Patents Assigned to Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
  • Patent number: 11951091
    Abstract: Disclosed herein is a complex, a contrast agent and the method for treating a disease related to CXCR4 receptor. The complex is configured to bind the CXCR4 receptor, and is used as a medicament for diagnosis and treatment of cancers and other indications related to the CXCR4 receptor.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: April 9, 2024
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Chien-Chung Hsia, Chung-Hsin Yeh, Cheng-Liang Peng, Chun-Tang Chen
  • Patent number: 11897172
    Abstract: A polar plate is fabricated. The polar plate is flexible and made of a plastic graphite composite. No matter a supporting member is used for calendering or not, a thin polar plate with controllable thickness is fabricated. The polar plate is excellent in blocking the through-transmission of vanadium ions and the limit of blending ratio of conductive carbon is broken through. The longitudinal through-transmission volume resistivity (proportional resistance to thickness) is greatly improved by adjusting the blending ratio of conductive carbon for meeting the demand of conductivity. In the mean time, the present invention strengthens the rigidity required for the thin polar plate while providing large-area polar plate fabrication for industrial use and convenience and provides a cooling and pressing method for patterning a composite polar plate. An integrated mold is thus obtained to replace the conventional polar plate which needs to be processed and prepared with runner.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: February 13, 2024
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Hung-Hsien Ku, Ning-Yih Hsu, Han-Jou Lin, Tai-Feng Hung, Qiao-Ya Chen
  • Patent number: 11830986
    Abstract: A quantum battery manufacturing method includes: providing a p-type semiconductor substrate including a first conductive substrate and a p-type semiconductor layer disposed on one surface of the first conductive substrate; providing an n-type semiconductor substrate including a second conductive substrate and an n-type semiconductor layer disposed on one surface of the second conductive substrate; and forming an electricity storage layer between the p-type semiconductor substrate and the n-type semiconductor substrate, and attaching two sides of the electricity storage layer respectively to the p-type semiconductor layer and the n-type semiconductor layer to form a quantum battery. The electricity storage layer is formed by heating a thermoplastic polymer to soften and become a liquid, mixing the liquid with energized core-shell particles, and coating a substrate with the mixture. Core-shell particles are disposed on a conductive substrate and irradiated with ultraviolet rays for energization.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: November 28, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Min-Chuan Wang, Bo-Hsien Wu, Shang-En Liu
  • Patent number: 11817556
    Abstract: A composite gel polymer electrolyte lithium battery structure includes a positive electrode, a negative electrode and an electrolyte film component. The electrolyte film component, disposed between the positive electrode and the negative electrode, includes a separator and at least one electrolyte film. The at least one electrolyte film is at least consisted of sulfolane and/or propylene carbonate (PC), a lithium salt material, a solid-state polymer material and fire-retardant additives. In addition, a method for fabricating the composite gel polymer electrolyte lithium battery structure is also provided.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: November 14, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Shang-En Liu, Tien-Hsiang Hsueh, Min-Chuan Wang
  • Patent number: 11693146
    Abstract: A calculation method for a dual-energy X-ray imaging system is provided. The calculation method for the dual-energy X-ray imaging system includes the following steps. A plurality of material attenuation coefficient ratio of the dual-energy projection image are established according to the reference materials with known material characteristics. The effective atomic number of each reference material and the material attenuation coefficient ratio are used to establish a calibration data set. A rational polynomial approximation method is adopted to obtain the characteristic model related to the material attenuation coefficient ratio of the reference material and the effective atomic number of the reference material. The material attenuation coefficient ratio of the dual-energy projection image of unknown material is established.
