Abstract: A suspension of the medicament brought to sufficiently fine particle size to be usable subsequently if necessary in injectable suspensions, is produced in the midst of a liquid in which it is itself insoluble and containing in the dissolved state one or several normally solid non-antigenic organic constituents. The solvent is then removed.

Abstract: The invention relates to nutritious materials containing proteins wherein said proteins are originated from osmosensitive microorganisms, i.e. microorganisms the cell walls of which are spontaneously broken when brought into contact with a medium of low osmotic pressure.

Abstract: The invention relates to a device and a method for carrying out simultaneously multiple analyses in a liquid medium. The device comprises a compartment for introducing liquid, communicating through a distribution channel with separate analysis compartments. Each analysis compartment is provided with valve-forming means, such as a ball, isolating the liquid contained in the analysis compartment from the liquid remaining in the distribution channel. The device is particularly suitable for microbiological analyses.

Abstract: The invention relates to a magnetic gel which is useful for immunoezymatic determinations.Said gel consisting, for example, of polyacrylamideagarose and magnetic particles, coupled with an antibody, can be used for rapid determinations of the antigens contained in a biological liquid, the presence of magnetic particles permitting rapid separation of the gel from the reaction medium by means of a magnetic field and considerably shortening the time required for determinations.

Abstract: The invention relates to a device and a method for carrying out simultaneously multiple analyses in a liquid medium. The device comprises a compartment for introducing liquid, communicating through a distribution channel with separate analysis compartments. Each analysis compartment is provided with valve-forming means, such as a ball, isolating the liquid contained in the analysis compartment from the liquid remaining in the distribution channel. The device is particularly suitable for microbiological analyses.

Abstract: Base medium for the constitution of culture media for microorganisms.It has a sufficient viscosity for strict aerobic microorganisms, even mobile, to be able to develop only at the surface or close to the latter, this viscosity however not exceeding that which would result in too great a decrease in fluidity, preventing sedimentation of microorganisms in this medium, under the effect of gravity.Application to the characterization or to the identification of microorganisms.

Abstract: The water is heated to convert it into steam; the steam is passed from a container into a superheating zone and then condensed in the form of purified water. The superheating zone contains at least in part, a packing of a material inert with respect to steam and impurities possibly present in the latter. The steam is superheated in said zone by means of supplementary heating to a temperature exceeding 300.degree. C., and reaching notably from 400.degree. to 700.degree. C., preferably from 500.degree. to 700.degree. C. Highly purified apyrogenic water freed from undesired organic substances, useful in research in physical chemistry, physics, biochemistry or molecular biology or in the medical field is, produced by this process.

Abstract: The photometer for automatic sample analysis comprises an optical bench emitting a measuring lightbeam, a series of transparent cells containing the samples for analysis and for sucessive presentation in the beam and result recording and processing means. A set of rectilinear presentation means each supporting a juxtaposed row of cells is arranged in parallel side by side in a magazine. Means for selecting and extracting each presentation means successively from the set of the latter are provided. A movable carriage supports the optical bench with means for moving said carriage at reading speed parallel to the row of cells selected such that the measuring beam of the bench sucessively traverses each cell of said row.

Abstract: A novel process of separating from an aqueous medium at least one protein or at least one morphologically organized unit by liquid exclusion chromatography on a solid support previously passivated by treatment with an aqueous solution of a non-proteinic polymer. In this process, the chromatographic support is submitted, prior to the chromatographic operation, to a second passivation consisting in contacting the support with an aqueous solution of a protein which has a molecular weight lower than that of the protein to be separated, and which is adapted to be adsorbed by said support. The support and/or the liquid to be treated are sterilized with antiseptic agent selected from the group constituted by the lower aliphatic halogenated hydrocarbons.

Abstract: A process for coupling biological substances by covalent bonds that involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. The process makes it possible, for example, to couple antibodies to enzymes for determining or detecting said antibodies.The process can be used for the determination of antitetanic antibodies in human serum.

Abstract: An immunostimulant from bacterial cells of Salmonella typhimurium or Listeria monocytogenes; it promotes non-specific resistance to pathogens which has no antigenic relationship to the immunostimulant.

