Abstract: An autonomous delivery device can make unattended deliveries of customer orders to predetermined locations. The device includes a plurality of compartments containing portions of the order or all of the order or a number of separately deliverable orders. The device includes a compartment opening such that on arrival at the predetermined location the contents of the or each compartment may be automatically dispensed.

Abstract: A storage system includes a plurality of rails or tracks arranged in a grid pattern above the stacks of containers. The grid pattern includes a plurality of grid spaces and each stack is located within a footprint of only a single grid space. A load handling device is configured to move laterally on the rails or tracks above the stacks. The load handling device includes a container receiving space located above the rails or tracks in use and a lifting device arranged to lift a container from a stack into the container receiving space. The load handling device includes a mechanism for enabling lateral movement of the device in one of two transverse directions by enabling either a first or second set of wheels to selectively engage the first or second set of rails or tracks.

Abstract: The invention provides an optoelectronic device comprising: (i) a porous dielectric scaffold material; and (ii) a semiconductor having a band gap of less than or equal to 3.0 eV, in contact with the scaffold material. Typically the semiconductor, which may be a perovskite, is disposed on the surface of the porous dielectric scaffold material, so that it is supported on the surfaces of pores within the scaffold. In one embodiment, the optoelectronic device is an optoelectronic device which comprises a photoactive layer, wherein the photo-active layer comprises: (a) said porous dielectric scaffold material; (b) said semiconductor; and (c) a charge transporting material. The invention further provides the use, as a photoactive material in an optoelectronic device, of: (i) a porous dielectric scaffold material; and (ii) a semi-conductor having a band gap of less than or equal to 3.0 eV, in contact with the scaffold material.

Abstract: Certain examples described herein relate to estimating dimensions of an enclosed space such as a room using a monocular multi-directional camera device. In examples, a movement of the camera device around a point in a plane of movement is performed, such as by a robotic device. Using the monocular multi-directional camera device, a sequence of images are obtained at a plurality of different angular positions during the movement. Pose data is determined from the sequence of images. The pose data is determined using a set of features detected within the sequence of images. Depth values are then estimated by evaluating a volumetric function of the sequence of images and the pose data. A three dimensional volume is defined around a reference position of the camera device, wherein the three-dimensional volume has a two-dimensional polygonal cross-section within the plane of movement. The three dimensional volume is then fitted to the depth values to determine dimensions for the polygonal cross-section.

Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of IMK cells by increasing the expression of specific transcription factors associated with NK cell production.

Abstract: The present invention relates to the use of compounds which display activity as inhibitors of the human N-myristoyl transferases (NMT) in the treatment of MYC addicted cancers, such as, for example, cancers comprising MYC overexpression. The present invention also relates to the use of compounds which display activity as inhibitors of NMT, in combination with one or more other therapeutic agents, in the treatment of MYC addicted cancers and/or MYC dysregulated cancers.

Abstract: A system, comprising: a storage workspace including a first framework defined by a series of first uprights, the first uprights supporting a grid of two substantially perpendicular sets of rails; and a plurality of containers for storing objects, wherein the plurality of containers are arranged in stacks, each stack of containers is located underneath a grid space in the workspace; and a grid extension including a continuation of the two substantially perpendicular sets of rails, and wherein the plurality of containers can be moved by one or more load handling devices between the storage workspace and an area beneath the grid extension, wherein the area beneath the grid extension is configured for positioning a roll cage such that containers can be placed or removed from the roll cage.

Abstract: Embodiments relate to methods, systems, and devices for managing trading information. The method includes receiving non-indicative price information and indicative price information from communications between a representative user and customer users. The method includes categorizing indicative and non-indicative price information. The method includes generating candidate trading records, including indicative price candidate trading records and non-indicative price candidate trading records. The method includes generating a confidence indicia for each indicative price candidate trading record and non-indicative price candidate trading record.

Abstract: A foot stretching device for stretching the structures of a foot comprises a base for receiving a rear portion of the foot to be stretched and a toe plate for receiving the toes of the foot to be stretched. The toe plate is disposed on and pivotable relative to the base. The device further comprises a member coupled to and/or configured to engage the toe plate, such that a tensile force applied to the member by a user pivots the toe plate relative to the base. and thus the user's toes relative to the rear portion of their foot. This action causes the toes to move into a more extended position thus producing a stretch in the tissues of the foot, in particular the musculature associated with the planar fascia.

