Abstract: Foundry coke products, and associated methods and systems for melting iron in a cupola furnace with the coke products are disclosed herein. A representative method can include receiving a population of coke products and iron in a cupola furnace, and melting the iron in the cupola furnace to form molten iron having a carbon content higher than a carbon content of the received iron. The coke products can comprise (i) an elongate shape including a length:width dimension of at least 1.5:1, (ii) an ash fusion temperature of no more than 2400° F., and/or (iii) a coke reactivity index (CRI) of at least 30%.

Abstract: The present technology is generally directed to vent stack lids and associated systems and methods. In particular, several embodiments are directed to vent stack lids having improved sealing properties in a coke processing system. In a particular embodiment, a vent stack lid comprises a first lid portion proximate to and at least partially spaced apart from a second lid portion. The vent stack lid further comprises a first sealing portion coupled to the first lid portion and a second sealing portion coupled to the second lid portion. In several embodiments, the second sealing portion at least partially overlaps the first sealing portion over the space between the first and second lid portions. In further embodiments, at least one of the first or second sealing portions includes layers of tadpole seals, spring seals, rigid refractory material, and/or flexible refractory blanket.

Abstract: The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.

Abstract: Techniques for creating and managing wagers on possible states within a live event, such as possible outcomes of subparts of a sporting event or other possible occurrences within the event. An initial state and multiple possible future states of a performance parameter of the event are determined based on state information of the event. A betting market may be created by determining probabilities and odds for the possible future states. Bets may be made on the possible future states via a touch-sensitive display. A payout may be made to a winner who selects a possible future state that actually occurs.

Abstract: In some embodiments, techniques for creating fabricable segmented designs for physical devices are provided. A proposed segmented design is determined based on a design specification. The proposed segmented design includes a plurality of segments that each includes an indication of a material for the segment. The proposed segmented design also includes lattice members and lattice voids. A size of the lattice members and a size of the lattice voids are greater than a size of the segments and are greater than or equal to at least one of a minimum feature width and a minimum feature spacing of a fabrication system Performance of the proposed segmented design is simulated. One or more lattice members and lattice voids are chosen to change to improve the performance of the proposed segmented design.

Abstract: A system and method of treating target tissue in a patient's eye, which includes generating a light beam, deflecting the light beam using a scanner to form first and second treatment patterns, delivering the first treatment pattern to the target tissue to form an incision that provides access to an eye chamber of the patient's eye, and delivering the second treatment pattern to the target tissue to form a relaxation incision along or near limbus tissue or along corneal tissue anterior to the limbus tissue of the patient's eye to reduce astigmatism thereof.

Abstract: A multi-dimensional latent space (defined by an Encoder model) corresponds to projections of sequences of aptamers. An architecture of the Encoder model, a hyperparameter of the Encoder model, or a characteristic of a training data set used to train the Encoder model was selected using an assessment of an encoding-efficiency of the Encoder model that is based on: a predicted extents to which representations in an embedding space are indicative of specific aptamer sequences to which a probability distribution of the embedding space differs from a probability distribution of a source space that represents individual base-pairs; generating projections in the latent space using representations of aptamers and the Encoder model; identifying one or more candidate aptamers for the particular target using the projections and the Decoder model; and outputting an identification of the one or more candidate aptamers.

Abstract: Some techniques relate to projecting aptamer representations into an embedding space and clustering the representations. A cluster-specific binding metric can be defined for each cluster based on aptamer-specific binding metrics of aptamers associated with the cluster. A subset of the clusters can be selected based on the cluster-specific binding metrics. Identifications of aptamers assigned to the subset of clusters can then be output.

Abstract: Disclosed is a system enabling micro-adjustments in headlamps having upper and lower modules. A link exists between the upper and lower modules, the length of the link is made to be adjustable. The lower module is located on a pivot so that adjustments made to the length of the link result in a desired lighting pattern.

Abstract: A laser eye surgery system focuses light along a beam path to a focal point having a location within a lens of the eye. The refractive index of the lens is determined in response to the location. The lens comprises a surface adjacent a second material having a second refractive index. The beam path extends a distance from the surface to the focal point. The index is determined in response to the distances from the surface to the targeted focal point and from the surface to the actual focal point, which corresponds to a location of a peak intensity of an optical interference signal of the focused light within the lens. The determined refractive index is mapped to a region in the lens, and may be used to generate a gradient index profile of the lens to more accurately place laser beam pulses for incisions.

