Abstract: The present invention provides a method of aligning a quadrate wafer in a first photolithography process. The method includes: step A: fabricating mask aligning markers in a periphery region of a mask, which is used for a first exposure process of the quadrate wafer, around a mask pattern of the mask; step B: during the first exposure process, positioning the quadrate wafer in a preset region by using the mask aligning markers on the mask, and exposing the quadrate wafer through the mask; and step C: performing alignment for the quadrate wafer during a second exposure process and subsequent exposure processes by using aligning markers on the quadrate wafer that are obtained during the first exposure process. The method may be easily and reliably performed to ensure intact dies at periphery of a quadrate wafer to be produced and thus render increased yield of chips.

Abstract: Provided in one embodiment is a method of identifying a stable phase of an ordering binary alloy system comprising a solute element and a solvent element, the method comprising: determining at least three thermodynamic parameters associated with grain boundary segregation, phase separation, and intermetallic compound formation of the ordering binary alloy system; and identifying the stable phase of the ordering binary alloy system based on the first thermodynamic parameter, the second thermodynamic parameter and the third thermodynamic parameter by comparing the first thermodynamic parameter, the second thermodynamic parameter and the third thermodynamic parameter with a predetermined set of respective thermodynamic parameters to identify the stable phase; wherein the stable phase is one of a stable nanocrystalline phase, a metastable nanocrystalline phase, and a non-nanocrystalline phase.

Abstract: The invention relates to the medicine, namely to an agent for reducing the cholesterol and triglycerides in the blood plasma. The agent claimed comprises a nanocomposite that is a carbon-containing nanoparticles coated with the organic alkyl functional groups representing the residuals —C4H9, —C6H11, —C8H15, —C10H21, —C16H33, —C18H35. These groups are deposited by the covalent modification using diazonium salts of the general formula XC6H4N2+Y?, where X is the alkyl residual —C4H9, —C6H11, —C8H15, —C10H21, —C16H33, or C18H35, Y is the anion HSO4?, Cl?, BF4? or TsO?. The invention provides an effective reduction of cholesterol and triglyceride presented in the blood plasma.

Abstract: Disclosed herein is a high-capacity slurry electrode for use in a flow energy storage system, comprising: an electrolyte; electrode active particles, distributed in the electrolyte, functioning as an electrode active material in an electrochemical flow capacitor storage system; and a redox active material, dissolved in the electrolyte, behaving as a pseudo-capacitor through a redox reaction on a surface of the electrode active material, wherein the high-capacity slurry electrode exhibits both capacitor properties based on the electrode active particles and pseudo-capacitor properties based on the redox active material.

Abstract: The present invention is related to a radiolabeled active targeting pharmaceutical composition, including: a bioconjugate and a radionuclide, wherein the bioconjugate includes a biomolecule and a metal nanoparticle, wherein the biomolecule has an affinity for receptors on the surface of a cell membrane and is selected from the group consisting of a peptide and a protein. The present invention further provides a method for evaluating a thermal adjuvant therapy for tumors and a kit thereof. The above-mentioned pharmaceutical composition is applied to evaluate a tumor accumulation time, so as to establish the optimal policy for a radiofrequency- or laser-induced thermal adjuvant therapy for tumors.

Abstract: The invention generally provides a sieve valve including: a substrate defining a channel; a flexible membrane adapted and configured for deployment at an intersection with the channel; and one or more protrusions extending into the channel from the substrate or the flexible membrane. The one or more protrusions define a plurality of recesses extending beyond the intersection between the channel and the flexible membrane; A microfluidic circuit including one or more sieve valves. In particular embodiments, the circuit comprises one or more input/output valves. The one or one or more input/output valves can include one or more input valves and one or more output valves. The microfluidic circuit can further include a mixing circuit. At least one of the sieve valves can be positioned between the one or more input/output valves and the mixing circuit. The invention further provides methods of using the device for the analysis of samples comprising cells.

Abstract: Disclosed is a filter including a second layer disposed between a first layer and a third layer. The first layer is composed of iron. The second layer is composed of 1 part by volume of lithium fluoride, 20 to 50 parts by volume of aluminum, and 50 to 80 parts by volume of aluminum fluoride. The third layer is composed of 1 part by weight of lithium fluoride and 99 to 100 parts by weight of magnesium fluoride.

Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and ?-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The present invention relates to a nanometal-flake graphite composite and a method of manufacturing the same, and more particularly, to a nanometal-flake graphite composite, in which nanometal-flake graphite, in which crystallized nanometal particles are highly densely bonded to the surface of flake graphite, is coated with polydopamine to form a polydopamine coating layer which significantly improves properties such as bonding properties between flake graphite basal planes, adhesiveness with other media, and dispersibility, and a method of manufacturing the nanometal-flake graphite composite.

