Abstract: The present invention relates to an image sensor comprising a microlens array, and to a manufacturing method thereof. The method of the present invention includes gradually increasing the aluminum composition ratio of a compound semiconductor as the latter gradually gets farther from a substrate, to enable a microlens-forming layer to grow, and making the oxidation rate of the region adjacent to the substrate slower and the oxidation rate of the region farther from the substrate faster, making the interface between the oxidized region and the unoxidized region into a lens shape after the completion of oxidation. The thus-made lens is integrated into an image sensor. The present invention reduces costs for manufacturing image sensors in which a microlens is integrated, increases the signal-to-noise ratio and resolution of the image sensor, and achieves improved sensitivity.

Abstract: The disclosure relates to Compounds of Formula (1) : and pharmaceutically acceptable salts thereof wherein Z1, Z2, Z3, Xa, Xb, Xc, Y, X2, and X4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof, and methods to treat or prevent a condition, such as cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof.

Abstract: Provided are a single-stranded nucleic acid aptamer specifically binding to E. coli and a method for detecting E. coli using the same. The method, kits or sensors of the present disclosure enable E. coli to be specifically detected among microorganisms existing in a water system, but also be applied in fields such as food sanitation or medical diagnosis.

Abstract: Technologies are presented for power optimization of datacenter networks in a hierarchical perspective. In some examples, a two-level power optimization model may be established to reduce the power consumption of datacenter networks by switching off network switches and links while still guaranteeing full connectivity and maximum link utilization. The model may be implemented by solving a capacitated constraint multi-commodity flow (CMCF) problem employing simple heuristic techniques. A power status of network switches may be determined according to a network traffic matrix and the CMCF optimization determined at core-level and at pod-level. A complementary process to provision whole network connectivity and to meet quality of service (QoS) goals may also be performed.

Abstract: The invention relates to a reactor system, comprising a heat-exchange unit and a reaction unit that are assembled together into a structure. The heat-exchange unit has a plurality of plate or corrugated-plate heat exchangers, and is formed so as to attachable/detachable to/from the reaction unit and insertable into the latter. Accordingly, a catalyst may be attached to a heat-transfer surface of a heat exchanger by a washcoat method or the like, thus maximizing heat-transfer efficiency and enabling the easy removal or reattachment of the catalyst when the enabling the easy removal or reattachment of the catalyst at the end of the lifespan of the catalyst.

Abstract: A method of preparing (S)-2-amino-5-methoxytetralin hydrochloride[(S)-2-amino-5-methoxyl-1,2,3,4-tetrahydronaphthalene hydrochloride], comprising the steps of: (1) producing a compound (I) by addition-elimination reaction of 5-methoxy-2-tetralone and R-(+)-a-phenylethylamine; (2) producing a compound (II) by reduction reaction of the compound (I) with a reducing agent; and (3) producing a compound (II) hydrochloride by reacting the compound (II) with a salt-forming agent, then carrying out reduction reaction with a palladium-carbon catalyst to produce (S)-2-amino-5-methoxytetralin hydrochloride. The method can significantly increase the yield of (S)-2-amino-5-methoxytetralin hydrochloride with short synthetic path, low preparation cost and less pollution, which is environmentally friendly and is suitable for medical industrialized production. The structural formulae of the compound (I) and the compound (II) are: resepectively.

Abstract: A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer or a water-soluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer. The composition also includes a second water-swellable, water-insoluble polymer that provides for a phase separating film forming composition. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening, and removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Abstract: The condensing apparatus 71 includes: a compressor 10 which has a compression part 20 compressing a working fluid; a condenser 13 which condenses the working fluid compressed by the compression part 20; and a spray mechanism 81 including a nozzle 82 which sprays a cooling fluid into a fluid passage 91 to cool the working fluid flowing through the fluid passage 91 between a discharge opening CS2 of the compression part 20 and an inlet 13a of the condenser 13.

Abstract: A nanostructured anode of solid oxide fuel cell with high stability and high efficiency and a method for manufacturing the same are revealed. This anode comprising a porous permeable metal substrate, a diffusion barrier layer and a nano-composite film is formed by atmospheric plasma spray. The nano-composite film includes a plurality of metal nanoparticles, a plurality of metal oxide nanoparticles, and a plurality of gas pores that are connected to form nano gas channels. The metal nanoparticles are connected to form a 3-dimensional network that conducts electrons, while the metal oxide nanoparticles are connected to form a 3-dimensional network that conducts oxygen ions. The network formed by metal oxide nanoparticles has certain strength to separate metal nanoparticles and prevent aggregation or agglomeration of the metal nanoparticles. Thus this anode can be applied to a solid oxide fuel cell operating in the intermediate temperatures (600˜800° C.) with high stability and high efficiency.

