed on the other side of the measurement tank along the main optical axis and the triggering gun is placed on the other side of the tank.Type: ApplicationFiled: January 15, 2021Publication date: February 16, 2023Applicant: HORIBA ABX SASInventors: Philippe GENNEVAUX, Nelly RONGEAT
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Patent number: 11385158Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (Type: GrantFiled: October 30, 2018Date of Patent: July 12, 2022Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SASInventors: Pierre Blandin, Anais Ali-Cherif, Aurelien Daynes, Estelle Gremion, Damien Isebe
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Patent number: 11376556Abstract: A device for shaking and sampling biological liquids that is able to take a sample of a biological liquid in a tube including a shaker designed to mix a rack holding one or more tubes by performing a succession of tilting movements between two shaking positions. The shaker is also arranged to tilt beyond the shaking position furthest away from the insertion position of a rack to discharge same by gravity.Type: GrantFiled: July 25, 2017Date of Patent: July 5, 2022Assignee: HORIBA ABX SASInventors: Jean Emmanuel Laravine, Charlène Muzellier
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Publication number: 20220196538Abstract: A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).Type: ApplicationFiled: April 24, 2020Publication date: June 23, 2022Applicants: HORIBA ABX SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE MONTPELLIERInventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NlCOUD
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Patent number: 11366128Abstract: A biological analysis system comprising at least one inlet and one outlet, at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising a region for the exchange of tube holding racks with the conveyor. The conveyor and the at least one inlet of the biological analysis system comprise a reader of an identifier of a tube holding rack which reader is designed to communicate an identifier it has read to a controller of the biological analysis system, which controller is designed to apply a specific treatment to a tube holding rack identified by the reader of the conveyor and the identifier of which has not previously been read by the reader of the at least one inlet of the biological analysis system.Type: GrantFiled: January 17, 2018Date of Patent: June 21, 2022Assignee: HORIBA ABX SASInventors: Florent Beauducel, Philippe Benezeth, Thibault Cres
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Patent number: 11360109Abstract: A biological analysis system comprises at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising at least one inlet and one outlet for racks of tubes, and at least one exchange region for exchanging racks of tubes with the conveyor, which exchange region is distinct from the inlet and from the outlet. The inlet of at least two biological analysis devices each form an inlet of the biological analysis system for racks of tubes, and the outlet of at least two biological analysis devices each form an outlet of the biological analysis system for racks of tubes. The biological analysis system further comprises a controller designed to command the transfer of a rack of tubes received in the biological analysis system via the conveyor to another biological analysis device according to the operations to be performed on the tubes in that rack and/or according to a respective workload status of the biological analysis devices.Type: GrantFiled: January 17, 2018Date of Patent: June 14, 2022Assignee: HORIBA ABX SASInventors: Florent Beauducel, Philippe Benezeth, Thibault Cres
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Publication number: 20220018756Abstract: A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.Type: ApplicationFiled: December 16, 2019Publication date: January 20, 2022Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS, IPRASENSE SASInventors: Pierre BLANDIN, Cédric ALLIER, Olivier CIONI, Lionel HERVE, Pierre JOLY, Jean-Marc DINTEN
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Publication number: 20210387190Abstract: A device for preparing a solution from a sample and a reagent, the device includes a microfluidic array having a sample supply inlet, a reagent supply inlet, a discharge outlet, a solution collection outlet, a sampling zone to which the inlets are connected, first and second preparation chambers connected to the sampling zone, arranged to either side of the sampling zone such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone, the first preparation chamber having a volume that is variable between a minimum volume and a calibrated volume. The device includes valves interrupting the flow of the fluid at least at the two inlets and the collection and discharge outlets.Type: ApplicationFiled: November 7, 2019Publication date: December 16, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SASInventors: Yves FOUILLET, Anais ALI-CHERIF
