Patents Assigned to Incyte Genomics
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Patent number: 7105315Abstract: The invention provides a transmembrane protein that is differentially expressed in neoplastic disorders. It also provides for the use of the protein, a cDNA encoding the protein, and antibodies that specifically bind the protein in various methods to diagnose, stage, treat, or monitor the treatment of a neoplastic disorder.Type: GrantFiled: July 1, 2002Date of Patent: September 12, 2006Assignee: Incyte Genomics, Inc.Inventors: Amy K. W. Lasek, Mariah R. Baughn, Yalda Azimzai
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Publication number: 20060035315Abstract: The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.Type: ApplicationFiled: February 23, 2001Publication date: February 16, 2006Applicant: Incyte Genomics, Inc.Inventors: Henry Yue, Y Tang, Preeti Lal, Jennifer Policky, Danniel Nguyen, Janice Au-Young, Monique Yao, Farrah Khan, Narinder Walia, Ameena Gandhi, Catherine Tribouley, Chandra Arvizu, Michael Thornton, Barrie Greene, Roberto Hernandez, Mark Borowsky, Madhu Sanjanwala
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Publication number: 20040265891Abstract: The invention provides a polypeptide which encodes human presenilin variant. It also provides for the use of the cDNA and protein in the diagnosis, prognosis, treatment and evaluation of therapies for cancer or neurodegenerative or immune disorders. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.Type: ApplicationFiled: July 12, 2004Publication date: December 30, 2004Applicant: Incyte Genomics, Inc.Inventors: Chandra Arvizu, Lynn E. Murry, Matthew R. Kaser
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Publication number: 20040111674Abstract: Disclosed are methods, media and systems for graphically displaying computer-based biomolecular sequence information. Generally, biomolecular sequence information may be graphically depicted in a variety of different forms in accordance with the present invention. The sequence information may be composed of nucleotide or amino acid sequence information or both. The graphical depictions may be in several different formats providing different information relating to the sequences, and may be displayed in one or more screens of a computer user interface.Type: ApplicationFiled: November 3, 2003Publication date: June 10, 2004Applicants: Incyte Genomics, Inc., Incyte Pharmaceuticals, Inc.Inventors: Alex George Koleszar, Frank D. Russo, Joe Don Heath, Stephanie F. Berry, Rachel J. Wright, Peter A. Covitz, Yvonne R. Boldt, Lee Crawford
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Patent number: 6742004Abstract: Disclosed is a relational database system for storing and manipulating biomolecular sequence information, the database including genomic libraries for a plurality of types of organisms, the libraries having multiple genomic sequences, at least some of which represent open reading frames located along a contiguous sequence on each the plurality of organisms' genomes, and a user interface capable of receiving a selection of two or more of the genomic libraries for comparison and displaying the results of the comparison. The system also provides a user interface capable of receiving a selection of one or more probe open reading frames for use in determining homologous matches between such probe open reading frame(s) and the open reading frames in the genomic libraries, and displaying the results of the determination.Type: GrantFiled: March 15, 2002Date of Patent: May 25, 2004Assignee: Incyte Genomics, Inc.Inventors: Cathryn E. Sabatini, Joe Don Heath, Peter A. Covitz, Tod M. Klingler, Frank D. Russo, Stephanie F. Berry
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Publication number: 20040018188Abstract: The invention provides polynucleotides that encode SPARC-related proteins. It also provides for the use of the polynucleotide, protein, and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides methods for using the polynucleotides, proteins and antibodies.Type: ApplicationFiled: September 18, 2002Publication date: January 29, 2004Applicant: Incyte Genomics, Inc.Inventors: Michael G. Walker, Randi E. Krasnow, Lynn E. Murry
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Publication number: 20040010136Abstract: The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes of the composition.Type: ApplicationFiled: November 26, 2002Publication date: January 15, 2004Applicant: Incyte Genomics, Inc.Inventors: Janice Au-Young, Jeffrey J. Seilhamer
