Patents Assigned to INSTITUTE
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Publication number: 20170319541Abstract: The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C (PKC) in a subject identified with memory loss slowing or reversing memory loss. The present invention provides methods of stimulating cellular growth, neuronal growth, dendritic growth, dendritic spine formation, dendritic spine density, and the translocation of ELAV to proximal dendrites, and synaptic remodeling. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to stimulate the synthesis of proteins sufficient to consolidate long-term memory. The present invention also provides methods of contacting a protein kinase C (PKC) activator with a PKC activator in a manner sufficient to downregulate PKC.Type: ApplicationFiled: March 24, 2014Publication date: November 9, 2017Applicant: Blanchette Rockefeller Neuroscience InstituteInventor: Daniel L. ALKON
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Publication number: 20170322083Abstract: Disclosed are a time division spread spectrum code-based optical spectroscopy system capable of controlling irradiation power and a method for controlling the optical spectroscopy system. The optical spectroscopy system may comprise: a light transmission unit for irradiating light to a particular region of a subject by means of a light source, wherein the light is irradiated so that the overall energy is consistently maintained by reducing the light irradiation time and increasing the strength of the light; and a light receiving unit for collecting emergent light which has passed through the particular region.Type: ApplicationFiled: November 14, 2014Publication date: November 9, 2017Applicant: Korea Advanced Institute of Science and TechnologyInventors: Hyeon Min BAE, Jong Kwan CHOI, Min Gyu CHOI, Jae Myoung KIM, Gun Pil HWANG
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Publication number: 20170324078Abstract: An apparatus and a method for making lithium iron phosphate are disclosed. The apparatus comprises a raw material system to provide a raw material mixed solution of raw materials of a hydrothermal reaction or a solvothermal reaction; a tubular reaction device to make the raw material mixed solution in a plug flowing and reacting state to obtain a reacted material; and a kettle reaction device to make the reacted material in a complete mixing and reacting state to obtain a product. The method comprises providing a raw material mixed solution of raw materials of a hydrothermal reaction or a solvothermal reaction; making the raw material mixed solution in a plug flowing and reacting state to obtain a reacted material; and making the reacted material in a complete mixing and reacting state. The lithium iron phosphate can be continuously produced by the apparatus and method.Type: ApplicationFiled: July 26, 2017Publication date: November 9, 2017Applicants: Jiangsu Huadong Institute of Li-Ion Battery Co., L td., Tsinghua UniversityInventors: LI WANG, XIANG-MING HE, JING LUO, CHENG-HAO XU, JIAN-JUN LI, DAN LV, YU-MING SHANG, HONG-SHENG ZHANG
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Publication number: 20170321117Abstract: Colloidal perovskite nanoplatelets can provide a material platform, with tunability extending from the deep UV, across the visible, into the near-IR. The high degree of spectral tunability can be achieved through variation of the cation, metal, and halide composition as well as nanoplatelet thickness.Type: ApplicationFiled: May 3, 2017Publication date: November 9, 2017Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Mark Clayton Weidman, Michael Seitz, WIlliam Alfred Tisdale
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Publication number: 20170323843Abstract: A three-dimensional integrated circuit includes two or more stacks of one or more active layers; a gas-cooling layer separating the two or more stacks and a wireless interconnect between the two or more stacks enabling communication between the two or more stacks and system including a gas-cooled three-dimensional integrated circuit having wireless data interconnects is disclosed.Type: ApplicationFiled: May 5, 2017Publication date: November 9, 2017Applicant: Rochester Institute of TechnologyInventors: Amlan Ganguly, Satish G. Kandlikar
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Publication number: 20170320738Abstract: A solvothermal apparatus for making lithium iron phosphate is disclosed. The solvothermal apparatus comprises a manufacture unit and a recycle unit. The manufacture unit comprises a feeding device, a reaction device, a filtering device, and a countercurrent washing device which are sequentially connected to each other. The recycle unit comprises a flash evaporation device and a solid-liquid separation device connected to the flash evaporation device. A waste liquid produced by the manufacture unit is recycled by the recycle unit.Type: ApplicationFiled: July 25, 2017Publication date: November 9, 2017Applicants: Jiangsu Huadong Institute of Li-Ion Battery Co., L td., Tsinghua UniversityInventors: XIANG-MING HE, CHENG-HAO XU, LI WANG, JIAN-JUN LI, YU-MING SHANG, JIAN GAO, YAO-WU WANG
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Publication number: 20170324541Abstract: Disclosed are a method for acquiring synchronization in a cable network, and a physical (PHY) transmitter and PHY receiver. The method for acquiring synchronization in a cable network according to an embodiment includes receiving, by a PHY receiver, a signal from a PHY transmitter, and acquiring, by the PHY receiver, channel synchronization when a symbol in which a channel preamble exists is detected from the received signal and a position of a frequency in which a channel subcarrier exists is detected from the detected symbol by performing a cross correlation operation on the received signal and the channel preamble.Type: ApplicationFiled: February 24, 2017Publication date: November 9, 2017Applicant: Electronics and Telecommunications Research InstituteInventors: Jae Hwui BAE, Sang Jung RA, Jin Hyuk SONG, Dong Joon CHOI, Nam Ho HUR
