Patents Assigned to Immunolight, LLC
  • Publication number: 20130102054
    Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.
    Type: Application
    Filed: December 13, 2012
    Publication date: April 25, 2013
    Applicant: Immunolight, LLC
    Inventor: Immunolight, LLC
  • Patent number: 8389958
    Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength ?1 of radiation, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength ?1 or the second wavelength ?2, or with both ?1 and ?2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength ?2, generates the photostimulated reaction.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: March 5, 2013
    Assignees: Duke University, Immunolight, LLC
    Inventors: Tuan Vo-Dinh, Jonathan P. Scaffidi, Venkata Gopal Reddy Chada, Benoit Lauly, Yan Zhang, Molly K. Gregas, Ian Nicholas Stanton, Joshua T. Stecher, Michael J. Therien, Frederic A. Bourke, Jr., Zak Fathi, Jennifer Ann Ayres, Zhenyuan Zhang, Joseph H. Simmons, Stephen John Norton
  • Patent number: 8383836
    Abstract: Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferat
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: February 26, 2013
    Assignees: Duke University, Immunolight, LLC
    Inventors: Eric Toone, David Gooden, Tuan Vo-Dinh, Frederic A. Bourke, Jr.
  • Patent number: 8376013
    Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: February 19, 2013
    Assignees: Duke University, Immunolight, LLC
    Inventors: Frederic Avery Bourke, Jr., Tuan Vo-Dinh
  • Publication number: 20120089180
    Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
    Type: Application
    Filed: May 6, 2011
    Publication date: April 12, 2012
    Applicants: Duke University, Immunolight, LLC
    Inventors: Zakaryae Fathi, James Clayton, Harold Walder, Frederic A. Bourke, JR., Ian Stanton, Jennifer Ayres, Joshua T. Stecher, Michael Therien, Eric Toone, Dave Gooden, Mark Dewhirst, Joseph A. Herbert, Diane Fels, Katherine S. Hansen
  • Publication number: 20120064134
    Abstract: A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.
    Type: Application
    Filed: August 5, 2011
    Publication date: March 15, 2012
    Applicant: Immunolight, LLC
    Inventors: Frederic J. Bourke, JR., Harold Walder
  • Publication number: 20110263920
    Abstract: The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation
    Type: Application
    Filed: July 14, 2009
    Publication date: October 27, 2011
    Applicants: Duke University, Immunolight, LLC
    Inventors: Frederic A. Bourke, JR., Tuan Vo Dinh
  • Publication number: 20110126889
    Abstract: A system and a conversion element for power conversion. The power conversion system includes a power conversion device which produces electric power upon illumination and includes a light conversion device which down-converts and up-converts a radiant source of energy into a specific energy spectrum for the illumination of the power conversion device. The conversion element includes a first plurality of particles which upon radiation from a first radiation source radiate at a higher energy than the first radiation source, and includes a second plurality of particles which upon radiation from the first radiation source radiate at a lower energy than the first radiation source. At least one of the first plurality of particles and the second plurality of particles can be at least partially metal coated.
    Type: Application
    Filed: September 27, 2010
    Publication date: June 2, 2011
    Applicants: Immunolight, LLC, Duke University
    Inventors: Frederic A. BOURKE, JR., Zak Fathi, Ian Nicholas Stanton, Michael J. Therien
  • Publication number: 20110117202
    Abstract: Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength ?1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
    Type: Application
    Filed: November 10, 2010
    Publication date: May 19, 2011
    Applicants: Immunolight, LLC, Duke University
    Inventors: Frederic A. Bourke, JR., Zakaryae Fathi, Ian Nicholas Stanton, Michael J. Therien, Paul Rath Stauffer, Paolo MacCarini, Katherine Sarah Hansen, Diane Renee Fels, Cory Robert Wyatt, Mark Wesley Dewhirst
  • Publication number: 20110021970
    Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength ?1, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1.
    Type: Application
    Filed: April 21, 2010
    Publication date: January 27, 2011
    Applicants: Duke University, Immunolight, LLC
    Inventors: Tuan VO-DINH, Jonathan P. SCAFFIDI, Venkata Gopal Reddy CHADA, Benoit LAULY, Yan ZHANG, Molly K. GREGAS, Ian N. STANTON, Joshua T. STECHER, Michael J. THERIEN, Frederic A. BOURKE, JR., Harold WALDER, Zak FATHI, Jennifer A. AYRES, Zhenyuan ZHANG, Joseph H. SIMMONS, Stephen John NORTON
  • Publication number: 20100266621
    Abstract: Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferat
    Type: Application
    Filed: April 20, 2010
    Publication date: October 21, 2010
    Applicants: Duke University, Immunolight, LLC
    Inventors: Eric Toone, David Gooden, Tuan Vo-Dinh, Frederic A. Bourke, JR.
  • Publication number: 20100261263
    Abstract: A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength ?1 of radiation, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength ?1 or the second wavelength ?2, or with both ?1 and ?2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength ?2, generates the photostimulated reaction.
    Type: Application
    Filed: March 16, 2010
    Publication date: October 14, 2010
    Applicants: Duke University, Immunolight, LLC
    Inventors: Tuan VO-DINH, Jonathan P. SCAFFIDI, Venkata Gopal Reddy CHADA, Benoit LAULY, Yan ZHANG, Molly K. GREGAS, Ian N. STANTON, Joshua T. STECHER, Michael J. THERIEN, Frederic A. BOURKE, JR., Zak FATHI, Jennifer A. AYRES, Zhenyuan ZHANG, Joseph H. SIMMONS, Stephen John Norton
  • Publication number: 20100016783
    Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
    Type: Application
    Filed: April 3, 2009
    Publication date: January 21, 2010
    Applicants: Duke University, Immunolight, LLC
    Inventors: Frederic J. BOURKE, JR., Tuan Vo-Dinh, Harold Walder
  • Publication number: 20090294692
    Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.
    Type: Application
    Filed: March 10, 2009
    Publication date: December 3, 2009
    Applicants: Duke University, Immunolight, LLC
    Inventors: Frederic Avery Bourke, JR., Tuan Vo-Dinh