    Type: Grant
    Filed: January 12, 2022
    Date of Patent: July 4, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Chia-Hao Chang, Yu-Ching Ni, Sheng-Pin Tseng
  • Patent number: 11681054
    Abstract: A position-signal processing method for flat panel gamma imaging probe includes a modeling phase and a use phase. In the modeling phase, a weight direction for an imaging detector is defined, position centers and weight ratios of the imaging detector in the weight direction are utilized to obtain a distribution graph of the weight ratios to the position centers, and curve fitting is performed upon the distribution graph to obtain a position estimation curve. In the use phase, the position estimation curve is utilized to derive a position estimation value of a probe trigger event in a 2D crystal diagram, a position value of the probe in the 2D crystal diagram with respect to the position estimation value of the probe trigger event is obtained, and a crystal code is located in a crystal code look-up table for the position value of the probe in the 2D crystal diagram.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: June 20, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Hsin-Chin Liang, Chen-Han Cheng
  • Patent number: 11654203
    Abstract: Disclosed herein are a dual-targeted carbonic anhydrase IX complex, a contrast agent comprising the same, and a synthesizing method thereof. The dual-targeted carbonic anhydrase IX complex includes a carbonic anhydrase IX (CA9) binding peptide, a sulfonamide derivative, and a metal chelating agent. The dual-targeted carbonic anhydrase IX complex has potential for use as a molecular nuclear drug.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: May 23, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Siao-Syun Guan, Tsai-Yueh Luo, Tse-Zung Liao, Cheng-Liang Peng, Kun-Liang Lin
  • Patent number: 11658341
    Abstract: A method for manufacturing a gel-state flame-retardant electrolyte film includes the steps of: preparing a first solution having a high boiling-point solvent; adding a solid-state polymer material into the first solution, and performing a heating and stirring process to form a second solution; adding a flame-retardant electrolyte material and a flame-retardant water-absorbent material into the second solution for forming a third solution by well mixing; forming the third solution into a viscous matter; and, solidifying the viscous matter to form the gel-state flame-retardant electrolyte film. In addition, a gel-state flame-retardant electrolyte film, a gel-state electrolyte battery and a method for manufacturing the gel-state electrolyte battery are also provided.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: May 23, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Tien-Hsiang Hsueh, Shang-En Liu, Min-Chuan Wang, Bo-Hsien Wu, Shu-Mei Chang
  • Patent number: 11630219
    Abstract: A pressure-regulating large-area windowless airflow proportional counter is provided, which includes a chamber, a metal tray, a side cover, a gas cylinder, and a voltage input and signal output terminal. The chamber has a side opening. A large-area source is placed on the metal tray and the metal tray is moved into or out of the chamber via the side opening. The side cover is fixed to the side opening by an O-ring via a locking device to form an airtight structure. The gas cylinder is used to supply a dedicated gas into the chamber. The voltage-input/signal-output terminal is used to supply voltage to an anode wire net. The free electrons generated by the large-area source due to the free phenomenon are collected by the anode wire net, and outputted to a voltage signal processing module through the voltage-input/signal-output terminal for analysis of pulse height or pulse count.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: April 18, 2023
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Chin-Chi Chen, Ming-Chen Yuan
  • Patent number: 11466002
    Abstract: This invention discloses method for preparing a non-radioactive standard ?-CFT. Using cocaine hydrochloride as the starting material, and after a series of hydrolysis, dehydration, esterification and bonding reactions, a non-radioactive standard (2?-Carbomethoxy-3?-(4-fluoropenyl) tropane) is prepared. Furthermore, this preparation method has fewer steps, is easy to operate, and the purity of the product is as high as 97.97%. Therefore, the method for preparing a non-radioactive standard ?-CFT can promote the development of positron imaging in the diagnosis of Parkinson's disease.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: October 11, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Ching Yun Lee, Yu Chang
  • Patent number: 11369702
    Abstract: Disclosed herein are kits and methods for preparing radiopharmaceuticals. The kits and methods of the present disclosure can prepare the radiopharmaceuticals without using a heater and computer monitoring equipment. The kit includes a frozen crystal reaction vial, a reagent vial and a labeling holder, wherein the labeling holder contains a heating bag that can heat up to a high temperature of at least 95° C. by adding an aqueous solution.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: June 28, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Ming-Hsin Li, Shih-Wei Lo, Sheng-Nan Lo, Shih-Ying Lee, Su-Jung Chen
