Patents Assigned to Incyte Genomics, Inc.
  • Delayed rectifier potassium channel subunit
    Patent number: 6432687
    Abstract: The invention provides a human delayed rectifier potassium channel subunit (DRPCS) and polynucleotides which identify and encode DRPCS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of DRPCS.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: August 13, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Chandra Patterson, Neil C. Corley
  • Human phosphatase inhibitor protein
    Patent number: 6428949
    Abstract: The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.
    Type: Grant
    Filed: March 4, 1999
    Date of Patent: August 6, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Surya K. Goli
  • Bone remodeling genes
    Patent number: 6426186
    Abstract: The invention provides polynucleotides and polypeptides that are co-expressed with genes known to be involved in bone remodeling and osteoporosis. The invention also provides expression vectors, host cells, and methods for making a polypeptide, for screening or purifying ligands, and for diagnosing disorders associated with bone remodeling or osteoporosis.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: July 30, 2002
    Assignee: Incyte Genomics, Inc
    Inventors: Karen A. Jones, Wayne Volkmuth, Michael G. Walker
  • Normalization control for hybridization reactions
    Patent number: 6423535
    Abstract: Methods are provide for quantitatively determining the amount of polynucleotides in a sample. In one method, the distinct polynucleotide targets and standard polynucleotide targets are contacted with detectable probes and independently detectable single or double stranded complements to the standard targets under hybridization conditions. The hybridization pattern from the probe is compared to the hybridization pattern from the standard sequences to obtain quantitative information about the genetic profile of the labeled nucleic acid sample. Also provided are kits for the use of the methods.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: July 23, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle Arnold, Tod Bedilion, Erik Bjeldanes, Thomas P. Theriault, Warren Lei
  • Averaging multiple hybridization arrays
    Patent number: 6424921
    Abstract: Composite hybridization arrays and averaged hybridization arrays are provided. Composite hybridization arrays are formed from a user selected set of hybridization arrays, and once instantiated in a hybridization array database, are available for searching, analysis, and other data processing as with other types of hybridization arrays. This allows otherwise experiments using multiple different nucleotide microarrays to be efficiently consolidated and analyzed. Averaged hybridization arrays provided correctly averaged values from multiple user selected dual channel hybridization arrays.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: July 23, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Robert V. Gupta, Kirindi V. M. Choi, Robert A. Brahms, Doris Chang, Darryl V. K. Chong, John D. Burrill, Gregory Marcus, Gabor T. Bartha, Richard Head
  • Microarray hybridization chamber
    Patent number: 6420114
    Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids, undergoing a reaction. The apparatus comprises a means for creating a bubble within the film of fluid, and moving the bubble in the fluid, thereby mixing the fluid.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: July 16, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Tod Bedilion, Lozen Titsworth, Erik Bjeldanes, Douglas Gilliland, Lyle Arnold
  • Human beta-alanine-pyruvate aminotransferase
    Patent number: 6416755
    Abstract: The invention provides a human beta-alanine-pyruvate aminotransferase (HAPA) and polynucleotides which identify and encode HAPA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HAPA.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: July 9, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Preeti Lal, Neil C. Corley
  • Growth factor receptor binding protein
    Patent number: 6417329
    Abstract: The present invention provides a human growth factor receptor binding protein (GRBP) and polynucleotides which encode GRBP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing GRBP and for treating disorders associated with expression of GRBP.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: July 9, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Anthony P. Diegidio
  • Human cyclic nucleotide PDES
    Patent number: 6416991
    Abstract: The invention provides human cyclic nucleotide phosphodiesterases (HSPDE10A) and polynucleotides which identify and encode HSPDE10A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists and methods for diagnosing or treating disorders associated with expression of HSPDE10A.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: July 9, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Stephen C. Phillips, Jerry Lanfear, Lindsay Fawcett, Olga Bandman, Ian Harrow
  • Polymer coated surfaces for microarray applications
    Patent number: 6413722
