Patents Assigned to Institut de Recherche Pour le
-
Patent number: 11560544Abstract: The present invention concerns a process for isolating an archaeon of the order of commensal clade Methanomassiliicoccales, the use of a culture and/or isolation medium comprising a sterile extract of a bacterial culture of a bacterium of genus Eggerthella, for the isolation and/or culture of an archaeon of the order of commensal clade Methanomassiliicoccales, and a pure, isolated archaeon Methanomethylophilus alvus Mx-05. It also concerns a culture method of an archaeon of the order of commensal clade Methanomassiliicoccales.Type: GrantFiled: November 30, 2018Date of Patent: January 24, 2023Assignees: LESAFFRE ET COMPAGNIE, UNIVERSITÉ CLERMONT AUVERGNE, INSTITUT DE RECHERCHE POUR LE DÉVELOPPMENTInventors: Wajdi Ben Hania, Jean-François Brugere, Marie-Laure Fardeau, Bernard Ollivier
-
Patent number: 11559575Abstract: The invention relates to multi-epitopic peptide compounds obtained from PSA, HwB and LmLRAB proteins of Leishmania as well as to pharmaceutical compositions and vaccines for use against one or more leishmaniases.Type: GrantFiled: May 29, 2019Date of Patent: January 24, 2023Assignees: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT, INSTITUT PASTEUR DE TUNISInventors: Rachel Bras Gonçalves, Jean-Loup Lemesre, Amel Garnaoui, Elodie Petitdidier-Lesin
-
Publication number: 20220279814Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.Type: ApplicationFiled: July 31, 2020Publication date: September 8, 2022Applicants: SPECIALITES PET FOOD, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT POLYTECHNIQUE DE BORDEAUX, ABYSS INGREDIENTS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER, INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENTInventors: Fabienne GUERARD, Cloé OROY, Anne LEPOUDERE, Mathilde CHATAIGNER, Patrick ALLAUME, Anne-Laure DINEL, Corinne JOFFRE, Véronique PALLET, Fabienne LE GRAND
-
Publication number: 20210268056Abstract: The present invention relates to the abietane diterpene taxodione and to rosemary stem extract containing taxodione for their use in treating a muscle wasting diseases and/or disorders; it also relates to the use of taxodione as natural meat preserver.Type: ApplicationFiled: July 3, 2019Publication date: September 2, 2021Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, ECOLE PRATIQUE DES HAUTES ETUDES, UNIVERSITE MONTPELLIER III PAUL VALERY, INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT, FLORE EN THYMInventors: Nathalie Saint, Sylvie Rapior, Manon Vitou, Guillaume Bouguet, Gilles Carnac, Sylvie Morel
-
Publication number: 20210213114Abstract: The invention relates to multi-epitopic peptide compounds obtained from PSA, HwB and LmLRAB proteins of Leishmania as well as to pharmaceutical compositions and vaccines for use against one or more leishmaniases.Type: ApplicationFiled: May 29, 2019Publication date: July 15, 2021Applicants: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT, INSTITUT PASTEUR DE TUNISInventors: Rachel Bras Gonçalves, Jean-Loup Lemesre, Amel Garnaoui, Elodie Petitdidier-Lesin
-
Patent number: 11035759Abstract: Disclosed is a device for detecting at least one chemical species in a medium to be analyzed including a chemical sensor, the chemical sensor including: a substrate; a functionalized carrier intended for capturing and accumulating the chemical species and attached to a side of the substrate. The device also includes a unit for diffusion between the medium to be analysed and the functionalised carrier. The diffusion unit includes a vibration generating system connected to the chemical sensor in order to subject the chemical sensor to controlled vibrations.Type: GrantFiled: February 11, 2016Date of Patent: June 15, 2021Assignee: INSTITUT DE RECHERCHE POUR LE DEVELOPPMENT (IRD)Inventors: David Point, Anthony Gautier
-
Patent number: 10849943Abstract: The present invention relates to vaccine compositions comprising an attenuated mutant Zika virus. The inventors have introduced mutations at very specific positions that abrogate the N-glycosylation site on the E protein of the epidemic strain which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have also produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular, the present invention relates to an attenuated mutant Zika virus comprising a protein E of the epidemic strain wherein at least one amino acid residue at position 152, 156 or 158 is mutated.Type: GrantFiled: June 22, 2017Date of Patent: December 1, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE LA REUNION SAINT DENIS, INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventors: Philippe Despres, Gilles Gadea, Patrick Mavingui, Wildriss Viranaicken
