Patents Assigned to Indiana University Research and Technology Corporation
  • ANTIBACTERIALS AND/OR MODULATORS OF BIOFILM FORMATION AND METHODS OF USING THE SAME
    Publication number: 20180215704
    Abstract: Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.
    Type: Application
    Filed: January 12, 2018
    Publication date: August 2, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventors: William L. Scott, Martin J. O'Donnell, Jack Geno Samaritoni
  • DEVICE AND METHOD FOR SCAR SUBCISION
    Publication number: 20180214169
    Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.
    Type: Application
    Filed: August 10, 2016
    Publication date: August 2, 2018
    Applicants: Indiana University Research and Technology Corporation, Rose-Hulman Institute of Technology, Inc.
    Inventors: Luke G. Gutwein, Rajiv Sood, Barry Davignon
  • Tube securing device
    Patent number: 10034971
    Abstract: A tube securing device is provided comprising a base, a tube mount including a tube receptacle configured to receive a tube in communication with a cavity of a patient, a retainer, and at least one fastener mounted to one of the base and the retainer and configured to cooperate with the other of the base and the retainer to retain the tube mount between the base and the retainer.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: July 31, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Samer Abu-Sultaneh, Terri Bogue
  • Bidirectional electrical signal converter
    Patent number: 10033182
    Abstract: A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor-capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second LC circuit electrically connected to the synchronized transistor and the first inductor-capacitor circuit, a high-frequency switching transistor electrically connected to the second inductor-capacitor circuit and a direct current (DC) load, and a controller connected to the high-frequency switching transistor. The controller identifies an error between a measured DC output signal and a predetermined DC output signal that is applied to the DC load, and adjusts a duty cycle of a pulse width modulation (PWM) switching signal for the high-frequency transistor to reduce the identified error.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: July 24, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Afshin Izadian
  • METHOD FOR PRODUCING COLLAPSIBLE STRUCTURES
    Publication number: 20180202627
    Abstract: The present disclosure provides a method for producing light coverings that can take any arbitrary symmetrical volumetric forms and that can be flat-foldable or collapsible. The method can also be modified to produce other 3D structures that are collapsible by using other materials and assembly methods.
    Type: Application
    Filed: January 16, 2018
    Publication date: July 19, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Jiangmei Wu
  • Materials and methods for identifying and using yeast strains that metabolize pentose sugars in the presence of D-glucose
    Patent number: 10023837
    Abstract: Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: July 17, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Mark Goebl, Cary Woods, Ross Cocklin, Josh Heyen
  • Ion mobility spectrometer and method of operating same
    Patent number: 10024821
    Abstract: An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of the electric field sources in a manner that sequentially applies electric fields to the drift tube segments with a magnitude of at least one being different than the others to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. Alternatively, the length of at least one of the drift tube segments may be made different from those of the others to produce the same result. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: July 17, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventors: David Edward Clemmer, Michael A. Ewing
  • Carbonized polyaniline-grafted silicon nanoparticles encapsulated in graphene sheets for li-ion battery anodes
    Patent number: 10020500
    Abstract: A method for producing a graphene-composite material, including removing any oxide layer from each of a plurality of silicon nanoparticles, forming a polyaniline layer over each clean silicon nanoparticle, binding a graphene oxide sheet to the polyaniline layer of each particle, and carbonizing the polyaniline to yield a plurality of composite particles. Each composite particle has a graphene outer layer substantially encapsulating a silicon inner core.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: July 10, 2018
    Assignee: Indiana University Research And Technology Corporation
    Inventor: Jian Xie
  • Bicycle apparatuses for use in automotive testing
    Patent number: 10013894
    Abstract: An apparatus for repetitive use in automotive testing includes a body. The body includes a torso and a pair of legs. Each leg includes an upper portion and a lower portion pivotably connected to each other. An upper drive pivotably drives the upper portion of each of the pair of legs about a first pivot point disposed on a bottom portion of the torso. A lower drive pivotably drives the upper portion with respect to a corresponding lower portion of the leg. The upper drive and lower drive working in concert to articulate the upper and lower portions of the leg to replicate a pedaling motion.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: July 3, 2018
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Jidosha Kabushiki Kaisha, Indiana University Research and Technology Corporation
    Inventors: Stanley Yung-Ping Chien, Rini Sherony, Hiroyuki Takahashi, Jason Brink, Qiang Yi
  • Fluorescent-HAP: a diagnostic stain for HBV cores in cells
    Patent number: 10006913
    Abstract: Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: June 26, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Adam Zlotnick, Lichun Li, Michael S. Van Nieuwenhze, William W. Turner
  • METHOD AND APPARATUS FOR 3D FACIAL RECOGNITION
    Publication number: 20180165510
    Abstract: The present disclosure relates to methods and apparatuses for 3-D facial recognition using the Fast Multipole Method (FMM).
