Abstract: A hybrid propulsion system includes a wave rotor combustion engine operating in parallel with an electrical motor-generator element. The motor-generator element is coupled to the turbine shaft to selectively drive or be driven by the turbine shaft. In one mode of operation, the motor of the motor generator element is powered by a battery to provide rotational energy to the turbine shaft. In another mode of operation, the wave rotor combustion engine drives the generator to recharge the battery. The wave rotor combustion engine may be further directly coupled to auxiliary components without a gearbox to drive the components at substantially the same speed as the turbine shaft. The turbine rotor of the combustion engine includes a plurality of chambers defined by circumferentially spaced curved vanes that improves specific fuel consumption for the engine.

Abstract: A fluorophore and methods of detecting cations and hydrophobic environments using the fluorophore are disclosed. The fluorophore includes an imidazo[1,5-a]pyridinium ion core and has the formula where R1, R2, R3 and X? are as defined in the specification, and n is an integer from 1 to 4.

Abstract: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.

Abstract: The present disclosure provides a wearable device for the detection of mild traumatic brain injury, such as concussions, and methods of use thereof. Further disclosed are a method and system for detecting a mild traumatic brain injury.

Abstract: An electric motor is disclosed, comprising a stator and a rotor mounted relative to the stator to form a gap between a surface of the stator and a surface of the rotor, the gap having a width. One of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor about a central axis, and one of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor along the central axis in response to thermal expansion of at least one of the stator and the rotor to maintain the width of the gap.

Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional aGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.

Abstract: A rectal catheter is configured for improved pediatric care. The catheter includes a member that terminates into a rounded tip, a plug mounted about the member, the plug being made of a moldable material, a balloon mounted about the member between the rounded tip and the plug, a conduit that fluidly communicates with the balloon and that extends from the member to enable a pressure source to be operatively connected to the balloon to inflate the balloon, and a pressure relief valve operatively connected to the conduit, the pressure relief valve being configured to open the conduit to atmosphere pressure in response to a pressure in the conduit reaching a predetermined pressure. The predetermined pressure is selected to attenuate significantly risk of bowel perforation in pediatric patients.

Abstract: A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor-capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second LC circuit electrically connected to the synchronized transistor and the first inductor-capacitor circuit, a high-frequency switching transistor electrically connected to the second inductor-capacitor circuit and a direct current (DC) load, and a controller connected to the high-frequency switching transistor. The controller identifies an error between a measured DC output signal and a predetermined DC output signal that is applied to the DC load, and adjusts a duty cycle of a pulse width modulation (PWM) switching signal for the high-frequency transistor to reduce the identified error.

Abstract: Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful.

Abstract: The present disclosure provides a mass spectrometry cartridge and methods of use thereof.

Abstract: The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and pharmaceutical compositions containing them for treating mediated diseases.

Abstract: Methods for reducing intraocular pressure and treating glaucoma are disclosed. The methods include administering to an individual a composition comprising a TRPV4 agonist.

Abstract: Collagen based-matrices and methods of their use are described. More particularly, collagen-based matrices for differentiating stem cells and progenitor cells, and for producing and isolating blood vessels and vascularized graft constructs are described.

Abstract: Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.

Abstract: The present disclosure provides a method and system for estimating the clinical responsiveness of a patient to a dose of a plasminogen activating agent to treat a thrombosis, comprising determining a concentration of ?2-antiplasmin in a blood sample of the patient, determining a concentration of activated fibrinolysis inhibitor (“TAFI”) in the blood sample, determining a concentration of plasminogen activator Inhibitor 1 (“PAI-1”) in the blood sample, computing a clot lysis time (“CLT”) based on the concentrations of a2-antiplasmin, TAFI and PAI-1 using the equation CLT=?2,813.6+31.1*a2-antiplasmin (percent activity)+31.1*TAFI (percent activity)+1.49 PAI-1 (ug/L), and determining that the patient is at increased risk of hemorrhage when the computed CLT is less than a first predetermined cutoff time.

Abstract: A carbon composite material, including a plurality of spaced graphene sheets, each respective sheet having opposed generally planar surfaces, and a plurality of functionalized carbonaceous particles. At least some functionalized carbonaceous particles are disposed between any two adjacent graphene sheets, and each respective at least some functionalized carbonaceous particle is attached to both respective any two adjacent graphene sheets. Each respective graphene sheet comprises at least one layer of graphene and at least portions of respective any two adjacent graphene sheets are oriented substantially parallel with one another.

Abstract: A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium, potassium and combinations thereof, an electrolyte permeable membrane, and a metal dendrite seeding material disposed between the electrode and the membrane. The electrode, the membrane and the metal dendrite seeding material are positioned in an electrolyte matrix. At least one dendrite extends from the electrode toward the electrolyte permeable membrane combines with at least one dendrite extending from the dendrite seeding material.

Abstract: Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or glomerulonephritis-associated diseases, and in particular, Systemic Lupus Erythematosus (SLE).

Abstract: An apparatus and device for repetitive use in automotive testing is provided. The apparatus includes a frame dimensioned in the same shape as a bicycle frame. The frame includes a first support beam and a plurality of second support beams. The apparatus further includes an elastic member elastically coupling each of the plurality of second support beams to the first support beam so as to allow the frame to separate when impacted and be easily reassembled for further testing. The device includes a disk having a first radar transparent layer opposite a second radar transparent layer and a reflective film disposed between the first radar transparent layer and the second radar transparent layer. The reflective film has a radar cross section pattern similar to that of an actual bicycle wheel when seen by automotive radar.

Abstract: A bearingless and sealless rotary blood pump is disclosed which provides multidirectional flow intended to provide low-pressure, high-volume right-sided partial assist circulatory support in a univentricular Fontan circulation on a permanent basis. The pump includes a housing and an impeller suspended in the center of the housing. The housing incorporates flow optimization features between inlet and outlet ends, as well as with the impeller surface. Large fluid gaps maintained between impeller and housing eliminate any potential for blood flow obstruction. The impeller contains some motor components. It includes a central stator and surrounding rotor. The motor includes a brushless DC outrunner electrical motor design. An electromagnetic stator core is surrounded by a circumferential passive magnetic ring. The rotor is further levitated about the stator spindle by a plurality of axially and radially located passive magnetic and hydrodynamic journal bearings on both ends of the spindle.