Abstract: A pharmaceutical formulation containing 50-90% by weight a powdered extract of Andrographis paniculata and 5-50% by weight a powdered blocking agent. The formulation may further contain a pore-forming agent, a filler, a lubricant, or a glidant. Also described are a method for preparing this pharmaceutical formulation and a method for treating inflammatory disease, immunological disease, or respiratory disease with it.
Type:
Application
Filed:
December 15, 2010
Publication date:
June 16, 2011
Applicant:
Hutchison Medipharma Enterprises Limited, Offshore Group Chambers
Abstract: This invention relates to a compound of the following formula: wherein R1, R2, R3, G, and Z are defined herein. It also relates to is methods of treating autoimmune disease, cancer, and atherosclerosis with such a compound.
Abstract: A compound of Formula I: Each variable is defined in the specification. This invention relates to a method of decreasing a level of a cytokine (e.g., TNF? or interlukine such as IL-1?) in a subject with a compound of Formula I. It also relates to a method of treating a disorder mediated by an overproduction of a cytokine with such a compound.
Abstract: Substituted quinazoline compounds of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and X are defined herein. It also discloses a pharmaceutical composition containing one of these compounds.
Abstract: Pyrimidine compounds of the following formula: wherein R1, R2, R3, R4, R5, X, Q1, Q2, and Q3 are defined herein. Also disclosed is a method of treating cancer with one of these compounds.
Abstract: Pyrimidine compounds of the following formula: wherein R1, R2, R3, R4, R5, X, Q1, Q2, and Q3 are defined herein. Also disclosed is a method of treating cancer with one of these compounds.
Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.
Abstract: A traffic signal including a housing, a light source disposed within the housing, and a door operably attached to the housing. The door is configured such that photons generated by the light source may be sensed outside the housing. The traffic signal also includes a sensor attached to one of the door and the housing.
Abstract: This invention relates to a method of inhibiting the expression of TNF? or IL-1? with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
Type:
Grant
Filed:
March 11, 2005
Date of Patent:
December 1, 2009
Assignee:
Hutchison MediPharma Enterprises Ltd.
Inventors:
Xiaoqiang Yan, Tao Wang, Zhiming Ma, Ke Pan, Weihan Zhang, Jianrong Hong, Jeff Duan, Yu Cai
Abstract: Disclosed are methods for inhibiting TNF? expression, IL-1? expression, iNOS expression, and NF-?B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula:
Abstract: Quinazoline derivatives of the following formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.
Abstract: The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cells that over-express anti-apoptotic Bcl-2 family member proteins and typically exhibit reduced binding affinity for cytochrome B. Pharmaceutical uses of the agents and compositions include treating apoptosis-associated disease, such as neoplasia and drug resistance, are also disclosed.
Type:
Application
Filed:
June 25, 2007
Publication date:
August 13, 2009
Applicant:
Fred Hutchison Cancer Research Center
Inventors:
David M. Hockenberry, Julian A. Simon, Shie-Pon Tzung
Abstract: Provided are devices, methods, communication managers and user interface solutions that enable access to multiple services from a mobile communications device. A mobile communication device that provides telephony services via a PSTN also includes multiple communication channels that exploit packet data transfer via an IP network, for example enabling VoIP, instant messaging and other internet-based communication services to be initiated from a mobile telephone.
Type:
Application
Filed:
October 13, 2008
Publication date:
June 11, 2009
Applicant:
HUTCHISON WHAMPOA THREE G IP (BAHAMAS) LIMITED
Inventors:
Christopher Henry Seal, Gaetano Vitolo, Kevin David Joyce, Nadir El Yakhlifi
Abstract: Disclosed are methods for inhibiting TNF? expression, IL-1? expression, iNOS expression, and NF-?B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula:
Abstract: A compound of Formula I: Each variable is defined in the specification. This invention relates to a method of decreasing a level of a cytokine (e.g., TNF? or interlukine such as IL-1?) in a subject with a compound of Formula I. It also relates to a method of treating a disorder mediated by an overproduction of a cytokine with such a compound.