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Publication number: 20170322315Abstract: A measurement method for an air kerma conventional true value comprises: building a small-scale reference radiation field, then selecting a proper radiation source (4) and a source intensity for providing incident rays for a shielding box (1), subsequently selecting a plurality of gamma ray dose measurement instruments as experiment samples for building a prediction model to obtain a prediction model of the air kerma conventional true value of a check point, fmally placing a probe of an instrument to be detected on the check point (6), recording a scattering gamma spectrum detected by a gamma-ray spectrometer (9), and importing the prediction model to obtain the air kerma conventional true value. The method relates to the field of radiation protection detection or calibration, and has the beneficial effects that the result is accurate, the reference radiation field used is small in size, and the method is applied to measurement of the air kerma conventional true value.Type: ApplicationFiled: June 1, 2015Publication date: November 9, 2017Applicant: INSTITUTE OF NUCLEAR PHYSICS AND CHEMISTRY, CHINA ACADEMY OF ENGINEERING PHYSICSInventors: Benjiang MAO, Yixin LIU, Yang XU, Meng HE, Renhong ZHUO, Dezhi WEN, Dajie DING, Jing CHENG, Hui ZHENG
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Publication number: 20170320966Abstract: A humanized monoclonal antibody against the CD34 surface antigen is provided in the present disclosure. The humanized monoclonal antibody includes a light chain variable region and a heavy chain variable region. In which, a nucleotide sequence encoding the amino acid sequence for the light chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 9 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 9, and a nucleotide sequence encoding the amino acid sequence for the heavy chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 10 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 10.Type: ApplicationFiled: May 8, 2017Publication date: November 9, 2017Applicant: Industrial Technology Research InstituteInventors: Chia-Yu FAN, Min-Yuan CHOU
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Publication number: 20170324212Abstract: Disclosed herein is a single pulse laser apparatus that includes: a resonator having a first mirror, a second mirror, a gain medium, an electro-optic modulator (EOM) configured to perform single pulse switching, and an acousto-optic modulator (AOM) configured to perform mode-locking; a photodiode configured to measure a laser beam oscillated in the resonator; a synchronizer configured to convert an electrical signal, which is generated by measuring the laser beam, into a transistor-transistor logic (TTL) signal; a delay unit configured to set a delay time for the TTL signal to synchronize the EOM and the AOM and output a trigger TTL signal according to the delay time; an AOM driver configured to input the trigger TTL signal to the AOM that performs mode-locking and drive the AOM; and an EOM driver configured to input the trigger TTL signal to the EOM that performs single pulse switching and drive the EOM.Type: ApplicationFiled: December 14, 2016Publication date: November 9, 2017Applicant: Korea Institute of Science and TechnologyInventors: Young Min JHON, Joon Mo AHN, Min Ah SEO, Chul Ki KIM, Jae Hun KIM, Taik Jin LEE, Jae Bin CHOI, Deok Ha WOO
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Publication number: 20170320844Abstract: Disclosed is a method for preparing a 2,5-disubstituted furan compound. The 2,5-disubstituted furan compound is prepared in a simple, convenient and highly efficient way by reacting 2,3-dicarboxylic anhydride-7-oxabicyclo[2.2.1]hept-5-ene and/or furan with an acylating reagent and/or an alkylating reagent. The preparation method is simple and efficient, has a short process and less by-products, and the 2,5-disubstituted furan compound prepared by using the method has a high purity, and can satisfy the requirements for being used as a raw material for engineering plastics, such as high-performance polyesters, epoxy resins, polyamides, polyurethanes and the like, and as a chemical raw material and a pharmaceutical intermediate raw material.Type: ApplicationFiled: December 17, 2014Publication date: November 9, 2017Applicant: Ningbo Institute of Materials Technology & Engineering, Chinese Academy of SciencesInventors: Jinggang WANG, Xiaoqing LIU, Jin ZHU, Haining NA
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Publication number: 20170319483Abstract: A method for producing porous particles includes (1) a step of preparing a solution of an amphiphilic substance by dissolving the amphiphilic substance in a mixed solvent capable of being freeze-dried, (2) a step of producing a precipitate containing the amphiphilic substance by cooling the solution obtained in step (1) to a temperature equal to or less than a phase separation temperature of the solution, and thereafter holding the solution at the temperature, and (3) a step of producing porous particles by freeze-drying the solution containing the precipitate obtained in the step (2).Type: ApplicationFiled: November 16, 2015Publication date: November 9, 2017Applicant: National Institute for Materials ScienceInventors: Shaoling Zhang, Kohsaku Kawakami, Katsuhiko Ariga
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Publication number: 20170320737Abstract: A solvothermal method for making a lithium iron phosphate is disclosed. The waste liquid of a solvothermal reaction is treated synthetically by flash evaporation and a centrifugal separation to separate the water, the organic solvent, and the lithium sulfate, which is a byproduct from each other. One part of the separated organic solvent is reused as a reaction material of the solvothermal reaction to form a organic solvent recycle circuit. The other part of the separated organic solvent is mixed with the separated water to be used as a washing liquid. The washing liquid is retreated by flash evaporation and centrifugal separation to obtain the water and the organic solvent again to form a washing liquid circuit.Type: ApplicationFiled: July 25, 2017Publication date: November 9, 2017Applicants: Jiangsu Huadong Institute of Li-Ion Battery Co., Ltd., Tsinghua UniversityInventors: XIANG-MING HE, CHENG-HAO XU, LI WANG, JIAN-JUN LI, YU-MING SHANG, JIAN GAO, YAO-WU WANG
