Patents Assigned to Indiana University Research and Technology Corporation
  • Bacteriocidal peptides and uses thereof
    Patent number: 10435447
    Abstract: Peptide compositions having bacteriocidal peptides are described. Also described is a method of bacterial infections using compositions comprising bacteriocidal peptides or modified peptides with structural relationships to cathelicidins.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: October 8, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: C. Cheng Kao, Xiaoyan Lin
  • Electrospray imaging and deposition
    Patent number: 10436815
    Abstract: Methods for imaging a substrate include: inducing an electrospray from a nanopipette probe; varying a distance between the nanopipette probe and a surface of the substrate until a predefined electrospray current and/or a predefined distance threshold is reached; and determining a topography of the surface of the substrate based on feedback derived from distance dependency of the electrospray current. Apparatuses for performing scanning electrospray microscopy and methods for spatially controlled deposition of material on surfaces of substrates are described.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 8, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Lane Baker, Elizabeth Yuill, Tyler Yarger, Alicia Friedman, John Poehlman
  • Combination therapies for treatment of spinal muscular atrophy
    Patent number: 10420753
    Abstract: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 24, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Elliot J. Androphy, Kevin Hodgetts, Alyssa Nicole Calder
  • Microinverter
    Patent number: 10418914
    Abstract: A microinverter comprises a housing, a cover configured to connect to the housing, and electronics mounted within the housing to convert direct current from a solar panel to alternative current. The housing includes a first side wall, a second side wall perpendicular to the first side wall, and a mounting flange extending from the side walls, the mounting flange including a first channel configured to receive a first rail segment of the solar panel, a second channel configured to receive a second rail segment of the solar panel, and a mounting tab disposed between the channels to receive a fastener extending through one of the rail segments, thereby securing the housing to the solar panel with a single fastener.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: September 17, 2019
    Assignee: Indiana University Research & Technology Corporation
    Inventor: Euzeli dos Santos
  • Modular stent grafting methods and apparatus
    Patent number: 10413395
    Abstract: The present disclosure provides a modular stent assembly for deployment within a lumen. The assembly may include primary and secondary stent portions. Each stent portion includes a sheet having an incomplete annular profile. The sheet includes a graft material disposed on a wire matrix. Each stent portion further includes an aperture positioned in the sheet, and first and second side walls. The first side wall extends between the aperture and a first longitudinal edge of the sheet. The second side wall extends between the aperture and a second longitudinal edge of the sheet, which is spaced apart from the first edge. The stent portions mate to define an interior space in which is positioned an expandable securement stent. An outer wall of the securement stent is sized to compress the side walls of the stent portions between the body of the securement stent and a wall defining the lumen.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: September 17, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: A. George Akingba, Raghu L. Motaganahalli
  • METHOD OF DYNAMIC ADAPTIVE STREAMING FOR 360-DEGREE VIDEOS
    Publication number: 20190281318
    Abstract: Aspects of the subject disclosure may include, for example, maximizing a quality of experience when selecting encoding bitrates for downloading dynamically adaptive 360-degree video. Other embodiments are disclosed.
    Type: Application
    Filed: March 8, 2018
    Publication date: September 12, 2019
    Applicants: AT&T Intellectual Property I, L.P., Indiana University Research and Technology Corporation
    Inventors: Bo Han, Vijay Gopalakrishnan, Jackson Jarrell Pair, Vikash Sharma, Feng Qian, Qingyang Xiao
  • High torque density electric motor and/or generator
    Patent number: 10404135
    Abstract: An electric motor is disclosed, comprising a stator and a rotor mounted relative to the stator to form a gap between a surface of the stator and a surface of the rotor, the gap having a width. One of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor about a central axis, and one of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor along the central axis in response to thermal expansion of at least one of the stator and the rotor to maintain the width of the gap.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: September 3, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Matthew J. Rubin
  • USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS
    Publication number: 20190262350
    Abstract: The present disclosure provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, e.g. cancer, benign tumor, etc.). Related materials and methods are also provided herein.
    Type: Application
    Filed: May 14, 2019
    Publication date: August 29, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Vincent Gattone, Bonnie Blazer-Yost
  • PERSON-CENTERED HEALTH RECORD ARCHITECTURE
    Publication number: 20190267118
    Abstract: Methods for providing a health record architecture, comprising linking a patient's health information to relevant health data, automatically determining an applicability of current medical evidence, recommendations, or combinations thereof to the patient, and enriching a health record from external data sources are disclosed. Health record architectures are also disclosed.
