Abstract: The present disclosure relates to a breathing assistance apparatus for providing a breathing assistance to a user. The breathing assistance apparatus includes a first/second source configured with a first/second buffer. The first/second fluid is controllably transferred from the first/second source to the first/second buffer using any or combination of a first/second pressure regulators and one or more first/second valves. A mixing chamber configured with the first buffer and the second buffer to receive and mix the first fluid and the second fluid. A delivery tank configured with the mixing tank to controllably receive the third fluid through one or more fourth valves and a third pressure regulator. A user feed mask having an inlet configured with the delivery tank and user's face facilitating breathing assistance to the user.

Abstract: The present invention discloses a novel cost effective method for synthesis of protein/peptide amphiphiles irrespective of functional and structural classification of proteins useful in designing a vaccine candidate from antigenic protein. The protein modification of the present invention is universal and hence any protein/peptide can be converted into amphiphilic proteins/peptides.

Abstract: Present disclosure discloses a system for separating hydrogen from feed gas. The system includes at least one compressor adapted to pressurize the feed gas to predefined pressure. One or more adsorber columns are fluidly coupled to the compressor and are adapted to receive the pressurized feed gas, where the adsorber columns include a body and an adsorber bed, which is disposed within the body. The adsorber bed is configured to separate hydrogen from the feed gas. Further, the one or more adsorber columns includes a plurality of channels defined in at least one of the adsorber bed and adjacently along a length of the adsorber bed, where the channels are configured to channelize the hydrogen and regulate temperature of the adsorber bed. The configuration of the system aids in extracting pure hydrogen at low feed gas pressure.

Abstract: This disclosure relates to method and system for validating an Autonomous Vehicle (AV) stack. The method may include receiving an Operational Design Domain (ODD) and real-world data for evaluating at least one of an Advanced Driver Assistance System (ADAS) and the AV. The ODD is based on at least one feature of at least one of the ADAS and the AV. For each of a plurality of iterations, the method may further include generating a driving scenario based on the ODD of the AV and the real-world data through a Quality of Ride Experience (QoRE)-aware cognitive engine, plugging and running at least one of the ADAS and the AV algorithm based on the driving scenario, and determining a set of performance metrics corresponding to the at least one feature of at least one of the ADAS and the AV in the driving scenario based on the simulating.

Abstract: In one example, a system for product designing includes a storage unit and an interaction system communicably coupled with the storage unit. The interaction system includes at least one processor and a memory. The interaction system operates by provisioning an access to a at least one user and receive a communication from the at least one user for designing a product. The interaction system receives a reply from the at least one user and facilitates interaction among the at least one user based on the reply received from the at least one user to create a group of users. The group of users are provided with at least one designing tool for designing the product.

Abstract: This invention discloses bi-functional photoactivable fluorescent lipid probes for proximity labelling-based identification of membrane-associated proteins, and synthesis thereof. The photoactivable fluorescent lipid probe include a lipid moiety, a fluorophore, and a photoactivable moiety; where the fluorophore and the photoactivable moiety are covalently attached to the lipid moiety.

Abstract: The invention provides non-centrosymmetric organic crystals which show exceptional self-healing properties. More particularly, the present invention provides non-centrosymmetric substituted imidazole and Dialkyl 4,4?-methylenebis(azanediyl)dibenzoate Crystals and a process for preparation thereof. These highly crystalline materials, when broken into pieces, can self-propel and re-join in the blink of an eye and repair themselves so precisely that they become indistinguishable from the undisturbed materials.

Abstract: An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.

Abstract: Methods and materials for specific imaging of active enzyme in a live or intact cell are disclosed. The enzyme of interest tagged to reporter protein (donor) is exogenously expressed in a cell. The conversion of proenzyme to active enzyme (containing reporter protein) is achieved upon applying an appropriate stimulus to the target cells. The activated enzyme is labelled with an activity-based probe carrying a fluorophore (acceptor). The covalent labelling of active enzyme by the activity-based probe creates a FRET pair which provides the opportunity to exquisitely image the function of an “active enzyme”. This method is used for specific imaging of the function of active caspase-3,-7,-8,-9 and cathepsin-B and also for profiling of inhibitors of caspases and cathepsin B.

