Abstract: Provided is a composition for the prevention or treatment of Hutchinson-Gilford Progeria syndrome (HGPS) using gene editing, which contains sgRNA that hybridizes to mRNA encoding progerin, which causes HGPS, and a gene encoding Cas13 protein acting on the same. When introduced into the cell of a subject to be treated and only the mRNA encoding progerin is selectively cut. There is no need for co-prescribing with other therapies and fewer side effects occur than traditional farnesyltransferase inhibitors (FTIs). The efficiency is higher than when treated using homologous recombination (HR) at the DNA level, treatment using composition can be made reversibly, and the composition can be applied specifically compared to targeted treatment using RNAi (RNA interference), and has fewer side effects. Compared to treatment using CRISPR/Cas9, which directly acts on DNA and produces irreversible results, treatment using composition is reversible and selectively cut only mRNA encoding progerin, thereby ensuring safety.

Abstract: Provided are an amorphous boron nitride film, and a semiconductor device, a field effect transistor and an image sensor which include the same, and a method of manufacturing the amorphous boron nitride film. The amorphous boron nitride film includes a carbon atom-doped amorphous boron nitride compound, wherein an sp2 BN bonding structure and an sp3 BN bonding structure are included in the boron nitride film, an sp2/sp3 conjugated —C?C—C?C— dopant structure being distributed in 60% or less of the entire amorphous film.

Abstract: Disclosed herein is a method of decoding an image. The method includes determining a prediction mode of a current block as a merge mode with motion vector difference (MMVD), deriving a merge candidate list of the current block, deriving a motion vector predictor of the current block using the merge candidate list, deriving a motion vector difference of the current block, and deriving a motion vector of the current block using the motion vector predictor and the motion vector difference. Only some of candidates in the merge candidate list are used to derive the motion vector predictor.

Abstract: An analog-to-digital converter includes: a sample/hold circuit, which samples an analog signal, and outputs a first voltage; a digital-to-analog conversion circuit, which converts a digital signal to output a second voltage; an amplifier, which amplifies the first voltage and the second voltage; a noise shaping filter, which integrates a residual voltage corresponding to a difference between the amplified first voltage and the amplified second voltage, and generates a first integration voltage and a second integration voltage; a comparator, which compares a sum of the amplified first voltage, the first integration voltage, and the second integration voltage with the amplified second voltage; and a SAR logic, which outputs the digital signal according to a comparison result of the comparator, and controls the digital-to-analog conversion circuit.

Abstract: A method of manufacturing copolymer includes mixing and reacting a polyester, an aliphatic polyol or an aliphatic polyol oligomer, and a first catalyst in a first region of a screw to form a polyester polyol, and side-feeding a lactone or a lactam to a second region of the screw to copolymerize the lactone or a lactam and the polyester polyol to form a copolymer, wherein the first region and the second region are continuous connecting regions.

Abstract: An endoscopic system may include an endoscope including a handle and an elongate shaft extending distally therefrom. The handle may include a non-motorized and non-ratcheting actuation mechanism configured to articulate a distal tip portion of the elongate shaft. The distal tip portion may be articulatable in response to a manually applied force exerted upon the actuation mechanism. Removal of the manually applied force may lock the distal tip portion in its then-current configuration. The non-motorized and non-ratcheting actuation mechanism may include a clutch mechanism actuatable in response to an electrical signal generated in response to sensing a user-applied force to the actuating mechanism by a strain gauge.

Abstract: A modular radio frequency (RF) device includes N base units, each including a differential segmented array (DSA) tile with a support board and a two-dimensional (2D) array of electrically conductive tapered projections disposed on the support board. Neighboring pairs of the electrically conductive tapered projections form RF pixels. The N DSA tiles are arranged to form an RF aperture. The N base units are programmed to switch the RF aperture between a first operating mode and a second operating mode. In the first operating mode, the N base units are operated as at least two independent subsets with each subset operating as an RF transmitter or receiver independently of the other subsets. In the second operating mode all N base units coherently combine as a single phased array RF transmitter or receiver.

Abstract: The present invention provides a composite static rotary table and a method for protecting a composite static rotary table. The composite static rotary table comprises: a housing body provided with a mounting space; a rotary table body driven by a connecting mandrel to rotate; a base, the connecting mandrel being arranged through the base; an air stopping film arranged between the rotary table body and the base; and an auxiliary supporting assembly fixedly arranged in the mounting space and configured for assisting the rotary table body to be levitated relative to the base. The present invention is intended to solve the problem of ensuring the stable non-contact rotation of the rotary body of the rotary table relative to the base, while improving the bearing capacity of the rotary table.

Abstract: An apparatus useful for creating and measuring states of an entangled system, comprising a pair of interacting multi-level systems, each of systems comprising a state |g>, a state |r>, and state |r*>. One or more first electromagnetic fields excite a first transition between the ground state |g> and the state |r> to create an entangled system. One or more second electromagnetic fields are tuned between the state |r> and the intermediate state |r*> so that any population of the systems in |r*> are dark to a subsequent detection of a population in the systems in |g>, providing a means to distinguish the entangled system in the state |g> and the entangled system in the state |r>. In one or more examples, the systems comprise neutral Rydberg atoms.

Abstract: A vision-and-laser-fused 2.5D map building method includes: calculating inter-image frame transformation according to an RGB-D image sequence to establish a visual front-end odometer; taking a visual front-end initial estimation as an initial value of scanning matching, and performing laser front-end coarse-grained and fine-grained searches; performing loop closure detection, and performing back-end global optimization on a 2.5D map according to a detected closed loop; and performing incremental update on visual feature dimensions of the 2.5D map, and performing occupation probability update on grid dimensions. The 2.5D map is built using a method of fusing a laser grid and visual features, and compared with a pure laser map and a pure visual map, richness of dimensions is improved, and completeness of information expression is improved; the 2.5D map building method is not influenced by single sensor failure, and can still stably work in a scenario of sensor degradation.