-
Publication number: 20200360334Abstract: The present invention relates to compound of formula (I): wherein R is O—R3 or R1 and R2 are identical or different and are each independently H, (C1-C6)alkyl, —CO—(C1-C21)alkyl or —CO—(C11-C21)alkenyl group, provided that at least one of R1 or R2 is H or (C1-C6)alkyl, R3 is a —CO—(C11-C21)alkyl or —CO—(C11-C21)alkenyl group, or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof, for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability.Type: ApplicationFiled: November 12, 2018Publication date: November 19, 2020Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Superieure de Chimie, Institut de Recherche Pour le Developpement (IRD), Universite D'Aix-Marseille, Communaute Universites et Etablissements Universite Cote D AzurInventors: Céline Crauste, Joseph Vercauteren, Fransisco Veas, Thierry Durand, Nicolas Blondeau
-
Patent number: 10590174Abstract: The present invention relates to a genomic sequences encoding for an attenuated mutant Zika virus. The inventors have introduced some specific substitutions at very specific positions in the epidemic genomic sequence for restoring some fixation sites for miR-4279 that were originally present in the endemic genomic sequence. Moreover the inventors have additionally introduced mutation leading to the abrogation of the N-glycosylation site on the E protein which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular the present invention relates to a genomic sequence characterized by the sequence represented by SEQ ID NO:1 wherein at least one site of fixation for miR-4279 is restored.Type: GrantFiled: July 7, 2017Date of Patent: March 17, 2020Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE LA REUNION SAINT DENIS, INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Gilles Gadea, Michael Girardot, Philippe Despres
-
Publication number: 20190050535Abstract: The present invention relates to a method for classifying a measurement biological sample, comprising: acquisition of at least one DNA melting curve of the measurement biological sample, called at least one measurement curve; and determination that the measurement biological sample belongs to a defined group among different possible groups, by analysis of descriptors originating from the at least one measurement curve, characterized in that the descriptors comprise one or more points of the first derivative of each measurement curve and/or comprise one or more points of the second derivative of each measurement curve and/or one or more points of each measurement curve and/or one or more percentiles of each measurement curve. The invention also relates to a device implementing this method.Type: ApplicationFiled: January 23, 2017Publication date: February 14, 2019Applicants: UNIVERSITE DE MONTPELLIER, INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jean-Christophe Avarre, Christelle Reynes
-
Patent number: 10144977Abstract: The present invention relates to a novel hyperhalophilic strain and use thereof for the degradation of carbon-containing substrates, in particular making it possible to prepare novel polymers.Type: GrantFiled: April 30, 2015Date of Patent: December 4, 2018Assignees: Institut de Recherche Pour le Developpement (I.R.D.), Societe Interoleagineuse D'Assistance et de Developpement (SIA)Inventors: Bernard Ollivier, Wajdi Ben Hania, France Thevenieau, Abdeljabbar Hedi, Marie-Laure Fardeau
-
Patent number: 10106493Abstract: Compounds of formula wherein n is 0, 1 or 2; X is and Ar is a benzyl substituted at the meta position by a C1 to C8 alkoxy group, or a pharmaceutically acceptable salt thereof, for treating, preventing or inhibiting a parasitic disease, such as toxoplasmosis, in a subject are provided. Methods for preparing the compounds are also presented.Type: GrantFiled: July 17, 2014Date of Patent: October 23, 2018Assignees: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (I.R.D.), UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Denis Sereno, Gilles Labesse, Jean-Francois Alexandre Guichou, Corinne Loeuillet, Deborah Isabelle Garcia, Stephane Delbecq
-
Patent number: 9932376Abstract: The present invention relates to novel antimicrobial peptides, pharmaceutical compositions comprising said peptides, and the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.Type: GrantFiled: September 26, 2014Date of Patent: April 3, 2018Assignees: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: Ali Ladram, Denis Sereno, Thierry Foulon, Bruno Oury
-
