Patents Assigned to Institute for Basic Science
  • Patent number: 11190343
    Abstract: An electronic device including a key generator is disclosed. The key generator acquires a first affine map, a second affine map, and a third map, and generates a public key using the first affine map, the second affine map, and the third map, the third map is a system of multivariate quadratic polynomials having n variables and m equations, at least one of the multivariate quadratic polynomials has oil-oil quadratic terms with non-zero coefficients, and the third map includes at least one set for defining vinegar variables used in an Oil and Vinegar method and index sets for defining oil variables used in the Oil and Vinegar method, and each of the first affine map, the second affine map, and the third map is a finite field.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: November 30, 2021
    Assignee: INSTITUTE FOR BASIC SCIENCE
    Inventor: Kyung Ah Shim
  • Patent number: 11155604
    Abstract: The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 26, 2021
    Assignee: INSTITUTE FOR BASIC SCIENCE
    Inventors: Won Do Heo, Yun Ju Lee, Daseuli Yu, Byung Ouk Park
  • Patent number: 11149281
    Abstract: The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: October 19, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, AICT
    Inventors: Jin Soo Kim, Jungeun Kim, Sunghwa Choe, Je Wook Woo, Soon Il Kwon, Hyeran Kim
  • Patent number: 11136588
    Abstract: The present invention relates to method for preparing a plant from a protoplast comprising knocking-out or knocking-in one or more the endogenous gene of the protoplast, and the plant regenerated from a genome-modified protoplast prepared by the above method.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: October 5, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, AICT
    Inventors: Jin Soo Kim, Jungeun Kim, Sunghwa Choe, Je Wook Woo, Soon Il Kwon
  • Patent number: 11123409
    Abstract: Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: September 21, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Jin-Soo Kim, Jeong Hun Kim, Sung Wook Park, Kyoungmi Kim
  • Patent number: 11117958
    Abstract: Provided is an antibody that binds to human interleukin-2 (hIL-2), and more particularly to an anti-hIL-2 antibody that binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25. The anti-hIL-2 antibody of the subject matter binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25, thereby minimizing expansion of Treg cells. In addition, it stimulates the CD8+ T cells and NK cells that exhibit anti-tumor activity. Thus, the anti-hIL-2 antibody of the present invention is useful as a new anticancer therapeutic agent.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: September 14, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Charles D. Surh, Jun-Young Lee
  • Patent number: 11085875
    Abstract: The present invention relates to a high-speed imaging system for measuring a target object within a sample, comprising: a light source emitting a plane wave; an angle-adjustment mirror adjusting an angle of the plane wave emitted from the light source; an optical interferometer dividing the plane wave whose angle was adjusted by the angle-adjustment mirror into a reference wave and a sample wave and forming an interference wave between the reference wave reflected from a reference mirror and the sample wave reflected from the target object; a camera module obtaining the interference wave, and an imaging controller controlling the angle-adjustment mirror to adjust the angle of the plane wave sequentially, forming a time-gated reflection matrix by using the interference waves obtained by the camera module in accordance with each angle of the plane wave, and imaging the target object based on the time-gated reflection matrix.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: August 10, 2021
    Assignees: Korea University Research and Business Foundation, Institute For Basic Science
    Inventors: Won-Shik Choi, Moon-Seok Kim, Yong-Hyeon Jo, Seok-Chan Yoon
  • Patent number: 11078594
    Abstract: The present invention relates to a manufacturing method for single crystalline metal foil including: thermally treating poly-crystalline metal foil positioned to be spaced apart from a base to manufacture single crystalline metal foil, and a single crystalline metal foil manufactured thereby. According to the present invention, single crystalline metal foil having a large area may be obtained by thermally treating the poly-crystalline metal foil under a condition at which stress applied to the poly-crystalline metal foil is minimized.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: August 3, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Rodney S. Ruoff, Sunghwan Jin
  • Patent number: 11046661
    Abstract: The present invention relates to a method for producing a lactam compound from dioxazolone in the presence of a catalyst having a particular ligand, and to a lactam compound produced thereby, and can produce a lactam compound with excellent selectivity and an excellent yield by using the combination of a starting material having a particular functional group and a particular catalyst having a particular ligand.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: June 29, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sukbok Chang, Seung Youn Hong, Yoon Su Park, Yeongyu Hwang, Yeong Bum Kim
  • Publication number: 20210191098
    Abstract: According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.
    Type: Application
    Filed: October 16, 2018
    Publication date: June 24, 2021
    Applicants: Korea University Research and Business Foundation, Institute for Basic Science
    Inventors: Sang Hee SHIM, Ji Woong KWON
  • Publication number: 20210179719
    Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: December 3, 2020
    Publication date: June 17, 2021
    Applicants: INSTITUTE FOR BASIC SCIENCE, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gou Young Koh, Jeomil Bae, Jaeryung Kim
  • Patent number: 11013221
    Abstract: The present invention relates to: a transgenic Caenorhabditis elegans in which a glutamine tRNA 5? terminus-derived fragment (Gln 5?-tsRNA) is overexpressed; a preparation method therefor; and a method for screening for aging-associated factors by using the transgenic Caenorhabditis elegans. A transgenic Caenorhabditis elegans model provided in the present invention is an animal model in which Gln 5?-tsRNA is overexpressed such that aging is inhibited. When the model of the present invention is used, anti-aging mechanisms can be easily investigated, thereby significantly contributing to various research fields such as that of developing new anti-aging drugs and screening for age-inducing materials.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: May 25, 2021
    Assignees: POSTECH ACADEMY-INDUSTRY FOUNDATION, INSTITUTE FOR BASIC SCIENCE, DAEGU GYEONGBUK INSTITUTE OF SCIENCE
    Inventors: Hong Gil Nam, Gyoo Yeol Jung, Seung Jae Lee, Woo Seon Hwang, Gi Won Shin, Mi Hwa Seo
  • Publication number: 20210079083
    Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention provides an angiogenesis inhibitor and a composition for prevention and treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.
