Patents Assigned to Institut National de la Recherche Agronomique
  • Patent number: 11021508
    Abstract: The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyl, (ii) X represents —CH2—CH2—, or —CH?CH—, (iii) R2 is chosen from or an OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: June 1, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN
    Inventors: Anne Lespine, Roger Prichard, Cecile Menez
  • Patent number: 11013498
    Abstract: A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: —collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5), —and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 25, 2021
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Carole Schwintner, Hervé Affagard, Joël Dore
  • Publication number: 20210077574
    Abstract: The present invention relates to a phycocyanin composition for use in inhibiting bone resorption in humans or animals.
    Type: Application
    Filed: June 5, 2018
    Publication date: March 18, 2021
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
    Inventors: Véronique COXAM, Marie-Jeanne DAVICCO, Laurent LEOTOING, Fabien WAUQUIER
  • Patent number: 10920237
    Abstract: The invention relates to a method for increasing the frequency of meiotic recombination in plants, by inhibiting the RECQ4 or TOP3A protein, especially by mutagenesis or extinction of the RECQ4 or TOP3A gene coding for said protein. The invention can be used especially in the field of plant breeding and genetic mapping.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: February 16, 2021
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Raphaël Mercier, Mathilde Seguela-Arnaud, Wayne Crismani
  • Patent number: 10918678
    Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: February 16, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
  • Patent number: 10837030
    Abstract: The invention relates to a method for propagating yeast, for use in the production of a fermentation product from lignocellulosic biomass, including the steps that consist of: a. providing a reactor; b. placing in contact in said reactor: a population of yeasts capable of metabolising pentoses and hexoses, with 0.2 to 2.0 g of yeast solids per kg of prepared complete medium, raw marc from the pretreatment of the lignocellulosic biomass, with a solids content (MS) of 8% to 15%, nutrients, and cellulases, with 5 to 15 mg of proteins per gram of MS; and c. incubating the mixture at a temperature of 25° C. to 38° C., preferably 28° C. to 33° C., in microaerobiosis, in which the saccharification of the raw marc and the growth of the yeast are carried out simultaneously.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: November 17, 2020
    Assignees: LESAFFRE ET COMPAGNIE, AGRO INDUSTRIE RECHERCHES ET DEVELOPPEMENTS A.R.D., INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA
    Inventor: Flora Ghisoni
  • Patent number: 10822600
    Abstract: The invention relates to a process for producing cellulolytic or hemicellulolytic enzymes comprising A growth phase a) of a cellulolytic microorganism in a closed reactor, in the presence of at least one carbonaceous growth substrate in a concentration between 10 and 90 g/L, at a temperature of 25-30° C. and a pH of 4-5.5 An enzyme production phase b) in which at least one inducer carbonaceous substrate is added, at a temperature of 25-27° C. and a pH of 4-5, process in which the said inducer substrate is a pretreated pomace obtained from a pretreatment process of lignocellulosic material that has not undergone enzymatic hydrolysis and that is added in fed-batch or continuous mode, and which has particular characteristics: a hydrolysis yield greater than 80% in a test and an apparent viscosity, measured in the test, of less than 1 Pa·s for a shear rate of 10 s?1.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: November 3, 2020
    Assignees: IFP Energies nouvelles, AGRO INDUSTRIES RECHERCHE ET DEVELOPPEMENT, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Mohamed Fadhel Ben Chaabane, Celine Cohen
  • Publication number: 20200323237
    Abstract: A meat analogue may include a set protein emulsion, the protein emulsion having a protein and at least one insoluble particle. In some embodiments, at least a portion of the particle can include at least one mineral material selected from the group consisting of silicium, and calcium, such as one or more of rhombohedral calcite, scalenohedral calcite, silicon dioxide, and magnesium oxide; at least one organic material selected from the group consisting of a bone meal, a cartilage meal, a ground crustacean shell, a ground sea fish shell, and a ground egg shell; and/or a gelled vegetable gum, a gelled hydrocolloid, a polymerized vegetable gum, a polymerized hydrocolloid, or a mixture thereof. The meat analogue can be made by extruding the protein emulsion and cooling the extruded emulsion. The meat analogue can be cut into chunks and/or added to another comestible composition such as a gravy or broth.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 15, 2020
    Applicants: Université de Montpellier, Institut National de la Recherche Agronomique
    Inventors: Patrick Pibarot, Christian Sanchez, Marie-Héléne Morel
  • Publication number: 20200323238
    Abstract: A meat analogue may include a macrostructure of connected sheared fibers oriented parallel to one another and gaps positioned between the sheared fibers. The macrostructure may include meat and may include a vegetable protein. An extrusion system may include an extruder and a die. The extrusion system may produce a meat analogue. A meat analogue may include an animal protein. The extruder may be connectable to the die. The extrusion system may be configured to direct a material including an animal protein from the extruder to the die and through a fluid path extending through the die. The die may be configured to inject a fat or a fat analogue into the material such that the fat or the fat analogue is embedded but visually distinct from the material including the animal protein when the fat or the fat analogue and the material exit the die.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 15, 2020