Abstract: A growing system is described where living organisms are grown within containers in stacks. Above the stacks run load handling devices. The load handling devices take containers from the stacks and deposit them at service area stations where goods may be picked out. The containers may be provided with one or more of the following services: power, power control, heating, lighting, cooling, sensing, and data logging. The provision of these services within individual containers rather than across the system as a whole, allows for flexibility in storage whilst reducing cost and inefficiency.

Abstract: The invention provides inter alia compound as defined herein and its use in the prevention or treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, e.g. cancer.

Abstract: Electrolytic Etching/Deposition System. A system for continuous circuit fabrication comprising means for storing and dispensing the substrate, means for laminating the substrate, means for printing the substrate, means for optical inspection of the substrate, means for photolithography of the substrate, means for drying the substrate, means for developing the substrate, means for washing the substrate and means for electroplating the substrate.

Abstract: A robotic object handling system and robotic load handling device for operation thereon is disclosed. The object handling system includes a number of robotic load handling devices operational on a grid-like structure, the structure having sets of parallel tracks, disposed above a hive of stacked bins. The bins contain inventory items to be picked by the system. Load handling devices capable of carrying multiple bins of a single grid-spacing size or single bins of a multiple grid spacings are operational on the grid and retrieve and transport bins under the control of a computerised order picking utility.

Abstract: The present invention relates to anthelmintic compositions comprising two or more anthelmintic active agents selected from one or more of the following groups; imidazothiazoles such as levamisole, benzimidazoles such as oxfendazole, or fenbendazole, macrocylic lactones such as ivermectin or avermectin, salicylanilides, and praziquantel. The composition being in the form of stable granules that are readily dispersible in water so as to provide a homogenous mixture of the anthelmintic agents suitable for administration. Methods of preparing the composition are also described.

Abstract: Monodispersed metal nanoparticles are prepared by preparing a homogeneous metal complex solution by mixing metal salt with a complexing agent in solvent. A precipitating agent is added into the homogeneous metal complex solution to form a slurry. A homogeneous mixture of reducing agent and solvent is added to perform reducing reaction on the slurry to form metal nanoparticles in a controlled environment under gas purge. A capping agent is added to modify surface properties of metal nanoparticles. The metal nanoparticles are washed and the metal nanoparticles are recovered by phase extraction or centrifugation. The technique can be used to prepare conductive pastes with bimodal particle size distribution.

Abstract: A connector assembly for connecting articles to one another including a male connector insertable into a substantially U shaped receiving channel defined by a respective female connector, the female connector being adapted to be located in a receiving recess formed, in use, in one of at least two articles to be connected together, the receiving recess including a pair of diverging side walls and a narrowed neck region, the neck region defining an opening of the receiving recess, at least one pair of opposing inwardly facing shoulders being defined in the side walls of the receiving recess, outer sides of the female connector including cooperating projections adapted to engage the opposing shoulders of the receiving recess when the female connector is inserted into the receiving recess to retain the female connector in the receiving recess.

Abstract: The invention provides an optoelectronic device comprising a mixed-anion perovskite, wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions. The invention further provides a mixed-halide perovskite of the formula (I) [A][B][X]3 wherein: [A] is at least one organic cation; [B] is at least one divalent metal cation; and [X] is said two or more different halide anions. In another aspect, the invention provides the use of a mixed-anion perovskite as a sensitizer in an optoelectronic device, wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions. The invention also provides a photosensitizing material for an optoelectronic device comprising a mixed-anion perovskite wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions.

Abstract: An automated picking system robotic device testing station having rollers for engagement with the wheels of a robotic device; and a controller to vary the rotation of the rollers.

Abstract: The present invention related to identification of therapeutic agents of the treatment, diagnosis, and prevention of pulmonary hypertension.

Abstract: A surface or bulk acoustic wave device can be implanted in or worn on a human or animal body to monitor various parameters thereof. The device comprises a pair of interdigitated transducers spaced apart over the surface of a piezo-electric substrate that is exposed to the parameter to be monitored. The device is interrogated by a radio-frequency signal being supplied to one of the transducers and detected after reflection by the other transducer. The parameter is measured by comparison of the supplied and received signals.