Abstract: The present invention relates to an improved process for the preparation of Tazobactam of formula (I) having reduced content of cresol.

Abstract: A medication management system (MMS) includes a medication management unit (MMU) associated with a medical device. The MMU downloads a medication order to the medical device only if information from a first input matches information from a second input. The medical device receives delivery information only from the MMU. The medication order is performed only after delivery data validation. The MMU also determines drug-drug incompatibility. The MMU can modulate (start, stop, and dynamically adjust) medication order performance. The medical device wirelessly receives a patient ID to automatically associate with the patient. During delivery, the medical device caches an updated drug library to replace an existing one. The medical device displays a patient picture for validation. The MMU evaluates the performance of medical devices and caregivers based medical device feedback. The MMU adjusts the output of medical device information conveyed to a caregiver.

Abstract: An infusion system includes a pump, a fluid delivery line, a sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the sensor. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the sensor.

Abstract: In one aspect, the invention is directed to a port assembly for establishing fluid communication between a first container and a second container. The port assembly includes a retainer for connecting a first container, where the retainer is positioned in a cavity defined by a port housing that includes an axially fixed actuator. The housing also includes a plug member constructed to seal a fluid passageway between the port housing and an interior of a second container. The plug member is configured to move axially relative to the actuator. Rotation of the retainer relative to the actuator causes the plug member to move to an open position in which it does not seal a fluid passageway between the port housing and an interior of a second container. The rotation of the retainer relative to the port housing also causes the retainer to move axially relative to the port housing so that the actuator forces a stopper associated with a first container connected to the retainer into a first container.

Abstract: A method and system is disclosed for operating a medical device with or without a cassette in place. A method is disclosed for adding additional VTBI to an ongoing infusion without stopping the infusion and with maintaining the infusion parameters. A method and system is disclosed for changing the CCA without having to interrupt or completely stop an ongoing infusion. Quick titration buttons are provided to allow improved navigation between various delivery display screens.

Abstract: A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HCl (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.

Abstract: A syringe holder includes a body with a syringe retainer, an elongated finger and a stop member connected to the body. The finger inserts longitudinally into a socket on a pump without the aid of tools and permits the holder to move in multiple planes. The stop member limits such movement. The stop member can include a clip for releasably clamping onto a portion of a pump. The syringe retainer can include a hole in the body and may optionally include an adaptor mounted in or extending into the hole for detachably attaching a syringe. The syringe holder can be incorporated into a tube set assembly or an infusion system.

Abstract: A system for mixing the contents of a first container and a second container. The system includes the first container that has container body with an opening fluidly connected to a cavity defined by the container body, a first substance contained in the cavity, and a stopper sealing the opening. The second container includes a port assembly including a port housing connected to the second container and a retainer constructed to connect to the first container. The retainer is configured to rotate and move axially relative to the port housing, wherein relative rotation between the port housing and the retainer causes the retainer to move axially relative to the port housing. The port assembly further includes an axially fixed actuator constructed to force the stopper into the first container when the retainer is rotated relative to the port housing.

Abstract: A port assembly for establishing fluid communication between a first container and a second container. The port assembly includes a port housing for connection to a second container, and a retainer for connection to a first container, wherein the retainer rotates relative to the port housing and is constructed to move axially within the port housing. An actuator is axially fixed within the port housing and forces a stopper associated with a first container into a first container when the retainer moves axially within the port housing upon rotation of the retainer relative to the port housing. The assembly is configured to establish fluid communication between a first container and a second container upon rotation of the retainer relative to the port housing.

Abstract: An ultrasonic monitoring device includes a substrate, a plurality of ultrasonic transducer elements, a computer readable memory medium, a microprocessor, and a power source. The ultrasonic transducer elements are coupled to the substrate. Each ultrasonic transducer element is separately configured to transmit a signal to a target area of a mammal and to receive an echo return signal from the target area. The computer readable memory medium includes program instructions. The microprocessor is coupled to the ultrasonic transducer elements and to the computer readable memory medium for executing the program instructions to determine a physiological parameter of the mammal based on a combined analysis of the echo return signals received by the ultrasonic transducer elements. The power source is coupled to at least one of the ultrasonic transducer elements, the computer readable memory medium, or the microprocessor for supplying electrical energy.

Abstract: An infusion system and method for controlling the fluid flow from a pump includes a pump system that has a controller that utilizes an algorithm to control the flow rate of fluid through tubing. A plurality of electrodes operatively contacts an electrically conductive portion of the tubing that is also acted upon by the pump system. The electrodes monitor electrical properties of the tubing and provide an electric signal indicative thereof to the controller, which varies the flow rate of the fluid through the tubing as a result of the electric signal.

Abstract: A system and method of varying the flow rate of fluid from a medical pump through tubing includes determining an inner diameter of the tubing and fluid flow velocity of fluid in the tubing with a controller based on acoustic signals received by a capacitive micromachined ultrasonic transducer sensor system and then determining and adjusting a fluid flow rate of fluid in the tubing with the controller. In addition, the same sensor system also detects air bubbles in the fluid in the tubing.

Abstract: A system for mixing contents of a first container with contents of a second container. The system includes a first container, a second container, a device for establishing fluid communication between the first container and the second container, and a hanger for hanging the system, wherein the hanger is operable only when fluid communication between the first container and the second container has been established. The system can be used in a method for preventing medication delivery errors.

Abstract: A system and method for intermixing the contents of two containers. The system includes a first container, a second container, and a connector for providing fluid communication between the first and second containers. The connector includes at least one resilient retention member for securing the first container to the connector. In addition, the connector accommodates standard vials containing, for example, medicaments, and prevents the unwanted discharge of the contents of the vial into the environment.

Abstract: A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HCl (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.

Abstract: A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.

Abstract: Infusion systems and methods containing unique inner passage configurations are provided to improve the in-line detection of air in a fluid delivery line of an infusion system by reducing the problems associated with the presence of bouncing air bubbles and stuck fluid droplets in the fluid delivery line.

Abstract: The presently disclosed subject matter is directed to methods of treating post-operative pain by administering a combination of a lower than minimum approved dose of diclofenac and beta-cyclodextrin. The presently disclosed subject matter is also directed to methods of treating pain in high risk or obese mammals in need of analgesia.

Abstract: A method of aggregating and using medical device data from a plurality of remote institutions. The system and method electronically receives at a central computer system a plurality of established medical device data, each of the plurality of established medical device data being received from a respective medication delivery system, each of the respective medication delivery systems having a respective plurality of medical devices within the respective remote institution, such as medication delivery pumps, associated therewith and utilized therein. The system and method electronically combines and stores the plurality of established medical device data from each of the plurality of remote institutions within a memory, and electronically provides a remote client computer access to at least one of a central reporting application adapted for providing summary information to the remote client computer about the medical device data, and/or other applications.

Abstract: A system and method for verifying identification of an authorized person by biometrics prior to a patient controlled analgesic medication delivery to the patient and for monitoring the delivery of medication to a patient is disclosed, along with a monitoring system and method for controlling medication delivery based on at least one monitored patient condition.