    Type: Application
    Filed: November 13, 2017
    Publication date: August 29, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Zina Ben Miled, Titus Karl Ludwig Schleyer, Zachary Doyle King
  • Hepatitis B core protein modulators
    Patent number: 10392379
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 27, 2019
    Assignees: Assembly Biosciences, Inc., Indiana University Research And Technology Corporation
    Inventors: William Turner, Lee Daniel Arnold, Hans Maag, Mark Bures
  • Hepatitis B core protein modulators
    Patent number: 10377748
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 13, 2019
    Assignees: Assembly Biosciences, Inc., Indiana University Research And Technology Corporation
    Inventors: William Turner, Lee Daniel Arnold, Hans Maag, Leping Li, Mark Bures, Simon Haydar, Samson Francis
  • Salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
    Patent number: 10377780
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 13, 2019
    Assignees: The Governing Council of the University of Toronto, UTI Limited Partnership, Indiana University Research and Technology Corporation
    Inventors: Patrick Thomas Gunning, Sina Haftchenary, Brent David George Page, Samuel Weiss, Hema Artee Luchman, Melissa L. Fishel
  • Fluorescent microscope
    Patent number: 10371638
    Abstract: The present disclosure provides a method and system including a non-confocal microscope with an attached imaging fiber optic for direct and real time visualization of mammalian microscopic structures for diagnostic and therapeutic uses.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: August 6, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Hany Osman
  • CONCURRENT SUBTRACTIVE AND SUBTRACTIVE ASSEMBLY FOR COMPARATIVE METAGENOMICS
    Publication number: 20190237162
    Abstract: A method for characterizing disease-associated microbial marker genes comprising: counting k-mers of at least two samples; loading k-mers into an array; extracting reads based on differential sequence signatures; and assembling contigs and phylogenetically annotating the contigs.
    Type: Application
    Filed: September 30, 2017
    Publication date: August 1, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Yuzhen Ye
  • ELECTRONIC TABLET FOR USE IN MRI
    Publication number: 20190231229
    Abstract: A system for recording visually guided motor activity within a bore of an MRI machine, comprising a tablet configured for mounting within the bore of the MRI machine, the tablet comprising a shielded housing, a touchscreen display mounted within the housing, and a receiver board, an interface box coupled to a controller configured to control operation of the touchscreen display, the interface box being located remotely from the bore and comprising a transmitter board for processing signals from the controller and transmitting processed signals to the receiver board of the tablet, and a cable connected between the tablet and the interface box, the cable comprising a plurality of conductors to carry signals between the receiver board and the transmitter board.
    Type: Application
    Filed: February 4, 2019
    Publication date: August 1, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Jeffrey Sturgeon, Alexander Shroyer, Sophia Angela Vinci-Booher, Karin James
  • SYSTEMS AND METHODS FOR ACCURATE MEASUREMENT OF PROPRIOCEPTION
    Publication number: 20190216388
    Abstract: Stands for measuring proprioception comprising a hand layer comprising one or more vertically offset portions configured to ensure proper placement of a patient's hand in a predetermined position, a top cover coupled to the hand layer, wherein the top cover is designed to obscure the patient's view of the patient's hand, and a support element coupled to the hand layer and configured to support the hand layer at a predetermined angle are disclosed. Methods for measuring proprioception are also disclosed.
    Type: Application
    Filed: August 11, 2017
    Publication date: July 18, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Hannah J. Block
  • SYSTEMS AND METHODS FOR ACCESSING, COMBINING AND COLLABORATIVE FILTERING OF INFORMATION FROM MULTIPLE ELECTRONIC HEALTH RECORDS
    Publication number: 20190214114
    Abstract: Methods for generating a health management template for a patient condition including retrieving a healthcare template It corresponding to a patient condition, the healthcare template comprising a plurality of data fields, populating the data fields with patient data; and generating an updated healthcare template based on a user input, wherein the user input comprises at least one of a search request or a data option selection are disclosed. Systems are also disclosed.
    Type: Application
    Filed: September 6, 2017
    Publication date: July 11, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Titus Karl Ludwig Schleyer
  • METHOD FOR GENERATING MESODERM AND/OR ENDOTHELIAL COLONY FORMING CELL-LIKE CELLS HAVING IN VIVO BLOOD VESSEL FORMING CAPACITY
    Publication number: 20190211304
    Abstract: The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent stem cells into KDR+NCAM+APLNR+ mesoderm cells and/or SSEA5?KDR+NCAM+APLNR+ mesoderm cells is provided. The disclosed mesoderm cells may be used to generate blood vessels in vivo and/or further differentiated in vitro into endothelial colony forming cell-like cells (ECFC-like cells). Purified human cell populations of KDR+NCAM+APLNR+mesoderm cells and ECFC-like cells are provided. Test agent screening and therapeutic methods for using the cell populations of the present disclosure are provided.
    Type: Application
    Filed: August 4, 2017
    Publication date: July 11, 2019
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Mervin C. Yoder, Nutan Prasain
  • Adaptive video streaming over preference-aware multipath
    Patent number: 10348796
    Abstract: A processor performing functions of a video client may measure an occupancy of a video buffer, select a video chunk having a first video encoding bitrate based upon the occupancy, and provide a deadline for a delivery of the video chunk to a multipath transport layer module. The processor may further activate a deadline aware scheduler of the module when the occupancy exceeds a first threshold and when the deadline aware scheduler was previously disabled, and deactivate the deadline aware scheduler when the occupancy falls below a second threshold and when the deadline aware scheduler was previously enabled. The module may request packets of the video chunk from a video server and select at least one active interface for the video server to send each packet. The deadline aware scheduler may select whether a secondary network interface is to be an active interface or a non-active interface.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: July 9, 2019
    Assignees: AT&T Intellectual Property I, L.P., Indiana University Research and Technology Corporation
    Inventors: Bo Han, Lusheng Ji, Vijay Gopalakrishnan, Feng Qian
  • Use of TRPV4 antagonists to ameliorate hydrocephalus and related materials and methods
    Patent number: 10335414
    Abstract: The present invention provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, eg. cancer, benign tumor, etc.). Related materials and methods are also provided herein.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: July 2, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Vincent Gattone, Bonnie Blazer-Yost