Abstract: Provided is a method of a generating a skyrmion. The method includes a step of preparing a magnetic multilayer system and a step of generating a skyrmion at a temperature of 400° C. or higher by adjusting the magnetic anisotropy value and the magnetization value of the magnetic multilayer system.
Type:
Application
Filed:
November 20, 2020
Publication date:
January 20, 2022
Applicant:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Jun Woo CHOI, Hee Young KWON, Byoung Chul MIN, Suk Hee HAN, Hye Jung CHANG
Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
Type:
Application
Filed:
July 28, 2021
Publication date:
January 20, 2022
Applicants:
President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
Inventors:
Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
Abstract: A stable crystal of a salt of N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide may have desirable properties for a pharmaceutical drug substance, and more specifically N—[(R)-1-{(S)-2-hydroxy-2-phenylpropylamino}propan-2-yl]isoquinoline-6-sulfonamide dihydrochloride anhydride. A crystal of the anhydride may have characteristic peaks at 2? angles of 6.8±0.1°, 10.0±0.10, 12.7±0.10, 14.6±0.1°, 14.8±0.1°, 16.2±0.1°, 17.4±0.1°, 17.8±0.1°, 19.5±0.1°, 20.0±0.1°, 21.6±0.1°, 24.7±0.10, 25.5±0.1°, 25.8±0.1°, 29.8-0.1°, 39.5-0.1°, and/or 44.9±0.1° in powder X-ray diffraction spectrum.
Type:
Application
Filed:
December 16, 2019
Publication date:
January 20, 2022
Applicant:
D. WESTERN THERAPEUTICS INSTITUTE, INC.
Abstract: The invention relates to a carburizing bearing steel and a preparation method thereof. The carburizing bearing steel of the invention comprises: 0.18˜0.24 wt % of C, 0.4˜0.6 wt % of Cr, 0.20˜0.40 wt % of Si, 0.40˜0.70 wt % of Mn, 1.6˜2.2 wt % of Ni, 0.15˜0.35 wt % of Mo, 0.001˜0.01 wt % of S, 0.001˜0.015 wt % of P, 0˜0.20 wt % of Nb, 0˜0.20 wt % of V and the remaining is iron, wherein the contents of Nb and V are not 0 at the same time. In the invention, an appropriate amount of Nb and V is added in combination with other elements so as to refine the grain size, inhibit the generation of large granular carbides in the steel during carburization and improve the uniformity of the microstructure of steel materials, thus further enhancing the contact fatigue life of the carburizing bearing steel.
Type:
Application
Filed:
February 26, 2021
Publication date:
January 20, 2022
Applicant:
CENTRAL IRON & STEEL RESEARCH INSTITUTE
Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
Type:
Application
Filed:
February 25, 2021
Publication date:
January 20, 2022
Applicants:
Acceleron Pharma Inc., Ludwig Institute for Cancer Research Ltd.
Inventors:
Asya Grinberg, John Knopf, Robert S. Pearsall, Ravindra Kumar, Jasbir Seehra, Kristian Pietras
Abstract: A preparation method of a carbon-based selenium-enriched fertilizer for rice is disclosed. The preparation method of the carbon-based selenium-enriched fertilizer for rice includes planting a selenium-enriched plant material; collecting and concentrating a selenium-enriched extracting solution; preparing modified selenium-enriched biomass charcoal from the tertiary residues; and preparing the carbon-based selenium-enriched fertilizer. In the present disclosure, active organic selenium enriched and generated by plant is compounded with the biomass charcoal, so that the fixation and loss of the active selenium in soil are reduced, and the utilization efficiency of the selenium fertilizer is improved.
Abstract: An aspect of the disclosure includes a method for supporting voice service continuity, including: establishing a connection between an edge application server and a core network; and providing an IMS function to transmit an IMS information element to the core network by the edge application server during a handover procedure related to an IMS voice service.
Type:
Application
Filed:
December 10, 2020
Publication date:
January 20, 2022
Applicant:
Industrial Technology Research Institute
Abstract: The present invention provides a TiAl-based alloy, including: Al: 41 to 43 at %; Fe: 0 to 2.5 at %; Ni: 0 to 2.5 at %; Mo: 0 to 2.0 at %; W: 0 to 2.0 at %; Cr: 0 to 4.5 at %; Mn: 0 to 5.5 at %; V: 0 to 10 at %; Nb: 0 to 10 at %; C: 0.3 to 0.7 at %; and a remainder consisting of Ti and inevitable impurities, in which an alloy element parameter “P=(41.5?Al)/3+Fe+Ni+Mo+W+0.5 Cr+0.4 Mn+0.2 V+0.2 Nb—C” is in a composition range of 1.1 to 1.9, and the TiAl-based alloy has a microstructure consisting of a ? phase of 5 to 30 area %, a ? phase of 0.5 to 5 area %, and a lamellar structure occupying a remaining part.
Type:
Application
Filed:
December 13, 2019
Publication date:
January 20, 2022
Applicant:
National Institute for Materials Science
Abstract: Disclosed is an antioxidant for a polymer electrolyte membrane of a fuel cell including cerium hydrogen phosphate (CeHPO4). The presence of cerium hydrogen phosphate in the antioxidant enhances the dissolution stability of cerium and improves the ability to capture water, leading to an increase in proton conductivity. In addition, the cerium hydrogen phosphate has a crystal structure composed of smaller cerium particles. This crystal structure greatly improves the ability of the antioxidant to prevent oxidation of the electrolyte membrane. Also disclosed are an electrolyte membrane including the antioxidant, a fuel cell including the electrolyte membrane, a method for preparing the antioxidant, a method for producing the electrolyte membrane, and a method for fabricating the fuel cell.