Patent number: 9873715Abstract: The present invention relates to a compound of the following formula (I) or to a salt, hydrate, or pharmaceutically acceptable solvate thereof, in which R is a monosaccharide or disaccharide residue. The hydroxyl functions of the monosaccharide or disaccharide residue are, independently, optionally substituted for a (C1-C6) alkyl or —C(O)NH—(C1-C6) alkyl group. The invention also relates to the method for preparing said compound, to a pharmaceutical composition containing same, and to the use thereof as a drug, particularly for cancer treatment.Type: GrantFiled: January 24, 2014Date of Patent: January 23, 2018Assignees: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)Inventors: Isabelle Carletti, Georges Massiot
-
Patent number: 9855321Abstract: The present invention relates to combinations of polypeptides or of polynucleotides corresponding to a specific region of the N-terminal portion of the VAR2CSA protein of different parasitic families or lines of Plasmodium falciparum, and to their use in the prevention of pregnancy-associated malaria. The invention also relates to immunogenic compositions and to vaccines useful for preventing malaria in pregnant women.Type: GrantFiled: January 21, 2014Date of Patent: January 2, 2018Assignee: INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD)Inventors: Nicaise Tuikue Ndam, Philippe Deloron, Justin Doritchamou
-
Patent number: 9804158Abstract: The present invention relates to peptides and methods for the detection of anti-leishmanial antibodies in individuals suspected of infection with the protozoan parasite of the genus Leishmania, especially infection with a South American strain causing the American Tegumentary Leishmaniasis (ATL).Type: GrantFiled: July 2, 2013Date of Patent: October 31, 2017Assignees: Institut de Recherche pour le Développement, Universidad Peruana Cayetano HerediaInventors: Jorge Arevalo, Eric Deharo, Angela Privat-Maldonado
-
Patent number: 9765406Abstract: The oligonucleotide of sequence SEQ ID No.1: 5?-CTAGAGATCCCTCAGA-3?, and the complementary sequence thereof of sequence SEQ ID No.2: 5?-TCTGAGGGATCTCTAG-3? useful as probes to detect and quantify all HIV-1 circulating forms and their precursors SIVcpz/SIVgor.Type: GrantFiled: November 8, 2013Date of Patent: September 19, 2017Assignee: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)Inventors: Martine Peeters, Lucie Etienne
-
Patent number: 9730442Abstract: The present invention relates to the use of 4-phenylbutyric acid, or one of the salts thereof, for improving the resistance of plants to harmful biological organisms, in particular to bacteria, viruses and nematodes, and for inhibiting hypersensitive cell death induced by such harmful biological organisms. The present invention also relates to the use of 4-phenylbutyric acid, or one of the salts thereof, as an antimicrobial agent for preventing or treating plant diseases caused by phytopathogens.Type: GrantFiled: July 10, 2013Date of Patent: August 15, 2017Assignee: INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD)Inventors: Jean-Luc Cacas, Antony Champion
-
Patent number: 9688633Abstract: The present invention relates to new arylaminoalcohol derivatives of formula (I), and to a method for the preparation of such compounds: I The invention also relates to the use of these compounds as medicaments, and in particular for the prevention and/or the treatment of parasitic diseases caused by apicomplexan parasites such as malaria and toxoplasmosis. Finally, the invention relates to pharmaceutical compositions containing such compounds of formula (I) as active principles.Type: GrantFiled: March 14, 2014Date of Patent: June 27, 2017Assignee: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENTInventors: Ignacio Aldana Moraza, Silvia Victoria Blair Trujillo, Eric Deharo, Giovanny Garavito, Adela Mendoza Lizaldez, Silvia Perez-Silanes
-
Publication number: 20170042148Abstract: The use of a dicarboxylic acid having 2 to 5 carbon atoms to control the growth of holo- or hemiparasitic plants, as well as to the strain Azospirillum brasilense L4, registered with CNCM (Collection Nationale de Cultures de MicrOorganismes, France) under number I-4830, capable of producing a dicarboxylic acid exhibiting a bioherbicidal activity against Striga and Orobanche.Type: ApplicationFiled: April 28, 2015Publication date: February 16, 2017Applicants: UNIVERSITE CLAUDE BERNARD LYON I, INSTITUT D'ENSEIGNEMENT SUPERIEUR ET DE RECHERCHE EN ALIMENTATION, SANTE ANIMALE, SCIENCES AGRONOMIQ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, L'INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENTInventors: René BALLY, Gilles COMTE, Jacques BERNILLON, Floriant BELLVERT, Claire PRIGENT-COMBARET, Zo-Norosoa ANDRIANJAKA-CAMPS, Robin DUPONNOIS, Florence WISNIEWSKI-DYE, Cédric BERTRAND, Lucie MICHE