Patents Assigned to Immunolight, LLC
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Patent number: 9630022Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.Type: GrantFiled: January 27, 2014Date of Patent: April 25, 2017Assignees: IMMUNOLIGHT, LLC., DUKE UNIVERSITYInventors: Frederic Avery Bourke, Jr., Tuan Vo-Dinh
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Publication number: 20170096585Abstract: A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.Type: ApplicationFiled: March 18, 2015Publication date: April 6, 2017Applicant: IMMUNOLIGHT, LLCInventors: Zakaryae FATHI, Frederic Avery BOURKE, Harold WALDER
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Patent number: 9579523Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.Type: GrantFiled: September 11, 2015Date of Patent: February 28, 2017Assignees: IMMUNOLIGHT, LLC, DUKE UNIVERSITYInventors: Frederic Avery Bourke, Jr., Tuan Vo-Dinh
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Publication number: 20170050046Abstract: A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photo-activatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.Type: ApplicationFiled: April 22, 2015Publication date: February 23, 2017Applicants: IMMUNOLIGHT, LLC., DUKE UNIVERSITY, NORTH CAROLINA STATE UNIVERSITYInventors: Harold WALDER, Frederic A. BOURKE, Zakaryae FATHI, Wayne F. BEYER, Mark W. DEWHIRST, Mark OLDHAM, Justus ADAMSON, Michael NOLAN
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Publication number: 20170043178Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength ?1, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1.Type: ApplicationFiled: August 25, 2016Publication date: February 16, 2017Applicants: IMMUNOLIGHT, LLC., DUKE UNIVERSITYInventors: Tuan VO-DINH, Jonathan P. SCAFFIDI, Venkata Gopal Reddy CHADA, Benoit LAULY, Yan ZHANG, Molly K. GREGAS, Ian Nicholas STANTON, Joshua T. STECHER, Michael J. THERIEN, Frederic A. BOURKE, JR., Harold WALDER, Zak FATHI, Jennifer A. AYRES, Zhenyuan ZHANG, Joseph H. SIMMONS, Stephen John NORTON
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Publication number: 20170027197Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.Type: ApplicationFiled: October 11, 2016Publication date: February 2, 2017Applicant: IMMUNOLIGHT, LLC.Inventors: FREDERIC AVERY BOURKE, JR., ZAKARYAE FATHI, HAROLD WALDER, WAYNE F. BEYER, JR.
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Patent number: 9526914Abstract: Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength ?1, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1. The methods may further be performed by application of an initiation energy to activate a photoactivatable agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure.Type: GrantFiled: May 19, 2015Date of Patent: December 27, 2016Assignees: Duke University, Immunolight, LLCInventors: Tuan Vo-Dinh, Jonathan P. Scaffidi, Venkata Gopal Reddy Chada, Benoit Lauly, Yan Zhang, Molly K. Gregas, Ian Nicholas Stanton, Joshua T. Stecher, Michael J. Therien, Frederic A. Bourke, Jr., Harold Walder, Zak Fathi, Jennifer A. Ayres, Zhenyuan Zhang, Joseph H. Simmons, Stephen John Norton
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Patent number: 9526913Abstract: A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.Type: GrantFiled: January 30, 2014Date of Patent: December 27, 2016Assignees: DUKE UNIVERSITY, IMMUNOLIGHT, LLCInventors: Tuan Vo-Dinh, Jonathan P. Scaffidi, Venkata Gopal Reddy Chada, Benoit Lauly, Yan Zhang, Molly K. Gregas, Ian Nicholas Stanton, Joshua T. Stecher, Michael J. Therien, Frederic A. Bourke, Jr., Harold Walder, Zak Fathi, Jennifer A. Ayres, Zhenyuan Zhang, Joseph H. Simmons, Stephen John Norton
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Publication number: 20160362534Abstract: A method is provided for de-bonding objects contained in an article at an interface between the objects, wherein the objects are joined at the interface through an intermediate layer, which involves applying energy from a radiation source, wherein the energy is sufficient to cause destruction of bonds within the intermediate layer; and separating the two objects from one another.Type: ApplicationFiled: June 15, 2016Publication date: December 15, 2016Applicant: Immunolight, LLC.Inventors: Zakaryae FATHI, John PACANOVSKY, Frederic A. BOURKE, JR.
