Abstract: The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.

Abstract: The subject of the present invention is a novel mutant yeast strain, particularly a Yarrowia lipolytica strain, capable of accumulate a large quantity of lipids. The said strain does not express the GUT2 gene. According to one variant, the invention relates to mutant yeast strains, particularly Yarrowia lipolytica strains, which do not express the GUT2 gene and which furthermore do not carry out the ?-oxidation of lipids. Preferably, the mutant strains which do not express the GUT2 gene and which furthermore do not carry out ?-oxidation of lipids do not express the POX 2 through POX 5 genes, most preferably the POX 1 through 6 genes. The subject of the invention is also a method for producing the strains according to the invention and the use of the said strains in the production of lipids.

Abstract: The present invention relates to an in vitro method for diagnosing and/or predicting hereditary cerebellar ataxia in a dog, and/or identifying a dog which is healthy carrier of hereditary cerebellar ataxia, comprising determining the presence or absence of an homozygous or heterozygous genetic variation in the arylsulfatase G gene sequence in a biological sample from said dog, as compared with the arylsulfatase G gene sequence of a healthy non-carrier dog, wherein the presence of said homozygous genetic variation indicates that said dog is or will be affected by hereditary cerebellar ataxia, and the presence of said heterozygous genetic variation indicates that said dog is healthy carrier of hereditary cerebellar ataxia, said dog being of a breed selected in the group consisting of American Staffordshire Terrier, American Pit Bull Terrier and Pit Bull type.

Abstract: The invention relates to N protein-protein of interest fusion proteins, optionally in the form of soluble N protein-protein of interest/P protein complexes, the N and P proteins being proteins of a virus of the Paramyxoviridae family. When the protein of interest is an antigen, the invention relates also to vaccinal compositions and diagnostic reagents comprising those N protein-antigen fusion proteins or those N protein-antigen/P protein complexes. The N protein-protein of interest fusion protein can also be used as a “vector” for transporting into cells therapeutic molecules of interest, such as antivirals or anticancer agents.

Abstract: The present invention provides a nutritional composition and a pharmaceutical composition to be used for humans or animals comprising as active compound the oleuropein compound or one derivative thereof.

Abstract: Recombinant adenoviruses or pseudoviruses having a deletion of all or part of the region of the adenovirus genome corresponding to nucleotides 311 to 499 in canine adenovirus type 2 (GeneBank J04368). Therapeutic methods of using the recombinant adenovirus or pseudovirus.

Abstract: The invention concerns the reconstruction in vitro of non-human mammal embryos by a method which consists in treating the nucleus of a somatic donor cell prior to its transfer into a receiver cytoplasm, said treatment comprising controlled proteolysis of non-histone proteins, and inducing an isomorphic swelling of said nucleus.

Abstract: A method of modulating the microbial balance of the digestive ecosystem in a mammal comprising administering to a mammal in need thereof a composition comprising at least one nonpathogenic, hydrogenotrophic, acetogenic bacterial strain, along with a pharmaceutical and related methods, are described.

Abstract: A method for grafting a copolymer onto a polyolefin substrate includes the following steps: (a) irradiating the substrate with ionizing radiation to obtain an activated polyolefin substrate, (b) bringing into contact the activated polyolefin substrate with a mixture of at least two compounds in distilled water including: (i) from 10 to 40% by volume, related to the total volume of the reaction medium, of a hydrophilic unsaturated monomer selected from monomers having the formula: wherein R1 is H or methyl, R2 is —COOH, —NH2, —CON(R3)2, and R3 is H or methyl, (ii) from 20 to 50% by volume, related to the total volume of the reaction medium, of an antimicrobial agent having an average molecular weight of at least 200 g·mol?1, to thereby form a copolymer-grafted polyolefin substrate. Copolymer-grafted polyolefin substrates obtained by this method and a packaging material including copolymer-grafted polyolefin substrate are disclosed.

Abstract: The present invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as BCl-xL and Bcl-w), and pharmaceutical compositions comprising the same.

Abstract: The invention relates to a method for preparation of soluble N-protein/truncated P-protein complex of a virus of the family Paramyxoviridae, complexes prepared thus and the soluble N-proteins which may be isolated from said complexes. The invention further relates to vaccine compositions comprising said N-protein/truncated P-protein complexes or N-proteins from Paramyxoviridae.

Abstract: The invention relates to the production of plants with reduced development and a mutant gene of the GRAS family.

Abstract: A genetic system for controlling the type of floral development of a dicotyledon plant, includes the combination of two genetic control elements, respectively: a first genetic control element (A/a) present in a dicotyledon plant, in the form of a dominant allele (A), and a recessive allele (a), and a second genetic control element (G/g) present in a dicotyledon plant, in the form of a dominant allele (G), and a recessive allele (g), provided that the first genetic control element has been artificially inserted into the dicotyledon plant. This system enables the sex of the flowers of dicotyledon plants to be controlled and/or modified.

Abstract: The invention relates to an in vitro method for introducing a targeted genome modification into an oocyte or an egg and a method for performing a random insertion in the genome of a host cell.

Abstract: A method for identifying polymorphic markers associated with a hypercortisolism phenotype including comparing nucleic acid sequences, from multiple individuals, including all or part of a Cbg gene; and identifying mutations in the Cbg gene or sequences adjacent to it.

Abstract: The invention relates to the use of lactic bacteria of the species Lactobacillus farciminis for the treatment or prevention of a pathology of the digestive tube, especially an acute or chronic inflammatory pathology of the intestine.

Abstract: The invention concerns a complete feed composition for fish larvae, characterized in that it has a phospholipid content not less than 8.5 wt. % of dry matter of the feed.

Abstract: The invention concerns lactic acid bacteria overproducing exopolysaccharides following mutation in the gene coding for ?-phosphoglucomutase. Said mutants are useful, in particular for preparing fermented products or for producing exopolysaccharides.

Abstract: A method for determining the state of tension of a material at a given time, including the step of calculating the value of at least one parameter extracted from the ultrasonic signal received after propagation of an ultrasonic wave emitted in the material between an ultrasound source and at least an ultrasound emitter located at a fixed distance from the source, the value of the at least one parameter varying with the state of tension of the material, the variation of the at least one parameter being proportional or inversely proportional to the variation of the state of tension of the material.

Abstract: A method for identifying polymorphic markers associated with a hypercortisolism phenotype including comparing nucleic acid sequences, from multiple individuals, including all or part of a Cbg gene; and identifying mutations in the Cbg gene or sequences adjacent to it.