Patents Assigned to INSTITUTE
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Patent number: 9897587Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: GrantFiled: October 24, 2016Date of Patent: February 20, 2018Assignee: California Institute of TechnologyInventors: Periklis Pantazis, Ye Pu, Demetri Psaltis, John H. Hong, Scott E. Fraser
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Patent number: 9897611Abstract: Disclosed is a molecular library comprising a group of a plurality of molecules, wherein each member of the library is a polypeptide having a randomized sequence moiety and a microprotein moiety. The microprotein is a protein comprising an amino acid sequence of 30 or less amino acid residues having the ability to form a particular conformation by spontaneous folding in a solution and is, for example, chignolin comprising the amino acid sequence represented by SEQ ID NO: 1. Also, disclosed is a method for identifying a novel functional molecule using the library of the present invention.Type: GrantFiled: December 9, 2013Date of Patent: February 20, 2018Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Shinya Honda, Hideki Watanabe, Kazuhiko Yamasaki
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Patent number: 9895438Abstract: The present invention provides novel therapeutic applications of low dose naltrexone (LDN). Said applications have been determined in light of the discovery by the present inventors that naltrexone acts as an antagonist of Toll-like receptor 9 (TLR9), an innate immune receptor which elicits the production of inflammatory cytokines when agonized. Chronic inflammation and TLR9 overexpression are characteristics of a number of disorders, including certain cancers. Accordingly, the present invention provides novel uses of naltrexone in the treatment of a subject having a disorder characterized by TLR9 overexpression and/or overactivity of TLR9-mediated signalling. The present invention also provides novel uses of naltrexone in the supportive care of subject having a tumor/cancer, and methods of treating and providing supportive care to a subject, comprising the administration of naltrexone.Type: GrantFiled: May 12, 2014Date of Patent: February 20, 2018Assignee: Cancer Vaccine InstituteInventors: Angus Dalgleish, Rachel Allen
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Patent number: 9900243Abstract: Provided is a method and apparatus for setting a detour path in a wideband high frequency wireless system using a centralized Media Access Control (MAC) protocol. Here, in a wireless system using the centralized MAC protocol where a time synchronization and a band allocation may be performed by a single central control unit, when a signal blockage occurs while a data communication is being performed via a direct path between a source device and a destination device, the detour path may be quickly provided.Type: GrantFiled: February 16, 2015Date of Patent: February 20, 2018Assignee: Electronics and Telecommunications Research InstituteInventors: Seung Eun Hong, Kyeongpyo Kim, Yong Sun Kim, Hyoung Jin Kwon, Woo Yong Lee
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Patent number: 9900067Abstract: The present invention relates to a method and apparatus for transmitting and receiving data. A data transmission method from a sender terminal to a receiver terminal in a MIMO system using a variable frequency band according to one embodiment of the present invention comprises: repeatedly generating a signal field depending on a frequency band that is applied to the transmission of a data frame; generating a data field including the data; generating a data frame including the signal field and the data field; and transmitting the data frame to the receiver terminal. The present invention is advantageous in that a signal field which is transmitted together with the data being transmitted from the sender terminal to the receiver terminal in the MIMO system can be sent more efficiently.Type: GrantFiled: January 3, 2014Date of Patent: February 20, 2018Assignee: Electronics and Telecommunications Research InstituteInventors: Jong-Ee Oh, Minho Cheong, Sok-Kyu Lee
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Patent number: 9896457Abstract: Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.Type: GrantFiled: August 29, 2014Date of Patent: February 20, 2018Assignees: OP Bio Factory Co., Ltd., Seed Research Institute Co., Ltd.Inventors: Morita Iwami, Sachi Kato, Yoshimi Matsumoto, Hideo Naoki
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Patent number: 9900959Abstract: This light emitting paper includes a first transparent electrode, a second transparent electrode on the first transparent electrode, a cellulose layer between the first and second transparent electrodes, and light emitting particles in the cellulose layer. The cellulose layer includes cellulose nanofibrils having nanoscale diameters. Each of the light emitting particles includes one of a metal oxide, a metal sulfide, and a metal sulfur oxide and a dopant doped thereinto.Type: GrantFiled: September 2, 2016Date of Patent: February 20, 2018Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventor: Rae-Man Park
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Patent number: 9898666Abstract: An apparatus and method for providing primitive visual knowledge are disclosed. The method of providing primitive visual knowledge includes receiving an image in a form of a digital image sequence, dividing the received image into scenes, extracting a representative shot from each of the scenes, extracting objects from frames which compose the representative shot, extracting action verbs based on a mutual relationship between the extracted objects, selecting a frame best expressing the mutual relationship with the objects, which are the basis for the extracting of the action verbs, as a key frame, generating the primitive visual knowledge based on the selected key frame, storing the generated primitive visual knowledge in a database, and visualizing the primitive visual knowledge stored in the database to provide the primitive visual knowledge to a manager.Type: GrantFiled: January 22, 2016Date of Patent: February 20, 2018Assignee: Electronics and Telecommunications Research InstituteInventors: Kyu-Chang Kang, Yong-Jin Kwon, Jin-Young Moon, Kyoung Park, Chang-Seok Bae, Jeun-Woo Lee
