Abstract: A silicone modified lubricant includes a Group I, II, III, IV or V base oil in combination with a minor amount of a silicone oil. Further, the lubricant includes a dispersant such as a dispersant olefin copolymer which maintains the silicone oil dispersed in the base oil. The silicone oil reduces the surface tension of the lubricant thereby reducing power loss. Preferably the lubricant formation has a surface tension less than 28 mN/m, making it particularly suitable for dip lubrication systems.

Abstract: The present invention relates to conjugates formed from a cell-penetrating peptide carrier linked to a therapeutic molecule, wherein the peptide carrier is defined by specific domains and the therapeutic molecule is a nucleic acid formed of trinucleotide repeats. The present invention further relates to the use of such a conjugate in methods of treatment or as a medicament, especially in the treatment of trinucleotide repeat disorders such as myotonic dystrophy (DM1).

Abstract: An airport runway arrangement for commercial aircraft comprises a first runway section, a second runway section extending substantially in prolongation of the first runway section and an intermediate section between the first and second runway sections.

Abstract: A rotatable pressure relief valve assembly is provided. The assembly may comprise a butterfly valve, a spring actuator, and a diaphragm device having a flexible membrane. A linkage assembly may be provided with a first end and a second end, wherein the first end may be configured to engage with a terminal end of a piston of a spring actuator, and wherein the second end may be configured to engage with a latch arm of the diaphragm device. A pilot tube may be configured to transmit an inlet fluid pressure from the inlet side of the butterfly valve to the sealed chamber. The assembly may further comprise a buckling pin mechanism having a buckling pin. The diaphragm device may be configured to translate the inlet fluid pressure into a compressive force and to transmit the compressive force to the buckling pin, and the latch arm may be configured to disengage from the second end of the linkage assembly when the buckling pin has buckled.

Abstract: An explosion isolation device is disclosed. The explosion isolation device may comprise a conduit having a flap configured to rotate between an open position and a closed position within the conduit, and a holding mechanism configured to hold the flap in the open position. The holding mechanism may be configured to release the flap in the event of an explosion and the flap may be configured to rotate into the closed position after it is released. The device may include a sensor and an actuator configured to actuate the holding mechanism when an explosion is sensed. The conduit may be vertical.

Abstract: This invention relates to a process for obtaining lead (Pb) and/or tin (Sn) from a lead- and/or tin-based material using a deep eutectic solvent.

Abstract: A method of image processing is described. The method comprises receiving a set of at least three images of an object including at least two linearly-polarized images and at least one color image, wherein the three images have the same view of the object and are acquired under the same illumination condition in which either diffuse polarization or specular polarization dominates in surface reflectance, and wherein a set of Stokes parameters s0, s1 and s2 is determinable from the at least three images.

Abstract: A method of measuring states of qubits of a quantum processor, the method includes providing, to the qubits, a control signal to control states of n qubits in the quantum processor, where n is a natural number; performing a bit-flip to invert a state of at least one qubit of the qubits; reading out output qubit values of bit-flipped qubits based on the performing of the bit-flip; and generating an error model indicating a probability of occurrence of measurement errors in the output qubit values based on a result of the reading-out of the output qubit values.

Abstract: The invention relates to RNA constructs encoding (i) at least one therapeutic biomolecule; and (ii) at least one innate inhibitor protein (IIP). The constructs are RNA replicons and saRNA molecules, and the invention includes genetic constructs or vectors encoding such RNA replicons. The invention extends to the use of such RNA constructs and replicons in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: Apparatuses, methods, and systems are disclosed for data acknowledgment. One apparatus includes a transmitter that transmits data to a device. The apparatus may include a processor that determines a response window having multiple subframes for receiving an acknowledgement corresponding to the data. The apparatus may include a receiver that receives the acknowledgement within the response window.

Abstract: This invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders.

