Patents Assigned to Institute Pasteur
  • ACTIVE OR PASSIVE IMMUNIZATION AGAINST PROAPOPTOTIC NEUROTROPHINS FOR THE TREATMENT AND/OR PREVENTION OF NEURODEGENERATIVE DISEASES
    Publication number: 20100183645
    Abstract: The present invention relates to novel methods for combating cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammation as well as methods and means useful for said active or passive immunization.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 22, 2010
    Applicants: INSTITUT PASTEUR, INSTITUTO DE INVEST. BIO. CLEMENTE ESTABLE
    Inventors: Luis Hector Barbeito, Alvaro G. Estevez, Joseph S. Beckman, Mariana Pehar, Pedro Alzari, Maria Patricia Cassina
  • HIV-1, HIV-2, and SIV nucleotide fragments
    Patent number: 7759477
    Abstract: The invention relates to polypeptide fragments of HIV-1, HIV-2, and SIV, antibodies that bind to the polypeptides of the invention, methods of using the antibodies, and kits containing the antibodies. The invention also relates to polynucleotides that encode the polypeptide fragments of the invention.
    Type: Grant
    Filed: June 8, 2004
    Date of Patent: July 20, 2010
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Maurice Moncany, Luc Montagnier
  • Process for aligning macromolecules by passage of a meniscus and applications
    Patent number: 7754425
    Abstract: The subject of the present invention is a process for aligning a macromolecule (macromolecules) on the surface S of a support, characterized in that the triple line S/A/B (meniscus) resulting from the contact between a solvent A and the surface S and a medium B is caused to move on the said surface S, the said macromolecules having a part, especially an end, anchored on the surface S, the other part, especially the other end, being in solution in the solvent A. The subject of the present invention is also a process for detecting, measuring the intramolecular distance of, separating and/or assaying a macromolecule in a sample in which a process of alignment according to the invention is used.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: July 13, 2010
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique (CRNS)
    Inventors: David Bensimon, Aaron Bensimon, François Heslot
  • PROCESS FOR ENRICHING BASOPHILS IN A BLOOD SAMPLE
    Publication number: 20100167317
    Abstract: The present invention is based on the discovery that contrary to prior studies CD16 is expressed by basophils and as such provide methods and kits for enriching basophils in a blood sample.
    Type: Application
    Filed: August 3, 2009
    Publication date: July 1, 2010
    Applicant: INSTITUT PASTEUR
    Inventors: Marc DAERON, Nihad MEKNACHE
  • Immunogenic polypeptide isolated from mycobacterium avium subspecies paratuberculosis and uses thereof
    Patent number: 7744905
    Abstract: The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: June 29, 2010
    Assignees: Massey University, Institut Pasteur
    Inventors: Alan Murray, Christine Dupont
  • BIOSENSORS, METHOD FOR OBTAINING THE SAME AND USES THEREOF
    Publication number: 20100159480
    Abstract: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.
    Type: Application
    Filed: January 25, 2010
    Publication date: June 24, 2010
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Martial RENARD, Laurent Belkadi, Patrick England, Hugues Bedouelle
  • MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE
    Publication number: 20100158912
    Abstract: Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
    Type: Application
    Filed: September 11, 2009
    Publication date: June 24, 2010
    Applicant: INSTITUT PASTEUR
    Inventors: Marie-Lise Gougeon, Hela Saidi, Marie-Therese Melki, Beatrice Poirier-Beaudoin, Valerie Seffer
  • Methods of screening of PP1-interacting polypeptides or proteins, peptides inhibiting PP1c binding to Bcl-2 proteins, Bcl-xand Bcl-w, and uses thereof
    Patent number: 7741288
    Abstract: The present invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as BCl-xL and Bcl-w), and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: June 22, 2010
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie (Paris 6), Institut National de la Recherche Agronomique (INRA)
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo
  • PLASMODIUM FALCIPARUM ANTIGENS INDUCING PROTECTIVE ANTIBODIES
    Publication number: 20100150951
    Abstract: The present invention provides a vaccine against malaria containing a polypeptide having an epitope contained within a merozoite surface protein and a method for immunizing against malaria by administering the vaccine.
    Type: Application
    Filed: June 30, 2009
    Publication date: June 17, 2010
    Applicant: INSTITUT PASTEUR
    Inventor: Pierre DRUILHE
  • Method and device for 3 dimensional imaging of suspended micro-objects providing high-resolution microscopy
    Patent number: 7738695
    Abstract: A method for high-resolution image recording of at least one object with a microscope, includes the steps of: (a) positioning the object in a receptacle being arranged in the optical axis of the microscope, (b) generating at least two first data sets per object which represent intermediate images of the object with at least two different orientations relative to the optical axis of the microscope, wherein the different orientations of the object are provided by moving the object relative to the receptacle, and (c) evaluating the data sets for obtaining quantitative three dimensional information.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: June 15, 2010
    Assignees: Institut Pasteur, PerkinElmer Cellular Technologies Germany GmbH
    Inventors: Spencer Shorte, Torsten Müller, Thomas Schnelle
  • Cells and method for producing proteins comprising an unconventional amino acid
    Patent number: 7736899
    Abstract: The present invention relates to a method for providing bacterial or yeast cells with the capacity to produce a protein, the amino acid sequence of which comprises at least one unconventional amino acid. The method involves (a) introducing at least one missense mutation in a target codon of a gene encoding a protein required for the growth of the bacterial or yeast cells, where the mutated protein synthesized from the mutated gene is not functional in the bacterial or yeast cells. The method also involves (b) selecting the bacterial or yeast cells obtained in (a) in a culture medium which (1) does not contain a nutrient compensating for the loss of functionality of the mutated protein and (2) contains an unconventional amino acid which restores the functionality of the protein required for growth of the bacterial or yeast cells, in which the unconventional amino acid is that encoded by the target codon.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: June 15, 2010
    Assignee: Institut Pasteur
    Inventors: Philippe Marliere, Volker Doring, Henning Mootz
  • Strain of SARS-associated coronavirus and applications thereof
    Patent number: 7736850
    Abstract: The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: June 15, 2010
    Assignees: Institute Pasteur, Centre National de la Recherche Scientifique, Universite Paris 7
    Inventors: Sylvie Van Der Werf, Nicolas Escriou, Bernadette Crescenzo-Chaigne, Jean-Claude Manuguerra, Frederick Kunst, Benoît Callendret, Jean-Michel Betton, Valérie Lorin, Sylvie Gerbaud, Ana Maria Burguiere, Saliha Azebi, Pierre Charneau, Frédéric Tangy, Chantal Combredet, Jean-François Delagneau, Monique Martin
  • OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS
    Publication number: 20100145008
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Application
    Filed: December 4, 2007
    Publication date: June 10, 2010
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frederic Pecorari, Pedro Alzari
  • NUCLEOTIDE SEQUENCE ENCODING A MODULATOR OF NF-KB
    Publication number: 20100144615
    Abstract: The present invention relates to nucleotide sequences encoding a modulator of NF-?B, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-?B-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-?B, methods of detecting modulator of NF-?B using the antibodies, methods of treatment associated with NF-?B activation and to methods of identifying compounds which modulate the activity of the modulator of NF-?B.
