Patents Assigned to Indiana University Foundation
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Patent number: 4835140Abstract: The combination of clindamycin and primaquine or pharmaceutical salts thereof is effective in treating patients with Pneumocystis carinii pneumonia.Type: GrantFiled: August 20, 1987Date of Patent: May 30, 1989Assignee: Indiana University FoundationInventors: James W. Smith, Marilyn S. Bartlett, Sherry F. Queener
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Patent number: 4800279Abstract: Methods are disclosed for quantifying physical properties of gaseous, liquid or solid samples. The near-infrared absorbance spectra of a representative field of calibration samples are measured and recorded using a spectrophotometer. The absorbance spectra of the calibration samples are evaluated by a row-reduction algorithm to determine which wavelengths in the near-infrared spectrum, and associated weighting constants, are statistically correlated to the physical property being quantified. The near-infrared absorbance of actual samples is then measured at each of the correlated wavelengths, and then corrected by the corresponding weighting constants. A reference value for the physical property being quantified is then computed from the corrected measure of the absorbance of the sample at each of the correlated wavelengths.Type: GrantFiled: September 13, 1985Date of Patent: January 24, 1989Assignee: Indiana University FoundationInventors: Gary M. Hieftje, David E. Honigs, Thomas B. Hirschfeld
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Patent number: 4742223Abstract: A spectrometer for high-resolution particle energy loss spectroscopy is described. Specifically, the high-resolution particle energy loss spectrometer of the present invention comprises: source means for producing a collimated beam of particles; first stage monochromator means for selecting particles within a specified energy range; intermediate particle lens means for collimating, accelerating and decelerating the particles exiting from the first stage monochromator means; second stage monochromator means for selecting particles within a specified energy range; exit particle focusing means; input particle focusing means; cylindrical analyzer means for selecting particles with a specified energy range; and detector means for detecting impinging particles. The spectrometer described herein obtains higher system resolution at a given output current than other spectrometers known in the art.Type: GrantFiled: October 15, 1986Date of Patent: May 3, 1988Assignee: Indiana University FoundationInventor: Lawrence L. Kesmodel
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Patent number: 4659926Abstract: A spectrometer for high-resolution particle energy loss spectroscopy is described. Specifically, the high-resolution particle energy loss spectrometer of the present invention comprises: source means for producing a collimated beam of particles; first stage monochromator means for selecting particles within a specified energy range; intermediate particle lens means for collimating, accelerating and decelerating the particles exiting from the first stage monochromator means; second stage monochromator means for selecting particles within a specified energy range; exit particle focusing means; input particle focusing means; cylindrical analyzer means for selecting particles with a specified energy range; and detector means for detecting impinging particles. The spectrometer described herein obtains higher system resolution at a given output current than other spectrometers known in the art.Type: GrantFiled: August 26, 1985Date of Patent: April 21, 1987Assignee: Indiana University FoundationInventor: Lawrence L. Kesmodel
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Patent number: 4642778Abstract: A method is presented for spectral reconstruction which comprises first obtaining component concentrations of a series of mixtures, which component concentrations constitute a set of reference values. The spectral value of each member of that series of mixtures is measured at a first wavelength, which spectral value possesses contribution from individual components in the mixture, whose individual contribution is unknown. The spectral values for the series of mixtures are then mathematically cross-correlated with the component concentrations in said series of mixtures, at the first wavelength, thereby obtaining the spectral contribution for said components at that first wavelength. The spectral value of each member of that series of mixtures is measured at the second wavelength, which spectral values are then cross-correlated with component concentrations in the series of mixtures thereby obtaining the spectral contribution for said components at the second wavelength.Type: GrantFiled: March 2, 1984Date of Patent: February 10, 1987Assignee: Indiana University FoundationInventors: Gary M. Hieftje, David H. Honigs
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Patent number: 4642567Abstract: Improved two dimensional nuclear magnetic resonance imaging methods of the present invention are presented which comprise sensitizing a two dimensional slice of an object by standard procedures in a static magnetic field wherein the magnetization of the spins is transverse to the static field, applying a time varying magnetic field gradient to the sensitized two dimensional slice, detecting radiated electromagnetic energy from the two dimensional slice, and reconstructing spin information for each element within a slice from the detected radiated electromagnetic energy. In one aspect, the improvement is the use of an appropriate weighting function in the reconstruction to weight the detected radiated electromagnetic energy signals to compensate for the use of time varying magnetic field gradients that do not sample equal area elements of phase space in equal time intervals.Type: GrantFiled: June 4, 1984Date of Patent: February 10, 1987Assignee: Indiana University FoundationInventor: Jerome I. Kaplan
