Abstract: The disclosure relates to the field of pharmaceutical technology, in particular, to a compound pharmaceutical composition for treating skin inflammatory diseases, which is characterized in that an active ingredient of the compound pharmaceutical of the disclosure is composed of tofacitinib and crisaborole, and the composition has a stronger therapeutic effect and a lower dosage with a significant synergistic therapeutic effect. The pharmaceutical composition of the disclosure can be used to treat skin inflammatory diseases.

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

Abstract: As a means for artificially inducing functional endosperm in a seed plant without fertilization, provided is a nucleic acid molecule that contains a base sequence encoding a polypeptide capable of inducing endosperm development, said nucleic acid molecule being to be transferred into the genome of the seed plant and expressed therein so as to induce endosperm development in the seed plant without fertilization.

Abstract: A method for constructing an assembled recyclable rectangular working well with preset detachable door openings comprises steps of: (I) designing according to functional requirements for a rectangular working well; (II) constructing by supporting piles; (III) installing prefabricated top beam; (IV) edge protection construction; (V) alternate construction of earthwork excavation, retaining slabs and internal support breast beams; (VI) installing the ladder entering the rectangular working well; (VII) rectangular working well back cover; (VIII) demolition of the detachable subsection support piles in the door part and completing the construction of the assembled recyclable rectangular working well in the preset detachable door hole; (IX) after the operation in the well is completed, during the backfilling process of the rectangular working well, gradually recovering the working well components such as the retaining slab, the internal support girder, the prefabricated crown beam and the supporting piles.

Abstract: An operation method of a first terminal performing sidelink communication may comprise receiving a first sidelink signal from a second terminal; transmitting a second sidelink signal to a third terminal; comparing feedback priorities for the first sidelink signal and the second sidelink signal in a specific period; and based on a result of comparing the feedback priorities, transmitting or receiving one sidelink feedback signal among a sidelink feedback signal for the first sidelink signal and a sidelink feedback signal for the second sidelink signal in the specific period.

Abstract: The present invention relates to: coralmycin A and B, which are novel compounds exhibiting antimicrobial activity, an isomer thereof, a derivative thereof or a pharmaceutically acceptable salt thereof; a microorganism of the genus Corallococcus producing the same; and an antimicrobial use thereof. The coralmycin A and B have very strong antimicrobial activity against antibiotic-resistant bacteria such as MRSA, QRSA, VRE, VISA, etc.; Acinetobacter baumannii, which is a multidrug-resistant microorganism; and also against gram-positive microorganisms and gram-negative microorganisms. Therefore, the present invention can be very useful for prevention, treatment and alleviation of various microbial infections, and thus can be widely applied to the medical supply, quasi-drug, food, and feed industries.

Abstract: Disclosed are devices and methods using the devices for collecting biological and other specimens or substances from surfaces being interrogated for such contamination. Particular device aspects comprise a handle, with a frame at one end receptive to insertion and removal of a sampling medium (collecting member) intended for wiping against a surface, with the sampling member being held in place by passive projections from the frame without the need for the use of glue or articulating or moving parts. The Frame and/or the collecting member may also comprise at least one attached or integral scraping member or surface for breaking biofilms and thus making the microbes or other substances more available to being sampled by the collecting member.

Abstract: A sample is imaged using light-sheet imaging. The light-sheet imaging includes generating light, forming one or more light sheets from the light at one or more positions within the sample along respective illumination directions that are parallel with an illumination axis, and recording images of fluorescence emitted along a detection direction from the sample due to the optical interaction between the one or more light sheets and the sample. One or more properties relating to the light-sheet imaging are measured; the one or more measured properties are analyzed; and one or more operating parameters associated with the light-sheet imaging are adjusted based on the analysis of the one or more measured properties.

Abstract: The invention relates to a double-sided drilling fixture for die-forged pistons and a double-sided drilling process thereof. It overcomes the defects of low efficiency and accuracy of the double-sided drilling operation for die-forged pistons in the prior art. The invention comprises a die-forged piston, a fixture base assembly, an upper load-resisting assembly and a lower expansion-resisting assembly. The upper load-resisting assembly is installed on the fixture base assembly and disposed above the die-forged piston. A fixation base, whose upper surface shape is the same as internal surface shape of the die-forged piston, is installed above the fixture base assembly. The die-forged piston is sleeved on the fixation base. The invention achieves simultaneous drilling on both sides of the two rear skirt surfaces of die-forged pistons and delivers quick clamping and automatic fixation, significantly reducing the difficulty in the assembly of drilling plate and workpiece and increasing the alignment accuracy.

