Patents Assigned to Incyte Genomics
-
Publication number: 20030064397Abstract: The invention provides a cDNA which encodes a transmembrane protein differentially expressed in prostate and lung cancer. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, in particular, prostate or lung cancers. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: ApplicationFiled: July 24, 2002Publication date: April 3, 2003Applicant: Incyte Genomics, Inc.Inventors: Kimberly M. Spancake, Paula K. Rickert, Preeti G. Lal, Craig H. Ison
-
Patent number: 6534275Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.Type: GrantFiled: January 14, 2000Date of Patent: March 18, 2003Assignee: Incyte Genomics, Corp.Inventors: Susan G. Stuart, Phillip R. Hawkins, Jeffrey J. Seilhamer, Lynn E. Murry
-
Publication number: 20030049786Abstract: The invention provides a human transducin beta-1 subunit (TBS) and polynucleotides which identify and encode TBS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating or preventing diseases associated with expression of TBS.Type: ApplicationFiled: September 5, 2002Publication date: March 13, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Preeti Lal, Neil C. Corley, Purvi Shah
-
Patent number: 6531575Abstract: The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.Type: GrantFiled: April 10, 2000Date of Patent: March 11, 2003Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Jennifer L. Hillman, Surya K. Goli
-
Patent number: 6527689Abstract: The invention provides a human maternally transcribed protein (HMTP) and polynucleotides which identify and encode HMTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HMTP.Type: GrantFiled: July 15, 1999Date of Patent: March 4, 2003Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Preeti Lal, Neil C. Corley
-
Patent number: 6524579Abstract: The invention provides human RNA binding proteins (RNABP) and polynucleotides which identify and encode RNABP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RNABP.Type: GrantFiled: October 20, 1999Date of Patent: February 25, 2003Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn
-
Patent number: 6524799Abstract: The invention provides mammalian cDNAs which encode mammalian SPARC-related proteins. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides expression vectors and host cells for the production of the proteins and transgenic model systems.Type: GrantFiled: August 16, 2000Date of Patent: February 25, 2003Assignee: Incyte Genomics, Inc.Inventors: Michael G. Walker, Randi E. Krasnow
-
Patent number: 6524838Abstract: The invention provides human peptidyl-prolyl isomerases (HPPIP) and polynucleotides which identify and encode HPPIP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPPIP.Type: GrantFiled: August 15, 2000Date of Patent: February 25, 2003Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Preeti Lal, Neil C. Corley, Chandra Patterson, Mariah R. Baughn
-
Patent number: 6524819Abstract: The invention provides a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the mammalian nucleic acid molecule for the characterization, diagnosis, evaluation, treatment, of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule.Type: GrantFiled: July 11, 2000Date of Patent: February 25, 2003Assignee: Incyte Genomics, Inc.Inventors: Jeanne F. Loring, Debora W. Tingley, Carla M. Edwards, David G. Streeter
-
Publication number: 20030036510Abstract: The present invention provides novel human cell division cycle proteins (collectively called HCDC) and polynucleotides which identify and encode HCDC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCDC. The invention also provides pharmaceutical compositions containing HCDC or antagonists to HCDC, and in the use of these compositions for the treatment of diseases associated with the expression of HCDC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCDC for the treatment of diseases associated with the expression of HCDC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HCDC or anti-HCDC antibodies which specifically bind to HCDC.Type: ApplicationFiled: May 28, 2002Publication date: February 20, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Jennifer L. Hillman, Janice Au-Young, Gary B. Zweiger
-
Patent number: 6518029Abstract: The invention provides human hydrolase-like molecules (HHLM) and polynucleotides which identify and encode HHLM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HHLM.Type: GrantFiled: July 7, 2000Date of Patent: February 11, 2003Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Preeti Lal, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Purvi Shah
-
Patent number: 6514751Abstract: The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.Type: GrantFiled: August 20, 2001Date of Patent: February 4, 2003Assignee: Incyte Genomics, Inc.Inventors: Timothy W. Johann, Sang Chul Park
-
Publication number: 20030022306Abstract: The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.Type: ApplicationFiled: August 28, 2002Publication date: January 30, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Phillip R. Hawkins
-
Publication number: 20030022254Abstract: The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of these nucleic acid sequences in a model system for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with expression of the mammalian nucleic acid sequence. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.Type: ApplicationFiled: September 4, 2002Publication date: January 30, 2003Applicant: Incyte Genomics, Inc.Inventors: Matthew R. Kaser, Mariah R. Baughn
-
Publication number: 20030022332Abstract: The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.Type: ApplicationFiled: August 6, 2002Publication date: January 30, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Surya K. Goli
-
Patent number: 6511833Abstract: The invention provides human fatty acid beta-oxidation enzymes (HUFA) and polynucleotides which identify and encode HUFA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUFA.Type: GrantFiled: January 11, 2000Date of Patent: January 28, 2003Assignee: Incyte Genomics, Inc.Inventors: Olga Bandman, Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
-
Patent number: 6509175Abstract: The present invention provides new methods of synthesizing cDNAs, methods of verifying full-length cDNAs, methods of producing cDNA libraries enriched for full-length inserts, and the like.Type: GrantFiled: April 11, 2001Date of Patent: January 21, 2003Assignee: Incyte Genomics, Inc.Inventors: Glenn K. Fu, Laura L. Stuve, Walter H. Lee, Irene Ni
-
Patent number: 6509155Abstract: The invention provides mammalian nucleic acid molecules and fragments thereof. It also provides for the use of the mammalian nucleic acid molecules for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with cell signaling, the immune system, and cell proliferation, particularly colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecules.Type: GrantFiled: February 18, 2000Date of Patent: January 21, 2003Assignee: Incyte Genomics, Inc.Inventors: Tod M. Klinger, Elizabeth A. Stewart, Henry Yue, Mariah R. Baughn
-
Patent number: 6506571Abstract: The invention provides a human glutathione-S-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HGST.Type: GrantFiled: November 29, 2000Date of Patent: January 14, 2003Assignee: Incyte Genomics, Inc.Inventors: Henry Yue, Neil C. Corley, Purvi Shah
-
Publication number: 20030008311Abstract: The present invention provides a human histone-like protein (HLP) and polynucleotides which identify and encode HLP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTP and for treating disorders associated with the expression of HLP.Type: ApplicationFiled: June 4, 2002Publication date: January 9, 2003Applicant: Incyte Genomics, Inc., formerly known as Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Surya K. Goli, Hong Zhang