    Type: Application
    Filed: May 27, 2016
    Publication date: June 14, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Matthew William Anderson, Thomas Sterling, Bo Zhang
  • Method and apparatus for virtual 3D model generation and navigation using opportunistically captured images
    Patent number: 9998684
    Abstract: A method and device for opportunistically collecting images of a location via a mobile device, the device including algorithms that allow the selective winnowing of collected images to facilitate the creation of a 3D model from the images while minimizing the storage needed to hold the pictures.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: June 12, 2018
    Assignees: Indiana University Research and Technology Corporation, The United States of America as Represented by the Secretary of the Navy
    Inventors: Apu Kapadia, Md Zahidur Rahman, David Crandall, Robert E. Templeman
  • MATERIALS AND METHODS FOR TREATING BACTERIAL INFECTIONS USING C-1 GENTAMICIN
    Publication number: 20180147229
    Abstract: Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 31, 2018
    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Bruce A. MOLITORIS, Mark C. WAGNER, Ruben M. SANDOVAL, Mark Gerard GOEBL
  • INHIBITION OF LNCRNA HOTAIR AND RELATED MATERIALS AND METHODS
    Publication number: 20180148720
    Abstract: Embodiments disclosed herein concern compositions and methods for treating a condition characterized by overexpression of long non-coding RNA HOTAIR. In certain embodiments, synthetic polynucleotide analogs capable of hybridizing with a target sequence domain of HOTAIR are provided. The synthetic polynucleotide analogs can be formulated into a pharmaceutical composition for treating a subject having or at risk of having a condition characterized by HOTAIR overexpression. In certain embodiments, the pharmaceutical composition can resensitize a subject to a chemotherapeutic agent. Other embodiments concern uses for HOTAIR-targeting synthetic polynucleotide analogs, including methods for determining HOTAIR expression in a sample.
    Type: Application
    Filed: May 20, 2016
    Publication date: May 31, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Ali Rayet Ozes, Kenneth P. Nephew
  • Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
    Patent number: 9974759
    Abstract: Methods of treating orthostatic hypotension are disclosed. The methods include administering to a subject in need thereof an effective amount of a beta 2 (?2) adrenoceptor antagonist, and in particular, the specific ?2 adrenoceptor antagonist, 3-(isopropylamino)-1-[(7-methyl-4-indanyl)oxy]butan-2-ol.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: May 22, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Peng-Sheng Chen
  • Modified viral structural protein with antiviral activity
    Patent number: 9968650
    Abstract: This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective virion production. The dominant negative structural protein mimics antiviral drugs through structural and biochemical interactions during virus assembly. An effective gene therapy model for chronic viral infected diseases is proposed in this disclosure, as represented by HBV Cpdominant1 to clear viral infection.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: May 15, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Adam Zlotnick, Dan Loeb
  • Material and methods for treating developmental disorders including comorbid and idiopathic autism
    Patent number: 9956189
    Abstract: The present invention is directed to a method of treating a subject with autism spectrum disorder by administering an acetylaminopropane sulfonate.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: May 1, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Craig A. Erickson
  • HEPATITIS B VIRAL ASSEMBLY EFFECTORS
    Publication number: 20180099952
    Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
    Type: Application
    Filed: April 15, 2016
    Publication date: April 12, 2018
    Applicants: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.
    Inventors: Lee Daniel Arnold, Hans Maag, William W. Turner, Jr.
  • Methods for preventing and treating chronic kidney disease (CKD)
    Patent number: 9926562
    Abstract: The present invention relates to methods for preventing and treating chronic kidney disease (CKD).
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: March 27, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ASSITANCE PUBLIQUE—HOPITAUX DE PARIS, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Christos Chatziantoniou, Jean-Claude Dussaule, Simon J. Conway
  • FLOW ASSEMBLY FOR CELLS
    Publication number: 20180079998
    Abstract: In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path configured to receive the plurality of cells and the buffer. The plurality of cells are in a single-file orientation and the buffer generally surrounds the single-file orientation of the plurality of cells when in the third flow path.
    Type: Application
    Filed: March 31, 2016
    Publication date: March 22, 2018
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Lisa M. Jones, Aimee Rinas