Abstract: Disclosed herein is a single pulse laser apparatus that includes: a resonator having a first mirror, a second mirror, a gain medium, an electro-optic modulator (EOM) configured to perform single pulse switching, and an acousto-optic modulator (AOM) configured to perform mode-locking; a photodiode configured to measure a laser beam oscillated in the resonator; a synchronizer configured to convert an electrical signal, which is generated by measuring the laser beam, into a transistor-transistor logic (TTL) signal; a delay unit configured to set a delay time for the TTL signal to synchronize the EOM and the AOM and output a trigger TTL signal according to the delay time; an AOM driver configured to input the trigger TTL signal to the AOM that performs mode-locking and drive the AOM; and an EOM driver configured to input the trigger TTL signal to the EOM that performs single pulse switching and drive the EOM.

Abstract: This invention provides a novel screening system for identifying p53 mimetics/agonists. Also provided are small organic molecules that act as effective p53 mimetics/agonists.

Abstract: The present invention relates to a time delay estimation device. The time delay estimation device of the present invention includes a sound signal detection unit configured to detect sound signals through a plurality of microphones, a frequency domain conversion unit configured to convert the detected sound signals into signals of a frequency domain, and a time delay estimation unit configured to estimate a time delay on the basis of a slope of a phase difference between the sound signals converted into the frequency domain.

Abstract: Provided are a nanostructure and an optical device including the nanostructure. The nanostructure is formed on a two-dimensional material layer such as graphene and includes nanopatterns having different shapes. The nanopatterns may include a first nanopattern and a second nanopattern and may be spherical; cube-shaped; or poly-pyramid-shaped, including a triangular pyramid shape; or polygonal pillar-shaped.

Abstract: A liquid-crystal photo-alignment layer that is composed of polymer stabilized azo dyes is provided, where a polymer network is introduced in the photo-alignment layer for stabilization. The photo-alignment layer is realized based on a two-step irradiation to first achieve molecule alignment to form the photo-alignment layer and then stabilize this layer. To realize the photo-alignment layer, a pre-determined surface of the substrate is first coated with a film of mixture. The mixture comprises an azo dye and a monomer preferably mixed in an optimal concentration of 0.67 wt/wt. The azo dye and the monomer have light-absorption peaks at different wavelengths such that photo-alignment of the azo-dye molecules and stabilization of the photo-alignment layer by polymerization of the monomer are achievable by two separate exposures of light to the film.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof.

Abstract: A microscope has a light source for generating a light beam having a wavelength, ?, and beam-forming optics configured for receiving the light beam and generating a Bessel-like beam that is directed into a sample. The beam-forming optics include an excitation objective having an axis oriented in a first direction. Imaging optics are configured for receiving light from a position within the sample that is illuminated by the Bessel-like beam and for imaging the received light on a detector. The imaging optics include a detection objective having an axis oriented in a second direction that is non-parallel to the first direction. A detector is configured for detecting signal light received by the imaging optics, and an aperture mask is positioned.

Abstract: A gateway, system and method for multiple radio access technology service are provided. The gateway is between base stations and a core network, including a receiving module, determining module and processing module. The receiving module receives a packet from the base stations or the core network through a tunnel between the base stations and the core network. The determining module determines whether the packet has a virtual IP header. If the packet has a virtual IP header, the processing module deletes the virtual IP header and replaces it with a tunnel header to transmit the packet to the core network through the tunnel by the tunnel header. If the packet has no virtual IP header, the processing module forwards the packet to the core network through the tunnel. The disclosure enhances transmitting and processing performance of the packet when the packet is transmitted through only a single tunnel.

Abstract: A bit interleaver, a bit-interleaved coded modulation (BICM) device and a bit interleaving method are disclosed herein. The bit interleaver includes a first memory, a processor, and a second memory. The first memory stores a low-density parity check (LDPC) codeword having a length of 16200 and a code rate of 2/15. The processor generates an interleaved codeword by interleaving the LDPC codeword on a bit group basis. The size of the bit group corresponds to a parallel factor of the LDPC codeword. The second memory provides the interleaved codeword to a modulator for 64-symbol mapping.

Abstract: Provided are apparatuses and methods of resampling event data for quantitative improvement of a PET image, which acquire a quantitatively-improved new PET image by analyzing a storage format of list data prior to conversion into the PET image and nonparametrically resampling event data from the list data based on the analysis results to improve noise and statistical characteristics thereof. The quantitatively improved new PET image may be acquired by analyzing a storage format of list data constituting the PET image and nonparametrically resampling event data to improve noise and statistical characteristics thereof.