Abstract: Analogues of PYY differing from native human PYY by substitution of Ser23 with Ala23, Glu23, Lys23, Gln23 or AIB23. Further optional features include substitutions at further positions, loss of the Tyr1 residue of native human PYY and amidation of the C-terminus. Suitable for use as pharmaceuticals for treating and preventing disorders, in particular diabetes and obesity.

Abstract: The present invention relates to a method for determining conversion of a subject from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS), the method comprising: a. providing a sample obtained from the subject, wherein the subject has, or is suspected of having, CIS (preferably has CIS); b. measuring a concentration of: i. one or more polypeptides in the sample; and/or ii. one or more metabolites in the sample; c. comparing the measured concentration with the concentration of the same one or more polypeptides and/or metabolites, respectively, in a reference standard; and d. determining that the subject will convert from CIS to CDMS based on the comparison, or determining that the subject will not convert from CIS to CDMS based on the comparison. The invention also relates to methods for diagnosing multiple sclerosis (MS), to methods for determining prognosis of MS and to therapeutics and their uses in a method of treating MS in a subject.

Abstract: A method for monitoring the production of a material such as graphene in a liquid dispersion in real time, comprises supplying the liquid dispersion to a fluid gap defined between a first layer and an opposed second layer, wherein the first layer is light-transmissive and wherein the second layer has a diffusely reflective surface facing the first layer. The diffusely reflective surface is illuminated with light from a light source and light reflected from the diffusely reflective surface is detected at an associated photodetector. A light path from the light source to the photodetector comprises the light passing through the transmissive layer towards the diffusely reflective surface through the fluid gap, reflecting off the diffusely reflective surface and passing back through the fluid gap towards and onwards through the transmissive layer. The concentration of the material in the liquid dispersion can be determined from the detected reflected light.

Abstract: A load handling device is disclosed for retrieving, transporting, and delivering containers in a storage system having a grid structure formed of two substantially perpendicular sets of rails or tracks located above stacks of containers. An exemplary load handling device can include a wheel assembly, a container receiving space, and a plurality of vehicle modules. The wheel assembly can include a first set of wheels to guide movement of the load handing device in a first direction and a second set of wheels to guide movement of the load handing device in a second direction. Each of the vehicle modules can include a container lifting means arranged to lift a container into the container receiving space and each of the vehicle modules can be moveable to adjust the spacing of the containers in the load handling device.

Abstract: An animal feed supplement and an animal feed composition comprising said animal feed supplement and methods of making said animal feed supplement and animal feed composition.

Abstract: A method of fabricating one or more colour centres in a crystal is described. The method comprises focusing a laser into a crystal to induce the creation, modification, or diffusion of defects within a focal region of the laser. Fluorescence detection is used to determine when one or more colour centres are formed within the focal region and the laser is terminated when a desired number of colour centres have been formed. The method enables colour centres to be formed in a crystal with a high degree of control in terms of both the number and location of colour centres within the crystal, and a degree of control over other parameters such as colour centre orientation and local environment. In particular, it is possible to form a well-defined pattern of colour centres within a crystal.

Abstract: The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.

Abstract: A method of image processing is described. The method comprises receiving a set of at least three images of an object including at least two linearly-polarized images and at least one color image, wherein the three images have the same view of the object and are acquired under the same illumination condition in which either diffuse polarization or specular polarization dominates in surface reflectance, and wherein a set of Stokes parameters s0, s1 and s2 is determinable from the at least three images.

Abstract: The disclosed non-volatile memory cell comprises a storage layer of an electrically insulating polarisable material in which data is recordable as a direction of electric polarisation, preferably of ferroelectric material, arranged between a magnetically frustrated layer, preferably of Mn-based antiperovskite piezomagnetic material and a conduction electrode. The magnetically frustrated layer has a different change in density of states relative to the conduction electrode in response to a change in electric polarisation of the storage layer, such that an electron or spin tunnelling resistance across the storage layer is dependent on the direction of electric polarisation.