Abstract: The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes of Leishmania coding for an excretion/secretion antigen.

Abstract: The present invention relates to a polyketide molecule of the following formula (I): or a pharmaceutically acceptable salt thereof, where R1 is a hydrogen atom or a (C1-C7) alkyl group, as well as the method of preparation and use thereof, in particular as an anticancer agent.

Abstract: The disclosure provides novel antigens involved in gestational malaria, and more particularly to polynucleotide and polypeptide sequences, conjugates, cloning vectors including the sequences for the preparation of immunogenic compositions and vaccines, antibodies, and to their for treating gestational malaria. Diagnostic methods and kits are described.

Abstract: The invention relates to an antigenic structure that contains a tryptophan epitope, characterised in that said structure is made up of a tryptophan pattern W or a peptide of 3 or 4 amino acids comprising a pattern W, coupled with glutaraldehyde. The invention can he used for screening trypanosomiasis in humans or animals.

Abstract: A method for the cleanup of site/sediments contaminated by heavy metals, or by chlorobenzoate, polychlorobenzoates, monochlorophenol, polychlorophenols, polychlorobiphenyl (PCB) compounds or phosphogypsum, includes treating the contaminated sites/sediments by anaerobic mesophilic bacteria (Mesotoga lineage) belonging to the order of Thermotogales.

Abstract: Method for the microbiological production of cinnamoyl amide derivatives of amino acids, certain products that result therefrom and uses thereof, especially as antioxidants.

Abstract: The aim of the invention is to use sulphate-reducing thermophilic archaeobacteria for carrying out a method for degrading linear or branched, saturated or unsaturated, when necessary sulphur, aromatic hydrocarbons under anaerobic conditions.

Abstract: The present invention relates to specific regions of the N-terminal portion of the VAR2CSA protein and to the use of such specific regions in the prevention of pregnancy-associated malaria. The invention also provides immunogenic compositions and vaccines that are useful for preventing malaria in pregnant women.

Abstract: The invention provides a composition for the inoculation in a plant of agrobacteria transfected by expression vectors, in order to produce in said plant a protein of interest or a derivative of said protein, by deletion or by mutation, characterised in that it comprises agrobacteria transfected by at least one expression vector, comprising a nucleotide sequence insert that codes for said protein or a derivative of said protein, and agrobacteria transfected by a plurality of expression vectors, each comprising at least one nucleotide sequence insert that codes for proteins having a silencing suppressor effect.

Abstract: The invention relates to salts of 2-substituted quinolines, the manufacturing method for same, and use of the same for the production of drugs. Said salts are advantageous in that the same can be obtained in crystalline form, which facilitates their implementation in the manufacture of pharmaceutical compositions.

Abstract: The present invention relates to an antimicrobial peptide characterised in that said peptide includes the sequence SEQ ID No. 1 or the sequence SEQ ID No. 2, the sequence SEQ ID No. 2 representing a fragment of the sequence SEQ ID No. 1, for use as a drug. Advantageously according to the invention, the peptide having sequence SEQ ID No. 1 is used specifically for treating bacterial, viral and/or parasitic infections, and the peptide having sequence SEQ No. 2 is used for treating bacterial and/or viral infections.

Abstract: The present invention relates the use of aprotinin in the treatment of parasitic diseases or infections that affect domesticated mammals, in particular the cattle, especially bovines. In particular, aprotinin finds application in the fight against pathogenic effects induced by parasites in the Trypanosomatidae family, such as the protozoa that belong to the Trypanosoma genus or Leishmania genus. The invention also relates to the use of aprotinin for the prognosis of bovine tolerance to trypanosomosis infections.

Abstract: The present invention relates to a polyketide molecule of the following formula (I): or a pharmaceutically acceptable salt thereof, where R1 is a hydrogen atom or a (C1-C7) alkyl group, as well as the method of preparation and use thereof, in particular as an anticancer agent.

Abstract: The present invention relates to rosmarinic acid and to the derivatives thereof, expressed by the compounds of general formula (I), for the use thereof to prevent and/or treat disorders caused by ciguatoxin poisoning and for preparing a pharmaceutical composition for preventing and/or treating disorders caused by ciguatoxin poisoning.

Abstract: The invention relates to a device (1) for connecting/disconnecting a submersible connector (100) provided with a male portion (101) and a female portion (102), to a related connection/disconnection method, as well as to the various potential uses of said device. The device includes means (11, 12) for moving at least one of said male or female portions of the connector (100) between a connection position and a disconnection position and vice versa, and is characterized in that it further includes a system (16) for injecting a fluid (20) around the male (101) and female (102) portions of the connector (100) when the latter passes from the connection position thereof to the disconnection position thereof and vice versa, in order to insulate the same from the water surrounding the connector (100), the injection system (16) being located outside the connector (100).

Abstract: The invention relates to an expression vector of a gene coding for an antigenic protein of Leishmania promastigote, characterized in that it comprises a PSA gene insert in opposite orientation. The invention can be applied to the development of mutants under-expressing, or no longer expressing, genes coding for an antigenic protein of Leishmania promastigote, and to the therapeutic and/or vaccine-oriented uses thereof.

Abstract: The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.

Abstract: Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use.

Abstract: A method for the mass production of fish belonging to the order of Cypriniforms, notably to the family of Cobitidae, from spawners which are raised in closed circuit.

Abstract: The present invention relates to the use, for the preparation of a medicament intended for the treatment or the prevention of pathologies linked to, or caused by mycobacteria, of at least one of the compounds of the following formula (I): in which B represents in particular a nitrogen atom, and R1, R2, R3, R4, R5, R6, R7 and R8 represent in particular a hydrogen atom.