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Publication number: 20170320039Abstract: A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization.Type: ApplicationFiled: May 3, 2017Publication date: November 9, 2017Applicant: Massachusetts Institute of TechnologyInventors: Ruixuan Gao, Ishan Gupta, Edward S. Boyden
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Publication number: 20170320182Abstract: A CNC machine shaping tool is efficiently used by monitoring human audible sound during shaping. A sound information set is created for a tool shaping a workpiece. Shaping sounds are recorded and sliced into short term units. A human operator assigns tool condition labels to each slice. Short term units are combined into mid term units. Noise is reduced by profiling. Mid term sound related features of time and frequency domains are extracted. Dimensionality is reduced by robust principal component analysis. The principal component set is balanced, e.g. by SMOTE. A classifier and principal components are selected. An information set of patterns of values of selected principal components for the tool is created. In an industrial setting, shaping sounds are recorded, noise reduced and select principal component vector values are compared to the tool condition labeled patterns of values in the information set to identify tool condition before deterioration.Type: ApplicationFiled: May 4, 2017Publication date: November 9, 2017Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventor: Hyunsoo Jeong
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Publication number: 20170319156Abstract: Provided is a method of generating a virtual x-ray image, the method including: obtaining a 3-dimensional (3D) image of a patient; determining a projection direction of the 3D image in consideration of a position relationship between an x-ray source of an x-ray device and the patient; and generating a virtual x-ray image by projecting the 3D image on a 2D plane in the determined projection direction.Type: ApplicationFiled: April 27, 2017Publication date: November 9, 2017Applicant: Daegu Gyeongbuk Institute of Science and TechnologyInventors: Jae-Sung HONG, Sang-Seo JEON, Seong-Pung LEE
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Publication number: 20170321222Abstract: Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of the formation or maintenance of cytoplasmic inclusions of TDP-43. Compounds identified by such screens can be used to treat or prevent TDP-43 proteinopathies such as frontotemporal lobar degeneration or amyotrophic lateral sclerosis.Type: ApplicationFiled: July 14, 2017Publication date: November 9, 2017Applicant: Whitehead Institute for Biomedical ResearchInventors: Susan L. Lindquist, Aaron D. Gitler
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Patent number: 9808798Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.Type: GrantFiled: April 22, 2013Date of Patent: November 7, 2017Assignee: California Institute of TechnologyInventors: Rustem F. Ismagilov, Qichao Pan, Stefano Begolo
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Patent number: 9813235Abstract: Technology is generally described for improving resistance to cache timing attacks made on block cipher encryption implementations. In some examples, the technology can include identifying one or more tunable parameters of the block cipher encryption algorithm; creating multiple encryption algorithm implementations by varying one or more of the parameter values; causing a computing system to encrypt data using the implementations; measuring average execution times at the computing system for the implementations subjecting the implementations to a cache timing attack; measuring average execution times at the computing system for the implementations subjected to a cache timing attack; computing a time difference between the average execution times for the implementations when not subjected and when subjected to a cache timing attack; selecting an implementation having a lower time difference; and using the selected implementation for a subsequent encryption operation.Type: GrantFiled: April 25, 2013Date of Patent: November 7, 2017Assignee: INDIAN INSTITUTE OF TECHNOLOGY KHARAGPURInventors: Debdeep Mukhopadhyay, Chester Dominic Rebeiro
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Patent number: 9812886Abstract: A method of diagnosing a battery and adaptively adjusting charging modes of the battery includes the steps of initially charging the battery using a constant current mode, wherein the battery is charged by a fix current in the constant current mode; monitoring a deterioration index by a battery management system (BMS), the deterioration index including a highest temperature (Tempmax), an instantaneous temperature difference (?Temp), an instantaneous voltage difference (?V), an instantaneous internal resistance (IRmax), and a state of charge (SoC) of the battery; when Temp exceeds a predetermined temperature threshold, pausing charging the battery; charging the battery by a constant power charging mode when Tempmax becomes smaller than 90% of the predetermined temperature threshold, wherein the battery is charged by a fix electric power in the constant power mode; charging the battery by the constant current charging mode when Tempmax becomes smaller than 50% of the predetermined temperature thresh old.Type: GrantFiled: December 18, 2015Date of Patent: November 7, 2017Assignee: NATIONAL CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Wen-Chen Lih, Chiu-Hua Tseng, Shiow-Yueh Ma, Yu-Min Liao