Abstract: The invention relates to an efficient method for synthesizing self-assembling artificial proteins (SAPs) utilizing a catalytic host-guest system. The process involves encapsulating hydrophobic probes with cyclodextrin, performing site-specific protein bioconjugation, and employing a second catalysis cycle for enhanced labeling. SAPs produced through this method are versatile and find applications in therapeutic delivery and diagnostics. The process is simplified, scalable, cost-effective, and environmentally sustainable, addressing the challenges of traditional SAP synthesis. By offering improved yield, functionality, and structural integrity, this invention advances the potential of SAPs in medical and industrial fields.

Abstract: Examples of a system (100, 200) and a method (300) for converting a biomass feedstock into a hydrogen rich syngas, are described. The system (100, 200) includes a gasification reactor (102) including an inlet (104) with a lock hopper, an outlet (106), and side walls (108) between the inlet (104) and the outlet (106). The system (100) may further include a plurality of injectors (110, 202) protruding inside the gasification reactor (102) up to a certain depth along the length of the gasification reactor (102). In another example, the plurality of injectors (110, 202) may also be inclined at an angle with respect to the side walls (108) of the gasification reactor (102). The system (100, 200) further comprises a plurality of thermocouples (112) for determining a temperature profile of the gasification reactor (102.

Abstract: The present disclosure provides methods for inhibiting entry of a virus into a host cell using picolinic acid or a salt or derivative thereof. The present disclosure also provides methods for treating or preventing a viral infection in a subject by administering picolinic acid or a salt or derivative thereof. In particular, the methods of the present disclosure are effective for enveloped viruses and syncytium-forming viruses. In some embodiments, the present disclosure provides methods of treating or preventing a SARS CoV-2, Influenza A virus, human parainfluenza virus, herpes simplex virus, Japanese encephalitis virus, Zika virus, or a flavivirus infection.

Abstract: There is provided markers, systems, and methods for creating and utilizing a marker containing identification information. The embodiments include an identifying marker comprised of high temperature material for tracking a component in a high temperature environment. The marker may be disposed on the component such that the marker is subject to high temperatures while affixed to the component. The marker may provide the ability to track a history of the component the marker is attached to for maintenance.

Abstract: Embodiments of present disclosure relates to method and gesture prediction system for predicting gesture of subjects for controlling AV during navigation. The gesture prediction system obtains data from sensors and generates context information of environment of AV. The gesture prediction system generates parameters for sampling frames for determining gesture of subjects. The gesture prediction system estimates current pose, and subsequent poses by extrapolating current pose and subsequent poses using deep learning techniques. Further, the gesture prediction system infers current behaviour of subjects by classifying current pose and subsequent poses into one of predefined gesture categories. The gesture prediction system predicts gesture of subjects based on current behaviour, context information and location information of subjects for controlling AV during navigation. Thus, the present disclosure forecast gestures of subjects at a faster rate and controls the AV during the navigation.

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

Abstract: The present disclosure discloses a compliant mechanism (100) for application of radial resistance on a simulation endoscope (101). The mechanism (100) comprises a support plate (102), a ring member (103) rotatably mounted on the support plate (102) and a plurality of flexible beam assemblies (104) configured in an inner circumference of the ring member (103). The plurality of flexible beam assemblies (104) comprises a first beam (104a) connectable to the ring member (103) and a second beam (104b) connectable to the support plate (102), the circular motion of at least one of the support plate (102) and the ring member (103), relative to each other, moves the plurality of flexible beam assemblies (104) radially inward and radially outward to selectively apply radial resistance on the simulation endoscope (101). The complaint mechanism (100) of present disclosure are joint less mechanisms which are free from backlash and friction in joints.

Abstract: Methods of fabrication and nano-sensor and nano-sensor array thereof are provided. A sensing electrode assembly can be patterned on a sacrificial layer of a substrate. The sensing electrode assembly can comprise a pair of contact pads and an electrode element coupled to and disposed between the pair of contact pads. The sensing electrode assembly can be formed on the patterned sensing electrode assembly. The sacrificial layer below a portion of the electrode element can be removed to obtain a suspended electrode element. The suspended electrode element can be oxidized at a first predetermined temperature to obtain a pair of electromigrated regions and a notch portion between the pair of the electromigrated regions. The notch portion can be used to detect a gaseous component in an ambient gas at a second predetermined temperature.

Abstract: The present disclosure discloses the polypeptide fragment having an amino acid sequence with at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, and SEQ ID NO: 6. The present disclosure also discloses nucleic acid fragment encoding the polypeptide fragment as described herein. Moreover, the present disclosure also discloses recombinant construct, recombinant vector and recombinant host cells. Also disclosed herein is an immunogenic composition comprising the polypeptide fragment as described herein, and a method for preparing the said immunogenic composition. The immunogenic composition is in form of vaccine. The polypeptide fragment and/or immunogenic composition is capable of eliciting protection against severe acute respiratory syndrome coronavirus 2. A kit comprising the polypeptide, or the immunogenic composition as described herein is also disclosed.