Type:
Application
Filed:
September 8, 2020
Publication date:
January 20, 2022
Applicant:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
So Young LEE, Seung Ju LEE, Hyun Seo PARK, Jin Young KIM, Sung Jong YOO, Jong Hyun JANG, Hyoung-Juhn KIM, Hee-Young PARK
Abstract: Disclosed is an image segmentation method including receiving an image to be segmented and segmenting the received image by using a neural network learned through a Mumford-Shah function-based loss function.
Type:
Application
Filed:
July 15, 2021
Publication date:
January 20, 2022
Applicant:
Korea Advanced Institute of Science and Technology
Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.
Type:
Application
Filed:
October 29, 2019
Publication date:
January 20, 2022
Applicant:
Peter MacCallum Cancer Institute
Inventors:
Michael Kershaw, Clare Slaney, Bianca Von Scheidt
Abstract: Disclosed herein are genetically modified herpesviruses for the treatment of cancer. Also provided are methods of treating cancer using genetically modified herpesviruses.
Abstract: The present disclosure seeks to perform real-time video streaming on a mobile device toward maintaining user QoE even under bandwidth constraints while being acceptable to the lightweight computing capacity of the mobile device. To this end, the embodiments apply deep neural network-based SR to a small number of pre-selected video frames and utilize the video frames to which SR is applied to enhance the resolution of the remaining frames, wherein the pre-selected frames are chosen for SR within a preset quality margin. Additionally, the present disclosure provides an apparatus and a method for SR acceleration for real-time video streaming under the lightweight computing capacity and video-specific constraints of a mobile device, which allow a server to deliver multiple options on a deep neural network and a cache profile including SR application information and enable the mobile device to select an option suitable for its computing capacity.
Type:
Application
Filed:
February 12, 2021
Publication date:
January 20, 2022
Applicant:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Dong Su HAN, Hyun Ho YEO, Young Mok JUNG, Chan Ju CHONG
Abstract: Disclosed herein are an apparatus and method for recommending federated learning based on recognition model tendency analysis. The method for recommending federated learning based on recognition model tendency analysis in a server device may include analyzing the tendency of a recognition model trained using reinforcement learning by each of multiple user terminals, grouping the multiple user terminals according to the tendency of the recognition model, and transmitting federated-learning group information including information about other user terminals grouped together with at least one of the multiple user terminals.
Type:
Application
Filed:
December 2, 2020
Publication date:
January 20, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Jin-Hyeok JANG, Do-Hyung KIM, Jae-Hong KIM, Jae-Yeon LEE, Min-Su JANG, Jeong-Dan CHOI
Abstract: The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2?-fluoro-[1,1?-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).
Type:
Application
Filed:
July 22, 2021
Publication date:
January 20, 2022
Applicants:
THE BROAD INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
David B. Sykes, David Scadden, Timothy A. Lewis, Andreas Janzer, Hanna Meyer, Detlef Stöckigt
Abstract: Systems and methods for automatically generating solver code for a nonlinear model predictive controller are disclosed. In one embodiment, a method of automatically generating solver code for a nonlinear model predictive control solver includes receiving an optimal control problem code, wherein the optimal control problem code represents an optimal control problem comprising a cost function, one or more constraints, and a continuous time model representing dynamics of a system. The method further includes receiving a discretization method preference, a linearization point preference, and a parameter specification, and encoding the optimal control problem into an optimization problem by discretizing the optimal control problem according to the discretization method preference, and linearizing the optimal control problem according to the linearization point preference. The method further includes generating the solver code from the optimization problem.
Type:
Application
Filed:
July 17, 2020
Publication date:
January 20, 2022
Applicant:
Toyota Research Institute, Inc.
Inventors:
Sarah Koehler, Soonho Kong, Frank N. Permenter, Kevin Zaseck, Avinash Balachandran
Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
Type:
Application
Filed:
July 26, 2021
Publication date:
January 20, 2022
Applicants:
HESPERIX SA, THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Alexander Gabibovich Gabibov, Richard A. Lerner, Alexey Anatolievich Belogurov, Jia Xie
Abstract: A multi junction laminated laser photovoltaic cell includes a cell unit laminated body and upper and lower electrodes electrically connected with the bottom and top of the cell unit laminated body, respectively, wherein the cell unit laminated body includes more than 6 laminated PN-junction subcells, adjacent two subcells are connected in series via tunnel junctions, wherein each PN-junction subcell uses a semiconductor single crystal material with a specific band gap as the absorption layer, the multiple subcells at least have two different band gaps, and the band gaps of the subcells are arranged in such an order that they decrease successively from the light incidence side to other side of the photovoltaic cell.
Type:
Application
Filed:
June 21, 2019
Publication date:
January 20, 2022
Applicant:
SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS (SINANO), CHINESE ACADEMY OF SCIENCES
Abstract: A decision engine includes: a genetic algorithm framework including a knowledge base of standard configurations, a candidate selector generator and a selector to select a candidate configuration from a plurality of preferred standard configurations in response to the candidate selector generator; a parallelized reasoning framework including an attack surface reasoning algorithm module to compute the security and cost tradeoffs of an attack surface associated with each candidate configuration; and a user interface framework including a web service engine where users can interact and provide feedback on direction of an evolution used in a genetic algorithm search for evolving defenses.
Type:
Application
Filed:
July 14, 2021
Publication date:
January 20, 2022
Applicants:
Raytheon BBN Technologies Corp., Florida Institute of Technology, Inc.
Inventors:
Thomas C. Eskridge, Marco M. Carvalho, Brett Benyo, Michael Atighetchi, Fusun Yaman