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Publication number: 20030232349Abstract: The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.Type: ApplicationFiled: October 18, 2002Publication date: December 18, 2003Applicant: Incyte Genomics, Inc.Inventors: Angelo M. Delegeane, Ameena R. Gandhi, April J. A. Hafalia, Dyung Aina M. Lu, Chandra S. Arvizu, Catherine M. Tribouley, Debopriya Das, Deborah A. Kallick, Danniel B. Nguyen, Ernestine A. Lee, Farrah A. Khan, Henry Yue, Janice Au-Young, Jennifer A. Griffin, Jennifer L. Policky, Jayalaxmi Ramkumar, Junming Yang, Kavitha Thangavelu, Li Ding, Liam Kearney, Mariah R. Baughn, Mark L. Borowsky, Madhusudan Sanjanwala, Monique G. Yao, Neil Burford, Narinder K. Chawla, Preeti G. Lal, Sally Lee, Stephen Todd, Terence P. Lo, Y. Tom Tang, Vicki S. Elliott, Yalda Azimzai, Yan Lu
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Publication number: 20030216311Abstract: The invention provides a human maternally transcribed protein (HMTP) and polynucleotides which identify and encode HMTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HMTP.Type: ApplicationFiled: January 9, 2003Publication date: November 20, 2003Applicant: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Preeti Lal, Neil C. Corley
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Patent number: 6649737Abstract: The invention provides human galactosyltransferases (HUGA) and polynucleotides which identify and encode HUGA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HUGA.Type: GrantFiled: August 12, 1999Date of Patent: November 18, 2003Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Purvi Shah, Chandra Patterson
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Publication number: 20030207299Abstract: The invention provides human human kinases (PKIN) and polynucleotides which identify and encode PKIN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PKIN.Type: ApplicationFiled: November 1, 2002Publication date: November 6, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Danniel B. Nguyen, Narinder K. Chawla, April J. A. Hafalia, Monique G. Yao, Ameena R. Gandhi, Rajagopal Gururajan, Li Ding, Chandra S. Arvizu, Henry Yue, Mariah R. Baughn, Catherine M. Tribouley, Michael B. Thornton, Vicki S. Elliott, Yan. Lu, Craig H. Ison, Janice K. Au-Young, Y. Tom Tang, Yalda Azimzai, John D. Burrill, Gregory A. Marcus, Kurt A. Zingler, Dyung Aina M. Lu, Preeti G. Lal, Jayalaxmi Ramkumar, Bridget A. Warren, Liam Kearney, Jennifer L. Policky, Kavitha Thangavelu, Neil Burford
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Patent number: 6643634Abstract: Disclosed are methods, media and systems for graphically displaying computer-based biomolecular sequence information. Generally, biomolecular sequence information may be graphically depicted in a variety of different forms in accordance with the present invention. The sequence information may be composed of nucleotide or amino acid sequence information or both. The graphical depictions may be in several different formats providing different information relating to the sequences, and may be displayed in one or more screens of a computer user interface.Type: GrantFiled: December 2, 2002Date of Patent: November 4, 2003Assignee: Incyte Genomics, Inc.Inventors: Alex George Koleszar, Frank D. Russo, Joe Don Heath, Stephanie F. Berry, Rachel J. Wright, Peter A Covitz, Yvonne R. Boldt, Lee Crawford
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Publication number: 20030198975Abstract: The invention provides human proteins associated with cell growth, differentiation, and death (CGDD) and polynucleotides which identify and encode CGDD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CGDD.Type: ApplicationFiled: October 31, 2002Publication date: October 23, 2003Applicant: Incyte Genomics, Inc.Inventors: Yalda Azimzai, Janice Au-Young, Sajeev Batra, Mariah R. Baughn, Shanya D. Becha, Mark L. Borowsky, Neil Burford, Li Ding, Vicki S. Elliott, Brooke M. Emerling, Ameena R. Gandhi, Kimberly J. Gietzen, Jennifer A. Griffin, April J. A. Hafalia, Cynthia D. Honchell, Preeti G. Lal, Soo Yeun Lee, Dyung Aina M. Lu, Chandra S. Arvizu, Jayalaxmi Ramkumar, Roopa M. Reddy, Madhusudan S. Sanjanwala, Y. Tom Tang, Narinder K. Chawla, Yu-Mei E. Wang, Bridget A. Warren, Yuming Xu, Junming Yang, Monique G. Yao, Henry Yue, Yeganeh Zebarjadian