Abstract: State estimation in an electric power system includes acquiring electrical measurements from the electric power system at a reporting rate of the electrical measurements, processing the electrical measurements into sequence data including positive sequence data, processing positive sequence data by an observable state estimator to generate a plurality of estimated states including a plurality of estimated observable states, parameters of the observable state estimator being updated by a first training module in a first time thread, processing the plurality of estimated states by an unobservable state estimator to generate a plurality of estimated unobservable states, parameters of the unobservable state estimator being updated by a second training module in a second time thread independent of the first time thread, and outputting a plurality of final estimated states generated by concatenating the plurality of estimated observable states and the plurality of estimated unobservable states.

Abstract: An electric pedal control device for an aircraft, the device comprising several pedal transmission assemblies, each of the pedal transmission assemblies comprising an electric motor, an elastic connector, a transmission mechanism, an angular displacement sensor, and a pedal, wherein the angular displacement sensor is configured to acquire rotational position information about the pedal; transmission mechanism revolute pairs of the transmission mechanisms in the pedal transmission assemblies are connected via a mechanical connecting rod mechanism to effect linkage; and a controller of the electric pedal control device is configured to receive the rotational position information, and to control, according to the rotational position information, the electric motors to dampen the elastic connectors.

Abstract: Operational events associated with a target physical device can be detected for mitigation by implementing some aspects described herein. For example, a system can apply a sliding window to received sensor measurements at successive time intervals to generate a set of data windows. The system can determine a set of eigenvectors associated with the set of data windows by performing principal component analysis on a set of data points in the set of data windows. The system can determine a set of angle changes between pairs of eigenvectors. The system can generate a measurement profile by executing an integral transform on the set of angle changes. One or more trained machine-learning models are configured to detect an operational event associated with the target physical device based on the measurement profile and generate an output indicating the operational event.

Abstract: A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint-corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

Abstract: The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.

Abstract: Computer implemented methods and computerized apparatus for posture, dimension and shape measurements of at least one 3D object in a scanned 3D scene are provided. The method comprises receiving a point cloud and performs 3D geometric feature extraction. In one embodiment, the 3D geometric feature extraction is based on a 3D hybrid voxel-point structure, which comprises a hybrid voxel-point based normal estimation, a hybrid voxel-point based plane segmentation, a voxel-based geometric filtering, a voxel-based edge detection and a hybrid voxel-point based line extraction. Through the process of 3D geometric feature extraction, the geometric features are then passed to the geometric-based dimension and shape measurements for various applications. After 3D geometric feature extraction, a further process of feature-based object alignment is performed.

Abstract: The present invention provides a recombinant exosome and uses thereof. More particularly, the present invention provides a recombinant exosome wherein a phagocytosis promoting protein is presented on the surface thereof.

Abstract: A method and an apparatus for removing a motion artifact of a radar are provided. The method includes: obtaining a radar signal for a target to be measured by the radar; measuring posture of the radar; estimating a motion artifact caused by movement of the radar based on a vertical angle, a horizontal angle based on the posture of the radar, and displacement; and correcting the radar signal according to the motion artifact. The posture of the radar includes the vertical angle at which the radar signal is radiated in a vertical direction about a central axis, the horizontal angle at which the radar signal is radiated in a horizontal direction about the central axis, and the displacement of the radar according to the movement of the radar.

Abstract: The invention relate to SNP and InDel markers associated with a cucumber male sterility gene and a screening method thereof. The cucumber male sterility gene is acquired by screening according to the markers. Specifically, the screening method includes following steps: (1) configuring groups; (2) building a library and sequencing; (3) adopting bulked segregation analysis (BSA); and (4) performing competitive allele specificity PCR (KASP), finely mapping a sterility gene, and acquiring SNP or InDel locus in close linkage with sterility character. The acquiring of the male sterility gene provides an effective tool for quick identification of cucumber male sterility plants and efficient production of cucumber hybrid species.

Abstract: Embodiments relate to a wearable robot hand device removable from a hand structure, including: at least one of first and second exglove modules as one or more exglove modules attached to the hand structure, the first exglove module being attached to a surface of the hand structure and the second exglove module being attached onto a exglove of the first exglove module.

Abstract: The present invention generally relates to a microjet array for use as a thermal management system for a heat generating device, such as an RF device. The microjet array is formed in a jet plate, which is attached directly to the substrate containing the heat generating device. Additional enhancing features are used to further improve the heat transfer coefficient above that inherently achieved by the array. Some of these enhancements may also have other functions, such as adding mechanical structure, electrical connectivity or pathways for waveguides. This technology enables higher duty cycles, higher power levels, increased component lifetime, and/or improved SWaP for RF devices operating in airborne, naval (surface and undersea), ground, and space environments. This technology serves as a replacement for existing RF device thermal management solutions, such as high-SWaP finned heat sinks and cold plates.