Patents Assigned to Institut fur Diagnostikforschung GmbH
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Publication number: 20100129293Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: January 26, 2010Publication date: May 27, 2010Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjórn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 7445767Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: March 22, 2006Date of Patent: November 4, 2008Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20060165598Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: March 22, 2006Publication date: July 27, 2006Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20060165599Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: March 22, 2006Publication date: July 27, 2006Applicant: Institut fur Diagnostikforschung GmbHInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 7025949Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: May 7, 2001Date of Patent: April 11, 2006Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20060036072Abstract: The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or neurotensin, the use of these compounds as optical diagnostic agents, and diagnostic agents that contain these compounds.Type: ApplicationFiled: July 25, 2003Publication date: February 16, 2006Applicant: Institut fur Diagnostikforschung GmbHInventors: Kai Licha, Andreas Becker, Wolfhard Semmler, Bertram Wiedenmann, Carsten Hessenius, Rudolf Volkmer-Engert, Jens Schneider-Mergner
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Patent number: 6926885Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: June 26, 2002Date of Patent: August 9, 2005Assignees: Institut fur Diagnostikforschung GmbH, Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20050169844Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: March 29, 2005Publication date: August 4, 2005Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6913743Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: February 19, 2003Date of Patent: July 5, 2005Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20050106106Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: December 16, 2004Publication date: May 19, 2005Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Publication number: 20030170179Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: February 19, 2003Publication date: September 11, 2003Applicant: Institut fur Diagnostikforschung GMBH an der freien Universita (copy)Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6576221Abstract: The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to the invention are characterized in that they consist of an iron-containing core, a primary coat (synthesis polymer), and a secondary coat (targeting polymer) and, optionally, of pharmaceutic adjuvants, pharmaceuticals, and/or adsorption mediators/enhancers.Type: GrantFiled: November 30, 1999Date of Patent: June 10, 2003Assignees: Institut fur Diagnostikforschung GmbH, Der Freien Universitat BerlineInventors: Mayk Kresse, Detlev Pfefferer, Rüdiger Lawaczek, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Jukl, Udo Swiderski
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Publication number: 20030026763Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: June 26, 2002Publication date: February 6, 2003Applicant: Institut Fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christopher -Stephen Hilger
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Publication number: 20020141943Abstract: The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes.Type: ApplicationFiled: September 26, 2001Publication date: October 3, 2002Applicant: INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBHInventors: Mayk Kresse, Detlev Pfefferer, Ruediger Lawaczeck, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Ebert, Udo Swiderski
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Publication number: 20020087071Abstract: The invention relates to a new process for graphic visualization and diagnosis of thrombi as well as the use of particle suspensions for the production of contrast media for the visualization of thrombi with use of nuclear spin tomography.Type: ApplicationFiled: September 14, 2001Publication date: July 4, 2002Applicant: Institut fur Diagnostikforschung GmbHInventors: Stephen Schmitz, Mayk Kresse, Susanne Wagner
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Publication number: 20010055567Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: ApplicationFiled: May 7, 2001Publication date: December 27, 2001Applicant: Institut Fur Diagnostikforschung GmbH An Der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6319488Abstract: This invention relates to colloidal systems charged with polymethine dyes and having suitable photophysical and pharmacological properties, their use as a contrast medium in fluorescence and transillumination diagnostics in the near infrared spectral range, as well as methods for their production.Type: GrantFiled: April 9, 1998Date of Patent: November 20, 2001Assignee: Institut für Diagnostikforschung GmbH an der Freien Universität BerlinInventors: Kai Licha, Björn Riefke, Werner Weitschiess, Dieter Heldmann, Violetta Sudmann
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Patent number: 6258340Abstract: This invention relates to a in-vivo diagnostic method based on near infrared ra ation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: March 6, 2000Date of Patent: July 10, 2001Assignees: Institut fur Diagnostikforschung GmbH, der Freien Universitat BerlinInventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
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Patent number: 6143275Abstract: This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds.The compound according to the invention has the general formula (I)M--Lwherein M represents a radionuclide of Tc or Re and L a ligand of the general formula (II)B--CO--CR.sup.1 R.sup.2 --A--CR.sup.3 R.sup.4 --CO--D (II)These new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.Type: GrantFiled: March 8, 1996Date of Patent: November 7, 2000Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat BerlinInventors: Christoph-Stephan Hilger, Ludger Dinkelborg, Wolfgang Kramp, Hans-Martin Schier
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Patent number: 6083485Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.Type: GrantFiled: November 7, 1997Date of Patent: July 4, 2000Assignees: Institut fur Diagnostikforschung GmbH, der Freien Universitat BerlinInventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger