Abstract: Modular iron-containing nanoparticles are disclosed, as well as their production and use in diagnosis and therapy. The nanoparticles are characterised in that they have an iron-containing core, a primary coat (synthetic polymer) and a secondary coat (target polymer), and optional auxiliary pharmaceutical substances, pharmaceuticals and/or adsorption mediators.
Type:
Grant
Filed:
June 25, 1997
Date of Patent:
April 11, 2000
Assignees:
Institut fur Diagnostikforschung GmbH, Der Freien Universitat Berline
Inventors:
Mayk Kresse, Detlev Pfefferer, Rudiger Lawaczek, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Jukl, Udo Swiderski
Abstract: This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds.The compound according to the invention has the general formula (I)M--Lwhere M represents a radionuclide and L a ligand of the general formula (II).It was found, surprisingly, that these new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are excellently suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.
Type:
Grant
Filed:
December 9, 1996
Date of Patent:
October 5, 1999
Assignee:
Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
Inventors:
Christoph-Stephan Hilger, Ludger Dinkelborg, Wolfgang Kramp, Hans-Martin Schier
Abstract: The invention relates to new 3,8-substituted deuteroporphyrin derivatives with various substituents in positions 13 and 17 of the porphyrin skeleton, pharmaceutical agents containing these compounds, their use in diagnosis and therapy as well as process for the production of these agents.
Type:
Grant
Filed:
May 24, 1995
Date of Patent:
December 15, 1998
Assignee:
Institut Fur Diagnostikforschung GmbH
Inventors:
Christoph Stephan Hilger, Franz Karl Maier, Heinz Gries, Ulrich Niedballa, Johannes Platzek, Mary Lee-Vaupel, Wolfgang Ebert, Jurgen Conrad, Josef Gaida
Abstract: Porphyrin complex compounds consisting of a meso-tetraphenylporphyrin ligand of general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have varying meanings, and an ion of an element of atomic numbers 21-32, 38, 39, 42-51 or 58-83 as well as optionally one or more physiologically harmless cation(s) of inorganic and/or organic bases, amino acids or amino acid amides are valuable diagnostic agents.
Type:
Grant
Filed:
September 26, 1995
Date of Patent:
October 7, 1997
Assignee:
Institut fur Diagnostikforschung GmbH
Inventors:
Franz Karl Maier, Wolfgang Ebert, Mary Lee-Vaupel, Heinz Gries, Jurgen Conrad
Abstract: The invention relates to cyctopentadienylcarbonyl.sup.99m Tc complexes of general formula I ##STR1## in which --XR can have various meanings. These new complexes of .sup.99m technetium can be used in the field of medical diagnosis. The invention further relates to a process for the production of complexes according to the invention.
Type:
Grant
Filed:
January 29, 1993
Date of Patent:
July 23, 1996
Assignee:
Institut Fur Diagnostikforschung GmbH/an der Freien Universitat Berlin
Abstract: The invention relates to nanocrystalline magnetic particles consisting of gnetic iron oxide core of Fe.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or mixtures thereof and an envelope chemisorbed to said core, the method for preparation of these particles as well as the use thereof in medical diagnostics and/or therapy. The magnetic particles, according to the invention, are characterized by composition of the coating material of natural or synthetic glycosaminoglycans and/or their derivatives with molecular weights of 500 Da to 250,000 Da, if necessary, covalently cross-linked with appropriate cross-linking agents and/or modified by specific additives.
Type:
Grant
Filed:
May 13, 1992
Date of Patent:
June 27, 1995
Assignee:
Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
Inventors:
Mayk Kresse, Rudiger Lawaczeck, Detlef Pfefferer
Abstract: The invention relates to compounds having the general formula I ##STR1## where A if required can contain a functional and/or activated group C for coupling to selectively concentrating compounds or can contain a selectively concentrating compound coupled via the group C. B and B' are functional groups for coordinate bonding of groups carrying metal ions. The novel compounds are for forming complexes with radioactive metal ions, more particularly rhenium and technetium isotopes, and are used in medical diagnosis and therapy.
Type:
Grant
Filed:
August 22, 1990
Date of Patent:
April 12, 1994
Assignee:
Institut fur Diagnostikforschung GmbH
Inventors:
Reinhard Neumeier, Wolfgang Kramp, Helmut R. Macke