Abstract: The invention provides GTPase activating proteins, their encoding cDNAs, and antibodies that specifically bind the proteins. The invention also provides for the use of these compositions in the diagnosis, prognosis, treatment and evaluation of progression and treatment of signaling, immune, and cell proliferative disorders, particularly colon cancer.
Type:
Application
Filed:
October 29, 2002
Publication date:
July 10, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Tod M. Klinger, Elizabeth A. Stewart, Henry Yue, Mariah R. Baughn
Abstract: The invention provides a human insulin receptor tyrosine kinase substrate (IRS-p53h) and polynucleotides which identify and encode IRS-p53h. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of IRS-p53h.
Type:
Grant
Filed:
March 23, 1998
Date of Patent:
July 8, 2003
Assignee:
Incyte Genomics, Inc.
Inventors:
Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Mariah Baughn
Abstract: The invention provides a mammalian cDNA which encodes a mammalian an RVP-1 variant. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of Crohn's disease. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Type:
Grant
Filed:
June 22, 2000
Date of Patent:
July 8, 2003
Assignee:
Incyte Genomics, Inc.
Inventors:
Lynn E. Murry, Jennifer L. Hillman, Y. Tom Tang, Chandra Patterson
Abstract: The invention provides a mammalian cDNA which encodes a mammalian Ankrd2V. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of muscle disorders such as muscle hypertrophy and particularly clear cell sarcoma. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Abstract: The invention provides cDNAs that are significantly co-expressed with known lung surfactant and surfactant synthesis genes. The invention also provides compositions, expression vectors, host cells, proteins encoded by the cDNAs and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis, treatment and evaluation of therapies for lung disorders.
Type:
Application
Filed:
September 6, 2002
Publication date:
July 3, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Michael G. Walker, Peter A. Spiro, Lynn E. Murry
Abstract: The invention provides polynucleotides that encode SPARC-related proteins. It also provides for the use of the polynucleotide, protein, and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides methods for using the polynucleotides, proteins and antibodies.
Type:
Application
Filed:
September 18, 2002
Publication date:
June 26, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Michael G. Walker, Randi E. Krasnow, Lynn E. Murry
Abstract: The present invention relates to a composition comprising a plurality of polynucleotide sequences. The composition can be used as probes or array elements.
Type:
Application
Filed:
December 5, 2002
Publication date:
June 26, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Roopa Reddy, Karl J. Guegler, Janice Au-Young
Abstract: The invention provides human fatty acid beta-oxidation enzymes (HUFA) and polynucleotides which identify and encode HUFA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUFA.
Type:
Application
Filed:
December 10, 2002
Publication date:
June 26, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Olga Bandman, Jennifer L. Hillman, Karl J. Guegler, Neil C. Corley, Y. Tom Tang, Purvi Shah
Abstract: The invention provides multichannel pipette heads and autopipettors for loading, measuring, transporting and dispensing, particularly from one micro-plate to another. An exemplary multichannel pipette head comprises a pump housing, pistons, a drive plate, an aspiration drive and bearing rails, wherein the pump housing comprises chambers adapted to receive the pistons, the pistons each comprise a shaft, the drive plate retains the pistons and translocates the piston shafts through the chambers, the aspiration drive translocates the drive plate along the bearing rails which pass through the drive plate and attach to the pump housing.
Abstract: The invention provides a human delayed rectifier potassium channel subunit (DRPCS) and polynucleotides which identify and encode DRPCS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of DRPCS.
Type:
Application
Filed:
July 30, 2002
Publication date:
June 19, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Jennifer L. Hillman, Chandra Patterson, Neil C. Corley
Abstract: The invention provides a T cell death-associated protein, its encoding cDNA, and an antibody that specifically binds the protein. It also provides for the use of the cDNAs, protein and antibodies thereto to diagnose, stage, treat or monitor the progression or treatment of cancer, particularly breast adenocarcinoma.
Type:
Application
Filed:
October 23, 2002
Publication date:
June 19, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Henry Yue, Chandra S. Arvizu, Neil C. Corley, Karl J. Guegler
Abstract: The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.
Abstract: The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells, agonists, antibodies or antagonists. The invention also provides methods for treating or preventing diseases associated with expression of human PAP-2.
Abstract: The invention provides a human arsenite-resistance protein (NITE) and polynucleotides which identify and encode NITE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NITE.
Type:
Application
Filed:
December 2, 2002
Publication date:
June 12, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Jennifer L. Hillman, Neil C. Corley, Chandra Patterson
Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel purinergic PU2 receptor (PNR) expressed in human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which encode PNR, expression vectors for the production of purified PNR, antibodies capable of binding specifically to PNR, hybridization probes or oligonucleotides for the detection of PNR-encoding nucleotide sequences, genetically engineered host cells for the expression of PNR, and diagnostic tests based on PNR-encoding nucleic acid molecules or antibodies produced against the polypeptide PNR.
Type:
Application
Filed:
September 11, 2002
Publication date:
June 12, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Roger Coleman, Janice Au-Young, Susan G. Stuart, Karl J. Guegler
Abstract: The invention provides a cDNA which encodes a human prostate-associated protease differentially expressed in prostate cancer. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of prostate cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Type:
Application
Filed:
September 4, 2002
Publication date:
June 5, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Kimberly M. Spancake, Olga Bandman, Preeti G. Lal
Abstract: The invention provides a human microtubule-associated protein (HMAP) and polynucleotides which identify and encode HMAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HMAP.
Abstract: The present invention provides a novel human tumor suppressor (NHTS) and polynucleotides which identify and encode NHTS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHTS and a method for producing NHTS. The invention also provides for agonists, antibodies, or antagonists specifically binding NHTS, and their use, in the prevention and treatment of diseases associated with expression of NHTS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHTS for the treatment of diseases associated with the expression of NHTS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHTS.
Abstract: The invention provides a human neurotrimin homolog (HNH) and polynucleotides which identify and encode HNH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HNH.
Abstract: The invention provides a Ras association domain containing protein, its encoding mammalian cDNA, and an antibody that specifically binds the protein. It also provides for the use of the cDNAs, complements, and variants thereof and of the protein, portions thereof and antibodies thereto to diagnose, stage, treat or monitor the progression or treatment of cell proliferative and inflammatory disorders.
Type:
Application
Filed:
October 10, 2002
Publication date:
May 29, 2003
Applicant:
Incyte Genomics, Inc.
Inventors:
Michael G. Walker, Tod M. Klinger, Randi E. Krasnow