Patents Assigned to Institut National de la Recherche Agronomique
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Patent number: 11021508Abstract: The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyl, (ii) X represents —CH2—CH2—, or —CH?CH—, (iii) R2 is chosen from or an OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.Type: GrantFiled: May 24, 2018Date of Patent: June 1, 2021Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNInventors: Anne Lespine, Roger Prichard, Cecile Menez
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Patent number: 11013498Abstract: A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: —collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5), —and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.Type: GrantFiled: April 22, 2016Date of Patent: May 25, 2021Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Carole Schwintner, Hervé Affagard, Joël Dore
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Publication number: 20210077574Abstract: The present invention relates to a phycocyanin composition for use in inhibiting bone resorption in humans or animals.Type: ApplicationFiled: June 5, 2018Publication date: March 18, 2021Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)Inventors: Véronique COXAM, Marie-Jeanne DAVICCO, Laurent LEOTOING, Fabien WAUQUIER
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Patent number: 10920237Abstract: The invention relates to a method for increasing the frequency of meiotic recombination in plants, by inhibiting the RECQ4 or TOP3A protein, especially by mutagenesis or extinction of the RECQ4 or TOP3A gene coding for said protein. The invention can be used especially in the field of plant breeding and genetic mapping.Type: GrantFiled: March 27, 2015Date of Patent: February 16, 2021Assignee: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Raphaël Mercier, Mathilde Seguela-Arnaud, Wayne Crismani
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Patent number: 10918678Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.Type: GrantFiled: January 23, 2017Date of Patent: February 16, 2021Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
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Patent number: 10837030Abstract: The invention relates to a method for propagating yeast, for use in the production of a fermentation product from lignocellulosic biomass, including the steps that consist of: a. providing a reactor; b. placing in contact in said reactor: a population of yeasts capable of metabolising pentoses and hexoses, with 0.2 to 2.0 g of yeast solids per kg of prepared complete medium, raw marc from the pretreatment of the lignocellulosic biomass, with a solids content (MS) of 8% to 15%, nutrients, and cellulases, with 5 to 15 mg of proteins per gram of MS; and c. incubating the mixture at a temperature of 25° C. to 38° C., preferably 28° C. to 33° C., in microaerobiosis, in which the saccharification of the raw marc and the growth of the yeast are carried out simultaneously.Type: GrantFiled: May 26, 2016Date of Patent: November 17, 2020Assignees: LESAFFRE ET COMPAGNIE, AGRO INDUSTRIE RECHERCHES ET DEVELOPPEMENTS A.R.D., INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRAInventor: Flora Ghisoni
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Patent number: 10822600Abstract: The invention relates to a process for producing cellulolytic or hemicellulolytic enzymes comprising A growth phase a) of a cellulolytic microorganism in a closed reactor, in the presence of at least one carbonaceous growth substrate in a concentration between 10 and 90 g/L, at a temperature of 25-30° C. and a pH of 4-5.5 An enzyme production phase b) in which at least one inducer carbonaceous substrate is added, at a temperature of 25-27° C. and a pH of 4-5, process in which the said inducer substrate is a pretreated pomace obtained from a pretreatment process of lignocellulosic material that has not undergone enzymatic hydrolysis and that is added in fed-batch or continuous mode, and which has particular characteristics: a hydrolysis yield greater than 80% in a test and an apparent viscosity, measured in the test, of less than 1 Pa·s for a shear rate of 10 s?1.Type: GrantFiled: March 24, 2017Date of Patent: November 3, 2020Assignees: IFP Energies nouvelles, AGRO INDUSTRIES RECHERCHE ET DEVELOPPEMENT, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Mohamed Fadhel Ben Chaabane, Celine Cohen
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Publication number: 20200323237Abstract: A meat analogue may include a set protein emulsion, the protein emulsion having a protein and at least one insoluble particle. In some embodiments, at least a portion of the particle can include at least one mineral material selected from the group consisting of silicium, and calcium, such as one or more of rhombohedral calcite, scalenohedral calcite, silicon dioxide, and magnesium oxide; at least one organic material selected from the group consisting of a bone meal, a cartilage meal, a ground crustacean shell, a ground sea fish shell, and a ground egg shell; and/or a gelled vegetable gum, a gelled hydrocolloid, a polymerized vegetable gum, a polymerized hydrocolloid, or a mixture thereof. The meat analogue can be made by extruding the protein emulsion and cooling the extruded emulsion. The meat analogue can be cut into chunks and/or added to another comestible composition such as a gravy or broth.Type: ApplicationFiled: April 8, 2020Publication date: October 15, 2020Applicants: Université de Montpellier, Institut National de la Recherche AgronomiqueInventors: Patrick Pibarot, Christian Sanchez, Marie-Héléne Morel
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Publication number: 20200323238Abstract: A meat analogue may include a macrostructure of connected sheared fibers oriented parallel to one another and gaps positioned between the sheared fibers. The macrostructure may include meat and may include a vegetable protein. An extrusion system may include an extruder and a die. The extrusion system may produce a meat analogue. A meat analogue may include an animal protein. The extruder may be connectable to the die. The extrusion system may be configured to direct a material including an animal protein from the extruder to the die and through a fluid path extending through the die. The die may be configured to inject a fat or a fat analogue into the material such that the fat or the fat analogue is embedded but visually distinct from the material including the animal protein when the fat or the fat analogue and the material exit the die.Type: ApplicationFiled: April 8, 2020Publication date: October 15, 2020Applicants: Université de Montpellier, Institut National de la Recherche AgronomiqueInventors: Patrick Pibarot, Christophe Joseph Etienne Schmitt, Christian Sanchez, Marie-Héléne Morel