    Type: Application
    Filed: August 17, 2020
    Publication date: March 18, 2021
    Applicants: INSTITUTE FOR BASIC SCIENCE, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gou Young Koh, Jeomil Bae, Mi Jeong Kim, Jin-Sung Park, Su Jin Seo, Jaeryung Kim, Jang Ryul Park, Pilhan Kim, Wangyuhl Oh
  • Patent number: 10934320
    Abstract: Provided are a transition metal compound including a novel carbene compound as a ligand, a preparation method thereof, and an application thereof. The transition metal compound according to the present invention may form a structurally stable complex and also have a HOMO-LUMO energy gap and singlet-triplet transition energy which are significantly low as compared with a conventional transition metal compound. In addition, according to the present invention, the transition metal compound may be synthesized in large quantities by a very simple method, thereby having high commercial utility, and thus, an application using the compound is expected.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: March 2, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Hayoung Song, Kimoon Kim, Eunsung Lee, Hyunho Kim
  • Publication number: 20210054267
    Abstract: According to the present invention, an organic light-emitting composite and a method of manufacturing the organic light-emitting composite are provided. According to exemplary embodiments, an organic light-emitting composite includes a polymer matrix; a first light-emitting material provided in the polymer matrix; and a second light-emitting material provided in the polymer matrix and obtained by oxidizing the first light-emitting material, wherein the second light-emitting material may have the same molecular weight as that of the first light emitting-material.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 25, 2021
    Applicants: Institute for Basic Science, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Hee Cheul CHOI, Jin Young KOO, Minkyung LEE
  • Patent number: 10874854
    Abstract: The present invention relates to a mesh electrode for cardiac resynchronization therapy, and a manufacturing method therefor. More specifically, the present invention relates to: a mesh electrode for cardiac resynchronization therapy, formed from a wire composed of a first biocompatible rubber layer in which silver nanowires are dispersed, and a second biocompatible rubber layer famed so as to be adjacent to the first biocompatible rubber layer; and a manufacturing method therefor.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: December 29, 2020
    Assignees: Seoul National University R&DB Foundation, INSTITUTE FOR BASIC SCIENCE
    Inventors: Dae-Hyeong Kim, Taeghwan Hyeon, Hye Jin Hwang, Jinkyung Park, Suji Choi
  • Patent number: 10858662
    Abstract: The present invention relates to a method for regulating gene expression, comprising introducing into a cell each of a recombinant vector which expresses a first domain comprising N-terminus of a Cas9 protein, and a recombinant vector which expresses a second domain comprising C-terminus of a Cas9 protein, a composition comprising the recombinant vectors, a kit for regulating gene expression, and a method for intracellular production of Cas9 protein. Moreover, the present invention relates to a transformed cell introduced with a viral vector which packages the first domain, and a viral vector which packages the second domain, and to a composition comprising a virus produced therefrom.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: December 8, 2020
    Assignee: INSTITUTE FOR BASIC SCIENCE
    Inventors: Jin Soo Kim, Tae Young Koo
  • Publication number: 20200292734
    Abstract: A wavelength multiplexing device is disclosed. When light is irradiated on a first longitudinal end region of a metal nano-structure, surface plasmon polaritons are generated in the first longitudinal end region. The surface plasmon polaritons and the light are coupled with each other to form first coupled surface plasmon polaritons, wherein the first coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure. When the first coupled surface plasmon polaritons reach a two-dimensional material layer, excitons are induced in the two-dimensional material layer, wherein the induced excitons and the first coupled surface plasmon polaritons are coupled with each other to form second coupled surface plasmon polaritons. The second coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure toward a second longitudinal end thereof.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicants: Research & Business Foundation Sungkyunkwan University, Institute for Basic Science
    Inventors: Hyun Seok LEE, Young Hee LEE
  • Publication number: 20200292733
    Abstract: A wavelength multiplexing device is disclosed. When light is irradiated on a first longitudinal end region of a metal nano-structure, surface plasmon polaritons are generated in the first longitudinal end region. The surface plasmon polaritons and the light are coupled with each other to form first coupled surface plasmon polaritons, wherein the first coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure. When the first coupled surface plasmon polaritons reach a two-dimensional material layer, excitons are induced in the two-dimensional material layer, wherein the induced excitons and the first coupled surface plasmon polaritons are coupled with each other to form second coupled surface plasmon polaritons. The second coupled surface plasmon polaritons propagate along and on a surface of the metal nano-structure toward a second longitudinal end thereof.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicants: Research & Business Foundation Sungkyunkwan University, Institute for Basic Science
    Inventors: Hyun Seok LEE, Young Hee LEE
  • Patent number: 10770718
    Abstract: A lithium-sulfur secondary battery includes a cathode current collector and a cathode electrode on the cathode current collector. The cathode electrode includes a porous carbon interlayer electrode including a plurality of carbon fibers, metal sulfide catalyst particles dispersed and positioned on the porous carbon interlayer electrode, and sulfur-based active material particles dispersed on the porous carbon interlayer electrode to be attached thereto and including sulfur.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: September 8, 2020
    Assignees: Seoul National University R&DB Foundation, Institute For Basic Science
    Inventors: Yung-Eun Sung, Chunjoong Kim, Jungjin Park