Abstract: Mycobacterium tuberculosis protein having a molecular weight of 28.779 Da, and hybrid proteins containing at least portions of its sequence. These proteins may in particular be used in vaccines or for the detection of specific tuberculosis antibodies.

Abstract: A signal amplification system comprises a bacterial multi-hybrid system, and more preferably a two-hybrid system, of at least two chimeric polypeptides containing a first chimeric polypeptide corresponding to a first fragment of an enzyme and a second chimeric polypeptide corresponding to a second fragment of an enzyme or a modulating substance capable of activating said enzyme. The first fragment is fused to a molecule of interest and the second fragment or the modulating substance is fused to a target ligand. The activity of the enzyme is restored by the in vivo interaction between the molecule of interest and the target ligand. Signal amplification is generated and, for example, triggers transcriptional activation. The signal amplification system is useful in a method of selecting a molecule of interest, which is capable of binding to target ligand, wherein the interaction between the molecule of interest and the target ligand is detected with the signal amplification system as a kit therefor.

Abstract: The invention concerns DNA fragments derived from the genomic DNA of HPV-33. These fragments are selected from the group of fragments extending between the nucleotide extremities defined hereafter in relation to the nucleotide-numbering in FIGS.

Abstract: The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The implant comprises a biocompatible support intended to the biological anchoring of cells; cells having the capacity of expressing and secreting naturally or after recombination a predetermined compound, for example a compound having a therapeutical interest; and a constituent capable of inducing and/or promoting the geling of said cells. The invention also relates to a kit for the preparation of the implant as well as to a new recombinant retroviral vector comprising a provirus DNA sequence modified in that the genes gag, pol and env have been deleted at least partially so as to obtain a proviral DNA capable of replication. The invention also relates to recombinant cells comprising the new retroviral vector.

Abstract: Peptide sequences are disclosed which immunologically mimic proteins encoded by the env and gag regions of LAV-2, a retrovirus associated with AIDS. The peptide can be used in various specific binding assays to detect the presence of antibodies to LAV-2 in individuals previously exposed to the virus. The peptides enable one to distinguish the presence of antibodies to LAV-2 from antibodies to HIV-1.

Abstract: The invention discloses a molecule or polypeptide composition characterized by the presence in its structure of one or more peptide sequences bearing all or part of one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of proteins resulting from the infectious activity of P. falciparum in hepatic cells.

Abstract: Cloning of DNA fragments which code for the light chain or the heavy chain variable domain of the D7C2 monoclonal antibody within a baculovirus. The invention also concerns the expression of these DNA fragments in insect host cells, the anti-rhesus D recombinant monoclonal antibody so obtained and its use.

Abstract: This invention relates to plant cells, plants, and seeds expressing a polypeptide having larvicidal activity. In particular, the invention relates to plant cells, plants, and seeds expressing the N-terminal region of a polypeptide toxic against the larvae of Lepidoptera of the Noctuidae family, and preferably against S.littoralis.

Abstract: The subject of the invention is amino acid sequences of the AC-Hly from B. pertussis. B. parapertussis and/or B. bronchiseptica, carrying epitopes capable of inducing a protective immune response against infection by Bordetella. The subject of the invention is antibodies, especially monoclonal antibodies, directed against these epitopes.

Abstract: A process for aligning a macromolecule on the surface S of a support comprises forming a triple line S/A/B (meniscus) resulting from contact between a solvent A and the surface S and a medium B is caused to move on the surface S. The macromolecule has a part, especially an end, anchored on the surface S. The other part, especially the other end, is in solution in the solvent A. A process for detecting, measuring the intramolecular distance of, separating and/or assaying a macromolecule in a sample using the process of alignment is provided.

Abstract: The invention relates to a novel retrovirus isolated from patients in West Africa that is capable of causing lymphadenopathies and the acquired immune deficiency syndrome (AIDS). This virus, which was originally designated “LAV type II”, “LAV-II”, or “West African AIDS retrovirus”, has been subsequently renamed the human immunodeficiency virus type 2 (HIV-2). Two isolates were obtained, characterized, and designated HIV-2MIR and HIV-2ROD (C.N.C.M. deposit nos. I-502 and I-532, respectively). Radioimmunoprecipitation (RIPA) and Western blot analyses involving patient antisera identified viral proteins with molecular weights of 16 Kd (p16), 26 Kd (p26), 130-140 Kd (gp130-140), and 36 Kd (gp36). The claimed invention is directed toward kits for the detection of HIV-2 antigens comprising polyclonal and monoclonal antisera directed against these proteins.

Abstract: This invention provides recombinant mycobacterium strains of pathogenic origin that have been attenuated by the inactivation of a gene coding for a metabolic protein, specifically a gene coding for a protein necessary for the biosynthesis of a purine or a pyrimidine base, and more precisely, the purC gene that codes for an enzyme of the metabolic pathway of purine biosynthesis. The recombinant mycobacterium of this invention have a reduced capacity to propagate in a mammalian host, but remain viable in the host for a period of time sufficient to induce an protective immune response against the natural pathogenic mycobacterium counterpart.

Abstract: The invention relates to a process of attaching an end of a nucleic acid on a surface by providing a solution having a pH that allows for specific attachment of an end of a nucleic acid to a surface. The surface, the solution, and the nucleic acid are contacted to attach the end of the nucleic acid to the surface.

Abstract: Disclosed herein is a method for treating a patient with a neurological disease by determining a patient's BCHE allele status.

Abstract: A variant of a LAV virus, designated LAVMAL and capable of causing AIDS. The cDNA and antigens of the LAVMAL virus can be used for the diagnosis of AIDS and pre-AIDS.

Abstract: The invention discloses a molecule or polypeptide composition characterized by the presence in its structure of one or more peptide sequences bearing all or part of one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of proteins resulting from the infectious activity of P. Falciparum in hepatic cells. Also disclosed is the use of these molecules in tests, and a kit for in vitro diagnosis of paludism from a biological sample from the individual in whom the disease is to be detected.

Abstract: Oligonucletodie sequences are disclosed specific to H. pylori urease and useful as DNA probes and primers in the detection of H. pylori infection in humans.

Abstract: The claimed invention is directed toward in vitro methods for the detection of human immunodeficiency virus type 2 (HIV-2) antibodies employing polypeptide fragments of HIV-2 Gag.

Abstract: A process for aligning a macromolecule (macromolecules) on the surface S of a support is characterized in that the triple line S/A/B (meniscus) resulting from the contact between a solvent A and the surface S and a medium B is caused to move on the said surface S, the said macromolecules having a part, especially an end, anchored on the surface S, the other part, especially the other end, being in solution in the solvent A. The subject of the present invention is also a process for detecting, measuring the intramolecular distance of, separating and/or assaying a macromolecule in a sample in which a process of alignment according to the invention is used.

Abstract: A method for detecting a predisposition to hepatocellular carcinoma (HCC) using a unique panel of primers for identifying genetic alterations that are linked to HCC, as well as kits for carrying out the methods, are disclosed.