    Type: Application
    Filed: August 13, 2008
    Publication date: June 10, 2010
    Applicant: INSTITUT PASTEUR
    Inventors: Shoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
  • Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens
    Patent number: 7732563
    Abstract: A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen, such as a eukaryotic amino acid racemase, in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: June 8, 2010
    Assignee: Institut Pasteur
    Inventors: Paola Minoprio, Mario Arala-Chaves, Sara Isabel Mansinho Fernandes de Almeida, legal representative, Antonio Coutinho, Bernardo Reina San Martin, Catherine Rougeot, Wim Degrave, Alain Cosson
  • Method for the diagnosis of genetic diseases by molecular combing and diagnostic kit
    Patent number: 7732143
    Abstract: The invention concerns a method for detecting or locating one or several genes of one or several specific A DNA sequence or one or several molecules reacting with DNA on a B DNA characterised in that it consists in: (a) fixing and combing a certain amount of said B DNA on a combing surface; (b) reacting the product of the B combing with one or several probes, linked with the gene(s) or specific A DNA sequences, or with the molecules capable of reacting with DNA; (c) extracting information corresponding to at least one of the following categories: (1) the position of the probes, (2) the distance between the probes, (3) the size of the probes (the total sum of sizes for quantifying the number of hybridised probes) for determining therefrom the presence, the location and/or the amount of genes or specific A DNA sequences. This method can be used in particular for the diagnosis of genetic diseases.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: June 8, 2010
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Aaron Bensimon, David Bensimon, Xavier Michalet
  • Characterization of the I-I endonuclease from fission yeast
    Patent number: 7732194
    Abstract: Isolated DNAs encoding the enzyme I-SpomI and its recognition and cutting site are provided. The DNA sequences can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: June 8, 2010
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie (Paris VI)
    Inventors: Stefan Pellenz, Bernard Dujon, Alexis Harington, John Sullivan Harington, legal representative, Eoné de Wet, legal representative, Bernd Schafer
  • Nucleotide vector, composition containing such vector, and vaccine for immunization against hepatitis
    Patent number: 7732423
    Abstract: Nucleotide composition containing a vector and vaccine for immunization against hepatitis. Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of the gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A nucleotide vector composition when administered to even chronic HBV carriers is capable of breaking T cell tolerance to the surface antigens of hepatitis B virus. A vaccine preparation containing bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: June 8, 2010
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Marie-Louise Michel, Maryline Mancini
  • METHOD OF PRODUCING A MULTICHIMERIC MOUSE AND APPLICATIONS TO STUDY THE IMMUNOPATHOGENESIS OF HUMAN TISSUE-SPECIFIC PATHOLOGIES
    Publication number: 20100138938
    Abstract: The invention relates to a method of producing a multichimeric mouse comprising a functional xenogenic (human) immune system restricted to the MHC class I and/or class II molecules (HLA molecules) of the xenogenic species solely, and a functional tissue. The invention relates also th the use of the multichimeric mouse obtainable by said method, to study the immunopathogenesis of tissue-specific diseases (infectious, tumoral or auto-immune pathologies) and to their applications to design and test vaccines or immunotherapeutic agents against these pathologies.
    Type: Application
    Filed: July 13, 2007
    Publication date: June 3, 2010
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS DESCARTES
    Inventors: Sylvie GARCIA, Eric TARTOUR
  • LENTIVIRUS PSEUDOTYPED WITH INFLUENZA HEMAGGLUTININ AND METHODS OF USE
    Publication number: 20100137412
    Abstract: Highly effective pseudotyping of lentiviral vector with influenza HA, NA and M2 packaging gene constructs at the proper ratios. Lentivirus vector pseudotyped with influenza HA, especially pseudotyped with H5 and neuraminidase. Methods of inducing immune responses to influenza antigens or for transducing genes into cells to which influenza antigens bind using such lentivirus vectors. Methods for screening drugs which inhibit influenza infection using lentivirus pseudotyped with HA.
    Type: Application
    Filed: June 29, 2009
    Publication date: June 3, 2010
    Applicant: INSTITUT PASTEUR OF SHANGHAI
    Inventors: Paul ZHOU, Cheguo Tsai, Tetsuya Toyoda, Philippe Buchy