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Patent number: 9900785Abstract: A wireless device capable of enabling improvement in reliability of communication, enlargement of cell regions, improvement in PER and improvement in system performance is provided. The wireless device according to an embodiment is a wireless device which transmits information for a counterpart wireless device, and includes a signal processing unit which generates a symbol sequence; a transmission vector calculating unit which converts the symbol sequence into a plurality of transmission symbol sequences, and controls phases of the transmission symbol sequences to be a same phase or an opposite phase based on a channel estimation to the counterpart wireless device; and a plurality of antennas each of which transmits the plurality of transmission symbol sequences.Type: GrantFiled: January 10, 2014Date of Patent: February 20, 2018Assignee: NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGYInventors: Gabriel Porto Villardi, Hiroshi Harada
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Patent number: 9899222Abstract: A trench structure on a SiC substrate and method for fabricating thereof is provided. The fabricating method includes: providing a SiC substrate; forming a protection layer on the SiC substrate; forming an resisting layer on the protection layer; patterning the resisting layer and the protection layer to form an opening; patterning the SiC substrate by using the patterned resisting layer as a hard mask to form a trench; removing the patterned resisting layer; performing a high-temperature annealing process to form a rounded bottom of the trench; and removing the protection layer.Type: GrantFiled: December 21, 2015Date of Patent: February 20, 2018Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Kuan-Wei Chu, Ming-Jinn Tsai
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Patent number: 9895485Abstract: An IV pole attachment apparatus includes an attachment portion, a first appendage, a second appendage, a receiving portion, protrusions, and an appendage connection portion. The IV pole attachment apparatus is constructed of silicone or another form of elastomeric substance. One end of IV pole attachment apparatus is a ring-shaped attachment portion. The attachment portion is seamlessly molded to the appendage connection portion. Appendage connection portion is seamlessly connected to the first appendage and the second appendage. The first appendage contains three spaced protrusions molded in a linear consecutive arrangement into the appendage. The first appendage is pulled through the receiving portion. The greater diameter of the protrusions keeps them from easily passing back thorough the aperture of the receiving portion and allows for a buckling action that secures the IV pole attachment apparatus to an IV pole.Type: GrantFiled: August 18, 2016Date of Patent: February 20, 2018Assignee: Clinical Biotechnology Research Institute at RSFHInventors: Lauren McNeill, Christopher Lienhop
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Patent number: 9895087Abstract: A wearable apparatus for measuring position and action of an arm includes: a main frame worn on an upper body of a user; and an arm motion-measuring unit connected to a side of the main frame, having a plurality of joints, and worn on an arm of a user, in which at least any one of the joints of the arm motion-measuring unit has a straight-motional degree of freedom. Accordingly, an instructor can conveniently move both arms in the apparatus, can precisely instruct a two-arm robot in motions of the instructor's arms, can reduce learning time of the robot, and can make the robot quickly and accurately learn the motions.Type: GrantFiled: October 19, 2015Date of Patent: February 20, 2018Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Hoo-Man Lee, Joong-Bae Kim, Young-Bong Bang, Chang-Hyuk Lee, Ji-Won Choi
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Patent number: 9896443Abstract: Compounds of formula (1a) and pharmaceutically acceptable salts, solvates, and hydrates thereof and related methods of modulatin perforin activity on a cell: wherein Ring A is selected from a 6-10 membered aryl, 5-6 membered cycloalkyi, 5-6 membered heteroaryl or 5-6 membered heterocyclyl, wherein the heteroaryl and heterocyclyl rings comprise at least one heteroatom selected from N, O or S; and wherein the aryl, cycloalkyi, heteroaryl or heterocyclyl rings are optionally substituted with 1 to 3 substituents selected from halo, nitro, —C1-Cealkyl, —C1-Ceaminoalkyl, —C1-C6hydroxyalkyl, -haloC1-C6alkyl, —C1-C6alkoxyl, -haloC1—C<aIkoxyl, heteroaryl, aryl, hydroxyl, —C(0)Ci-C6alkyl, —OC(0)Ci-C6alkyl, —CH2OC(O)CrC6alkyl, —C(O)OC1, —C6alkyI, —NHC(O)C1, —C6alkyl, —NHS(O)2C1-C6alkyl, —S(O)2C1-C6alkyl, —S(O)2NH2, and —C(O)NJJ; Ring B is a 6-10 membered arylene or a 5-6 membered heteroarylene comprising at least one heteroatom selected from N, 0 or S; and wherein the aryl or heteroaryl is optionally, substituted witType: GrantFiled: August 21, 2013Date of Patent: February 20, 2018Assignee: Peter MacCallum Cancer InstituteInventors: Julie Ann Spicer, William Alexander Denny, Christian Karl Miller, Patrick David O'Connor, Kristiina Huttunen, Joseph A. Trapani, Geoff Hill, Kylie Alexander
