Patents Assigned to Incyte Genomics, Inc.
  • CAF1-related protein
    Publication number: 20020160477
    Abstract: The invention provides a human CAF1-related protein (CAFRP) and polynucleotides which identify and encode CAFRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CAFRP.
    Type: Application
    Filed: April 5, 2002
    Publication date: October 31, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Neil C. Corley, Henry Yue
  • Human GTPase-associated proteins
    Publication number: 20020160488
    Abstract: The invention provides human GTPase-associated proteins (GPAP) and polynucleotides which identify and encode GPAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GPAP.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 31, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson
  • Human kallikrein
    Patent number: 6472195
    Abstract: The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKALL. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HKALL.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 29, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Preeti Lal
  • Human tumor suppressor
    Patent number: 6472508
    Abstract: The present invention provides a novel human tumor suppressor (NHTS) and polynucleotides which identify and encode NHTS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHTS and a method for producing NHTS. The invention also provides for agonists, antibodies, or antagonists specifically binding NHTS, and their use, in the prevention and treatment of diseases associated with expression of NHTS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHTS for the treatment of diseases associated with the expression of NHTS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHTS.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: October 29, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Sam La Brie, Surya K. Goli
  • Human transferase
    Patent number: 6471959
    Abstract: The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HUTRAN.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 29, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Preeti Lal, Olga Bandman, Jennifer L. Hillman, Karl J. Guegler, Gina A. Gorgone, Neil C. Corley, Chandra Patterson
  • HUMAN VESICLE BINDING PROTEIN
    Publication number: 20020155553
    Abstract: The present invention provides a human vesicle binding protein (MVBP) and polynucleotides which identify and encode MVBP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing MVBP and for treating or preventing disorders associated with expression of MVBP.
    Type: Application
    Filed: July 26, 1999
    Publication date: October 24, 2002
    Applicant: INCYTE GENOMICS, INC.
    Inventors: OLGA BANDMAN, PHILLIP R. HAWKINS
  • Transcription factor regulatory protein
    Patent number: 6465200
    Abstract: The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of these nucleic acid sequences in a model system for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with expression of the mammalian nucleic acid sequence. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: October 15, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Matthew R. Kaser, Mariah R. Baughn
  • Transducin beta-1 subunit
    Patent number: 6465619
    Abstract: The invention provides a human transducin beta-1 subunit (TBS) and polynucleotides which identify and encode TBS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating or preventing diseases associated with expression of TBS.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 15, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Preeti Lal, Neil C. Corley, Purvi Shah
  • Chemokine expressed in fetal spleen, its production and uses
    Publication number: 20020142398
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode FSEC, expression vectors for the production of purified FSEC, antibodies capable of binding specifically to FSEC, hybridization probes or oligonucleotides for the detection of FSEC-encoding nucleotide sequences, genetically engineered host cells for the expression of FSEC, diagnostic tests for chemokine activation based on FSEC-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
    Type: Application
    Filed: May 29, 2002
    Publication date: October 3, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Roger Coleman, Craig G. Wilde, Jeffrey J. Seilhamer
  • Human NIM1 kinase
    Patent number: 6458561
    Abstract: The invention provides a nucleic acid molecule which encodes the human NIM1 kinase. It also provides for the use of the nucleic acid molecule, fragments, variants and complements thereof and of the protein, portions thereof and antibodies thereto for characterization, diagnosis, evaluation, treatment, or prevention of disorders associated with expression. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic organism or model system.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: October 1, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Angela Molteni, Paola Magnaghi, Roberta Bosotti, Emanuela Scacheri, Antonella Isacchi, David M. Hodgson
  • Cyclophilin-type peptidyl-prolyl CiS/trans isomerase
    Patent number: 6458575
    Abstract: The invention provides a human cyclophilin-type peptidyl-prolyl cis/trans isomerase (CPCI) and polynucleotides which identify and encode CPCI. The invention also provides expression vectors, host cells, antibodies, agonists, and antagnists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of CPCI.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: October 1, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Translational regulator
    Publication number: 20020132330
    Abstract: The invention provides a human translational regulator (TRANAC) and polynucleotides which identify and encode TRANAC. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of TRANAC.
    Type: Application
    Filed: March 12, 2002
    Publication date: September 19, 2002
    Applicant: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Phillip R. Hawkins
  • Duplex probes for hybridization reactions
    Patent number: 6448013
    Abstract: Methods are provide for quantitatively determining the amount of polynucleotides in a sample. In one method, the distinct polynucleotide targets and standard polynucleotide targets are contacted with detectable probes and independently detectable single or double stranded complements to the standard targets under hybridization conditions. The hybridization pattern from the probe is compared to the hybridization pattern from the standard sequences to obtain quantitative information about the genetic profile of the labeled nucleic acid sample. Also provided are kits for the use of the methods.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 10, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle Arnold, Tod Bedilion, Erik Bieldanes, Thomas P. Theriault, Warren Lei
  • Colon cancer marker
    Patent number: 6448041
    Abstract: The invention provides a cDNA which encodes a colon cancer marker. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer and polyps. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: September 10, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Amy K. Wolven, Randi E. Krasnow, Bridget A. Warren, Mariah R. Baughn
  • Ndr2-related proteins
    Patent number: 6444430
    Abstract: The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: September 3, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Susan G. Stuart, Janice Au-Young, Jennifer L. Hillman, Purvi Shah, Henry Yue
  • Protein phosphatase
    Patent number: 6436637
    Abstract: The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: August 20, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Surya K. Goli, Preeti Lal, Neil C. Corley, Hong Zhang
  • Methods and compositions for producing full length cDNA libraries
    Patent number: 6436676
    Abstract: Methods and compositions are provided for producing full-length cDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length cDNA libraries are employed.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: August 20, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Karl Guegler, Ruoying Tan, Michael J. Rose
  • Human nucleic acid methylases
    Patent number: 6436683
    Abstract: The invention provides a human nucleic acid methylases (HNAM) and polynucleotides which identify and encode HNAM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HNAM.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: August 20, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Preeti Lal, Neil C. Corley, Karl J. Guegler, Henry Yue
  • Human mitochondrial chaperone protein
    Patent number: 6432915
    Abstract: The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: August 13, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Surya K. Goli
  • Human aspartic proteases
    Patent number: 6432690
    Abstract: The invention provides human aspartic proteases (NHAP) and polynucleotides which identify and encode NHAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NHAP.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: August 13, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Hong Xu, Sandra A. Bruno, Laura A. Elsenboss, Michael Fogliano, Victoria L. Cohan, Olga Bandman