  • Patent number: 11369268
    Abstract: A brain-function image data augmentation method includes: a step of providing a target database including a plurality of image-data information; a step of, based on a plurality of image-data expected information in an expectation-value database, calculating a ratio of the plurality of image-data expected information with respect to different ages; a step of, based on the plurality of image-data information and the ratio, obtaining image-data ratio information with respect to an estimated age; a step of establishing a relationship for each pair of the image-data information and the image-data expected information; a step of, based on the relationship, the ratio and the image-data information, calculating an estimated image-data information with respect to the estimated age; and, a step of combining linearly the estimated image-data information and the image-data ratio information so as to generate an augmented image-data information with respect to the estimated age.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: June 28, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Fan-Pin Tseng, Yu-Ching Ni, Wen-Bin Lin
  • Patent number: 11327117
    Abstract: An apparatus is provided for measuring the power of electrolytes at different positions of a flow battery by switching six-way valves without reconnecting channels. With the measurements at the positions, weighting is processed to obtain power corresponding to charging statuses for determining accurate power. The charging and discharging of voltage and current of the battery are controlled for constant operations with high efficiency. Consequently, the efficiency of power conversion is improved; energy consumption is reduced; and the battery is always run within a safe power-range for avoiding accidents or damages to the battery. In addition, the present invention is further applicable to a device monitoring the features of a battery unit. The six-way valves online monitor the power at center positions by switching. The values measured at different positions are aimed at the abnormality of the battery unit for processing adjustment or offline replacement to maintain best operation performance.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: May 10, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Hung-Hsien Ku, Ning-Yih Hsu, Chin-Lung Hsieh, Yi-Hsin Hu, Qiao-Ya Chen
  • Patent number: 11276851
    Abstract: The present invention provides an electrochemical unit, a manufacturing method for the same and a use of the same as a component of batteries, and an electrochemical device including the same. The electrochemical unit includes a mixture layer and a transition metal oxide layer. The mixture layer includes an oxide made of a first transition metal, an oxide made of a second transition metal, and a first alkali metal. The transition metal oxide layer is disposed on one side of the mixture layer, where the transition metal oxide layer includes a third transition metal oxide.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: March 15, 2022
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Min-Chuan Wang, Yu-Lin Yeh, Yu-Chen Li, Ding-Guey Tsai, Der-Jun Jan
  • Patent number: 11260345
    Abstract: A desiccant wheel is provided to be rotatable. Through the body of the wheel or a surface adsorbent, water vapor in humid air flow is adsorbed. By passing a high-temperature air flow through the wheel, the body or surface coating is regenerated with moisture removed. Along a cross-section radial, the wheel is divided into different areas. The body has three-dimensionally inter-connected pores. The pores can be of different types. The wheel is a complete concentric cylinder or a concentric cylinder comprising equal or unequal sectors. The equal or unequal sectors are separated with each other. The wheel can rotate at a fixed speed for continually repeating a process of adsorbing, transiting, and regenerating. Thereby, drying can be carried out without causing physical or chemical change to heat-sensitive material, which also improves drying efficiency, reduces size, lowers power consumption, and helps in carbon reduction for industry.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 1, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Heng Yi Li, Tsair-Fuh Huang, Sheng-Fu Yang, Po-Hsiu Kuo, Yu-Ren Chen, How-Ming Lee, To-Mei Wang
  • Patent number: 11258263