    Applicants: Université de Montpellier, Institut National de la Recherche Agronomique
    Inventors: Patrick Pibarot, Christophe Joseph Etienne Schmitt, Christian Sanchez, Marie-Héléne Morel
  • Patent number: 10787655
    Abstract: A process for producing oligosaccharides from lignocellulosic biomass, having the following steps: a) pre-treating the biomass in a pre-treatment reactor (1) in order to provide an effluent containing a pre-treated substrate; b) enzymatic hydrolysis of the pre-treated substrate contained in the effluent from step a) in a reactor, in the presence of cellulases such that a hydrolysate containing glucose, cellulases and water is produced; c) removing at least a portion of the hydrolysate from step b) comprising a liquid fraction; d) reducing the water content of said portion of the hydrolysate in step c) such that the liquid fraction of the hydrolysate has a water content of less than 65% by weight with respect to the total weight of the liquid fraction; e) incubating the hydrolysate from step d) at a temperature in the range 40° C. to 70° C. for the time necessary to produce an effluent enriched in oligosaccharides.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 29, 2020
    Assignees: IFP ENERGIES NOUVELLES, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, ARGO INDUSTRIES RECHERCHE ET DEVELOPPEMENT
    Inventors: Etienne Jourdier, Caroline Aymard, Fadhel Ben Chaabane
  • Publication number: 20200277556
    Abstract: The present disclosure relates to an additive for treating beverages made from plant musts, particularly wine, beer, cider or fruit juices, and more particularly for improving the quality of such beverages, namely, for example, protein stability and for avoiding the cloudiness of such beverages. In its broadest application, such an additive includes a cysteine protease and a cofactor.
    Type: Application
    Filed: September 26, 2018
    Publication date: September 3, 2020
    Applicants: OENOTROPIC INNOVATION, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL D'ETUDES SUPERIEURES AGRONOMIQUES DE MONTPELLIER
    Inventors: François-Xavier SAUVAGE, Sacha BAUDOIN, Aude VERNET, Amélie BREYSSE, Julie RETTMAN
  • Patent number: 10760100
    Abstract: The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n-butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 1, 2020
    Assignees: Institut National des Sciences Appliquees, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique
    Inventors: Philippe Soucaille, Isabelle Meynial-Salles, Céline Foulquier, Antoine Riviere
  • Patent number: 10736925
    Abstract: The present invention relates to a method of selecting or identifying probiotic strains capable of acting on the absorption of water in the colon, and use thereof as medicinal products in the treatment and/or prevention of diarrhea. The invention relates in particular to the strain of Bacillus subtilis CU1 for use in the treatment and/or prevention of diarrhea.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: August 11, 2020
    Assignees: LESAFFRE ET COMPAGNIE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA, ECOLE NATIONALE SUPERIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE (BORDEAUX SCIENCES AGRO)
    Inventors: Marie Khuong Huu, Jean Fioramonti, Maria Urdaci
  • Patent number: 10736849
    Abstract: Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than ?50° C., preferably of between ?70° C. and ?100° C., followed by the lyophilisation thereof.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 11, 2020
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Audrey Chapron, Fernanda Fonseca, Olivier David
  • Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • Patent number: 10695403
    Abstract: The present invention relates to an FGF19 polypeptide for use in increasing muscle fiber size in the treatment of muscle atrophy in a mammal.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 30, 2020
    Assignees: Universite Claude Bernard Lyon, Institut National de la Recherche Agronomique (INRA), Institut National de la Santè et de la Recherche Médicale (INSERM), Bergen Teknologioverforing AS
    Inventors: Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Jérome Ruzzin
  • Publication number: 20200188533
    Abstract: A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.
    Type: Application
    Filed: December 26, 2019
    Publication date: June 18, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventor: Pierre FAFOURNOUX
  • Patent number: 10674686
    Abstract: The invention relates to a dominant mutation in the TDM gene leading to the production of 2n gametes in plants, to the plants comprising said mutation, and to their use in plant breeding. The invention relates also to plants in which the dominant mutation in the TDM gene is combined with the inactivation of a gene involved in meiotic recombination in plants and a gene involved in the monopolar orientation of the kinetochores during meiosis. These plants which produce apomeiotic gametes are also useful in plant breeding.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: June 9, 2020
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Raphaël Mercier, Marta Cifuentes, Laurence Cromer
  • Publication number: 20200157591
    Abstract: Celluloses, notably nanocelluloses, and more particularly processes for manufacturing cellulose fibers and for defibrillating cellulose-based substrates. Most particularly, processes for defibrillating cellulose-based substrates and manufacturing celluloses, in particular nanocelluloses (NC), using a new family of fungal lytic polysaccharide monooxygenases (LPMOs).
    Type: Application
    Filed: July 31, 2018
    Publication date: May 21, 2020
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
    Inventors: Bernard CATHALA, Jean-Guy BERRIN, Ana VILLARES, Céline MOREAU
  • Patent number: 10647739
    Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 12, 2020
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUTE NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sandrine Morel, Isabelle Andre, Yoan Brison, Emmanuelle Cambon, Yannick Malbert, Denis Pompon, Magali Remaud-Simeon, Philippe Urban