    Abstract: Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H2N—(CH2)n—SiX3 where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: July 2, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle J. Arnold, Samuel P. Sawan, Paul H. Lee
  • SNP detection
    Patent number: 6410231
    Abstract: The invention provides methods, compositions and systems for detecting multiple single nucleotide polymorphisms (SNPs) in a population of target polynucleotides in parallel in a sandwich assay employing SNP probes, capture polynucleotides and, optionally, auxiliary polynucleotides. The relative affinities of the SNP probes for the corresponding SNP regions can be increased with reagents which normalize the melting temperatures of the probes and/or by positionally facilitating interactions between the SNP probe, the SNP region, the capture polynucleotide and/or the auxiliary polynucleotides, such as through a minor groove binder. The probes may comprise a degenerate set of all possible same-sized polynucleotides and the capture polynucleotides are generally immobilized and arrayed at corresponding discrete elements in high density.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: June 25, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle Arnold, Thomas Theriault, Tod Bedilion
  • Human GTPase-associated proteins
    Patent number: 6410267
    Abstract: The invention provides human GTPase-associated proteins (GPAP) and polynucleotides which identify and encode GPAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GPAP.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: June 25, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson
  • Toxicological response markers
    Patent number: 6403778
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: June 11, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer
  • Human phospholipase A2 protein
    Patent number: 6399301
    Abstract: The invention provides a human phospholipase A2 protein PHPLA2 and polynucleotides which identify and encode PHPLA2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PHPLA2.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 4, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Phillip R. Hawkins, Olga Bandman, Karl J. Guegler, Purvi Shah, Neil C. Gorley
  • Multichannel pipette head
    Patent number: 6399024
    Abstract: The invention provides multichannel pipette heads and autopipettors for loading, measuring, transporting and dispensing, particularly from one micro-plate to another. An exemplary multichannel pipette head comprises a pump housing, pistons, a drive plate, an aspiration drive and bearing rails, wherein the pump housing comprises chambers adapted to receive the pistons, the pistons each comprise a shaft, the drive plate retains the pistons and translocates the piston shafts through chambers, the aspiration drive translocates the drive plate along the bearing rails which pass through the drive plate and attach to the pump housing.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: June 4, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: JoeBen Bevirt, Josh Guyot
  • Subunits of NADH dehydrogenase
    Patent number: 6399345
    Abstract: The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: June 4, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Olga Bandman, Surya K. Goli, Jennifer L. Hillman
  • Ras proteins
    Patent number: 6391580
    Abstract: The invention provides seven human Ras proteins (RASP) and polynucleotides which identify and encode RASP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RASP.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: May 21, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Jennifer L. Hillman, Y. Tom Tang, Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson, Sajeev Batra, Mariah R. Baughn
  • Novel human stem cell antigens
    Publication number: 20020058241
    Abstract: The present invention provides polynucleotides encoding stem cell antigens, the partial sequences for which were initially isolated from THP-1 and bladder tumor cDNA libraries and which identify and encode novel human stem cell antigens. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding the stem cell antigens. The invention also provides for the use of purified stem cell antigens for the diagnosis and treatment of diseases associated with the expression of the stem cell antigens. Additionally, the invention provides for antibodies, antisense molecules and inhibitors of the stem cell antigens.
    Type: Application
    Filed: August 23, 2001
    Publication date: May 16, 2002
    Applicant: Incyte Genomics, Inc.
    Inventor: Janice Au-Young
  • Human short-chain dehydrogenase
    Patent number: 6387613
    Abstract: The invention provides a human short-chain dehydrogenase (HSCD) and polynucleotides which identify and encode HSCD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HSCD.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: May 14, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Preeti Lal, Neil C. Corley
  • Polymer coated surfaces for microarray applications
    Patent number: 6387631
    Abstract: Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H2N—(CH2)n—SiX3 where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: May 14, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Lyle J. Arnold, Samuel P. Sawan, Paul H. Lee