Abstract: Provided herein are deuterated compounds and compositions useful in increasing PPAR? activity. The compounds and compositions provided herein are useful for the treatment of PPAR? related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

Abstract: Provided herein are compositions and methods of treating muscular dystrophy (MD), such as administering an effective amount of a composition that increases the expression of JAG1, a composition comprising a JAG1 agonist, or a composition that promotes JAG1 signaling. Also provided are methods of prognosing MD or evaluating responsiveness to treatment for MD, e.g., by measuring an expression level of JAG1, and methods of identifying a compound for the treatment of MD.

Abstract: Chemically anchoring long-chain polymer networks of tough hydrogels on solid surfaces can represent a general strategy to design tough and functional bonding between hydrogels and solid materials, achieving interfacial toughness over 1000 Jm?2.

Abstract: Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

Abstract: A system, method, and computer program product for presenting a video. A method of the present invention includes a link-map, where the link-map comprises one or more segments and one or more links between segments and where each link is associated with a user category. The method further includes retrieving a current segment to play for a user associated with a user category. The retrieving includes traversing a link of the link-map based on the user category. The retrieving further includes selecting the current segment to play from the plurality of segments based on traversing the link-map. The method further includes playing the current segment. The method further includes repeating the retrieving and playing steps until an end condition is reached.

Abstract: Provided are a method of buffering a media transport stream in a heterogeneous network environment and an image receiving apparatus using the same. A first transport stream corresponding to a first image through a first network is received and a second transport stream corresponding to a second image through a second network is received. The first image corresponding to the first transport stream is buffered based on a preset minimum transmission delay difference, and then the buffered first image and the second image corresponding to the second transport stream are processed.

Abstract: The present invention provides methods of treatment for hematological malignancies involving synergistic combination of a proteasome inhibitor, a glucocorticoid, an arsenic-containing compound, and ascorbic acid or a derivative thereof provide an unexpected efficacy in the treatment for hematological disorders. The hematological disorders treated by the current invention include multiple myeloma, and may also include hematological disorders that are refractory to prior cancer treatments, or relapsed hematologic disorders.

Abstract: The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or IL12p40. The composition comprises neural stem cells and a neurotrophic factor, which is constructed by IL12p40 as at least one subunit. The methods to enhance nerve regeneration comprise providing a nerve regeneration composition comprising a neurotrophic factor containing IL12p40 as at least one subunit to a subject. The composition of the methods can further comprise neural stem cells.

Abstract: An aqueous tumor-targeting liposome nanoparticle composition comprises an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises a legumain-targeting lipid component and polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.

Abstract: Aromatic farnesyl compound and application of a pharmaceutical salt thereof as an inhibitor of ?-glucosidase, dipeptidyl peptidase-4, aldose reductase, protein tyrosine phosphatase-1B or HMG-CoA reductase, or use thereof in preparing medicine and functional healthcare products having a liver protective function and/or for treating and/or preventing type II diabetes, diabetic retinopathy, diabetic foot disease, and hyperlipidemia.

Abstract: A multi-stage process for recovering acid gas from natural gas having high acid gas contents utilizes two or more membrane absorption contactors arranged in series. The first membrane absorption contactor uses a physical solvent to remove a high volume of acid gas transferred across a membrane, and to reduce the acid gas content in the natural gas to a lower level that can be managed using chemical solvents. The second and, if needed, subsequent membrane absorption contactors can use a chemical solvent to remove acid gas transferred across the respective membranes and reduce the acid gas content in the natural gas to very low levels, if needed, depending on product specifications.

Abstract: The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition 2,4-disulfonyl ?-phenyl tertiary butyl nitrone and N-acetylcysteine (NAC). Preferably, the compositions for treating AAT will be administered orally. However, other methods which deliver the compositions for treating AAT systemically to the body should work equally well.

Abstract: A charged particle beam irradiation apparatus according to an embodiment includes: a first scanning electromagnet device configured to deflect a charged particle beam to a second direction that is substantially perpendicular to a first direction along which the charged particle beam enters, the first scanning electromagnet device having an aperture on an outlet side larger than that on an inlet side; and a second scanning electromagnet device configured to deflect the charged particle beam to a third direction that is substantially perpendicular to the first direction and the second direction, the second scanning electromagnet device having an aperture on an outlet side larger than that on an inlet side, the first scanning electromagnet device and the second scanning electromagnet device being disposed to be parallel with the first direction.

Abstract: A hydraulic fracturing system and method for enhancing effective permeability of earth formations to increase hydrocarbon production, enhance operation efficiency by reducing fluid entry friction due to tortuosity and perforation, and to open perforations that are either unopened or not effective using traditional techniques, by varying a pump rate and/or a flow rate to a wellbore.

Abstract: A user authentication system for an electronic device for use with a plurality of wireless wearable medical sensors (WMSs) and a wireless base station that receives a biomedical data stream (biostream) from each WMS. The system includes a BioAura engine located on a server, the server has a wireless transmitter/receiver with receive buffers that store the plurality of biostreams, the biostream from a single WMS lacks the discriminatory power to identify the user, the BioAura engine has a look up stage and a classifier, the classifier generates an authentication output based on the plurality of biostreams, the authentication output authenticates the user's access to the electronic device. The wireless base station has a transmitter/receiver having receive buffers that store the biomedical data from each WMS, the wireless base station has a communication engine that retrieves the biostream from each WMS and transmits the plurality of biostreams to the server.

Abstract: A foldable display, a flexible display and an icon controlling method are provided. The icon controlling method may include the following steps. A detecting unit detects a displaying area of a display panel. A controlling unit changes a grouping level of multiple icons according to the displaying area.

Abstract: A low density parity check (LDPC) encoder, an LDPC decoder, and an LDPC encoding method are disclosed. The LDPC encoder includes first memory, second memory, and a processor. The first memory stores an LDPC codeword having a length of 64800 and a code rate of 7/15. The second memory is initialized to 0. The processor generates the LDPC codeword corresponding to information bits by performing accumulation with respect to the second memory using a sequence corresponding to a parity check matrix (PCM).

Abstract: Provided is a photodetector including a substrate, a first doped region on the substrate, a second doped region having a ring structure, wherein the second doped region is provided in the substrate, surrounds the first doped region and is horizontally spaced apart from a side of the first doped region, an optical absorption layer on the first doped region, a contact layer on the optical absorption layer, a first electrode on the contact layer, and a second electrode on the second doped region.

Abstract: Disclosed are an airplane system including duplex modules, and a control method thereof. The control method of the airplane system includes: receiving, by each of a plurality of duplex modules, a corresponding event command from a client; performing, by a first module, a first event specified by the event command in response to the event command; performing, by a second module different from the first module, a second event specified by the event command after the first event is completed; and returning a first response signal indicating a result of the performance of the first event and a second response signal indicating a result of the performance of the second event to the client, in which the client compares the first response signal and the second response signal, and determines whether the plurality of duplex modules is synchronized or has an error.

Abstract: The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.