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Patent number: 10787655Abstract: A process for producing oligosaccharides from lignocellulosic biomass, having the following steps: a) pre-treating the biomass in a pre-treatment reactor (1) in order to provide an effluent containing a pre-treated substrate; b) enzymatic hydrolysis of the pre-treated substrate contained in the effluent from step a) in a reactor, in the presence of cellulases such that a hydrolysate containing glucose, cellulases and water is produced; c) removing at least a portion of the hydrolysate from step b) comprising a liquid fraction; d) reducing the water content of said portion of the hydrolysate in step c) such that the liquid fraction of the hydrolysate has a water content of less than 65% by weight with respect to the total weight of the liquid fraction; e) incubating the hydrolysate from step d) at a temperature in the range 40° C. to 70° C. for the time necessary to produce an effluent enriched in oligosaccharides.Type: GrantFiled: November 18, 2013Date of Patent: September 29, 2020Assignees: IFP ENERGIES NOUVELLES, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, ARGO INDUSTRIES RECHERCHE ET DEVELOPPEMENTInventors: Etienne Jourdier, Caroline Aymard, Fadhel Ben Chaabane
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Publication number: 20200277556Abstract: The present disclosure relates to an additive for treating beverages made from plant musts, particularly wine, beer, cider or fruit juices, and more particularly for improving the quality of such beverages, namely, for example, protein stability and for avoiding the cloudiness of such beverages. In its broadest application, such an additive includes a cysteine protease and a cofactor.Type: ApplicationFiled: September 26, 2018Publication date: September 3, 2020Applicants: OENOTROPIC INNOVATION, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL D'ETUDES SUPERIEURES AGRONOMIQUES DE MONTPELLIERInventors: François-Xavier SAUVAGE, Sacha BAUDOIN, Aude VERNET, Amélie BREYSSE, Julie RETTMAN
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Patent number: 10760100Abstract: The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n-butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.Type: GrantFiled: July 22, 2016Date of Patent: September 1, 2020Assignees: Institut National des Sciences Appliquees, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche AgronomiqueInventors: Philippe Soucaille, Isabelle Meynial-Salles, Céline Foulquier, Antoine Riviere
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Patent number: 10736925Abstract: The present invention relates to a method of selecting or identifying probiotic strains capable of acting on the absorption of water in the colon, and use thereof as medicinal products in the treatment and/or prevention of diarrhea. The invention relates in particular to the strain of Bacillus subtilis CU1 for use in the treatment and/or prevention of diarrhea.Type: GrantFiled: October 10, 2018Date of Patent: August 11, 2020Assignees: LESAFFRE ET COMPAGNIE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA, ECOLE NATIONALE SUPERIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE (BORDEAUX SCIENCES AGRO)Inventors: Marie Khuong Huu, Jean Fioramonti, Maria Urdaci
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Patent number: 10736849Abstract: Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than ?50° C., preferably of between ?70° C. and ?100° C., followed by the lyophilisation thereof.Type: GrantFiled: December 19, 2016Date of Patent: August 11, 2020Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Audrey Chapron, Fernanda Fonseca, Olivier David
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Patent number: 10723999Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.Type: GrantFiled: December 19, 2014Date of Patent: July 28, 2020Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYONInventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
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Patent number: 10695403Abstract: The present invention relates to an FGF19 polypeptide for use in increasing muscle fiber size in the treatment of muscle atrophy in a mammal.Type: GrantFiled: June 24, 2016Date of Patent: June 30, 2020Assignees: Universite Claude Bernard Lyon, Institut National de la Recherche Agronomique (INRA), Institut National de la Santè et de la Recherche Médicale (INSERM), Bergen Teknologioverforing ASInventors: Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Jérome Ruzzin
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Publication number: 20200188533Abstract: A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.Type: ApplicationFiled: December 26, 2019Publication date: June 18, 2020Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Pierre FAFOURNOUX
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Patent number: 10674686Abstract: The invention relates to a dominant mutation in the TDM gene leading to the production of 2n gametes in plants, to the plants comprising said mutation, and to their use in plant breeding. The invention relates also to plants in which the dominant mutation in the TDM gene is combined with the inactivation of a gene involved in meiotic recombination in plants and a gene involved in the monopolar orientation of the kinetochores during meiosis. These plants which produce apomeiotic gametes are also useful in plant breeding.Type: GrantFiled: June 1, 2015Date of Patent: June 9, 2020Assignee: Institut National de la Recherche AgronomiqueInventors: Raphaël Mercier, Marta Cifuentes, Laurence Cromer
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Publication number: 20200157591Abstract: Celluloses, notably nanocelluloses, and more particularly processes for manufacturing cellulose fibers and for defibrillating cellulose-based substrates. Most particularly, processes for defibrillating cellulose-based substrates and manufacturing celluloses, in particular nanocelluloses (NC), using a new family of fungal lytic polysaccharide monooxygenases (LPMOs).Type: ApplicationFiled: July 31, 2018Publication date: May 21, 2020Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)Inventors: Bernard CATHALA, Jean-Guy BERRIN, Ana VILLARES, Céline MOREAU
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Patent number: 10647739Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.Type: GrantFiled: March 24, 2015Date of Patent: May 12, 2020Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUTE NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Sandrine Morel, Isabelle Andre, Yoan Brison, Emmanuelle Cambon, Yannick Malbert, Denis Pompon, Magali Remaud-Simeon, Philippe Urban