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Patent number: 4559449Abstract: A spectrometer for high-resolution particle energy loss spectroscopy is described. Specifically, the high-resolution particle energy loss spectrometer of the present invention comprises: source means for producing a collimated beam of particles; first stage monochromator means for selecting particles within a specified energy range; intermediate particle lens means for collimating, accelerating and decelerating the particles exiting from the first stage monochromator means; second stage monochromator means for selecting particles within a specified energy range; exit particle focusing means; input particle focusing means; cylindrical analyzer means for selecting particles with a specified energy range; and detector means for detecting impinging particles. The spectrometer described herein obtains higher system resolution at a given output current than other spectrometers known in the art.Type: GrantFiled: May 23, 1984Date of Patent: December 17, 1985Assignee: Indiana University FoundationInventor: Lawrence L. Kesmodel
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Patent number: 4514509Abstract: A rapid, sensitive, and specific method for diagnosing Legionnaires' disease through the detection of antigens excreted by the patient and a method for preparing anti-Legionella immunoglobulin G for use in such diagnostic method.Type: GrantFiled: September 21, 1981Date of Patent: April 30, 1985Assignee: Indiana University FoundationInventors: Richard B. Kohler, Arthur C. White
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Patent number: 4503206Abstract: Tetrafluoroethylene is reacted in an aqueous environment with hydroxyl radicals, generating a mixture of water soluble and water insoluble .alpha.,.omega.-perfluorodicarboxylic acids.Type: GrantFiled: December 22, 1982Date of Patent: March 5, 1985Assignee: Indiana University FoundationInventor: Ivan M. Robinson
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Patent number: 4492322Abstract: A device for accurately dispensing small volumes of liquids in the form of uniform droplets. The dispensing device communicates with a source of compressed air which, during start-up transience of the dispensing device, directs a jet of compressed air at the trajectory of dispensed droplets, thereby deflecting the droplets out of their normal trajectory and away from the collecting surface or container and allowing accurate dispensing.Type: GrantFiled: April 30, 1982Date of Patent: January 8, 1985Assignee: Indiana University FoundationInventors: Gary M. Hieftje, John Shabushnig
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Patent number: 4466952Abstract: Novel estratriene and estratetraene compositions bearing a dicarbadodecaboranyl substituent at the 17-position have been prepared which possess high uterotropic and estrophilic activity useful in boron neutron capture destruction of cancerous cells.Type: GrantFiled: January 12, 1983Date of Patent: August 21, 1984Assignee: Indiana University FoundationInventor: Harry E. Hadd
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Patent number: 4428928Abstract: Incorporation of talc in dentifrice preparations based on calcined kaolins enhances the rheological properties of such dentifrices. In addition, new and more effective dentifrice preparations may be obtained by employing therein a cleaning and polishing constituent comprising a mixture of calcined kaolin, talc and titanium dioxide. Additionally, anticariogenic adjuvants, such as sodium fluoride and stannous fluoride, especially a 1:2 molar mixture thereof, may be incorporated in such dentifrice preparations.Type: GrantFiled: June 28, 1982Date of Patent: January 31, 1984Assignee: Indiana University FoundationInventors: Joseph C. Muhler, Mark S. Putt
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Patent number: 4418053Abstract: The application discloses new dental prophylactic cleaning and polishing agents predominantly comprising magnesium metasilicate particles obtained by thermally treating selected minerals.Type: GrantFiled: February 4, 1982Date of Patent: November 29, 1983Assignee: Indiana University FoundationInventors: Joseph C. Muhler, Mark S. Putt
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Patent number: 4400372Abstract: An improved chewing gum capable of cleaning and imparting a high degree of polish to the teeth comprises a chewing gum base, at least one non-toxic source of acid, and calcined kaolin particles, the median diameter of which is about 2 micrometers or less, substantially all of the particles being less than about 20 micrometers in diameter. Such a chewing gum cleans and imparts a high degree of polish to the teeth without unduly abrading or scratching them. When regularly chewed, such a gum, in addition to cleaning and polishing the dental enamel, also inhibits the reformation of dental plaque.Type: GrantFiled: January 15, 1982Date of Patent: August 23, 1983Assignee: Indiana University FoundationInventors: Joseph C. Muhler, Carl J. Kleber, Ronald L. Ream, David M. Moore