Abstract: A positioning method using images and radio waves may include: estimating a distance and an angle from the positioning reference node to a positioning target terminal; identifying an obstacle or reflective object in a vicinity of the positioning target terminal or on a path between the positioning target terminal and the positioning reference node by using image information on the positioning target terminal at a position estimated by the distance and the angle; estimating an incident angle or a reflection angle of a radio wave signal reflected by the reflective object identified based on the image information; and estimating a position of the positioning target terminal based on the reflection angle and the distance.

Abstract: The present invention discloses an enhanced, self-healable or recoverable and recyclable 3D printed article and a preparation method and use thereof. By introducing a functional monomer into a 3D printing system, a self-healable or recoverable 3D printed article is prepared or the interface strength of the 3D printed article is enhanced; or by using at least one monofunctional thermoplastic photosensitive resin monomer as one of 3D printing raw materials, a recyclable 3D printed article is prepared.

Abstract: The disclosure discloses a stress gradient high-efficiency non-destructive detection system based on frequency domain calculation of broadband swept frequency signals, and a detection method thereof. The detection method includes: step 1: calibrating an LCR wave velocity of an object to be measured; step 2: calculating a starting frequency and a cut-off frequency of broadband swept frequency signals based on the LCR wave velocity of the object to be measured in the step 1 and a stress gradient measuring range in a depth direction of the object to be measured; step 3: converting phase delay to time delay information based on the phase delay of the starting frequency and the cut-off frequency in the step 2; and step 4: determining stresses of depths corresponding to different frequency components based on the time delay information in the step 3 to finally realize layer-by-layer scanning of stresses at different depths of the measured object.

Abstract: A method of manufacturing a holographic pattern-expressing organogel, by using a dithering mask, according to an aspect of the present disclosure includes: preparing a dithering mask including white pixels and black pixels arranged in periodic patterns; photocuring a polymer by passing an ultraviolet ray through the dithering mask; passing a first solvent through the cured polymer; and passing a second solvent through the cured polymer through which the first solvent is passed.

Abstract: Provided are a molecular sieve catalyst, a preparation method therefor, an application thereof. The molecular sieve catalyst contains a modified Na-MOR molecular sieve, and the modification comprises: organic ammonium salt exchange, dealumination treatment, and ammonium ion exchange. The catalyst obtained by the method is used in dimethyl ether for one-step production of methyl acetate. The catalyst has high activity and stable performance, and the needs of industrial production can be satisfied.

Abstract: The present application provides a compound eye camera device comprising a plurality of ommatidia arranged in a column or a row, and each of the ommatidia comprises an optical element and corresponding photosensitive units; each of the ommatidium columns corresponds to at least one ommatidium-column visual plane, the at least one ommatidium-column visual plane passing through the optical center of each ommatidium in the ommatidium column and a position near the center of at least one photosensitive unit of each ommatidium; each photosensitive unit intersects at least one ommatidium-column visual plane, and sight line of each photosensitive unit passes through the center of the photosensitive unit and the optical center of the ommatidium where the photosensitive unit is located; and a processor is configured to generate images based on information received by the photosensitive units, and to process the images to obtain information regarding the photographed object.

Abstract: A video signal decoding device comprises a processor, wherein: the processor decodes a sequence parameter set (SPS) raw byte sequence payload (RBSP) syntax included in a bitstream of a video signal, and decodes the bitstream on the basis of the decoding result of the SPS RBSP syntax; the SPS RBSP syntax includes a first syntax element related to the number of one or more sub-pictures configuring one picture, and a second syntax element indicating whether to process a boundary of the one or more sub-pictures as a boundary of the one picture on the basis of the first syntax element; and the second syntax element is parsed only when the number of the one or more sub-pictures is two or more.

Abstract: The present invention provides biomarker and biomarker panels useful for diagnostic methods evaluating liver disease status in a subject, monitoring liver disease, distinguishing between liver diseases, treating subjects evaluated by diagnostic methods of the invention, providing diagnostic tests for evaluating liver disease status in a subject, and kits there for.

Abstract: A liquid-phase reactor has an outer cylinder and an inner cylinder disposed along an axial direction of the reactor. The outer cylinder has a top head, a straight cylinder section and a bottom head. An annular space is formed between the inner cylinder and the outer cylinder. A top end of the inner cylinder is open and is in communication with the annular space. The inner cylinder has an upper cylinder and a lower cylinder sequentially from top to bottom. The upper cylinder is positioned in the straight cylinder section, with its cross-sectional area being gradually reduced from top to bottom. The lower cylinder is positioned in the bottom head, with its cross-sectional area being gradually increased from top to bottom. An inorganic membrane tube extending along the axial direction of the reactor is provided in the lower cylinder so that a shell-and-tube structure is formed.

Abstract: A prestressed fish-belly reaction frame, a pile foundation bearing capacity detection device and application thereof, which includes: a core junction; a reaction beam including a plurality of beam units symmetrically arranged around the core junction with the core junction as a center, each beam unit has a first end and a second end, the first end is connected and fixed to the core junction, and the second end is connected and fixed to a pile top of an anchor pile when the pile foundation bearing capacity is detected; a prestressed assembly including a plurality of prestressed tendons, each prestressed tendon passes through an upper end of the core junction, a first end of each prestressed tendon is connected and fixed to the second end of one beam unit, a second end thereof is connected and fixed to the second end of the symmetrical beam unit.