Abstract: This invention relates to a method of preparing an immunological agent. It also concerns the product obtained and its application.The method is characterized by:contacting a parasiticidal drug with a previously defined total extract of antigens of the corresponding parasite in such a manner that the previously defined target antigens attach themselves to the drug,thereupon, possibly, effecting a removal of the target antigens from the said drug.

Abstract: The invention relates to novel processes and devices for the analysis of samples of very small volume.The process consists in taking definite amounts of reagents by capillarity on the end of fine rods, then recovering the amounts taken by centrifugation, the reagents being projected to the bottom of the same container. The device comprises elements for taking up, associated with a container able to be centrifuged.The process and the device are particularly useful for enzymatic micro-analyses.

Abstract: A multi-penetration vaccination apparatus comprising a mounting having on e side a manually engageable portion for the handling of the apparatus and on the other side one or more levels of supports adapted for removable press-fit of one extremity of concentric sleeves, the free extremity of the sleeves and the central support having a plurality of points for penetration into the skin of the subject. Vaccine is supplied to the points so as to penetrate into the skin along with such points. The vaccine can be contained in a reservoir formed at the bottom of a cover which is mounted on the outer-most of the sleeves to form a sealed enclosure for such vaccine, the points being immersed in the vaccine. Alternatively, the central support can be formed with a bore in which a vaccine capsule is inserted so as to supply vaccine to the points at the time of penetration thereof into the skin of the subject.

Abstract: The immunostimulant agent is extracted from splenic cells of animal origin from Ehrlich ascites cells or from bacteria, such as Bacillus subtilis or Saccharomyces cerevisiae. A suspension of these cells or of these bacteria is formed with a mixture of solvents containing a halogenated hydrocarbon and an alcohol. The insoluble fractions are separated, the liquid fraction evaporated under reduced pressure and at reduced temperature, and the solid residue taken up again in chloroform. The chloroform solution containing the abovementioned immunostimulant agent is recovered by filtration. A suspension in an injectable liquid vehicle of the immunostimulant agent is in the form of particles or micelles whose dimensions are sufficiently small for said suspension to be injectable in man or animal.

Abstract: An aqueous solution in a neutral medium of the tuberculoprotein C is subjected to the action of an ionized substance before carrying out three different separation processes which consist in bringing the tuberculoprotein C into solution in water in a proportion of 5% by weight and in neutralizing. The first process consists in adding the ionized substance in an alcohol medium and in carrying out ultracentrifugation for two hours at 40,000 g in order to obtain tuberculoproteins CA in the form of a supernatant liquid. The second process consists in adding a solution of the ionized substance, in carrying out ultrafiltration, concentration and precipitation with trichloroacetic acid in order to obtain the tuberculoprotein CB. The third process consists in adding a solution of the ionized substance then gel-filtering in order to eliminate the molecules having a molecular weight above 200,000 g and in precipitating with trichloroacetic acid in order to obtain a tuberculoprotein CC.

Abstract: A method and apparatus designed for the purpose of determining quickly and with high resolution the spatial distribution of radioactivity within an object emitting radioactive particles, especially those of low energy. A gas-filled position sensitive detector is used having an elongated electrode wire enclosed inside of and running the length of the detector. The object is placed inside the detector in close proximity to the wire. An electric circuit means is operably connected to the wire to determine the point along the wire at which an emitted particle is sensed. A two-or three-dimensional spatial distribution can be obtained by using a plurality of such wires.

Abstract: An improved aqueous gel of calcium phosphate, useful for preparation of adsorbed vaccines, prepared by contacting an antigen with an aqueous gel obtained by reacting an aqueous solution of dibasic sodium phosphate with an aqueous solution of calcium chloride, wherein the calcium chloride solution is poured as rapidly as possible, within less than 3 minutes, into said phosphate solution, in a proportion substantially equal to 1 mol PO.sub.4 HNa.sub.2 for 1 mol CaCl.sub.2, under stirring; the mixture thus obtained is still stirred while its pH is adjusted to a value very near 7, and the gel formed is subsequently decanted and washed. The gel is composed of calcium and phosphate ions in proportions such that the ratio Ca/P is 1.62 to 1.85, and exhibits a settling rate of 1 to 20 mm in 10 minutes at 20.degree. C when containing 0.07 atoms Ca per liter.