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Patent number: 11199488Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.Type: GrantFiled: December 20, 2017Date of Patent: December 14, 2021Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SASInventors: Pierre Blandin, Anais Ali-Cherif, Estelle Gremion, Sebastien Raimbault, Olivier Cioni, Aurelien Daynes
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Publication number: 20210131944Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.Type: ApplicationFiled: December 20, 2017Publication date: May 6, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES AlTERNATIVES, HORIBA ABX SASInventors: Pierre BLANDIN, Anais ALI-CHERIF, Estelle GREMION, Sebastien RAIMBAULT, Oliver CIONI, Aurelien DAYNES
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Patent number: 10845286Abstract: A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave.Type: GrantFiled: March 22, 2017Date of Patent: November 24, 2020Assignees: COMMISSARIAT Á L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, HORIBA ABX SAS, IPRASENSE SASInventors: Cedric Allier, Anais Ali Cherif, Pierre Blandin, Geoffrey Esteban, Lionel Herve, Damien Isebe
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Publication number: 20200326269Abstract: The invention is a method for estimating a representative volume of particles of interest (10 i) immersed in a sample, the sample extending in at least one plane, referred to as the sample plane (P 10), the sample comprising a sphering agent, capable of modifying the shape of the particles, the method comprising the following steps: a) illuminating the sample by means of a light source (11), the light source emitting an incident light wave (12) propagating towards the sample (10) along a propagation axis (Z); b) acquiring, by means of an image sensor (16), an image (I 0) of the sample (10), formed in a detection plane (P 0), the sample being arranged between the light source (11) and the image sensor (16), each image being representative of a light wave (14) referred to as an exposure light wave, to which the image sensor (16) is exposed under the effect of illumination; c) using the image of the sample (I 0), acquired during step b), and a holographic propagation operator, to calculate a complex expression (Type: ApplicationFiled: October 30, 2018Publication date: October 15, 2020Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SASInventors: Pierre BLANDIN, Anais ALI-CHERIF, Aurelien DAYNES, Estelle GREMION, Damien ISEBE
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Patent number: 10794922Abstract: A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes and a sampling apparatus capable of collecting a biological liquid sample in a tube. The device also comprises a scheduler arranged to specify an order of sampling from the tubes independently of the order in which the tubes are positioned in the respective racks and the order in which the racks are inserted into the device. The scheduler is arranged to control the agitator and the sampling apparatus to process the tubes in accordance with the sampling order.Type: GrantFiled: November 9, 2016Date of Patent: October 6, 2020Assignee: HORIBA ABX SASInventors: Sylvain Andlauer, Florent Beauducel, Philippe Benezeth
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Patent number: 10641697Abstract: A device for counting particles comprises a detector arranged to produce an electrical measurement signal in response to the passage of one or more particles, and a comparator arranged to compare the measurement signal with a threshold signal and to increment a counting value when the measurement signal exceeds the threshold signal, characterized in that it furthermore comprises a threshold-adjusting circuit that applies a lowpass filter to the measurement signal, and that is connected to the comparator in order to use the resulting signal as threshold signal.Type: GrantFiled: April 1, 2016Date of Patent: May 5, 2020Assignee: HORIBA ABX SASInventor: Guilhem Couderc
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Patent number: 10481076Abstract: A method for identifying a state of a cell contained in a sample, including: illuminating the sample using a light source by producing an incident light wave propagating toward the sample; then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between the light source and the matrix-array photodetector such that the matrix-array photodetector is exposed to a light wave resulting from interference between the incident light wave and a diffraction wave produced by each cell; applying a numerical reconstruction algorithm to the image acquired by the matrix-array photodetector, to estimate a characteristic quantity of the light wave reaching the matrix-array detector, at a plurality of distances from the matrix-array photodetector. The value of the characteristic quantity, or its variation as a function of distance, allows the state of the cell to be determined from among predetermined states.Type: GrantFiled: March 23, 2016Date of Patent: November 19, 2019Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, IPRASENSE SAS, HORIBA ABX SASInventors: Cedric Allier, Geoffrey Esteban, Lionel Herve