Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.

Abstract: The present invention generally relates to polymers and particles, such as nanoparticles. The particles and polymers generally include one or more buffering components. Additionally, the particles and polymers may include two or more components that impart useful properties (functionalities). The particles and polymers, for example, may include a buffering component and a degradable component. As described herein, the particles and polymers may also include a hydrophilic component and/or a cleavable bond component. The particles and polymers described herein have been found to be particularly effective when used for delivery of one or more agents, such as one or more pharmaceutical agents. Other aspects of the invention are directed to methods of using or administering such particles or polymers, kits involving such particles or polymers, and the like.

Abstract: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

Abstract: The disclosure provides a dual-catalysis system for direct conversion of olefins to alcohols. The cooperative catalytic system contains one oxidizing catalyst and one transfer-hydrogenation catalyst. A wide variety of olefins, including aromatic and aliphatic olefins, can be used as the reactant. The transformation proceeds with anti-Markovnikov selectivity, and in some aspects provides primary alcohols as major products. The disclosure further provides a system for oxidation of olefins with anti-Markovnikov selectivity.

Abstract: Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be utilized in organic reactions.

Abstract: Apparatus, system and method for medical analysis of a seated individual, includes determining the aortic valve opening; the PTT; and calculating the PWV. Determining the aortic valve opening includes collecting BCG data while sitting on a seat and determining the timing of the aortic valve opening, taking into account posture. Measuring the aortic pulse wave transit time includes collecting BCG data while sitting on a seat capable of measuring changes in apparent weight; determining the timing of the aortic valve opening; detecting the arrival of the pulse wave at the end point; and measuring the relative timings of the two events. Calculating the PWV includes determining a length of the arterial segment through which a pulse wave is to be measured between a start point and an end point; and dividing the determined length of the arterial segment by the PTT.

Abstract: A method for growing a transition metal dichalcogenide on a substrate, the method including providing a growth substrate having a first side and a second side opposite the first side; providing a source substrate having a first side and a second side opposite the first side; depositing a transition metal oxide on at least a portion of the first side of the source substrate; combining the growth substrate with the source substrate such that the first side of the growth substrate contacts the transition metal oxide, the combining producing a substrate stack; exposing the substrate stack to a chalcogenide gas, whereby the transition metal oxide reacts with the chalcogenide gas to produce a layer of a transition metal dichalcogenide on at least a portion of the first side of the growth substrate; and removing the source substrate from the growth substrate having the layer of the transition metal dichalcogenide thereon.

Abstract: A novel computational QSAR approach that provides sub-molecular correlations that are specific to individual lobes of the pertinent molecular orbitals.

Abstract: Materials and methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force improving the dynamic performance of the metamaterial by impeding dynamic excitation. The engineered aggregate generally comprise a multilayer resonant structure having at least a relatively heavy inner core surrounded by at least a compliant coating layer. The geometry and stiffness of the relative layers can be tuned to engineer a desired resonant frequency response within the aggregate for a chosen frequency range. The engineered aggregates are disposed in a matrix material to form a metamaterial. The engineered aggregates may be disposed within a mortar matrix to form a concrete metamaterial suitable for use, for example, in structural applications, including bunkers, shelters, etc.

Abstract: In permeability lung edema, cardiogenic lung edema or neonatal respiratory distress, there is heterogeneous liquid distribution throughout the lungs. The excess alveolar liquid reduces gas exchange. Mechanical ventilation is used to improve gas exchange. In the presence of heterogeneous liquid distribution, there are surface tension-dependent stress concentrations in septa separating aerated from flooded alveoli. Mechanical ventilation, by inflating the lung above normal volumes, thus increasing surface tension above normal, exacerbates the stress concentrations and consequently injures, or exacerbates pre-existing injury of, the alveolar-capillary barrier. Any means of lowering surface tension should lessen ventilation injury of the lung. In the present invention, dilute exogenous surfactant solution or surfactant protein C solution interacts with albumin to lower surface tension, likely through effective promotion of surfactant lipid adsorption.

Abstract: An optical-to-optical inline spatial domain multiplexing (SDM) de-multiplexer for SDM communication comprising a plurality of concentric core layers each having a beveled output end and a cladding layer concentrically surrounding each core layer. The cladding layer has an index that is lower than the index of the core layer it surrounds. Also included is a system for SDM communication comprising at least one optical source to transmit optical energy, an SDM optical carrier fiber to receive optical energy from the source and output a plurality of SDM signals, a SDM de-multiplexer as described above wherein the SDM signals output from the carrier fiber are each incident upon one of the core layers, optical output fibers positioned to couple SDM signals from each cladding layer, and a photodetector communicatively coupled to the outputs of the optical output fibers to couple the SDM signals output from the optical output fibers.

Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: Three-dimensional patterning methods of a three-dimensional microstructure, such as a semiconductor wire array, are described, in conjunction with etching and/or deposition steps to pattern the three-dimensional microstructure.

Abstract: Embodiments described herein generally relate to compositions comprising a graphene oxide species. In some embodiments, the compositions advantageously have relatively high oxygen content, even after annealing.

Abstract: Methods and devices for preparing microscale polymer relief structures from a thin polymer layer on an absorbing substrate are described. The described methods are ultrafast (about 8 nanoseconds) and allow formation of patterned microstructures having complex morphologies and narrow line widths that are an order of magnitude smaller than the masks used in the methods.

Abstract: A method includes attaching a partially processed CMOS wafer to a second wafer to produce a combined wafer. The second wafer comprises a first region including a material different from silicon. The method also includes forming devices in the first region or in a second region of the combined wafer having a material different from silicon.

Abstract: Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyzes of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.

Abstract: Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.

Abstract: A node processor and method for performing matrix operations includes storing, in memory, non-zero matrix elements of a first sparse matrix, non-zero matrix elements of a second sparse matrix, and matrix elements of a sparse results matrix mapped to the node processor. A matrix communications module exchanges with other node processors, non-zero matrix elements of one or more of the first sparse matrix, second sparse matrix, and sparse results matrix. An arithmetic logic unit generates partial results based on the non-zero matrix elements of the first sparse matrix and on the non-zero matrix elements of the second sparse matrix stored in memory. The arithmetic logic unit further generates a final value for each matrix element of the sparse results matrix mapped to the node processor based on the partial results generated by the arithmetic logic unit and on partial results received from the other node processors.