Abstract: An apparatus configured to purify air and sanitizing including a main base including one or more buttons configured to operate the apparatus, a lid attachable to the main base and that includes one or more ventilation perforations to intake air and an orifice to output purified air, a filter adjacent to the one or more ventilation perforations and enclosed in the lid, wherein the filter is configured to remove at least bacteria from atmospheric air and extract purified air, a fan configured to intake atmospheric air into the filter and blow purified air extracted from the filter outside of an orifice of the lid, a tank configured to store liquid, wherein the liquid includes at least liquid sanitizer, a pump configured to output liquid stored in a tank, and a cavity section that includes an outlet configured to output the liquid sanitizer in response to actuation of the pump.

Abstract: A vaporizer heating element assembly has a case structure with a plurality of walls collectively defining a case interior. An upper wall has an access opening, a left wall has a reservoir window, and a lower wall has a vaporization window. A thin plate heating element formed from an electrically conductive material is positioned within the case structure parallel to the lower wall and adjacent the vaporization window. A liquid transport structure is configured for transporting liquid by capillary action from a liquid intake surface to a liquid outflow surface and is disposed within the case interior so that the liquid intake surface is adjacent the reservoir window and the liquid outflow surface is adjacent or in contact with the thin plate heating element. The heating element assembly also has an access closure sized and configured to seal the access opening.

Abstract: A method implemented in an ophthalmic surgical laser system that employs a resonant scanner, scan line rotator, and XY- and Z-scanners, for forming a corneal flap in a patient's eye with improved bubble management during each step of the flap creation process. A pocket cut is formed first below bed level, followed by the bed connected to the pocket cut, then by a side cut extending from the bed to the anterior corneal surface. The pocket cut includes a pocket region located below the bed level and a ramp region connecting the pocket region to the bed. The bed is formed by a hinge cut and a first ring cut at lower laser energies, followed by a bed cut and then a second ring cut, which ensures that any location in the flap bed is cut twice to minimize tissue adhesion. The side cut is formed by multiple side-cut layers at different depths which are joined together. All cuts are formed by scanning a laser scan line generated by the resonant scanner.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for governing phenotypic outcomes in plants. One method includes obtaining a model input comprising time series data, wherein the time series data comprises, for each previous time point of one or more previous time points, at least one of i) first multi-omics data corresponding to a plant at the previous time point, or ii) phenotypic data corresponding to the plant at the previous time point; and processing the model input using a machine learning model to obtain a model output that comprises, for each future time point of one or more of future time points, a prediction of at least one of i) a phenotype of the plant at the future time point, or ii) second multi-omics data corresponding to the plant at the future time point.

Abstract: Methods described herein include receiving data from flowing a plurality of aptamers over a sample of tumor cells randomly affixed to a surface of a microfluidic device. The tumor cells may include one or more unknown tumor subtypes of cells. The plurality of aptamers may include a plurality of aptamer families. Each aptamer family of the plurality of aptamer families may be determined to bind to at least one possible subtype of the tumor cells. The data may include a measure of binding affinity of each aptamer family to the tumor cells. The method may include analyzing the measure of the binding affinity of each aptamer family to the tumor cells. The analyzing may include classifying the binding affinity. The method may also include determining one or more aptamer families that characterize the one or more unknown tumor subtypes of cells based on the classifying.

Abstract: Lit image projection lamp and assemblies and methods to use the same to generate three-dimensional images. In an exemplary embodiment of a projection device of the present disclosure, the projection device comprises a light source and a curved lens positioned at a first distance from the light source, wherein the curved lens is a lenticular lens, having a concave portion and a convex portion, and wherein the projection device is configured to generate a homogenous light bar image from light emitted from the light source that passes through the curved lens.

Abstract: A composite wick is provided for use in a micro-vaporizer having a fluid reservoir and a heating element. The composite wick comprises a wick body positionable so that its upstream surface is in fluid communication with the fluid reservoir and the downstream surface is disposed in opposition to a surface of the heating element. The wick body comprises at least one base wick structure having a plurality of tortuous passages that collectively provide a capillary effect to draw fluid from the reservoir and transport it toward the downstream surface. The wick body further comprises an active material positioned within the wick body so that vaporizable fluid drawn through the wick body contacts and interacts with the active material. The active material is selected to impart a desired characteristic to the vaporizable fluid.