Abstract: The invention provides methods and apparatus for stable generation and delivery of solid nano-particles in aerosols that simultaneously maintain high nano-particle concentration, and which avoid coagulation and agglomeration of the nano-particles. The apparatus includes a Collison nebulizer is in communication with a plenum. The Collison nebulizer includes a port for introducing a helium gas flow into the Collison nebulizer. The plenum includes component(s) for providing flow of uniform axially symmetrical dry air around the nano-particles entrained in the helium gas flow in the plenum. Preferably, the plenum includes an uniformity screen and a reduction in the plenum circumference downstream from the uniformity screen. In some preferred aspects, the invention provides methods of introducing nanoparticles into the lungs of test animals. The present invention allows more than 0.5 mass % of the nano-particles to be deposited in an animal's lungs.

Abstract: Re-usable ceramic magic angle spinning (MAS) NMR rotors constructed of high-mechanic strength ceramics are detailed that include a sample compartment that maintains high pressures up to at least about 200 atmospheres (atm) and high temperatures up to about least about 300° C. during operation. The rotor designs minimize pressure losses stemming from penetration over an extended period of time. The present invention makes possible a variety of in-situ high pressure, high temperature MAS NMR experiments not previously achieved in the prior art.

Abstract: An inclined PET device is provided in which the cut plane of a detector ring upon which a plurality of PET detectors are disposed is inclined so that it does not intersect perpendicularly with the long axis of a bed that carries a subject to be examined and in which an open space that passes through the bed in a direction perpendicular to the long axis thereof is formed, in order to enable access to the subject to be examined. The PET detectors are disposed and stacked in a direction parallel to the long axis of the bed. Thereby, the number of PET detectors is reduced and device cost is reduced, while the detector ring as well as the device can be miniaturized. At the same time, the open space that passes through the bed in a direction perpendicular to the long axis can be preserved.

Abstract: An anesthetic and therapeutic composition for use in aquaculture includes an essential oil preferably thyme oil that is mixed with ethanol in an amount of one part essential oil preferably thyme oil to five parts ethanol. The essential oil ethanol mixture is then dispersed in water preferably seawater to provide 10 to 60 ppm of essential oil. The oxygen in the composition is between about 5.00 and 6.5 mg/L and in a preferred embodiment is enhanced by an agar stabilizer. The invention also contemplates treating fish such as sheam and sobaity and shrimp and seahorse to reduce stress and maintain a temperature of about 20°-27° C.

Abstract: There is provided a combustion apparatus for reducing generation of NOx by securing more time for mixing fuel and air and uniformly mixing fuel and air. The combustion apparatus includes: a modifying part configured in the center to modify supplied hydrocarbon-based fuel and air and discharge high temperature modified gas including hydrogen to an outlet; and a supply part configured at an outer side of the outlet to jet fuel and air to one side of the modified gas discharged from the modifying part to form a flame at a position spaced apart by a pre-set distance from the outlet.

Abstract: A method for forming graphene includes providing a substrate and subjecting the substrate to a reduced pressure environment. The method also includes providing a carrier gas and a carbon source and exposing at least a portion of the substrate to the carrier gas and the carbon source. The method further includes performing a surface treatment process on the at least a portion of the substrate and converting a portion of the carbon source to graphene disposed on the at least a portion of the substrate.

Abstract: The present invention provides a pharmaceutical composition comprising a protein having ?-galactosidase activity for treating Fabry disease, which causes no allergic side effect, which is highly stable in blood (plasma) and which can readily be taken up by a cell of an affected organ. The pharmaceutical composition for treating Fabry disease of the invention comprises, for example, a protein which acquires an ?-galactosidase activity through alteration of the structure of the active site of wild-type human ?-N-acetylgalactosaminidase.

Abstract: A retinal prosthesis including a microelectrode array, a polymer layer and a layer of bioactive molecule is provided. The microelectrode includes a plurality of microelectrodes. The polymer layer partly encapsulates the microelectrode array, in which the microelectrodes are exposed on the surface of the polymer layer. The layer of bioactive molecules is immobilized on the surface of the microelectrode.

Abstract: Provided is a method and system for browsing Internet of Things (IoT) so as to browse resource-limited things with rich UI. The method includes; at a user terminal, recognizing tag information attached to an intelligent thing and confirming an address of a things domain corresponding to the tag information via a dynamic domain name system (DDNS) server; accessing the intelligent thing based on the address of the things domain and acquiring a default web page; at the user terminal, accessing a fixed content provision server and receiving fixed content of the default web page; and, at the user terminal, acquiring dynamic content to be displayed on a web page via the intelligent thing.

Abstract: Methods and devices for the analysis of global positioning system (GPS) data are described. The methods and devices comprise several metrics to analyse GPS data, such as tracking coverage, signal to noise ratio, multipath noise, positioning and receiver clock, troposphere and data noise.

Abstract: Methods and a computer program product for deriving temperature information with respect to surfaces within a scene that is imaged radiometrically. A time sequence of radiometric data is acquired in frames viewed from distinct angles. A three-dimensional structure of the scene is derived, allowing viewing angles and distances to the imaged surfaces to be inferred. Normalized surface areas of the imaged surfaces are calculated based on the inferred viewing angles and emissivities of the imaged surfaces are corrected accordingly. Corrections also account for background radiation impinging on the imaged surfaces. The radiometric data are converted to a perceptible temperature map of the imaged surfaces.