Abstract: A method and activity recognition system for recognising activities in surrounding environment for controlling navigation of an autonomous vehicle is disclosed. The activity recognition system receives first data feed from neuromorphic event-based camera and second data feed from frame-based RGB video camera. The first data feed comprises high-speed temporal information encoding motion associated with change in surrounding environment at each spatial location, and second data feed comprises spatio-temporal data providing scene-level contextual information associated with surrounding environment. An adaptive sampling of second data feed is performed with respect to foreground activity rate based on amount of foreground motion encoded in first data feed. Further, the activity recognition system recognizes activities associated with at least one object in surrounding environment by identifying correlation between both data feed by using two-stream neural network model.

Abstract: The present subject matter provides a High Mobility Electron Transistor (HEMT) comprising: a substrate, a nucleation layer provided on the substrate, a channel layer, and a buffer layer formed between the nucleation layer and the channel layer. The buffer layer comprises a vertical stack of p-n junctions. Each p-n junction of the vertical stack of p-n junctions comprises an n-type layer provided on a p-type layer. The n-type layer and the p-type layer are parallel to the substrate.

Abstract: This disclosure relates to method and system for validating an Autonomous Vehicle (AV) stack. The method may include receiving an Operational Design Domain (ODD) and real-world data for evaluating at least one of an Advanced Driver Assistance System (ADAS) and the AV. The ODD is based on at least one feature of at least one of the ADAS and the AV. For each of a plurality of iterations, the method may further include generating a driving scenario based on the ODD of the AV and the real-world data through a Quality of Ride Experience (QoRE)-aware cognitive engine, plugging and running at least one of the ADAS and the AV algorithm based on the driving scenario, and determining a set of performance metrics corresponding to the at least one feature of at least one of the ADAS and the AV in the driving scenario based on the simulating.

Abstract: This invention discloses bi-functional photoactivable fluorescent lipid probes for proximity labelling-based identification of membrane-associated proteins, and synthesis thereof. The photoactivable fluorescent lipid probe include a lipid moiety, a fluorophore, and a photoactivable moiety; where the fluorophore and the photoactivable moiety are covalently attached to the lipid moiety.

Abstract: The invention provides non-centrosymmetric organic crystals which show exceptional self-healing properties. More particularly, the present invention provides non-centrosymmetric substituted imidazole and Dialkyl 4,4?-methylenebis(azanediyl)dibenzoate Crystals and a process for preparation thereof. These highly crystalline materials, when broken into pieces, can self-propel and re-join in the blink of an eye and repair themselves so precisely that they become indistinguishable from the undisturbed materials.

Abstract: An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.

Abstract: The present invention relates to a nucleic acid construct. The nucleic acid construct includes a nucleic acid molecule configured to silence or reduce the expression of StBEL11 and/or StBEL29 and variants thereof, a 5? DNA promoter sequence, and a 3? terminator sequence, where the first nucleic acid molecule, the promoter sequence, and the terminator sequence are operatively coupled to permit transcription of the first nucleic acid molecule. The present invention is also directed to vectors, host cells, transgenic plants, and transgenic plant seeds, as well as non-transgenic mutant plants, and methods for altering tuber yield in a plant.

Abstract: The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.

Abstract: The present disclosure relates to a patternable process for coating functional and adherent graphene-like carbon on multiple substrate types using CO2 laser-induced photothermal pyrolysis in scanning mode. The poly furfuryl alcohol (PFA) synthesised via low-temperature polymerisation of furfuryl alcohol precursor without any additives was used to form graphene-like carbon material.

Abstract: Methods and devices for quantifying creatinine in a test sample are provided. The test sample is contacted with a sensing composition to obtain a product comprising a hydantoin-transition metal complex and ammonia. The sensing composition comprises creatinine deaminase and a transition metal salt. The creatinine deaminase enzymatically reacts with creatinine to provide the N-methyl hydantoin and ammonia. The N-methyl hydantoin forms the hydantoin-transition metal complex with the transition salt. A potential difference is applied to the product to measure a current signal provided by the hydantoin-transition metal complex. Concentration of N-methyl hydantoin is obtained based on the measured current signal using a calibration equation. The concentration of N-methyl hydantoin is correlated with concentration of creatinine to quantify the creatinine in the test sample.

Abstract: The present disclosure relates to an assay for determining drug-target engagement in real-time. Specifically, the present disclosure provides a method for determining drug candidate-target interaction in real-time in living systems using Activity-based Reporter Gene Technology-Bioluminescence Resonance Energy Transfer (AbRGT-BRET) based assay. The said assay is useful for High Throughput Screening of compounds to a specific target.