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Patent number: 4383219Abstract: A method for obtaining a spatial mapping using nuclear magnetic resonance. A sample is subjected to time dependent magnetic gradient fields having linear components in the X and Y directions, normalized so that the time dependency is eliminated in the vicinity of a line X.sub.0,X.sub.0,Z. A time independent gradient field is applied along this line. An initial RF pulse is applied to rotate the magnetization 180 degrees. This is followed by a 90 degree pulse and then a series of 180 degree pulses. It has been determined experimentally that the relaxation times T.sub.1 and T.sub.2 for ischemic muscle tissue are longer than T.sub.1 and T.sub.2 for normal tissue. The above-described pulse pattern enhances the differentiation between the ischemic and normal tissue, and can provide useful data in applications wherein data can only be acquired during a short period of time.Type: GrantFiled: August 19, 1980Date of Patent: May 10, 1983Assignee: Indiana University FoundationInventor: Jerome I. Kaplan
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Patent number: 4254259Abstract: By varying the acidity, solvent polarity, and temperature of the reaction of thiosemicarbazide with ethyl 4-chloroacetoacetate, ethyl 2-amino-6H-1,3,4-thiadiazine-5-acetate hydrochloride, ethyl 2-hydrazinothiazole-4-acetate, and ethyl 2-imino-3-aminothiazoline-4-acetate hydrochloride may be prepared selectively. Further derivatives may be prepared by benzoylation and nitrosation. These compounds have demonstrated utilities as herbicides.Type: GrantFiled: November 2, 1978Date of Patent: March 3, 1981Assignee: Indiana University FoundationInventors: Ernest E. Campaigne, Thomas Selby
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Patent number: 4214238Abstract: An inverted, compound pendulum, which may be set in motion by a seismic variance, activates a photoelectric switching system. Logic circuitry in electrical contact with the switching system discriminates in a pre-determined manner with respect to the repetition rate of signals transmitted by the switching system and selectively activates and controls an alarm. Circuitry in the device permits display of the device's status and interacts with a self-contained power source to permit continued operation despite interruption of external power.Type: GrantFiled: March 8, 1977Date of Patent: July 22, 1980Assignee: Indiana University FoundationInventors: William M. Adams, Robert F. Blakely, Charles R. Ellis, Judson Mead
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Patent number: 4194513Abstract: This application discloses an antenatal cell extracting device comprising a thin, flexible, plastic tube adapted for cervical insertion in a human female. A flexible closure is provided at the proximal end of the plastic tube, and passing through the flexible closure, the plastic tube and the distal end of the tube is a plunger. A valve in the form of a smooth ball, the diameter of which is greater than the diameter of the tube, is fixed to the end of the plunger, and, upon reciprocating movement of the plunger with reference to the tube, the valve is caused to open and close. Means are provided for causing fluid to flow through the tube when the valve is opened, such means, preferably taking the form of a syringe connection to the flexible closure.Type: GrantFiled: May 5, 1977Date of Patent: March 25, 1980Assignee: Indiana University FoundationInventors: Samuel A. Rhine, Joseph F. Thompson, Catherine G. Palmer
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Patent number: 4153732Abstract: Anticariogenic comestibles (i.e., food products that reduce the incidence and severity of dental caries) may be obtained by incorporating therein a cariostatic additive comprising a soluble aluminum ion containing salt and a member selected from the group consisting of adipic acid, ascorbic acid, and mixtures thereof. Dental health benefits of such products may be further enhanced by employing as a nutritive sweetening system therein a mixture of at least one first sweetening agent consisting of sorbitol and/or xylitol and at least one second sweetening agent consisting of dextrose and/or fructose, with the mixture containing at least about 75% of the first agent by weight of the mixture where dextrose is the second agent and at least about 60% of the first agent where fructose is the second agent.Type: GrantFiled: February 21, 1978Date of Patent: May 8, 1979Assignee: Indiana University FoundationInventors: Joseph C. Muhler, Carl J. Kleber, Ray G. Kelly
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Patent number: 4134999Abstract: Noncariogenic comestibles (i.e., food products that do not cause dental caries) may be obtained by employing as a nutritive sweetening system therein a homogenous mixture of at least one first sweetening agent consisting of sorbitol and/or xylitol and at least one second sweetening agent consisting of dextrose and/or fructose, with the mixture containing at least about 75% of the first agent by weight of the mixture where dextrose is the second agent and at least about 60% of the first agent where fructose is the second agent. Advantageously and optionally, such a sweetening system is provided in candies in association with adipic and/or ascorbic acid as a flavoring agent.Type: GrantFiled: November 29, 1977Date of Patent: January 16, 1979Assignee: Indiana University FoundationInventors: Joseph C. Muhler, Carl J. Kleber, Ray G. Kelly