Abstract: The invention provides low-molecular-weight over-sulfated polysaccharides with anti-heparanase activity prepared from marine native exopolysaccharides excreted by mesophilic marine bacteria from a deep-sea hydrothermal environment and relates to the use of these low-molecular-weight over-sulfated polysaccharides for the prevention or treatment of mucopolysaccharidoses, in particular mucopolysaccharidoses type III (Sanfilippo syndrome).

Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.

Abstract: The invention provides a low-molecular-weight (15 kDa) over-sulfated exopolysaccharide (GYS15) prepared from a marine native exopolysaccharide excreted by a mesophilic marine bacterium from a deep-sea hydrothermal environment, and relates to the use of this low-molecular-weight over-sulfated exopolysaccharide for the prevention or inhibition of metastases formation.

Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.

Abstract: Transformed Phaeodactylum tricornutum including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an N-acetylglucosaminyltransferase I and/or an ?-Mannosidase II and wherein at least one ?-N-acetylglucosaminidase of the transformed Phaeodactylum tricornutum has been inactivated. A method for producing a glycosylated polypeptide includes the steps of (i) culturing a transformed P. tricornutum as defined previously and (ii) purifying the polypeptide that is expressed and glycosylated in the transformed P. Tricornutum. The use of such a transformed P. tricornutum for producing a glycosylated polypeptide is also described.

Abstract: A novel microalgal strain whose lipid production has been enhanced compared to the wild type. The lipid content produced by the microalgae is particularly rich in neutral lipids. The use of the microalgal strain and the lipids are also described.

Abstract: The invention relates to a strain of Lactobacillus sakei called Lactobacillus sakei LHIS2885 strain, and to a strain derived from L. sakei LHIS2885. The invention also relates to the use of a strain of L. sakei, preferably the strain LHIS2885 or a strain derived from LHIS2885, for the preservation of food products, preferably products from the sea.

Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerization of said native EPSs followed by a step of sulphating the resulting depolymerized derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.

Abstract: A novel microalgal strain whose lipid production has been enhanced compared to the wild type. The lipid content produced by the microalgae is particularly rich in neutral lipids. The use of the microalgal strain and the lipids are also described.

Abstract: Transformed Phaeodactylum tricornutum including a nucleic acid sequence operatively linked to a promoter, wherein the nucleic acid sequence encodes an N-acetylglucosaminyltransferase I and/or an ?-Mannosidase II and wherein at least one ?-N-acetylglucosaminidase of the transformed Phaeodactylum tricornutum has been inactivated. A method for producing a glycosylated polypeptide includes the steps of (i) culturing a transformed P. tricornutum as defined previously and (ii) purifying the polypeptide that is expressed and glycosylated in the transformed P. Tricornutum. The use of such a transformed P. tricornutum for producing a glycosylated polypeptide is also described.

Abstract: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.

Abstract: A method of enzymatic extraction of chitin is realized in a single step wherein the chitin is obtained by enzymatic hydrolysis of raw material constituted by animal biomass including chitin, the enzymatic hydrolysis using an enzyme active in acid medium. Also disclosed is a process of optimization of the method of enzymatic extraction of chitin, as well as the chitin susceptible to be obtained by the method of enzymatic extraction.

Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.

Abstract: The invention provides chondrogenic differentiation media comprising chondrogenic growth factors and low-molecular-weight sulfated polysaccharide derivatives of marine native exopolysaccharides (EPS) excreted by mesophilic marine bacteria from deep-sea hydrothermal environments. The invention relates to methods for inducing chondrogenic differentiation in pluripotent or multipotent cells, to cartilage tissues obtained by such methods, and to the use of such cartilage tissues for therapeutic purposes.

Abstract: The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 ?g (m) g/ml.

Abstract: Exopolysaccharides, preferably obtained by fermenting bacteria from deep hydrothermal ecosystems, serve as agents for preventing the formation of unwanted biofilms on a surface. A method for protecting a surface by preventing the formation of the primary film leading to unwanted biofilms, includes placing the surface in contact with at least one exopolysaccharide, or grafting the exopolysaccharide onto the surface. A method for modifying the physical properties of a surface such that the adhesion of an unwanted bacterial biofilm to the surface is reduced is also described.

Abstract: A system for measuring or monitoring the quality of a liquid medium, has first and second sample-takeoff points in the liquid medium and a hydraulic circuit in which the samples taken off from said first and second sample-takeoff points circulate. The hydraulic circuit is mounted between the two sample-takeoff points and comprises two centrifugal impeller pumps, a measuring chamber situated between the two pumps, and a purge device mounted at a high point on the hydraulic circuit between one of the pumps and the measuring chamber. The whole of the hydraulic circuit is preferably totally immersed in the liquid medium.

Abstract: A method for controlled reduction of the weight average molar mass of a polysaccharide down to a lower and determined weight average molar mass, which method includes a step for mechanical milling of the polysaccharide by a ball mill, until the polysaccharide having the desired weight average molar mass is obtained.

Abstract: A method for recovering inert or living microparticles in which a rising liquid column is set up under negative pressure of an aqueous effluent that includes inert or living microparticles, and a foam is separated at the top of the column into a multiphase effluent enriched with inert or living microparticles relative to the aqueous effluent and into a mostly liquid effluent depleted of inert or living microparticles relative to the aqueous effluent. The invention also concerns the different applications of this method and an installation implementing this method.

Abstract: A device for salvaging a marine or submarine engine, this device comprising: a supple tie line (20) having a first end (21) to be connected to the engine (80), a bobbin (30) to which is connected a second end (22) of the supple tie line (20), the supple tie line being adapted to be wound around the bobbin, and a ballast charge (50) adapted to be combined with the bobbin (30). The bobbin (30) and the ballast charge (50) are such that the bobbin combined with the charge sinks, while the bobbin released from the charge floats; and the supple tie line (20) and the bobbin (30) cooperate such that the bobbin is released from the charge (50) by the unwinding of the supple tie line (20) wound around the bobbin (30).