    Abstract: An apparatus of solid oxide fuel cells (SOFC) is provided. The SOFCs generate power and are grid-tied. The apparatus comprises a power-generating side; and a grid-connecting side using an elementary household power management. The apparatus solves problems like low voltage, high current, voltage oscillation, voltage dips, long generator-starting time, etc. The apparatus is not only used as a stable power supply (base load), but also helps adjust the regional peak electricity demands. The features include the following: 1. A grid is tied, where output power does not pass through a direct-current boost converter and, thus, has no loss from it. 2. Injures, including voltage oscillation and sudden unloading after dumping, are reduced for avoiding further damages to cell sheets. 3. With the coordination of elementary power management and the integration of grid, the limitation of long-awaiting generator-starting time is crossed out and convenience of immediate power use is achieved.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: February 22, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Fang-Tzu Chuang, Chen-Min Chan, Ruey-Yi Lee
  • Patent number: 11247947
    Abstract: A method is provided to purify [F-18]FEONM under a high pressure. The synthesis processes of [F-18]FEONM are integrated. An isolation process of non-toxic radio-high performance liquid chromatography (radio-HPLC) is used to purify the crude product. The method integrates a convention [F-18]FDG synthesizer and a novel radio-HPLC system together in a heat chamber. After radiofluorinating the precursor, the reaction product is purified with an alumina solid-phase column in advance to obtain the crude product while fluorine-18 is removed. Then, diphenyl semipreparative HPLC column is used for a final purification. A non-toxic solvent is used for mobile-phase eluting to remove the unreacted precursor and the phase-transfer solvent. The radiofluorination has a reaction yield about 50 percent (%). The method has an uncorrected radiochemical yield of 10˜20%. Both of the radio-HPLC and the radio-thin layer chromatography (radio-TLC) have radiochemical purity higher than 95%.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: February 15, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Yean-Hung Tu, Li-Yuan Huang, Jenn-Tzong Chen, Tsai-Yueh Luo, Shiou-Shiow Farn, Wuu-Jyh Lin
  • Patent number: 11251452
    Abstract: A method is provided for restoring an electrolyte of vanadium (V) redox flow battery (VRFB). Electrolyte data of an original system are analyzed in advance. A reusable positive electrode is further equipped with a V electrolyte. A reductant for a stack of VRFB is used in coordination as an electrolysis device. After a long-term reaction with a VRFB having a high valence (greater than 3.5), an electrolyte at the positive electrode is directed out to a negative electrode of the electrolysis device; and, then, electrolysis is processed after accurate calculation. In the end, the internal fluid balancing method of the original system is combined. Thus, a harmless and quick valence restoration is processed for the electrolyte of the original system, which is a final resort for the restoration of V electrolyte.
    Type: Grant
    Filed: January 8, 2020
    Date of Patent: February 15, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Yu-De Zhuang, Chien-Hong Lin, Yi-Hsin Hu, Han-Wen Chou, Hwa-Jou Wei, Ning-Yih Hsu
  • Patent number: 11232950
    Abstract: The invention is a special designed pattern heterogeneous substrate, which is epitaxially deposited on a heterogeneous substrate by two step growth, and a thermal cycle annealing is added to reduce the lattice mismatch between the layers and the difference in thermal expansion coefficient, thereby obtaining a better stress. The quality of the semiconductor epitaxial layer is improved, and the present invention can easily grasp the timing of stress release when the semiconductor is grown on the heterogeneous substrate, avoid cracks in the semiconductor epitaxial layer, and form a crack free zone in the middle of the semiconductor epitaxial layer.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: January 25, 2022
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.O.C.
    Inventors: Jheng Hao Fang, Yu Li Tsai, Hsueh-Hui Yang, Chih Hung Wu, Hwen Fen Hong
  • Patent number: 11191718
    Abstract: The present invention provides an ophthalmic gel and a preparation method thereof. The ophthalmic gel comprises: an antibiotic; a nanocarrier, wherein the nanocarrier is used to load the antibiotic; and a biodegradable matrix, wherein the biodegradable matrix is compatible with the nanocarrier to carry the nanocarrier. When the ophthalmic gel of the present invention is applied to the surface of the cornea and conjunctiva of the eyes, the biodegradable matrix is automatically degraded and the nanocarrier carried by the biodegradable matrix will slowly release the antibiotic, loaded in the nanocarrier, at an appropriate rate to overcome the high-frequency use of general ophthalmic drugs and easily caused blurred vision; the present invention further comprises an ophthalmic gel preparation method.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: December 7, 2021
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C
    Inventors: Ming-Cheng Chang, Tsai-Yueh Luo, Cheng-Liang Peng, Kuan-Yin Chen