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Publication number: 20030194721Abstract: The invention relates to isolated polynucleotides, purified polypeptides, and compositions comprising pluralities of polynucleotides that are differentially expressed when foam cells are treated with oxidized low-density lipoprotein and LPS as associated with atherosclerosis. The invention also presents the use of the polynucleotides as elements on a substrate and provides methods for using the polynucleotides and polypeptides.Type: ApplicationFiled: September 18, 2002Publication date: October 16, 2003Applicant: Incyte Genomics, Inc.Inventors: Thomas Mikita, Dov Shiffman, J. Gordon Porter, Matthew R. Kaser
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Patent number: 6633817Abstract: A method and system for generating and searching a tree-structured index of window vectors that represent database sequences comprise a window vector generation module, a tree-structured index generation module, a query sequence partitioning module, and a retrieval component. The window vector generation module partitions a database sequence into a plurality of overlapping windows. Each window has a fixed length W comprising a fixed number of nucleotides, and the offset among windows is determined by a parameter &Dgr;. The window vector generation module then maps each database sequence window into a window vector. The database sequence window vector indicates the frequency of appearance of each k-tuple in the corresponding database sequence window. The tree-structured index generation module then generates a tree-structured index using the database sequence window vectors.Type: GrantFiled: December 29, 1999Date of Patent: October 14, 2003Assignee: Incyte Genomics, Inc.Inventors: Michael G. Walker, James Z. Wang, Eldar Y. Giladi
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Publication number: 20030186333Abstract: The invention provides a Down syndrome critical region 1-like 1 protein, its encoding cDNAs, and antibodies that specifically bind the protein. The invention also provides for the use of these compositions in the diagnosis, prognosis, treatment and evaluation of progression and treatment of neurodegenerative disorders.Type: ApplicationFiled: November 6, 2002Publication date: October 2, 2003Applicant: Incyte Genomics, Inc.Inventors: Jeanne F. Loring, Debora W. Tingley, Carla M. Edwards, David G. Streeter
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Publication number: 20030180931Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.Type: ApplicationFiled: January 29, 2003Publication date: September 25, 2003Applicant: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry
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Publication number: 20030175754Abstract: The invention provides RVP variant, its encoding cDNAs, and antibodies that specifically bind the protein. The invention also provides for the use of these compositions in the diagnosis, prognosis, treatment and evaluation of progression and treatment of cell proliferative disorders.Type: ApplicationFiled: November 5, 2002Publication date: September 18, 2003Applicant: Incyte Genomics, Inc.Inventors: Lynn E. Murry, Jennifer L. Jackson, Y. Tom Tang, Chandra S. Arvizu
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Publication number: 20030171268Abstract: The present invention provides a human LEA motif protein (HuLEAP) and polynucleotides which identify and encode HuLEAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HuLEAP and a method for producing HuLEAP. The invention also provides for agonists, antibodies, or antagonists specifically binding HuLEAP, and their use, in the prevention and treatment of diseases associated with expression of HuLEAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HuLEAP for the treatment of diseases associated with the expression of HuLEAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HuLEAP.Type: ApplicationFiled: June 26, 2001Publication date: September 11, 2003Applicant: Incyte Genomics, IncInventors: Jennifer L. Hillman, Surya K. Goli
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Publication number: 20030167480Abstract: The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.Type: ApplicationFiled: June 13, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Janice Au-Young, Jennifer L. Hillman, Purvi Shah, Henry Yue