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Publication number: 20160354467Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.Type: ApplicationFiled: August 2, 2016Publication date: December 8, 2016Applicant: IMMUNOLIGHT, LLC.Inventor: Frederic A. BOURKE, JR.
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Patent number: 9498643Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.Type: GrantFiled: November 4, 2015Date of Patent: November 22, 2016Assignee: IMMUNOLIGHT, LLCInventor: Frederic A. Bourke, Jr.
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Publication number: 20160331731Abstract: Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.Type: ApplicationFiled: July 27, 2016Publication date: November 17, 2016Applicants: IMMUNOLIGHT, LLC, DUKE UNIVERSITYInventors: Wenle XIA, David Gooden, Erik J. Soderblom, Eric J. Toone, Neil L. Spector, Wayne F. Beyer, JR., Harold Walder
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Publication number: 20160325111Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.Type: ApplicationFiled: May 11, 2016Publication date: November 10, 2016Applicants: IMMUNOLIGHT, LLC, DUKE UNIVERSITYInventors: Frederic A. BOURKE, JR., Tuan VO-DINH, Harold WALDER
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Patent number: 9488916Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.Type: GrantFiled: March 12, 2014Date of Patent: November 8, 2016Assignee: IMMUNOLIGHT, LLC.Inventors: Frederic Avery Bourke, Jr., Zakaryae Fathi, Harold Walder, Wayne F. Beyer, Jr.
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Publication number: 20160263393Abstract: Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength ?1, to generate a second wavelength ?2 of radiation having a higher energy than the first wavelength ?1.Type: ApplicationFiled: February 17, 2016Publication date: September 15, 2016Applicants: IMMUNOLIGHT, LLC, DUKE UNIVERSITYInventors: Tuan VO-DINH, Jonathan P. SCAFFIDI, Venkata Gopal Reddy CHADA, Benoit LAULY, Yan ZHANG, Molly K. GREGAS, Ian Nicholas STANTON, Joshua T. STECHER, Michael J. THERIEN, Frederic A. BOURKE, JR., Harold WALDER, Zak FATHI, Jennifer A. AYRES, Zhenyuan ZHANG, Joseph H. SIMMONS, Stephen John NORTON
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Patent number: 9439897Abstract: Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.Type: GrantFiled: January 23, 2015Date of Patent: September 13, 2016Assignees: IMMUNOLIGHT, LLC, DUKE UNIVERSITYInventors: Wenle Xia, David Gooden, Erik J. Soderblom, Eric J. Toone, Neil L. Spector, Wayne F. Beyer, Jr., Harold Walder
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Publication number: 20160243235Abstract: The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.Type: ApplicationFiled: November 20, 2015Publication date: August 25, 2016Applicants: Duke University, Immunolight, LLCInventors: Tuan VO-DINH, Frederic A. Bourke, JR.
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Publication number: 20160159065Abstract: A reactive polymer composition is provided, containing a (co)polymer that forms one or more reactive moities, either directly or indirectly, upon application of an ionizing radiation; and a multifunctional curing coagent, along with systems and methods for bonding substrates to one another using such a composition.Type: ApplicationFiled: December 4, 2015Publication date: June 9, 2016Applicant: Immunolight, LLCInventor: Zakaryae FATHI
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Patent number: 9358292Abstract: Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.Type: GrantFiled: November 6, 2007Date of Patent: June 7, 2016Assignee: Immunolight, LLCInventor: Frederic A. Bourke, Jr.
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Patent number: 9352040Abstract: Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.Type: GrantFiled: April 4, 2014Date of Patent: May 31, 2016Assignee: IMMUNOLIGHT, LLC.Inventor: Frederic Avery Bourke, Jr.