Patents Assigned to Immunex
  • Methods for increasing polypeptide production
    Publication number: 20050233415
    Abstract: The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and/or a xanthine derivative and/or an alkanoic acid can also be used, optionally at temperatures less than 37° C.
    Type: Application
    Filed: February 4, 2005
    Publication date: October 20, 2005
    Applicant: Immunex Corporation
    Inventors: Kirk Van Ness, Michael Trentalange, Bradley Dell, Jeffrey McGrew
  • Cytokine polypeptides
    Publication number: 20050233418
    Abstract: This invention relates to TMEM7 and TMEM7-related cytokines and to new members of the human cytokine polypeptide family, to methods of making such polypeptides, to methods of using them to treat conditions and diseases involving proliferation and/or differentiation of cells from pluripotent stem cell precursors, and to methods of using them to identify compounds that alter cytokine polypeptide activities.
    Type: Application
    Filed: October 15, 2004
    Publication date: October 20, 2005
    Applicant: Immunex Corporation
    Inventors: Peter Baum, Bruce Mosley
  • Human IL-1 epsilon DNA and polypeptides
    Patent number: 6949359
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: September 27, 2005
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Dirk E. Smith
  • Human IL-1 epsilon DNA and polypeptides
    Publication number: 20050208051
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, the use of such polypeptides in cellular and immune reactions, the use of such polypeptides in screening for agonists or antagonists of IL-1 epsilon activity, and kits comprising such polypeptides.
    Type: Application
    Filed: November 18, 2004
    Publication date: September 22, 2005
    Applicant: Immunex Corporation
    Inventors: John Sims, Dirk Smith
  • Screening assays for agonists or antagonists or receptor activator of NF-kappaB
    Publication number: 20050196801
    Abstract: The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO4 resorption.
    Type: Application
    Filed: April 4, 2005
    Publication date: September 8, 2005
    Applicant: Immunex Corporation
    Inventor: William Dougall
  • Viral proteins capable of binding LAR
    Publication number: 20050176640
    Abstract: A poxvirus protein designated A41L binds to leukocyte common-antigen-related protein (LAR). A41L is a secreted protein that can be purified from the culture supernatant of cells infected with certain poxviruses, or produced using recombinant DNA techniques. A41L polypeptides and LAR polypeptides, and nucleic acids encoding them, are provided herein. Also provided are methods of using such polypeptides and nucleic acids.
    Type: Application
    Filed: December 16, 2004
    Publication date: August 11, 2005
    Applicant: Immunex Corporation
    Inventors: Craig Smith, Raymond Goodwin
  • Feeding strategies for cell culture
    Patent number: 6924124
    Abstract: The invention is in the field of cell culture, particularly recombinant cell culture. More specifically, the invention relates to methods of fed batch CHO cell culture.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: August 2, 2005
    Assignee: Immunex Corporation
    Inventor: Pankaj Singh
  • Medium containing flt3 ligand for culturing hematophoietic cells
    Patent number: 6919206
    Abstract: Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3 -L finds use in treating patients with anemia, AIDS and various cancers.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: July 19, 2005
    Assignee: Immunex Corporation
    Inventors: Stewart D. Lyman, M. Patricia Beckmann
  • IL-1/TNF-?-activated kinase (ITAK), and methods of making and using the same
    Patent number: 6913893
    Abstract: Purified and isolated IL-1/TNF-?-activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 5, 2005
    Assignee: Immunex Corporation
    Inventors: John E. Sims, G. Duke Virca, Timothy A. Bird, Dirk M. Anderson
  • GNK interacting amino acid decarboxylase and methods of use thereof
    Patent number: 6911336
    Abstract: The present invention discloses a novel polypeptide that contains an amino acid decarboxylase domain, and is a substrate for caspase-3. Nucleic acids that encode the novel polypeptide and antibodies to the polypeptide are also part of the present invention. Methods of using the polypeptide, the nucleic acids and antibodies are also provided.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: June 28, 2005
    Assignee: Immunex Corporation
    Inventors: Pamela M. Holland, G. Duke Virca, Timothy A. Bird, Kirsten Garka
  • Method for treatment of tumors using photodynamic therapy
    Publication number: 20050129689
    Abstract: A method for treating tumor-bearing subjects that includes administering to the tumor bearing subject a therapeutically effective amount of a CD40 binding protein in conjunction with photodynamic therapy, is disclosed.
    Type: Application
    Filed: November 12, 2004
    Publication date: June 16, 2005
    Applicant: Immunex Corporation
    Inventors: William Fanslow, Elaine Thomas
  • Human IL-1 epsilon DNA and polypeptides
    Publication number: 20050131218
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.
    Type: Application
    Filed: November 12, 2004
    Publication date: June 16, 2005
    Applicant: Immunex Corporation
    Inventors: John Sims, Dirk Smith
  • Methods and host cells for improved cell culture
    Patent number: 6897040
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: May 24, 2005
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, Pranhitha Reddy
  • Methods for producing proteins in cultured cells
    Patent number: 6890736
    Abstract: The invention provides a method for increasing production of a protein by cultured mammalian cells comprising adding a DNA demethylating agent, for example a cytidine analogue, to the mammalian cell culture. The cytidine analogue can be 5-aza-2?-deoxycytidine (also called decitabine) or 5-bromo-2?-deoxycytidine-5?-monophosphate, among many other possible cytidine analogues.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: May 10, 2005
    Assignee: Immunex Corporation
    Inventors: Pranhitha Reddy, Brian D. Rasmussen
  • MyD88 adapter-like proteins
    Patent number: 6887684
    Abstract: There are disclosed MAL-1 polypeptides and active fragments of MAL-1, including fragments that associate with IRAK2. Further disclosed are DNAs encoding the polypeptides and fragments as well as methods of using the DNAs and polypeptides.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: May 3, 2005
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Timothy A. Bird, Luke A. J. O'Neill
  • Nucleic acids encoding human ataxin-1-like polypeptide IMX97018
    Patent number: 6887687
    Abstract: This invention relates to IMX97018, a new members of the human ataxin-1-like polypeptide family, methods of making such polypeptides, and to methods of using them to diagnose and treat neurological conditions and to identify compounds that alter IMX97018 polypeptide activities.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: May 3, 2005
    Assignee: Immunex Corporation
    Inventor: Dirk M. Anderson
  • Methods of inhibiting osteoclastogenesis
    Publication number: 20050089522
    Abstract: Provided here are methods of inhibiting RANKL-induced osteoclastogenesis in patients suffering from specific types of cancer.
    Type: Application
    Filed: November 30, 2004
    Publication date: April 28, 2005
    Applicant: Immunex Corporation
    Inventors: Dirk Anderson, Laurent Galibert
  • Screening assays for agonists and antagonists of receptor activator of NF-?B
    Patent number: 6884598
    Abstract: The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO4 resorption.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: April 26, 2005
    Assignee: Immunex Corporation
    Inventor: William C. Dougall
  • Methods for increasing polypeptide production
    Patent number: 6872549
    Abstract: The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and/or a xanthine derivative and/or an alkanoic acid can also be used, optionally at temperatures less than 37° C.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: March 29, 2005
    Assignee: Immunex Corporation
    Inventors: Kirk P. Van Ness, Michael T. Trentalange, Bradley D. Dell, Jeffrey T. McGrew
  • IL-1 delta DNA and polypeptides
    Publication number: 20050058625
    Abstract: DNA encoding IL-1 delta polypeptides and methods for using the encoded polypeptides are disclosed.
    Type: Application
    Filed: September 23, 2004
    Publication date: March 17, 2005
    Applicant: Immunex Corporation
    Inventor: John Sims