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Patent number: 9898648Abstract: A face recognition method of the present disclosure includes configuring aggregations of feature data that include a plurality of feature data of faces and match to a plurality of personnel data; extracting from an input image a plurality of input feature data that correspond to the feature data and that is equal to or more than a critical value; comparing an aggregation of input feature data that includes the input feature data with each of the pre-stored aggregations of feature data, and selecting from the aggregations of feature data an aggregation of feature data having the greatest similarity with the aggregation of the input feature data; and identifying a person on the image based on personnel data that matches the aggregation of feature data having the greatest similarity.Type: GrantFiled: February 16, 2016Date of Patent: February 20, 2018Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventor: Sang Yoon Oh
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Patent number: 9900096Abstract: An electro-optical circuit, includes in part, a modulator, a signal splitter, N signal paths each having one or more signal processing components, N photo-diodes and a signal combiner. The modulator modulates an optical signal using an electrical input signal. The splitter splits the modulated optical signal into N optical signals each delivered to a different one of the N paths for processing by the associated signal processing component(s). Each photo-diode converts an optical signal it receives from its associated optical signal processing component(s) to a current signal. The signal combiner combines the N current signals it receives from the N photo-diodes to generate an output current signal. The signal processing component(s) may be a variable optical delay component, a variable optical gain/attenuation component, or both thus enabling the output current signal to represent a filtered version of the electrical input signal.Type: GrantFiled: September 17, 2014Date of Patent: February 20, 2018Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Seyed Ali Hajimiri, Firooz Aflatouni, Behrooz Abiri
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Patent number: 9896203Abstract: An unmanned aerial vehicle includes a body portion, a plurality of driving portions, a plurality of arms and first and second landing members. The body portion is formed at a center thereof, and the body portion includes an inner space defined by an upper plate, a lower plate and a plurality of supporting frames that connect the upper plate with the lower plate. The plurality of driving portions generate an impellent force for a flight. Each of the plurality of arms has one end connected to the body portion and the other end connected to one of the driving portions.Type: GrantFiled: February 5, 2015Date of Patent: February 20, 2018Assignee: Korea Advanced Institute of Science and TechnologyInventors: Joung-Ho Kim, Youngwoo Kim
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Patent number: 9899184Abstract: An optical vacuum cryostage for correlative light and electron microscopy comprises a vacuum chamber, an anti-contamination system adapter interface, an electron microscope specimen holder adapter interface, an upper optical window, a lower optical window, a vacuum pumping system adapter interface and a vacuum valve, wherein the anti-contamination system adapter interface is arranged in one end of the vacuum chamber, the electron microscope specimen holder adapter interface is arranged in the other end of the vacuum chamber, the upper optical window is arranged on the upper wall of the vacuum chamber, the lower optical window is arranged on the lower wall of the vacuum chamber and opposite to the upper optical window.Type: GrantFiled: July 22, 2015Date of Patent: February 20, 2018Assignee: Institute of Biophysics, Chinese Academy of SciencesInventors: Gang Ji, Shuoguo Li, Fei Sun
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Patent number: 9896456Abstract: This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2.Type: GrantFiled: June 18, 2015Date of Patent: February 20, 2018Assignee: School Juridical Person Kitasato InstituteInventors: Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu
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Patent number: 9896547Abstract: Condensation of fluoro-substituted and silyl-substituted monomers provides polymers suitable for use, e.g., as engineering polymers. A monomer composition is condensed in the presence of a basic catalyst. The monomer composition contains a compound of formula F—X—F and a compound of formula (R1)3Si—Z—Si(R1)3, and forms an alternating X—Z polymer chain and a silyl fluoride byproduct. X has the formula -A(—R2-A)n-; each A is SO2, C(?O), or Het; R2 is an organic moiety; n is 0 or 1; Het is an aromatic nitrogen heterocycle; Z has the formula -L-R3-L; each L is O, S, or N(R4); and each R3 is an organic moiety, and R4 comprises H or an organic moiety.Type: GrantFiled: April 11, 2017Date of Patent: February 20, 2018Assignee: The Scripps Research InstituteInventors: Jiajia Dong, Valery Fokin, Larisa Krasnova, Luke R. Kwisnek, James S. Oakdale, K. Barry Sharpless
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Patent number: 9900738Abstract: Control systems and methods are disclosed for automatically identifying mobile communication devices located within a vicinity of a gunshot. The control system may discriminates gunshots from other environmental noise and determine the location of the gunshot from information provided by a set of acoustic sensors. Once the gunshot location is determined, the control system may automatically trigger activation of one or more cell site simulators located near the location of the gunshot to identify mobile communication devices within the vicinity. Further precision in identifying the locations of the mobile communication devices may be obtained by using information from radio frequency (RF) sensors that intercept wireless RF transmissions from the mobile communication devices communicating with the activated cell site simulator. The control system may be used as a tool identifying and tracking perpetrators of gun crime and may also be used to located witnesses who may otherwise not have come forward.Type: GrantFiled: December 16, 2016Date of Patent: February 20, 2018Assignee: Massachusetts Institute of TechnologyInventor: John Houston Doherty