Abstract: An information processing apparatus includes one or more memories; and one or more processors coupled to the one or more memories, the one or more processors being configured to decide a gain matrix based on an input metric, perform selection of first training data from a plurality of unlabeled training data, to be used for training a machine learning model, based on the gain matrix, and perform training of the machine learning model based on the first training data, a predicted label that is predicted from the first training data, and a loss function including the gain matrix.

Abstract: The present invention discloses monodisperse protein-dendron conjugates that self-assemble to generation-dependent supramolecular protein assemblies of different size and surface charges. The invention further provides a process for synthesis of protein-dendron conjugates containing hydrophobic dendron of different generations.

Abstract: The present invention relates to a nucleic acid construct. The nucleic acid construct includes a nucleic acid molecule configured to silence or reduce the expression of StBEL11 and/or StBEL29 and variants thereof, a 5? DNA promoter sequence, and a 3? terminator sequence, where the first nucleic acid molecule, the promoter sequence, and the terminator sequence are operatively coupled to permit transcription of the first nucleic acid molecule. The present invention is also directed to vectors, host cells, transgenic plants, and transgenic plant seeds, as well as non-transgenic mutant plants, and methods for altering tuber yield in a plant.

Abstract: The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.

Abstract: The present disclosure relates to a patternable process for coating functional and adherent graphene-like carbon on multiple substrate types using CO2 laser-induced photothermal pyrolysis in scanning mode. The poly furfuryl alcohol (PFA) synthesised via low-temperature polymerisation of furfuryl alcohol precursor without any additives was used to form graphene-like carbon material.

Abstract: The present disclosure relates to a method of protein structure and amino acid residue interaction prediction based on saturation suppressor mutagenesis screening of a protein of interest. The method of the instant disclosure can be adapted for multi-protein complexes, and is useful where crystal structure of a protein of interest is not available.

Abstract: Methods and devices for quantifying creatinine in a test sample are provided. The test sample is contacted with a sensing composition to obtain a product comprising a hydantoin-transition metal complex and ammonia. The sensing composition comprises creatinine deaminase and a transition metal salt. The creatinine deaminase enzymatically reacts with creatinine to provide the N-methyl hydantoin and ammonia. The N-methyl hydantoin forms the hydantoin-transition metal complex with the transition salt. A potential difference is applied to the product to measure a current signal provided by the hydantoin-transition metal complex. Concentration of N-methyl hydantoin is obtained based on the measured current signal using a calibration equation. The concentration of N-methyl hydantoin is correlated with concentration of creatinine to quantify the creatinine in the test sample.

Abstract: A High Electron Mobility Transistor (HEMT) having a reduced surface field (RESURF) junction is provided. The HEMT includes a source electrode at a first end and a drain electrode at a second end. A gate electrode is provided between the source electrode and the drain electrode. A reduced surface field (RESURF) junction extends from the first end to the second end. The gate electrode is provided above the RESURF junction. A buried channel layer is formed in the RESURF junction on application of a positive voltage at the gate electrode. The RESURF junction includes an n-type Gallium nitride (GaN) layer and a p-type GaN layer. The n-type GaN layer is provided between the p-type GaN layer and the gate electrode.

Abstract: A system for product designing includes a storage unit and an interaction system communicably coupled with the storage unit. The interaction system includes at least one processor and a memory. The interaction system operates by provisioning an access to at least one user and receive a communication from the at least one user for designing a product. The interaction system receives a reply from the at least one user and facilitates interaction among the at least one user based on the reply received from the at least one user to create a group of users. The group of users are provided with at least one designing tool for designing the product. Also disclosed is the method of product designing.

Abstract: The present disclosure relates to an assay for determining drug-target engagement in real-time. Specifically, the present disclosure provides a method for determining drug candidate-target interaction in real-time in living systems using Activity-based Reporter Gene Technology-Bioluminescence Resonance Energy Transfer (AbRGT-BRET) based assay. The said assay is useful for High Throughput Screening of compounds to a specific target.

Abstract: An electrochemically active device for collecting and retaining a biological sample with a bioanalyte, the device provided with at least a two-electrode member and an albumin-binding and an electrochemically active receptor in chemical contact with the two-electrode members and the biological sample. The present invention also provides a point-of-care biosensor with the device of the present invention and a method for measuring a bioanalyte in a biological sample. The device, point-of-care biosensor and the method of the present invention facilitate accurate measurements concentrations of urine albumin, human serum albumin (HSA), glycated albumin (GA) and methemalbumin (MHA) by determining redox current values in reduced volumes of biological samples.