Abstract: A process for fabricating a light detector with one or more antireflection (AR) and/or bandpass filter coatings deposited thereon by area-selective atomic layer deposition (ALD). The AR coatings may comprise a metal oxide or a metal fluoride, such as AlF3, Al2O3, and/or HfO2, and the bandpass filter coatings may comprise solar-blind bandpass filter coatings. The AR and/or bandpass filter coatings may be deposited with different thicknesses on different portions of the light detector using an intentional and controllable patterning by a lithography-based process. As a result, the AR and/or bandpass filter coatings provide a butcher-block style response profile with each of the different portions of the light detector targeting a specific bandpass of light. The AR and/or bandpass filter coatings comprise a linear variable filter (LVF) that provides a spatially varying response by the light detector.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material.

Abstract: The removal of acid gases (e.g., non-carbon dioxide acid gases) using sorbents that include salts in molten form, and related systems and methods, are generally described.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: This gel electrolyte contains a liquid, inorganic nanofibers, and a polymer obtained by polymerizing a compound which has an imidazolium salt having an alkenyl group represented by formula (1-1) and an imidazolium salt having an alkenyl group represented by formula (2-1) at both ends, and in which the compound is swelled by the liquid; the gel electrolyte exhibits proton conductivity equivalent to that of Nafion at room temperature, exhibits proton conductivity greater than or equal to that of Nafion at high temperatures exceeding 60° C., and has excellent strength. (In the formula, X? indicates monovalent anions, Y? represents mutually independent monovalent anions, and n represents an integer 1-20.

Abstract: An ankle-foot prosthesis comprises a foot structure having a foot keel leaf spring, a heel leaf spring, and an upper J leaf spring above the keel leaf spring. An ankle bearing block is mounted to the keel leaf spring and a shank shell is mounted to the ankle bearing block. A shank interface mounts to the shank shell. A processor controlled active element extends along an axis between the shank shell and the upper leaf-spring.

Abstract: Described herein are methods for suppressing an immune response in a subject, e.g., a subject with an autoimmune disease, by administering to the subject a therapeutically effective amount of recombinant CD5L, CD5L homodimers and/or CD5L:p40 heterodimers, or nucleic acids encoding any of these. Also described are methods for enhancing an immune response in a subject, e.g., a subject with cancer, infection, or an immune deficiency, by administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that binds specifically to CD5L, D5L homodimers and/or CD5L:p40 heterodimers, and inhibits their binding to the IL-23 receptor, or inhibits formation of the CD5L homodimer and/or CD5L:p40 heterodimer, or inhibitory nucleic acids that target CD5L and/or p40.

Abstract: A balance board coupled to a two-wheeled vehicle to provide a moving platform that an operator of the vehicle can use to stabilize the vehicle. The balance board includes a coupling mechanism, a frame, one or more moving elements, and one or more foot support pedals. In one example, the balance board is mechanically passive such that the balance board maintains contact with the ground surface without an externally applied force (e.g., by the operator/user of the vehicle). In one aspect, the balance board may be rotatable about multiple rotational degrees of freedom to allow the balance board to steer as the vehicle turns.

Abstract: Understanding the intent of human drivers and adapting to their driving styles is used to increased efficiency and safety of autonomous vehicles (AVs) by enabling them to behave in safe and predictable ways without requiring explicit inter-vehicle communication. A Social Value Orientation (SVO), which quantifies the degree of an agent's selfishness or altruism, is estimated by the AV for other vehicles to better predict how they will interact and cooperate with others. Interactions between agents are modeled as a best response game wherein each agent negotiates to maximize their own utility. A dynamic game solution uses the Nash equilibrium, yielding an online method of predicting multi-agent interactions given their SVOs. This approach allows autonomous vehicles to observe human drivers, estimate their SVOs, and generate an autonomous control policy in real time.

Abstract: We disclose an on-chip photonic spectroscopy system capable of dramatically improving the signal-to-noise ratio (SNR), dynamic range, and reconstruction quality of Fourier transform spectrometers. Secondly, we disclose a system of components that makes up a complete on-chip RF spectrum analyzer with low-cost and high-performance.

Abstract: Metal bioremediation and metal mining strategies can include compositions and methods.

Abstract: A method of performing Raman spectroscopy can include guiding a Raman pump beam with an optical fiber, where the Raman pump beam inducing fluorescence in the optical fiber. The beam and the fluorescence are coupled to a photonic integrated circuit (PIC) via the fiber. The beam is used to excite a sample in optical communication with the PIC via evanescent coupling and induces Raman scattering in the sample. The Raman scattering is collected via the PIC, and the Raman pump beam as well as the fluorescence is filtered out from the Raman scattering via the PIC.

Abstract: A composite fuel cell polymer electrolyte membrane. The composite membrane includes a polymer electrolyte membrane base material including first and second inorganic particles. The first and second inorganic particles are interspersed within the polymer electrolyte membrane base material and each other. The first and second inorganic particles have first and second surface properties and the first surface property is different than the second surface property.

Abstract: Compositions and methods relating to compositions that include metal-organic frameworks are generally described. In some embodiments, branched nanoparticles made at least in part of metal-organic frameworks are described. In some embodiments, the morphology and size of the branched nanoparticles are controlled by the presence of a chemical modulator during synthesis.

Abstract: Described are power line communication (PLC) systems, devices and techniques which are reliable and suitable for use in control applications which can operate with relatively low data rates while complying with governing regulatory rules. Such systems, devices and techniques enable demand-side management of electrical loads in a building or facility or other environment.

Abstract: A mechanical interface connecting a biological body segment, such as a limb, portion of a limb or other body segment, to a wearable device such as a prosthetic, orthotic or exoskeletal device, is fabricated by quantitatively mapping a characterized representation of the body segment to form a digital representation of the mechanical interface shape and mechanical interface impedance. The mechanical interface includes a continuous socket defining a contoured inside surface and a contoured outside surface, and includes a material having an intrinsic impedance that varies through the material, so that the intrinsic impedance varies along the contoured inside surface.

Abstract: Flow through reactors and related methods for use with slurries including water reactive particles are generally described.

Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.

Abstract: Systems and methods described herein relate to reconstructing a scene in three dimensions from a two-dimensional image. One embodiment processes an image using a detection transformer to detect an object in the scene and to generate a NOCS map of the object and a background depth map; uses MLPs to relate the object to a differentiable database of object priors (PriorDB); recovers, from the NOCS map, a partial 3D object shape; estimates an initial object pose; fits a PriorDB object prior to align in geometry and appearance with the partial 3D shape to produce a complete shape and refines the initial pose estimate; generates an editable and re-renderable 3D scene reconstruction based, at least in part, on the complete shape, the refined pose estimate, and the depth map; and controls the operation of a robot based, at least in part, on the editable and re-renderable 3D scene reconstruction.